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公开(公告)号:US20050085487A1
公开(公告)日:2005-04-21
申请号:US10961247
申请日:2004-10-08
申请人: Nicholas Carruthers , Wenying Chai , Curt Dvorak , James Edwards , Cheryl Grice , Jill Jablonowski , Lars Karlsson , Haripada Khatuya , Jennifer Kreisberg , Annette Kwok , Timothy Lovenberg , Kiev Ly , Barbara Pio , Chandravadan Shah , Siquan Sun , Robin Thurmond , Jianmei Wei , Wei Xiao
发明人: Nicholas Carruthers , Wenying Chai , Curt Dvorak , James Edwards , Cheryl Grice , Jill Jablonowski , Lars Karlsson , Haripada Khatuya , Jennifer Kreisberg , Annette Kwok , Timothy Lovenberg , Kiev Ly , Barbara Pio , Chandravadan Shah , Siquan Sun , Robin Thurmond , Jianmei Wei , Wei Xiao
IPC分类号: C07D307/84 , A61K31/496 , A61P1/04 , A61P7/00 , A61P9/06 , A61P17/06 , A61P19/02 , A61P25/28 , A61P29/00 , A61P37/04 , A61P37/06 , A61P37/08 , A61P43/00 , C07D209/42 , C07D401/12 , C07D403/06 , A61K31/454 , C07D413/02 , C07D417/02 , C07D43/02
CPC分类号: C07D401/12 , A61K31/496 , C07D209/42
摘要: Heterocyclic compounds and methods of making them and using them.
摘要翻译: 杂环化合物及其制备方法和使用方法。
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2.SUBSTITUTED PIPERAZINES AND PIPERIDINES AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR 有权
标题翻译: 作为神经元Y2受体的调节剂的替代哌嗪和哌啶公开(公告)号:US20070100141A1
公开(公告)日:2007-05-03
申请号:US11553556
申请日:2006-10-27
申请人: Pascal Bonaventure , Nicholas Carruthers , Wenying Chai , Curt Dvorak , Jill Jablonowski , Dale Rudolph , Mark Seierstad , Chandravadan Shah , Devin Swanson , Victoria Wong
发明人: Pascal Bonaventure , Nicholas Carruthers , Wenying Chai , Curt Dvorak , Jill Jablonowski , Dale Rudolph , Mark Seierstad , Chandravadan Shah , Devin Swanson , Victoria Wong
IPC分类号: C07D413/02 , C07D403/02 , C07D401/02
CPC分类号: C07D295/15 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/10 , C07D207/27 , C07D207/34 , C07D211/14 , C07D211/16 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/58 , C07D211/70 , C07D213/55 , C07D213/56 , C07D213/74 , C07D213/81 , C07D213/82 , C07D231/14 , C07D237/20 , C07D239/28 , C07D239/48 , C07D241/04 , C07D261/08 , C07D261/14 , C07D285/01 , C07D295/135 , C07D295/155 , C07D295/185 , C07D307/24 , C07D307/52 , C07D307/68 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D487/08
摘要: The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurological disorders; bone loss; substance related disorders; sleep/wake disorders; cardiovascular disease; obesity; or an obesity-related disorder. Compounds of the invention are also useful in modulating endocrine functions, particularly endocrine functions controlled by the pituitary and hypothalamic glands, and are therefore useful in the treatment or prevention of inovulation and infertility.
摘要翻译: 本发明提供了用于治疗或预防:抗焦虑障碍或抑郁症的新型非肽性NPY Y2受体抑制剂; 受伤的哺乳动物神经组织; 通过施用神经营养因子对治疗有反应的病症; 神经系统疾病; 骨质疏松 物质相关疾病; 睡眠/觉醒障碍 心血管疾病; 肥胖; 或肥胖相关疾病。 本发明的化合物还可用于调节内分泌功能,特别是由垂体和下丘脑腺体控制的内分泌功能,因此可用于治疗或预防未排卵和不育症。
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公开(公告)号:US20050070534A1
公开(公告)日:2005-03-31
申请号:US10949055
申请日:2004-09-24
申请人: Nicholas Carruthers , Wenying Chai , Scott Dax , Jill Jablonowski , Xiaobing Li , Timothy Lovenberg , William Murray , Dale Rudolph , Mark Seierstad , Mark Youngman
发明人: Nicholas Carruthers , Wenying Chai , Scott Dax , Jill Jablonowski , Xiaobing Li , Timothy Lovenberg , William Murray , Dale Rudolph , Mark Seierstad , Mark Youngman
IPC分类号: A61K31/404 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/52 , A61K31/5377 , A61K31/541 , A61P3/04 , A61P15/08 , A61P25/22 , A61P25/24 , C07D401/12 , C07D401/14 , C07D409/14 , C07D413/02 , C07D417/02 , C07D473/02 , C07D43/02
CPC分类号: C07D401/12 , C07D401/14 , C07D409/14
摘要: The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurological disorders; bone loss; substance related disorders; obesity; or an obesity-related disorder. Compounds of the invention are also useful in modulating endocrine functions, particularly endocrine functions controlled by the pituitary and hypothalamic glands, and are therefore useful in the treatment or prevention of inovulation and infertility.
