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公开(公告)号：US06810849B1
公开(公告)日：2004-11-02
申请号：US09600096
申请日：2001-06-07
申请人： Nicholas Robert Hirsch , Mark Donald Schaefer , Michael Paul Braun , Peter Hotz , Darrell Albert Wiatrowski , Ronald Lee Bartelt , Brian Hubbard
发明人： Nicholas Robert Hirsch , Mark Donald Schaefer , Michael Paul Braun , Peter Hotz , Darrell Albert Wiatrowski , Ronald Lee Bartelt , Brian Hubbard
IPC分类号： F02N100
CPC分类号： F16H57/043 , F01M1/04 , F01M3/00 , F01M9/10 , F01M11/0004 , F01M11/06 , F01M11/064 , F01M11/065 , F01M11/067 , F01M13/022 , F01M2011/0041 , F01M2013/0422 , F02B1/04 , F02B63/02 , F02B69/00 , F02B75/16 , F02B2075/027 , F02B2275/22 , F02B2275/30 , F02F1/305 , F05C2201/021
摘要： A four-stroke internal combustion engine is provided that is capable of use in many power tools, including those power tools subjected to tippable applications. There is provided within an engine housing an oil reservoir and a valve chamber which independently communicate with a crank chamber. A strategically placed divider and passageway, located within the engine housing, appropriately direct lubricant within the engine housing so that the internal cavity of the engine is lubricated during use in various operating attitudes, and so that the fluid flows to and is held in the proper chambers of the engine housing during storage. There is also provided a breather arrangement for an internal combustion engine which includes a cam shaft having a hollow passageway in communication with the crank chamber and the air intake system of the engine.
摘要翻译： 提供四冲程内燃机，其能够用于许多电动工具，包括经受可翻转应用的那些电动工具。 在发动机内部设有容纳油室和与腔室独立连通的阀室。 位于发动机壳体内的策略性分配和通道适当地直接在发动机壳体内引导润滑剂，使得发动机的内腔在各种操作态度的使用期间被润滑，并且使得流体流入并保持在适当的位置 存储期间发动机壳体的腔室。 还提供了一种用于内燃机的通气装置，其包括具有与曲轴室和发动机的进气系统连通的中空通道的凸轮轴。
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2.发明申请Methods and compositions comprising FATP5 for use in the diagnosis and treatment of metabolic disorders 审中-公开包含用于诊断和治疗代谢紊乱的FATP5的方法和组合物公开(公告)号：US20050054022A1
公开(公告)日：2005-03-10
申请号：US10919608
申请日：2004-08-17
申请人： Ruth Gimeno , Brian Hubbard
发明人： Ruth Gimeno , Brian Hubbard
IPC分类号： C12N20060101 , C12Q1/25 , G01N33/53 , G01N33/537 , G01N33/543 , G01N33/68 , G01N33/92
CPC分类号： G01N33/6893 , C12Q1/25 , G01N33/92 , G01N2333/9015 , G01N2500/04 , G01N2800/042 , G01N2800/044
摘要： The present invention provides methods for the identification of agents, e.g., therapeutic agents, that inhibit Fatty Acid Transport 5 (FATP5) activity, and methods of treating diseases or conditions associated with FATP5 function, e.g., obesity, insulin resistance, type 2 diabetes, dyslipidemia, fatty liver disease, and cardiovascular disease. Further aspects of the invention provide a transgenic FATP5 non-human knockout mammal, e.g., mouse, useful for elucidating the function of FATP5 in intact animals whose genomes comprise a wild-type FATP5 gene.
