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25 条记录 (耗时 0.04 秒)

    Medical device with a porous surface for delivery of a therapeutic agent
    4.
    发明授权
    Medical device with a porous surface for delivery of a therapeutic agent 有权
    具有用于递送治疗剂的多孔表面的医疗装置

    公开(公告)号：US08070797B2

    公开(公告)日：2011-12-06

    申请号：US12072666

    申请日：2008-02-27

    申请人： Aiden Flanagan ,  David McMorrow ,  Anthony Malone ,  Tim O'Connor

    发明人： Aiden Flanagan ,  David McMorrow ,  Anthony Malone ,  Tim O'Connor

    IPC分类号： A61F2/06

    CPC分类号： A61F2/06 ,  A61L31/082 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/416

    摘要： The present invention is generally directed to implantable medical devices for delivering therapeutic agents to the body tissue of a patient and methods for making such medical devices. In particular, the present invention is directed to implantable medical devices, such as intravascular stents, having a surface that includes a plurality of cavities and a plurality of pores and a composition disposed in the pores and/or cavities, as well as, implantable medical devices, such as intravascular stents, having a surface that has a coating composition disposed on the surface, wherein the coating composition includes a plurality of cavities and a plurality of pores and another coating composition disposed in the pores and/or cavities.

    摘要翻译： 本发明一般涉及用于将治疗剂递送到患者的身体组织的可植入医疗装置和用于制造这种医疗装置的方法。 特别地，本发明涉及可植入医疗装置，例如血管内支架，其具有包括多个空腔的表面和多个孔以及设置在孔和/或空腔中的组合物，以及植入式医疗 装置，例如血管内支架，其具有设置在表面上的涂层组合物的表面，其中所述涂层组合物包括多个空腔和多个孔以及设置在孔和/或空腔中的另一涂层组合物。

    Medical device with a porous surface for delivery of a therapeutic agent
    6.
    发明申请
    Medical device with a porous surface for delivery of a therapeutic agent 有权
    具有用于递送治疗剂的多孔表面的医疗装置

    公开(公告)号：US20080243231A1

    公开(公告)日：2008-10-02

    申请号：US12072666

    申请日：2008-02-27

    申请人： Aiden Flanagan ,  David McMorrow ,  Anthony Malone ,  Tim O'Connor

    发明人： Aiden Flanagan ,  David McMorrow ,  Anthony Malone ,  Tim O'Connor

    IPC分类号： B05D3/12 ,  A61F2/06

    CPC分类号： A61F2/06 ,  A61L31/082 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/416

    摘要： The present invention is generally directed to implantable medical devices for delivering therapeutic agents to the body tissue of a patient and methods for making such medical devices. In particular, the present invention is directed to implantable medical devices, such as intravascular stents, having a surface that includes a plurality of cavities and a plurality of pores and a composition disposed in the pores and/or cavities, as well as, implantable medical devices, such as intravascular stents, having a surface that has a coating composition disposed on the surface, wherein the coating composition includes a plurality of cavities and a plurality of pores and another coating composition disposed in the pores and/or cavities.

    摘要翻译： 本发明一般涉及用于将治疗剂递送到患者的身体组织的可植入医疗装置和用于制造这种医疗装置的方法。 特别地，本发明涉及可植入医疗装置，例如血管内支架，其具有包括多个空腔的表面和多个孔以及设置在孔和/或空腔中的组合物，以及植入式医疗 装置，例如血管内支架，其具有设置在表面上的涂层组合物的表面，其中所述涂层组合物包括多个空腔和多个孔以及设置在孔和/或空腔中的另一涂层组合物。

    Design of Interventional Cutting Balloon with Enhanced API Delivery Capability
    7.
    发明申请
    Design of Interventional Cutting Balloon with Enhanced API Delivery Capability 审中-公开
    具有增强的API传送能力的介入切割气球的设计

    公开(公告)号：US20130066257A1

    公开(公告)日：2013-03-14

    申请号：US13608237

    申请日：2012-09-10

    申请人： Martyn Folan ,  John Clarke ,  Aiden Flanagan ,  Anthony Malone ,  Tim O'Connor

    发明人： Martyn Folan ,  John Clarke ,  Aiden Flanagan ,  Anthony Malone ,  Tim O'Connor

    IPC分类号： A61B17/22 ,  A61M37/00

    CPC分类号： A61M25/104 ,  A61B17/320725 ,  A61B2017/22061 ,  A61M25/1002 ,  A61M2025/1004 ,  A61M2025/105 ,  A61M2025/1059 ,  A61M2025/1086

    摘要： A medical balloon assembly including an inflatable balloon and at least one cutting element extending from the balloon is disclosed. The inflatable balloon includes an outer wall facing outward and an inner wall facing outward. The cutting element comprises a plurality of openings therein including a first opening and a second opening. The first opening is closed off by a portion of the outer wall. The cutting element further includes a passageway extending from the first opening to the second opening. The passageway is defined by the cutting element and the portion of the outer wall which closes off the passageway. The passageway may contain a therapeutic agent.

