摘要:
The present application relates to humanized antibodies specific to the protofibrillar form of the beta-amyloid peptide, and to the use of said antibodies in the field of Alzheimer's disease.
摘要:
The present application relates to humanized antibodies specific to the protofibrillar form of the beta-amyloid peptide, and to the use of said antibodies in the field of Alzheimer's disease.
摘要:
The invention provides an implementing method of cloud numerical control system. The method implements a numerical control system with functions of online error compensation, CAD/CAPP/CAM/CNC integrating and interactively cooperative assembling machining control. The cloud numerical control system includes a small cloud numerical control system a large cloud numerical control system. The small cloud numerical control system focuses on inside control of a single numerical control machining device and includes a cloud control core node, cloud measure and control subnodes and fine-tuning driving units. The large cloud numerical control system is based on the small cloud numerical control system and performs interactively cooperative machining between multiple numerical control machining devices for different workpieces to be assembled.
摘要:
The present invention relates to a photosensitive detector with a composite dielectric gate MOSFET structure and its signal readout method. The MOSFET structure detector is formed on a p-type semiconductor substrate. N-type semiconductor regions locate on the two sides of the top part of the p-type semiconductor substrate to form a source and a drain. An underlying dielectric layer, a photo-electron storage layer, a top dielectric layer, and a control gate are stacked on the substrate in sequence. The top insulating dielectric layer can prevent the photoelectrons stored in the photo-electron storage layer from leaking into the control gate. The source and the drain are floating when photoelectrons are collected and injected into the photoelectron storing layer to be held therein. There is a transparent or semi-transparent window for detecting incident light forming on the substrate or gate surface. This invented detector has excellent scalability, basic compatibility with the flash memory fabricating technology, low leakage current, higher imaging speed than CCD, non-sensitivity to processing defects, larger dynamic range than other structures and higher accuracy of signal readout.
摘要:
An orally deliverable pharmaceutical composition comprises as a sole or first active ingredient a compound of Formula I defined herein or a pharmaceutically acceptable salt thereof, for example ABT-263 free base or ABT-263 bis-HCl salt, dispersed, in a free base equivalent amount of at least about 2.5% by weight of the composition, in a pharmaceutically acceptable carrier; wherein said active ingredient is in solid-state form and/or the composition further comprises, dispersed in the carrier, a pharmaceutically acceptable heavier-chalcogen antioxidant in an amount effective to inhibit oxidation of the active ingredient at a thioether linkage thereof. The composition is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.
摘要:
This invention provides an autonomous random dynamic cryptogram lock system which comprises a lock body and a key body. There are non-volatile memories in both the lock body and key body respectively and each memory stores a set of cryptogram corresponding. When unlocking the microprocessor in the lock body checks the cryptograms. If matching, the lock is unlocked, otherwise it gives up alarm. After unlocking, the microprocessor renews a set of the corresponding real random cryptogram in both memories for unlocking next time. It accomplishes one cryptoguard function every time.
摘要:
An open roof assembly comprises a drive assembly having a slider member. The slider member comprising a coupling member, a first lever member coupled to a sunshade member and a second lever member coupled to a closure member. Each lever member comprises a mating member for coupling with the slider member and a locking lever for releasably engaging a respective locking recess. The slider member is sequentially couplable to one of the lever members. When the slider member is coupled to the first lever member, the sunshade member may be opened or closed by moving the slider member. When the slider member is coupled to the second lever member, the closure member may be opened or closed by moving the slider member.
摘要:
The present invention provides compostions and methods useful for treating and preventing metabolic bone diseases and disorders by inhibition of Lp-PLA2. The compositions and methods are useful for treating and preventing metabolic bone diseases and disorders such as, for example osteoporosis, osteopenia and osteopenia related diseases and abnormal bone marrow.
摘要:
The present invention provides a conducting polymer, a synthesis method thereof, and an electroactive electrode covered with the said conducting polymer. The conducting polymer is synthesized as follows: use the polybasic acid as dopant and crosslinking agent, and polymerize monomers into conducting polymer hydrogel. The monomers are selected one or more from pyrrole or its derivatives, thiophene or its derivatives, aniline or its derivatives. The acid group of the polybasic acid contains phosphate or polybasic acid which contains at least two substituents per molecule selected from sulfate, nitrate or carboxylic in which the molecular weight of at least one acid group is no more than 800. The mole ratio of the acid group in polybasic acid to monomers of the conducting polymer is 1:12-12:1. The preparation applied in the invention is simple, and need not to import any impurity. The conducting polymer hydrogel has high ionic conductivity, super hydrophilicity, and good biocompatibility.
摘要:
The present invention relates to anhydrous and hydrated forms of Compound 1, which are useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising compounds of formula I and methods of using the compositions in the treatment of proliferative disorders.