摘要翻译： 本发明提供了用于鉴定抑制脂肪酸转运5（FATP5）活性的药剂，例如治疗剂的方法，以及治疗与FATP5功能相关的疾病或病症的方法，例如肥胖，胰岛素抵抗，2型糖尿病， 血脂异常，脂肪肝疾病和心血管疾病。 本发明的其它方面提供了转基因FATP5非人敲除哺乳动物（例如小鼠），其用于阐明在其基因组包含野生型FATP5基因的完整动物中FATP5的功能。
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公开(公告)号：USD621187S1
公开(公告)日：2010-08-10
申请号：US29298158
申请日：2007-11-29
申请人： Brian Hubbard
设计人： Brian Hubbard
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4.发明申请HUMAN DIACYLGLYCEROL ACYLTRANSFERASE 2 (DGAT2) FAMILY MEMBERS AND USES THEREFOR 审中-公开人类胆固醇ACYLTRANSFERASE 2（DGAT2）家族成员及其用途公开(公告)号：US20070166748A1
公开(公告)日：2007-07-19
申请号：US11684365
申请日：2007-03-09
CPC分类号： C12N9/1029 , A01K2217/05 , C07K16/40 , C12Q1/48 , C12Y203/0102 , G01N33/573 , G01N2333/91051 , G01N2800/044
摘要： The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules, designated DGAT2 family member nucleic acid molecules, which encode diacylglycerol acyltransferase family members. The invention also provides recombinant expression vectors containing DGAT2 family member nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DGAT2 family member gene has been introduced or disrupted. The invention still further provides isolated DGAT2 family member proteins, fusion proteins, antigenic peptides and anti-DGAT2 family member antibodies. Methods of use of the provided DGAT2 family member compositions for screening, diagnostic and therapeutic methods in connection, with obesity disorders are also disclosed.
摘要翻译： 本发明涉及用于诊断和治疗肥胖症及相关代谢紊乱的组合物和方法。 本发明提供编码二酰基甘油酰基转移酶家族成员的分离的核酸分子，称为DGAT2家族成员核酸分子。 本发明还提供了含有DGAT2家族成员核酸分子的重组表达载体，已引入表达载体的宿主细胞，以及导入或破坏了DGAT2家族成员基因的非人类转基因动物。 本发明还进一步提供分离的DGAT2家族成员蛋白，融合蛋白，抗原肽和抗DGAT2家族成员抗体。 还公开了所提供的DGAT2家族成员组合物用于与肥胖症有关的筛选，诊断和治疗方法的方法。
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公开(公告)号：US20060183210A1
公开(公告)日：2006-08-17
申请号：US11296615
申请日：2005-12-07
IPC分类号： C12P21/06
CPC分类号： C12N9/1029 , A01K2217/05 , C07K16/40 , C12Q1/48 , C12Y203/0102 , G01N33/573 , G01N2333/91051 , G01N2800/044
摘要： The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules, designated DGAT2 family member nucleic acid molecules, which encode diacylglycerol acyltransferase family members. The invention also provides recombinant expression vectors containing DGAT2 family member nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DGAT2 family member gene has been introduced or disrupted. The invention still further provides isolated DGAT2 family member proteins, fusion proteins, antigenic peptides and anti-DGAT2 family member antibodies. Methods of use of the provided DGAT2 family member compositions for screening, diagnostic and therapeutic methods in connection with obesity disorders are also disclosed.
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公开(公告)号：US20060134752A1
公开(公告)日：2006-06-22
申请号：US11347870
申请日：2006-02-06
CPC分类号： C12N9/1029 , A01K2217/05 , C07K16/40 , C12Q1/48 , C12Y203/0102 , G01N33/573 , G01N2333/91051 , G01N2800/044
摘要： The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules, designated DGAT2 family member nucleic acid molecules, which encode diacylglycerol acyltransferase family members. The invention also provides recombinant expression vectors containing DGAT2 family member nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DGAT2 family member gene has been introduced or disrupted. The invention still further provides isolated DGAT2 family member proteins, fusion proteins, antigenic peptides and anti-DGAT2 family member antibodies. Methods of use of the provided DGAT2 family member compositions for screening, diagnostic and therapeutic methods in connection with obesity disorders are also disclosed.
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公开(公告)号：US5853714A
公开(公告)日：1998-12-29
申请号：US411028
申请日：1995-03-27
申请人： Jeffrey S. Deetz , Bonnie Germain , Brian Hubbard , Lei Shi , Thomas Spitznagel , Dwight Winters
发明人： Jeffrey S. Deetz , Bonnie Germain , Brian Hubbard , Lei Shi , Thomas Spitznagel , Dwight Winters
CPC分类号： C07K14/5434
摘要： Methods for the purification of interleukin-12 (IL-12) is provided.
摘要翻译： 提供白细胞介素-12（IL-12）纯化方法。
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