    摘要翻译： 公开了一种医用气囊组件，其包括可充气球囊和从球囊延伸的至少一个切割元件。 充气气囊包括面向外的外壁和面向外的内壁。 切割元件包括多个开口，其中包括第一开口和第二开口。 第一开口被外壁的一部分封闭。 切割元件还包括从第一开口延伸到第二开口的通道。 通道由切割元件和封闭通道的外壁部分限定。 通道可以含有治疗剂。

    REDUCTION OF BURST RELEASE FROM THERAPEUTICALLY TREATED MEDICAL DEVICES
    8.
    发明申请
    REDUCTION OF BURST RELEASE FROM THERAPEUTICALLY TREATED MEDICAL DEVICES 审中-公开
    从治疗医疗器械减少爆发

    公开(公告)号：US20080097569A1

    公开(公告)日：2008-04-24

    申请号：US11857849

    申请日：2007-09-19

    申请人： Tim O'Connor ,  Aiden Flanagan ,  Dave McMorrow ,  Anthony Malone

    发明人： Tim O'Connor ,  Aiden Flanagan ,  Dave McMorrow ,  Anthony Malone

    IPC分类号： A61F2/06

    CPC分类号： A61L31/16 ,  A61F2250/0067 ,  A61L31/08 ,  A61L2300/602

    摘要： The present invention generally relates to the conditioning of coated medical devices such as stents. More specifically, the present invention relates to methods for positioning a medical device within an elution media for a predetermined time period to eliminate a burst release from the coating. Under methods and processes of the invention, a medical device target surface may be identified and coated with therapeutic. The coated surface of the medical device may then be positioned within an elution media for a predetermined period of time to release a predetermined amount of coating.

    摘要翻译： 本发明一般涉及诸如支架之类的涂覆的医疗装置的调理。 更具体地，本发明涉及用于将洗涤介质中的医疗装置定位在预定时间段内以消除从涂层中爆发释放的方法。 在本发明的方法和方法下，可以鉴定医疗器械靶表面并用治疗剂涂覆。 然后可以将医疗装置的涂覆表面定位在洗脱介质中预定的时间段以释放预定量的涂层。

    STENTS WITH DRUG ELUTING COATINGS
    9.
    发明申请
    STENTS WITH DRUG ELUTING COATINGS 审中-公开
    带药液涂层的手套

    公开(公告)号：US20080281409A1

    公开(公告)日：2008-11-13

    申请号：US11933517

    申请日：2007-11-01

    申请人： Anthony Malone ,  Tim O'Connor ,  Dave McMorrow ,  Aiden Flanagan

    发明人： Anthony Malone ,  Tim O'Connor ,  Dave McMorrow ,  Aiden Flanagan

    IPC分类号： A61F2/82

    CPC分类号： A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/622

    摘要： Provided is a coated medical device (e.g., a stent) comprising one or more surfaces having dispersed thereon a plurality of microparticles comprising an active pharmaceutical ingredient (API) and a polymer. Specifically, the microparticles are disposed on a device surface in a microparticulate phase coating, i.e., as discrete microparticles in the absence of a continuous phase coating. The medical device effectively adheres one or more APIs to its surface, and allows controlled release of the APIs from the device surface to a desired treatment area by using a minimal amount of polymer. The medical device is suitable for insertion or implantation into a subject, preferably a human. Also provided are methods for preparing and using the coated medical device.

    摘要翻译： 提供了包含一个或多个在其上分散有多个包含活性药物成分（API）和聚合物的微粒的表面的涂覆医疗装置（例如支架）。 具体地，微粒在微粒相涂层中的器件表面上，即在不存在连续相涂覆的情况下作为离散微粒布置。 医疗设备有效地将一个或多个API粘附到其表面，并且允许通过使用最少量的聚合物将API从设备表面控制释放到期望的治​​疗区域。 医疗装置适于插入或植入受试者，优选人。 还提供了制备和使用涂覆的医疗装置的方法。