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公开(公告)号：US06248756B1
公开(公告)日：2001-06-19
申请号：US09248883
申请日：1999-02-11
申请人： Neville J. Anthony , Christopher Dinsmore , Robert P. Gomez , John H. Hutchinson , John S. Wai , Theresa M. Williams , Ian M. Bell , Mark W. Embrey , Thorsten E. Fisher
发明人： Neville J. Anthony , Christopher Dinsmore , Robert P. Gomez , John H. Hutchinson , John S. Wai , Theresa M. Williams , Ian M. Bell , Mark W. Embrey , Thorsten E. Fisher
IPC分类号： A61K314468
CPC分类号： C07D401/06 , C07D211/62 , C07D401/12 , C07D401/14 , C07D413/14
摘要： The present invention is directed to compounds which inhibit farnesyl-protein transferas (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
摘要翻译： 本发明涉及抑制法尼基蛋白转移（Fatease-protein transferas，FTase）和致癌基因蛋白Ras的法呢基化的化合物。 本发明进一步涉及含有本发明化合物的化疗组合物和抑制法呢基蛋白转移酶的方法和癌基因蛋白Ras的法呢基化。
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公开(公告)号：US20070054892A1
公开(公告)日：2007-03-08
申请号：US10572236
申请日：2004-09-22
申请人： Richard Isaacs , Christopher Dinsmore , B. Trotter , Nigel Liverton , Douglas Beshore , Nathan Kett , Charles McIntyre , Kausik Nanda , David Claremon
发明人： Richard Isaacs , Christopher Dinsmore , B. Trotter , Nigel Liverton , Douglas Beshore , Nathan Kett , Charles McIntyre , Kausik Nanda , David Claremon
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/4709 , C07D413/02 , C07D403/02 , C07D401/02
CPC分类号： C04B35/632 , C07D217/22 , C07D217/26 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D409/12 , C07D417/04
摘要： The present invention relates to compounds of structural formula I: I useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
摘要翻译： 本发明涉及结构式I的化合物：可用作治疗心律失常的钾通道抑制剂等。
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公开(公告)号：US20060293358A1
公开(公告)日：2006-12-28
申请号：US11473273
申请日：2006-06-22
申请人： Christopher Dinsmore , Ana Gabarda Ortega , David Guerin , James Jewell , Jason Katz , Jongwon Lim , Michelle Machacek , Ryan Otte , Jonathan Young
发明人： Christopher Dinsmore , Ana Gabarda Ortega , David Guerin , James Jewell , Jason Katz , Jongwon Lim , Michelle Machacek , Ryan Otte , Jonathan Young
IPC分类号： A61K31/473 , C07D221/02
CPC分类号： C07D471/04 , C07D221/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07D487/04 , C07D491/10 , C07D491/113 , C07F7/1804
摘要： The present invention relates to 5H-benzo[4,5]cyclohepta[1,2-b]pyridine compounds, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
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公开(公告)号：US20060030595A1
公开(公告)日：2006-02-09
申请号：US11188466
申请日：2005-07-25
申请人： Mark Bilodeau , Christopher Dinsmore , Jeffrey Bergman , B. Trotter , Lou Neilson , Zhicai Wu , Peter Manley , John Hartnett
发明人： Mark Bilodeau , Christopher Dinsmore , Jeffrey Bergman , B. Trotter , Lou Neilson , Zhicai Wu , Peter Manley , John Hartnett
IPC分类号： A61K31/506 , A61K31/444 , C07D401/14 , C07D403/14
CPC分类号： C07D213/57 , C07D213/06 , C07D213/30 , C07D213/42 , C07D213/61 , C07D213/64 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/81 , C07D213/84 , C07D401/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to compounds having the structure useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
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![PYRAZOLO [3,4-B] PYRIDIN-4-ONE KINASE INHIBITORS](/abs-image/US/2012/08/30/US20120220624A1/abs.jpg.150x150.jpg)
公开(公告)号：US20120220624A1
公开(公告)日：2012-08-30
申请号：US13497660
申请日：2010-09-29
IPC分类号： A61K31/437 , A61P25/28 , C07D471/04
CPC分类号： C07D471/04
摘要： The present invention is directed to novel kinase inhibitors of general formula (I) and pharmaceutically acceptable salts thereof, and to the use of the kinase inhibitors of general formula (I) for treating diseases or disorders in which tau phosphorylation and cell cycle regulation is implicated, such as Alzheimer's Disease and cancer.
