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1.发明授权Human diacylglycerol acyltransferase 2 (DGAT2) family members and uses therefor 失效人二酰基甘油酰基转移酶2（DGAT2）家族成员及其用途公开(公告)号：US07910346B2
公开(公告)日：2011-03-22
申请号：US12378703
申请日：2009-02-17
CPC分类号： C12N9/1029 , A01K2217/05 , C07K16/40 , C12Q1/48 , C12Y203/0102 , G01N33/573 , G01N2333/91051 , G01N2800/044
摘要： The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules, designated DGAT2 family member nucleic acid molecules, which encode diacylglycerol acyltransferase family members. The invention also provides recombinant expression vectors containing DGAT2 family member nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DGAT2 family member gene has been introduced or disrupted. The invention still further provides isolated DGAT2 family member proteins, fusion proteins, antigenic peptides and anti-DGAT2 family member antibodies. Methods of use of the provided DGAT2 family member compositions for screening, diagnostic and therapeutic methods in connection with obesity disorders are also disclosed.
摘要翻译： 本发明涉及用于诊断和治疗肥胖症及相关代谢紊乱的组合物和方法。 本发明提供编码二酰基甘油酰基转移酶家族成员的分离的核酸分子，称为DGAT2家族成员核酸分子。 本发明还提供了含有DGAT2家族成员核酸分子的重组表达载体，已引入表达载体的宿主细胞，以及导入或破坏了DGAT2家族成员基因的非人类转基因动物。 本发明还进一步提供分离的DGAT2家族成员蛋白，融合蛋白，抗原肽和抗DGAT2家族成员抗体。 还公开了所提供的DGAT2家族成员组合物用于与肥胖症有关的筛选，诊断和治疗方法的方法。
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2.发明申请HUMAN DIACYLGLYCEROL ACYLTRANSFERASE 2 (DGAT2) FAMILY MEMBERS AND USES THEREFOR 审中-公开人类胆固醇ACYLTRANSFERASE 2（DGAT2）家族成员及其用途公开(公告)号：US20070166748A1
公开(公告)日：2007-07-19
申请号：US11684365
申请日：2007-03-09
CPC分类号： C12N9/1029 , A01K2217/05 , C07K16/40 , C12Q1/48 , C12Y203/0102 , G01N33/573 , G01N2333/91051 , G01N2800/044
摘要： The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules, designated DGAT2 family member nucleic acid molecules, which encode diacylglycerol acyltransferase family members. The invention also provides recombinant expression vectors containing DGAT2 family member nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DGAT2 family member gene has been introduced or disrupted. The invention still further provides isolated DGAT2 family member proteins, fusion proteins, antigenic peptides and anti-DGAT2 family member antibodies. Methods of use of the provided DGAT2 family member compositions for screening, diagnostic and therapeutic methods in connection, with obesity disorders are also disclosed.
摘要翻译： 本发明涉及用于诊断和治疗肥胖症及相关代谢紊乱的组合物和方法。 本发明提供编码二酰基甘油酰基转移酶家族成员的分离的核酸分子，称为DGAT2家族成员核酸分子。 本发明还提供了含有DGAT2家族成员核酸分子的重组表达载体，已引入表达载体的宿主细胞，以及导入或破坏了DGAT2家族成员基因的非人类转基因动物。 本发明还进一步提供分离的DGAT2家族成员蛋白，融合蛋白，抗原肽和抗DGAT2家族成员抗体。 还公开了所提供的DGAT2家族成员组合物用于与肥胖症有关的筛选，诊断和治疗方法的方法。
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公开(公告)号：US06872391B2
公开(公告)日：2005-03-29
申请号：US10256889
申请日：2002-09-27
IPC分类号： G01N33/50 , A61K38/00 , A61K48/00 , A61P1/14 , A61P3/04 , A61P3/10 , A61P7/00 , C07K14/47 , C07K14/575 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/68 , G01N33/15 , G01N33/58 , G01N33/68 , A61K39/395
CPC分类号： C07K14/5759 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K14/4702 , C12N2799/026 , G01N2500/00 , Y10S435/81
摘要： The invention provides isolated nucleic acids molecules, designated PGC-1 nucleic acid molecules, which encode proteins which can modulate various adipocyte-associated activities including, for example, thermogenesis in adipocytes, e.g., brown adipocytes, and adipogenesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PGC-1 gene has been introduced or disrupted. The invention still further provides isolated PGC-1 proteins, fusion proteins, antigenic peptides and anti-PGC-1 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为PGC-1核酸分子，其编码可调节各种脂肪细胞相关活性的蛋白质，包括例如脂肪细胞例如棕色脂肪细胞中的产热，以及脂肪形成。 本发明还提供了反义核酸分子，含有PGC-1核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中PGC-1基因被引入或破坏的非人类转基因动物。 本发明还进一步提供分离的PGC-1蛋白，融合蛋白，抗原肽和抗PGC-1抗体。 还提供了利用本发明组合物的诊断，筛选和治疗方法。
