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1.发明申请Polyelectrolyte multilayer films at liquid-liquid interfaces and methods for providing and using same 有权液 - 液界面的聚电解质多层膜及其提供和使用方法公开(公告)号：US20090023155A1
公开(公告)日：2009-01-22
申请号：US11483891
申请日：2006-07-10
CPC分类号： C08J5/20 , G01N21/6428
摘要： The present invention is directed to methods for providing a polyelectrolyte multilayer film at a liquid-liquid interface. Such methods include steps of sequentially-depositing layers of cationic and anionic polyelectrolytes at a liquid-liquid interface that is formed between immiscible first and second liquids whereby a polyelectrolyte multilayer film is provided at the liquid-liquid interface. In certain preferred embodiments, the first liquid is an aqueous solution and the second liquid is a liquid crystal. In alternative embodiments, the first liquid is an aqueous solution and the second liquid is an oil. The invention further encompasses polyelectrolyte multilayer films provided by the disclosed methods as well as applications utilizing such materials.
摘要翻译： 本发明涉及在液 - 液界面处提供聚电解质多层膜的方法。 这样的方法包括在不混溶的第一和第二液体之间形成的液 - 液界面顺序地沉积阳离子和阴离子聚电解质层，由此在液 - 液界面处提供聚电解质多层膜。 在某些优选实施方案中，第一液体是水溶液，第二液体是液晶。 在替代实施例中，第一液体是水溶液，第二液体是油。 本发明还包括通过所公开的方法提供的聚电解质多层膜以及利用这种材料的应用。
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公开(公告)号：US20100196947A1
公开(公告)日：2010-08-05
申请号：US12685209
申请日：2010-01-11
CPC分类号： C08J5/20 , G01N21/6428
摘要： The present invention is directed to methods for providing a polyelectrolyte multilayer film at a liquid-liquid interface. Such methods include steps of sequentially-depositing layers of cationic and anionic polyelectrolytes at a liquid-liquid interface that is formed between immiscible first and second liquids whereby a polyelectrolyte multilayer film is provided at the liquid-liquid interface. In certain preferred embodiments, the first liquid is an aqueous solution and the second liquid is a liquid crystal. In alternative embodiments, the first liquid is an aqueous solution and the second liquid is an oil. The invention further encompasses polyelectrolyte multilayer films provided by the disclosed methods as well as applications utilizing such materials.
摘要翻译： 本发明涉及在液 - 液界面处提供聚电解质多层膜的方法。 这样的方法包括在不混溶的第一和第二液体之间形成的液 - 液界面顺序地沉积阳离子和阴离子聚电解质层，由此在液 - 液界面处提供聚电解质多层膜。 在某些优选实施方案中，第一液体是水溶液，第二液体是液晶。 在替代实施例中，第一液体是水溶液，第二液体是油。 本发明还包括通过所公开的方法提供的聚电解质多层膜以及利用这种材料的应用。
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3.发明授权Polyelectrolyte multilayer films at liquid-liquid interfaces and methods for providing and using same 有权液 - 液界面的聚电解质多层膜及其提供和使用方法公开(公告)号：US07678545B2
公开(公告)日：2010-03-16
申请号：US11483891
申请日：2006-07-10
IPC分类号： G01N33/53
CPC分类号： C08J5/20 , G01N21/6428
摘要： The present invention is directed to methods for providing a polyelectrolyte multilayer film at a liquid-liquid interface. Such methods include steps of sequentially-depositing layers of cationic and anionic polyelectrolytes at a liquid-liquid interface that is formed between immiscible first and second liquids whereby a polyelectrolyte multilayer film is provided at the liquid-liquid interface. In certain preferred embodiments, the first liquid is an aqueous solution and the second liquid is a liquid crystal. In alternative embodiments, the first liquid is an aqueous solution and the second liquid is an oil. The invention further encompasses polyelectrolyte multilayer films provided by the disclosed methods as well as applications utilizing such materials.
摘要翻译： 本发明涉及在液 - 液界面处提供聚电解质多层膜的方法。 这样的方法包括在不混溶的第一和第二液体之间形成的液 - 液界面顺序地沉积阳离子和阴离子聚电解质层，由此在液 - 液界面处提供聚电解质多层膜。 在某些优选实施方案中，第一液体是水溶液，第二液体是液晶。 在替代实施例中，第一液体是水溶液，第二液体是油。 本发明还包括通过所公开的方法提供的聚电解质多层膜以及利用这种材料的应用。
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公开(公告)号：US08062853B2
公开(公告)日：2011-11-22
申请号：US12685209
申请日：2010-01-11
IPC分类号： G01N33/53
CPC分类号： C08J5/20 , G01N21/6428
摘要： The present invention is directed to methods for providing a polyelectrolyte multilayer film at a liquid-liquid interface. Such methods include steps of sequentially-depositing layers of cationic and anionic polyelectrolytes at a liquid-liquid interface that is formed between immiscible first and second liquids whereby a polyelectrolyte multilayer film is provided at the liquid-liquid interface. In certain preferred embodiments, the first liquid is an aqueous solution and the second liquid is a liquid crystal. In alternative embodiments, the first liquid is an aqueous solution and the second liquid is an oil. The invention further encompasses polyelectrolyte multilayer films provided by the disclosed methods as well as applications utilizing such materials.