摘要翻译： 本发明涉及通式（I）的新型激酶抑制剂及其药学上可接受的盐，以及通式（I）的激酶抑制剂用于治疗其中涉及tau磷酸化和细胞周期调节的疾病或病症的用途 ，如阿尔茨海默病和癌症。
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公开(公告)号：US20070043042A1
公开(公告)日：2007-02-22
申请号：US10571841
申请日：2004-09-17
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/4709 , C07D413/02 , C07D403/02 , C07D401/02
CPC分类号： C07D215/48 , C07D401/02 , C07D401/04 , C07D401/12 , C07D403/02 , C07D413/02 , C07D413/12 , C07D413/14
摘要： The present invention relates to compounds having the structure (I) useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
摘要翻译： 本发明涉及具有用作治疗心律失常的钾通道抑制剂的结构（I）的化合物等。
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公开(公告)号：US20060128783A1
公开(公告)日：2006-06-15
申请号：US10523286
申请日：2003-08-05
IPC分类号： A61K31/404 , C07D403/02 , C07D209/36
CPC分类号： C07D403/12 , C07D209/42 , C07D401/12 , C07D405/12 , C07D409/12
摘要： The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non-receptor type tyrosine kinases. The compounds of the instant invention possess a core structure that comprises an indole-sulfonamide moiety. The present invention is also related to the pharmaceutically acceptable salts, hydrates and stereoisomers of these compounds.
摘要翻译： 本发明涉及能够抑制，调节和/或调节受体型和非受体型酪氨酸激酶的信号转导的化合物。 本发明的化合物具有包含吲哚磺酰胺部分的核心结构。 本发明还涉及这些化合物的药学上可接受的盐，水合物和立体异构体。
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公开(公告)号：US5780488A
公开(公告)日：1998-07-14
申请号：US824588
申请日：1997-03-26
IPC分类号： C07D213/53 , C07D233/22 , C07D233/24 , C07D233/54 , A61K31/415 , A61K31/44 , C07D213/02
CPC分类号： C07D213/53 , C07D233/22 , C07D233/24
摘要： The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
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公开(公告)号：US20170240567A1
公开(公告)日：2017-08-24
申请号：US15519740
申请日：2015-10-21
申请人： Mark E. Scott , David Guerin , Danielle Molinari , Sam Kattar , Peter Fuller , Christopher Dinsmore , Normon Kong , Yunfeng Bai , Jianmin FU , Yumei Liu , Zhixiang Zheng
发明人： Mark E. Scott , David Guerin , Danielle Molinari , Sam Kattar , Peter Fuller , Christopher Dinsmore , Normon Kong , Yunfeng Bai , Jianmin FU , Yumei Liu , Zhixiang Zheng
IPC分类号： C07D519/00 , A61K31/4545 , A61K31/55 , A61K31/538 , A61K31/541 , A61K31/554 , A61K31/553 , C07D471/04 , A61K31/5377
CPC分类号： C07D519/00 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/5377 , A61K31/538 , A61K31/541 , A61K31/55 , A61K31/553 , A61K31/554 , A61P11/06 , A61P19/02 , A61P35/00 , C07D471/04
摘要： The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer. The present invention provides novel compounds which are inhibitors of JAKs. The invention also provides a method for the treatment and prevention of JAK-mediated diseases and disorders using the novel compounds, as well as pharmaceutical compositions containing the compounds.
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10.发明申请N-(2-CYANO HETEROCYCLYL) PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS 有权N-（2-氰基杂环基）吡唑并吡喃酮作为甘薯激酶抑制剂公开(公告)号：US20160272633A1
公开(公告)日：2016-09-22
申请号：US14778052
申请日：2014-03-19
申请人： Christopher DINSMORE , Peter FULLER , David GUERIN , Christopher F. THOMPSON , Qinglin PU , Mark E. SCOTT , Jason David KATZ , Ravi KURUKLASURIYA , Joshua T. CLOSE , Danielle FALCONE , Jason BRUDAKER , Hongbo ZENG , Yunfeng BAI , Jianmin FU , Norman KONG , Yumei LIU , Zhixiang ZHENG , MERCK SHARP & DOHME CORP.
发明人： Christopher Dinsmore , Peter Fuller , David Guerin , Christopher F. Thompson , Qinglin Pu , Mark E. Scott , Jason David Katz , Ravi Kuruklasuriya , Joshua T. Close , Danielle Falcone , Jason Brubaker , Hongbo Zeng , Yunfeng Bai , Jianmin Fu , Norman Kong , Yumei Liu , Zhixiang Zheng
IPC分类号： C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D519/00
摘要： Provided are compounds of Formula I, a JAK inhibitor, and use thereof for the treatment of JAK-mediated diseases by the application.
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