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公开(公告)号：US06426411B1
公开(公告)日：2002-07-30
申请号：US09203453
申请日：1998-12-01
IPC分类号： C07H2104
CPC分类号： C07K14/5759 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K14/4702 , C12N2799/026 , G01N2500/00 , Y10S435/81
摘要： The invention provides isolated nucleic acids molecules, designated PGC-1 nucleic acid molecules, which encode proteins which can modulate various adipocyte-associated activities including, for example, thermogenesis in adipocytes, e.g., brown adipocytes, and adipogenesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PGC-1 gene has been introduced or disrupted. The invention still further provides isolated PGC-1 proteins, fusion proteins, antigenic peptides and anti-PGC-1 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为PGC-1核酸分子，其编码可调节各种脂肪细胞相关活性的蛋白质，包括例如脂肪细胞例如棕色脂肪细胞中的产热，以及脂肪形成。 本发明还提供了反义核酸分子，含有PGC-1核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中PGC-1基因被引入或破坏的非人类转基因动物。 本发明还进一步提供分离的PGC-1蛋白，融合蛋白，抗原肽和抗PGC-1抗体。 还提供了利用本发明组合物的诊断，筛选和治疗方法。
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5.发明申请HUMAN DIACYLGLYCEROL ACYLTRANSFERASE 2 (DGAT2) FAMILY MEMBERS AND USES THEREFOR 审中-公开人类胆固醇ACYLTRANSFERASE 2（DGAT2）家族成员及其用途公开(公告)号：US20120177661A1
公开(公告)日：2012-07-12
申请号：US13424574
申请日：2012-03-20
IPC分类号： A61K39/395 , C12N5/10 , C12N1/21 , C12N1/19 , C12N9/10 , C07K16/40 , G01N33/566 , C12N9/96 , C12Q1/48 , C12Q1/68 , C12N9/99 , C12N5/071 , A61K38/45 , A61P3/04 , A61P3/06 , C12N15/54
CPC分类号： C12N9/1029 , A01K2217/05 , C07K16/40 , C12Q1/48 , C12Y203/0102 , G01N33/573 , G01N2333/91051 , G01N2800/044
摘要： The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules, designated DGAT2 family member nucleic acid molecules, which encode diacylglycerol acyltransferase family members. The invention also provides recombinant expression vectors containing DGAT2 family member nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DGAT2 family member gene has been introduced or disrupted. The invention still further provides isolated DGAT2 family member proteins, fusion proteins, antigenic peptides and anti-DGAT2 family member antibodies. Methods of use of the provided DGAT2 family member compositions for screening, diagnostic and therapeutic methods in connection with obesity disorders are also disclosed.
摘要翻译： 本发明涉及用于诊断和治疗肥胖症及相关代谢紊乱的组合物和方法。 本发明提供编码二酰基甘油酰基转移酶家族成员的分离的核酸分子，称为DGAT2家族成员核酸分子。 本发明还提供了含有DGAT2家族成员核酸分子的重组表达载体，已引入表达载体的宿主细胞，以及导入或破坏了DGAT2家族成员基因的非人类转基因动物。 本发明还进一步提供分离的DGAT2家族成员蛋白，融合蛋白，抗原肽和抗DGAT2家族成员抗体。 还公开了所提供的DGAT2家族成员组合物用于与肥胖症有关的筛选，诊断和治疗方法的方法。
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公开(公告)号：US20120076729A1
公开(公告)日：2012-03-29
申请号：US13375556
申请日：2010-06-02
申请人： Dinh Le Mary Chau , Jesper Gromada , Zhidan Wu
发明人： Dinh Le Mary Chau , Jesper Gromada , Zhidan Wu
IPC分类号： A61K38/18 , A61K39/395 , G01N33/566 , A61P35/00 , C12Q1/68 , G01N33/573 , A61K49/00 , A61K31/713
CPC分类号： A61K38/1825
摘要： The present application describes methods for treating and/or preventing cancer or a cancer symptom, e.g., AMPK-related cancers, in a patient in need thereof comprising administering to the patient a therapeutically effective amount of an FGF, e.g., FGF21, or an FGF agonist, or a pharmaceutical composition comprising the same.