摘要翻译： 本发明涉及在液 - 液界面处提供聚电解质多层膜的方法。 这样的方法包括在不混溶的第一和第二液体之间形成的液 - 液界面顺序地沉积阳离子和阴离子聚电解质层，由此在液 - 液界面处提供聚电解质多层膜。 在某些优选实施方案中，第一液体是水溶液，第二液体是液晶。 在替代实施例中，第一液体是水溶液，第二液体是油。 本发明还包括通过所公开的方法提供的聚电解质多层膜以及利用这种材料的应用。
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5.发明授权Silane-functionalized hydrophobic α(1→4)glucopyranose polymers and polymeric matrices for implantation or injection 有权硅烷官能化疏水性α（1→4）吡喃葡萄糖聚合物和聚合物基质用于植入或注射公开(公告)号：US08802121B2
公开(公告)日：2014-08-12
申请号：US12792365
申请日：2010-06-02
CPC分类号： A61K39/39591 , A61L17/005 , A61L17/145 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/256 , A61L2300/624 , C07K2317/55 , Y10T428/31663 , C08L71/02 , C08L67/04
摘要： Silane-functionalized hydrophobic α(1→4)glucopyranose polymers and polymeric matrices are described. Biodegradable matrices can be formed from hydrophobic α(1→4)glucopyranose polymers with reactive pendent silyl ether groups. Reaction of the silyl ether groups provides improved matrix formation through bonding to a device surface of a device, polymer-polymer crosslinking, or both. Biodegradable matrices can be used for the preparation of implantable and injectable medical devices, including those that release a bioactive agent.
摘要翻译： 描述了硅烷官能化的疏水性α（1→4）吡喃葡萄糖聚合物和聚合物基质。 生物可降解基质可以由具有反应性侧挂甲硅烷基醚基团的疏水性α（1→4）吡喃葡萄糖聚合物形成。 甲硅烷基醚基团的反应通过结合到器件的器件表面，聚合物 - 聚合物交联或两者来提供改进的基质形成。 可生物降解基质可用于制备可植入和可注射的医疗器械，包括那些释放生物活性剂的医疗器械。
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6.发明申请SILANE-FUNCTIONALIZED HYDROPHOBIC a(1-4)GLUCOPYRANOSE POLYMERS AND POLYMERIC MATRICES FOR IMPLANTATION OR INJECTION 有权硅烷官能化的疏水性（1-4）葡聚糖聚合物和用于植入或注射的聚合物基质公开(公告)号：US20100303879A1
公开(公告)日：2010-12-02
申请号：US12792365
申请日：2010-06-02
CPC分类号： A61K39/39591 , A61L17/005 , A61L17/145 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/256 , A61L2300/624 , C07K2317/55 , Y10T428/31663 , C08L71/02 , C08L67/04
摘要： Silane-functionalized hydrophobic α(1→4)glucopyranose polymers and polymeric matrices are described. Biodegradable matrices can be formed from hydrophobic α(1→4)glucopyranose polymers with reactive pendent silyl ether groups. Reaction of the silyl ether groups provides improved matrix formation through bonding to a device surface of a device, polymer-polymer crosslinking, or both. Biodegradable matrices can be used for the preparation of implantable and injectable medical devices, including those that release a bioactive agent.