摘要翻译: 本发明提供了用于治疗或预防:抗焦虑障碍或抑郁症的新型非肽性NPY Y2受体抑制剂; 受伤的哺乳动物神经组织; 通过施用神经营养因子治疗反应的病症; 神经系统疾病; 骨质疏松 物质相关疾病; 肥胖; 或肥胖相关疾病。 本发明的化合物还可用于调节内分泌功能,特别是由垂体和下丘脑腺体控制的内分泌功能,因此可用于治疗或预防排卵和不育症。
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公开(公告)号:US20060194837A1
公开(公告)日:2006-08-31
申请号:US11300880
申请日:2005-12-15
申请人: Nicholas Carruthers , Leslie Gomez , Jill Jablonowski , John Keith , Michael Letavic , Kiev Ly , Jennifer Miller , Emily Stocking , Ronald Wolin
发明人: Nicholas Carruthers , Leslie Gomez , Jill Jablonowski , John Keith , Michael Letavic , Kiev Ly , Jennifer Miller , Emily Stocking , Ronald Wolin
IPC分类号: A61K31/4709 , A61K31/47
CPC分类号: C07D405/12 , A61K31/47 , A61K31/4709 , C07D217/14 , C07D217/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/04 , C07D413/12 , C07D417/12
摘要: Certain tetrahydroisoquinoline compounds are histamine H3 receptor and serotonin transporter modulators useful in the treatment of histamine H3 receptor- and serotonin-mediated diseases.
摘要翻译: 某些四氢异喹啉化合物是可用于治疗组胺H 3受体和5-羟色胺介导的疾病的组胺H 3 N 3受体和5-羟色胺转运蛋白调节剂。
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公开(公告)号:US20080056991A1
公开(公告)日:2008-03-06
申请号:US11928006
申请日:2007-10-30
申请人: Richard Apodaca , Jill Jablonowski , Kiew Ly , Chandravadan Shah , Devin Swanson , Wei Xiao
发明人: Richard Apodaca , Jill Jablonowski , Kiew Ly , Chandravadan Shah , Devin Swanson , Wei Xiao
IPC分类号: C07D295/10 , A61K31/495 , A61K31/496 , A61K31/5355 , C07D401/10 , C07D413/10 , C07D417/10 , C07D403/10 , A61K31/55 , A61K51/04 , A61P37/08
CPC分类号: C07D295/192 , A61K49/0004 , A61K51/0459 , A61K51/0463 , A61K51/0465 , A61K51/0468 , A61K51/047
摘要: Substituted piperazinyl and diazepanyl benzamides and benzthioamides of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
摘要翻译: 式(I)的取代的哌嗪基和二氮杂环庚烷基苯甲酰胺和苯并硫代酰胺,含有它们的组合物,以及制备和使用它们来治疗组胺介导的病症的方法。
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公开(公告)号:US20070072837A1
公开(公告)日:2007-03-29
申请号:US11556941
申请日:2006-11-06
申请人: Richard Apodaca , Xiaohu Deng , Jill Jablonowski , Neelakandha Mani , Chennagiri Pandit , Wei Xiao
发明人: Richard Apodaca , Xiaohu Deng , Jill Jablonowski , Neelakandha Mani , Chennagiri Pandit , Wei Xiao
IPC分类号: A61K31/54 , A61K31/5375 , A61K31/513 , A61K31/496 , A61K31/495 , A61K31/396 , A61K31/444 , A61K31/4545
CPC分类号: C07D239/42 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/5355 , A61K31/5377 , A61K31/541 , C07D203/12 , C07D209/14 , C07D209/16 , C07D211/14 , C07D211/22 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/78 , C07D213/38 , C07D215/06 , C07D273/00 , C07D273/01 , C07D277/04 , C07D295/02 , C07D295/03 , C07D295/073 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D413/10 , C07D417/10 , C07D471/10 , C07D491/10 , C07D491/113
摘要: Substituted phenylalkynes of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
摘要翻译: 取代的式(I)的苯炔基,含有它们的组合物,以及制备和使用它们来治疗组胺介导的病症的方法。
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公开(公告)号:US20080103135A1
公开(公告)日:2008-05-01
申请号:US11874321
申请日:2007-10-18