摘要翻译： 本申请描述了在有需要的患者中治疗和/或预防癌症或癌症症状（例如AMPK相关癌症）的方法，包括向患者施用治疗有效量的FGF，例如FGF21或FGF 激动剂或包含其的药物组合物。
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公开(公告)号：US6166192A
公开(公告)日：2000-12-26
申请号：US86912
申请日：1998-05-29
申请人： Bruce M. Spiegelman , Pere Puigserver , Zhidan Wu
发明人： Bruce M. Spiegelman , Pere Puigserver , Zhidan Wu
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K39/395 , A61P3/00 , A61P3/04 , A61P3/10 , C07K14/47 , C07K14/575 , C07K16/18 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12Q1/68 , G01N33/566 , C07H21/04
CPC分类号： C07K14/5759 , A01K2217/05 , A01K2217/075 , A61K38/00 , C12N2799/026
摘要： The invention provides isolated nucleic acids molecules, designated PGC-1 nucleic acid molecules, which encode proteins which can modulate various adipocyte-associated activities including, for example, thermogenesis in adipocytes, e.g., brown adipocytes, and adipogenesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PGC-1 gene has been introduced or disrupted. The invention still further provides isolated PGC-1 proteins, fusion proteins, antigenic peptides and anti-PGC-1 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为PGC-1核酸分子，其编码可调节各种脂肪细胞相关活性的蛋白质，包括例如脂肪细胞例如棕色脂肪细胞中的产热，以及脂肪形成。 本发明还提供了反义核酸分子，含有PGC-1核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中PGC-1基因被引入或破坏的非人类转基因动物。 本发明还进一步提供分离的PGC-1蛋白，融合蛋白，抗原肽和抗PGC-1抗体。 还提供了利用本发明组合物的诊断，筛选和治疗方法。
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8.发明授权Human diacylglycerol acyltransferase 2 (DGAT2) family members and uses therefor 有权人二酰基甘油酰基转移酶2（DGAT2）家族成员及其用途公开(公告)号：US08334111B2
公开(公告)日：2012-12-18
申请号：US13015635
申请日：2011-01-28
CPC分类号： C12N9/1029 , A01K2217/05 , C07K16/40 , C12Q1/48 , C12Y203/0102 , G01N33/573 , G01N2333/91051 , G01N2800/044
摘要： The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules, designated DGAT2 family member nucleic acid molecules, which encode diacylglycerol acyltransferase family members. The invention also provides recombinant expression vectors containing DGAT2 family member nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DGAT2 family member gene has been introduced or disrupted. The invention still further provides isolated DGAT2 family member proteins, fusion proteins, antigenic peptides and anti-DGAT2 family member antibodies. Methods of use of the provided DGAT2 family member compositions for screening, diagnostic and therapeutic methods in connection with obesity disorders are also disclosed.
摘要翻译： 本发明涉及用于诊断和治疗肥胖症及相关代谢紊乱的组合物和方法。 本发明提供编码二酰基甘油酰基转移酶家族成员的分离的核酸分子，称为DGAT2家族成员核酸分子。 本发明还提供了含有DGAT2家族成员核酸分子的重组表达载体，已引入表达载体的宿主细胞，以及导入或破坏了DGAT2家族成员基因的非人类转基因动物。 本发明还进一步提供分离的DGAT2家族成员蛋白，融合蛋白，抗原肽和抗DGAT2家族成员抗体。 还公开了所提供的DGAT2家族成员组合物用于与肥胖症有关的筛选，诊断和治疗方法的方法。
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9.发明申请HUMAN DIACYLGLYCEROL ACYLTRANSFERASE 2 (DGAT2) FAMILY MEMBERS AND USES THEREFOR 审中-公开人类胆固醇ACYLTRANSFERASE 2（DGAT2）家族成员及其用途公开(公告)号：US20100035339A1
公开(公告)日：2010-02-11
申请号：US12433304
申请日：2009-04-30
CPC分类号： C12N9/1029 , A01K2217/05 , C07K16/40 , C12Q1/48 , C12Y203/0102 , G01N33/573 , G01N2333/91051 , G01N2800/044
摘要： The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules, designated DGAT2 family member nucleic acid molecules, which encode diacylglycerol acyltransferase family members. The invention also provides recombinant expression vectors containing DGAT2 family member nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DGAT2 family member gene has been introduced or disrupted. The invention still further provides isolated DGAT2 family member proteins, fusion proteins, antigenic peptides and anti-DGAT2 family member antibodies. Methods of use of the provided DGAT2 family member compositions for screening, diagnostic and therapeutic methods in connection with obesity disorders are also disclosed.
摘要翻译： 本发明涉及用于诊断和治疗肥胖症及相关代谢紊乱的组合物和方法。 本发明提供编码二酰基甘油酰基转移酶家族成员的分离的核酸分子，称为DGAT2家族成员核酸分子。 本发明还提供了含有DGAT2家族成员核酸分子的重组表达载体，已引入表达载体的宿主细胞，以及导入或破坏了DGAT2家族成员基因的非人类转基因动物。 本发明还进一步提供分离的DGAT2家族成员蛋白，融合蛋白，抗原肽和抗DGAT2家族成员抗体。 还公开了所提供的DGAT2家族成员组合物用于与肥胖症有关的筛选，诊断和治疗方法的方法。
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公开(公告)号：US20090281191A1
公开(公告)日：2009-11-12
申请号：US12299256
申请日：2007-05-02
IPC分类号： A61K31/16
CPC分类号： A61K31/00
摘要： Use of a ERRγ agonist Or pharmaceutically acceptable salt thereof, for the prevention, delay of progression or the treatment of diabetes, insulin resistance, metabolic disease/metabolic syndrome, dyslipdemia, obesity, overweight, Neurodegenerative diseases such as Parkinson's disease. Alzheimer's disease, Huntington's disease or improvement of exercise endurance capacity.
摘要翻译： 用于预防，延缓进展或治疗糖尿病，胰岛素抵抗，代谢性疾病/代谢综合征，血脂异常，肥胖症，超重，神经变性疾病如帕金森氏病的用途的γ激动剂或其药学上可接受的盐。 阿尔茨海默病，亨廷顿病或运动耐力能力的提高。
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