摘要翻译： 描述了硅烷官能化的疏水性α（1→4）吡喃葡萄糖聚合物和聚合物基质。 生物可降解基质可以由具有反应性侧挂甲硅烷基醚基团的疏水性α（1→4）吡喃葡萄糖聚合物形成。 甲硅烷基醚基团的反应通过结合到器件的器件表面，聚合物 - 聚合物交联或两者来提供改进的基质形成。 可生物降解基质可用于制备可植入和可注射的医疗器械，包括那些释放生物活性剂的医疗器械。
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公开(公告)号：US20100221834A1
公开(公告)日：2010-09-02
申请号：US12777320
申请日：2010-05-11
申请人： Nicholas L. Abbott , Jeffrey C. Mohr , Christopher J. Murphy , Elise Huang , Juan J. De Pablo , Sean P. Palecek , Nathan A. Lockwood
发明人： Nicholas L. Abbott , Jeffrey C. Mohr , Christopher J. Murphy , Elise Huang , Juan J. De Pablo , Sean P. Palecek , Nathan A. Lockwood
IPC分类号： C12N5/00
CPC分类号： C12N5/0068 , C12N5/0606 , C12N2533/50 , C12N2533/52 , C12N2533/54 , C12N2533/90
摘要： The present invention is directed to liquid crystalline substrates useful in the culture of cells and methods of their use. In certain embodiments, the invention provides methods and devices for imaging changes (e.g., reorganization) of extracellular matrix components by living cells.
摘要翻译： 本发明涉及可用于细胞培养的液晶底物及其使用方法。 在某些实施方案中，本发明提供了用于通过活细胞对细胞外基质组分的变化（例如重组）成像的方法和装置。
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公开(公告)号：US08097457B2
公开(公告)日：2012-01-17
申请号：US13085846
申请日：2011-04-13
申请人： Nicholas L. Abbott , Jeffrey C. Mohr , Christopher J. Murphy , Elise Huang , Juan J. DePablo , Nathan A. Lockwood , Sean P. Palecek
发明人： Nicholas L. Abbott , Jeffrey C. Mohr , Christopher J. Murphy , Elise Huang , Juan J. DePablo , Nathan A. Lockwood , Sean P. Palecek
IPC分类号： G01N33/53 , G01N33/567 , G01N33/566 , C12N5/00 , C12N5/02
CPC分类号： C12N5/0068 , C12N5/0606 , C12N2533/50 , C12N2533/52 , C12N2533/54 , C12N2533/90
摘要： The present invention is directed to liquid crystalline substrates useful in the culture of cells and methods of their use. In certain embodiments, the invention provides methods and devices for imaging changes (e.g., reorganization) of extracellular matrix components by living cells.
摘要翻译： 本发明涉及可用于细胞培养的液晶底物及其使用方法。 在某些实施方案中，本发明提供了用于通过活细胞对细胞外基质组分的变化（例如重组）成像的方法和装置。
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公开(公告)号：US07947500B2
公开(公告)日：2011-05-24
申请号：US12777320
申请日：2010-05-11
申请人： Nicholas L. Abbott , Jeffrey C. Mohr , Christopher J. Murphy , Elise Huang , Juan J. DePablo , Nathan A. Lockwood , Sean P. Palecek
发明人： Nicholas L. Abbott , Jeffrey C. Mohr , Christopher J. Murphy , Elise Huang , Juan J. DePablo , Nathan A. Lockwood , Sean P. Palecek
IPC分类号： G01N33/53 , G01N33/567 , G01N33/566 , C12N5/00 , C12N5/02
CPC分类号： C12N5/0068 , C12N5/0606 , C12N2533/50 , C12N2533/52 , C12N2533/54 , C12N2533/90
摘要： The present invention is directed to liquid crystalline substrates useful in the culture of cells and methods of their use. In certain embodiments, the invention provides methods and devices for imaging changes (e.g., reorganization) of extracellular matrix components by living cells.
摘要翻译： 本发明涉及可用于细胞培养的液晶底物及其使用方法。 在某些实施方案中，本发明提供了用于通过活细胞对细胞外基质组分的变化（例如重组）成像的方法和装置。
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公开(公告)号：US07732152B2
公开(公告)日：2010-06-08
申请号：US11565363
申请日：2006-11-30
申请人： Nicholas L. Abbott , Jeffrey C. Mohr , Christopher J. Murphy , Elise Huang , Juan J. De Pablo , Sean P. Palecek , Nathan A. Lockwood
发明人： Nicholas L. Abbott , Jeffrey C. Mohr , Christopher J. Murphy , Elise Huang , Juan J. De Pablo , Sean P. Palecek , Nathan A. Lockwood
IPC分类号： G01N33/53 , G01N33/567 , C12N5/00 , C12N5/02 , G01N33/566
CPC分类号： C12N5/0068 , C12N5/0606 , C12N2533/50 , C12N2533/52 , C12N2533/54 , C12N2533/90
摘要： The present invention is directed to liquid crystalline substrates useful in the culture of cells and methods of their use. In certain embodiments, the invention provides methods and devices for imaging changes (e.g., reorganization) of extracellular matrix components by living cells.
摘要翻译： 本发明涉及可用于细胞培养的液晶底物及其使用方法。 在某些实施方案中，本发明提供了用于通过活细胞对细胞外基质组分的变化（例如重组）成像的方法和装置。
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