申请人: Richard Apodaca , Xiaohu Deng , Jill Jablonowski , Neelakandha Mani , Chennagiri Pandit , Wei Xiao
发明人: Richard Apodaca , Xiaohu Deng , Jill Jablonowski , Neelakandha Mani , Chennagiri Pandit , Wei Xiao
IPC分类号: A61K31/54 , A61K31/445 , A61P25/00 , C07D401/02 , C07D417/02 , C07D239/02 , A61K31/5375
CPC分类号: C07D239/42 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/5355 , A61K31/5377 , A61K31/541 , C07D203/12 , C07D209/14 , C07D209/16 , C07D211/14 , C07D211/22 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/78 , C07D213/38 , C07D215/06 , C07D273/00 , C07D273/01 , C07D277/04 , C07D295/02 , C07D295/03 , C07D295/073 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D413/10 , C07D417/10 , C07D471/10 , C07D491/10 , C07D491/113
摘要: Substituted phenylalkynes of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
摘要翻译: 取代的式(I)的苯炔基,含有它们的组合物,以及制备和使用它们来治疗组胺介导的病症的方法。
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公开(公告)号:US20080096876A1
公开(公告)日:2008-04-24
申请号:US11874327
申请日:2007-10-18
申请人: Richard Apodaca , Xiaohu Deng , Jill Jablonowski , Neelakandha Mani , Chennagiri Pandit , Wei Xiao
发明人: Richard Apodaca , Xiaohu Deng , Jill Jablonowski , Neelakandha Mani , Chennagiri Pandit , Wei Xiao
IPC分类号: A61K31/4545 , A61K31/438 , A61K31/445 , A61K31/496 , A61K31/5375 , A61K31/54 , A61P11/00 , C07D295/112 , C07D401/14 , C07D491/107 , C07D471/10 , C07D417/10 , C07D413/10 , C07D401/10 , A61P25/00 , A61K31/541 , A61K31/5377 , A61K31/506 , A61K31/4709 , A61K31/454
CPC分类号: C07D239/42 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/5355 , A61K31/5377 , A61K31/541 , C07D203/12 , C07D209/14 , C07D209/16 , C07D211/14 , C07D211/22 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/78 , C07D213/38 , C07D215/06 , C07D273/00 , C07D273/01 , C07D277/04 , C07D295/02 , C07D295/03 , C07D295/073 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D413/10 , C07D417/10 , C07D471/10 , C07D491/10 , C07D491/113
摘要: Substituted phenylalkynes of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
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公开(公告)号:US20060258859A1
公开(公告)日:2006-11-16
申请号:US11490394
申请日:2006-07-20
申请人: Richard Apodaca , Xiaohu Deng , Jill Jablonowski , Neelakandha Mani , Chennagiri Pandit , Wei Xiao
发明人: Richard Apodaca , Xiaohu Deng , Jill Jablonowski , Neelakandha Mani , Chennagiri Pandit , Wei Xiao
IPC分类号: C07D417/02 , C07D413/02 , C07D403/02 , C07D401/02
CPC分类号: C07D239/42 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/5355 , A61K31/5377 , A61K31/541 , C07D203/12 , C07D209/14 , C07D209/16 , C07D211/14 , C07D211/22 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/78 , C07D213/38 , C07D215/06 , C07D273/00 , C07D273/01 , C07D277/04 , C07D295/02 , C07D295/03 , C07D295/073 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D413/10 , C07D417/10 , C07D471/10 , C07D491/10 , C07D491/113
摘要: Substituted phenylalkynes of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
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