公开(公告)号：US08167581B2

公开(公告)日：2012-05-01

申请号：US12439855

申请日：2007-09-03

申请人： Niklaus Schneeberger ,  Véronique Vallet ,  Eric Chappel

发明人： Niklaus Schneeberger ,  Véronique Vallet ,  Eric Chappel

IPC分类号： F04B49/10 ,  A61M1/00

CPC分类号： A61M5/14244 ,  A61M5/16881 ,  A61M2005/14264 ,  A61M2205/0244

摘要： A device for delivering a liquid including a pump, and an anti-siphon valve external to the pump is disclosed. The anti-siphon valve includes an inlet channel connected to the outlet duct of the pump, and an outlet channel, between which a seat and a moving member are disposed that are suitable for co-operating together and that define, between the inlet channel and the outlet channel, a leaktight liquid flow zone. The moving member is suitable for going from an opening position making it possible for liquid to flow through the flow zone, to a closure position in which the moving member comes into contact with the seat of the valve and prevents any flow through the flow zone, the moving member being subjected to the pressure of a reference chamber that is not in fluid communication with the outlet channel.

摘要翻译： 公开了一种用于输送包括泵的液体和在泵外部的防虹吸阀的装置。 防虹吸阀包括连接到泵的出口管道的入口通道和出口通道，在该出口通道之间设置有适于协同操作的座和移动构件，并且限定入口通道和 出口通道，密封液体流通区域。 移动构件适于从打开位置开始，使得液体可以流过流动区域到关闭位置，在该位置移动构件与阀座接触并防止流过流动区域的任何流动， 移动构件经受与出口通道不流体连通的参考室的压力。

公开(公告)号：US20100028170A1

公开(公告)日：2010-02-04

申请号：US12439855

申请日：2007-09-03

申请人： Niklaus Schneeberger ,  Véronique Vallet ,  Eric Chappel

发明人： Niklaus Schneeberger ,  Véronique Vallet ,  Eric Chappel

IPC分类号： F04B49/22 ,  A61M5/145

CPC分类号： A61M5/14244 ,  A61M5/16881 ,  A61M2005/14264 ,  A61M2205/0244

摘要： The invention relates to a device for delivering a liquid, which device comprises a pump, and an anti-siphon valve external to the pump and having an inlet channel connected to the outlet duct of the pump, and an outlet channel, between which channels a seat and a moving member are disposed that are suitable for co-operating together and that define, between the inlet channel and the outlet channel, a leaktight liquid flow zone, said moving member being suitable for going from an opening position making it possible for liquid to flow through said flow zone, to a closure position in which the moving member comes into contact with the seat of the valve and prevents any flow through said flow zone, said moving member being subjected to the pressure of a reference chamber that is not in fluid communication with the outlet channel. Application to obtaining a pump for injecting liquid medication.

摘要翻译： 本发明涉及一种用于输送液体的装置，该装置包括泵，以及在泵的外部的防虹吸阀，并具有连接到泵的出口管道的入口通道，以及出口通道，通道 座椅和移动构件被设置成适于共同操作并且在入口通道和出口通道之间限定泄漏的液体流动区域，所述移动构件适于从打开位置开始，使得可以进行液体 流过所述流动区域到关闭位置，在该关闭位置，移动构件与阀座接触并防止任何流动通过所述流动区域，所述移动构件受到参考室的压力不在 与出口通道的流体连通。 应用于获得注射液体药物的泵。

公开(公告)号：US09822774B2

公开(公告)日：2017-11-21

申请号：US13512463

申请日：2010-11-19

申请人： Niklaus Schneeberger ,  Eric Chappel

发明人： Niklaus Schneeberger ,  Eric Chappel

IPC分类号： F04B43/04 ,  F04B19/00

CPC分类号： F04B43/046 ,  F04B19/006 ,  F04B43/043

摘要： A micropump in the form of a stack comprising, in succession, a flexible diaphragm, a pumping chamber and a closing-off plate, said pumping chamber communicating with the outside, for example via the flexible diaphragm; said diaphragm being furthermore secured to an actuator arranged outside the micropump, characterized in that said diaphragm is secured to the actuator by way of at least one element in the form of a strip, which is rigid along its main axis and flexible in the direction perpendicular to its main axis.

公开(公告)号：US09192720B2

公开(公告)日：2015-11-24

申请号：US13059507

申请日：2008-10-22

申请人： Eric Chappel ,  Niklaus Schneeberger ,  Frédéric Neftel

发明人： Eric Chappel ,  Niklaus Schneeberger ,  Frédéric Neftel

IPC分类号： F04B17/00 ,  A61M5/168 ,  F04B43/04 ,  A61M5/142

CPC分类号： F04B51/00 ,  A61M5/14224 ,  A61M5/168 ,  A61M5/16854 ,  A61M5/365 ,  A61M2005/16863 ,  A61M2005/16868 ,  A61M2205/0244 ,  A61M2205/0294 ,  A61M2205/3355 ,  A61M2205/70 ,  F04B43/043

摘要： The invention concerns a pumping device that includes a pump having a pumping chamber with a variable volume, an inlet that communicates with the pumping chamber and a valve, an outlet that communicates with the pumping chamber and a valve, and an actuator adapted to change the volume of the pumping chamber. A fluidic pathway in the pumping device includes the inlet, the pumping chamber, the outlet, and a downstream line situated downstream of the outlet valve. The pumping device also includes a pressure sensor for measuring the pressure between the valves of the pathway, and a processing means for processing the received pressure data from the pressure sensor. The invention also concerns a method for detecting a dysfunction in the pumping device.

摘要翻译： 本发明涉及一种泵送装置，其包括具有可变容积的泵送室的泵，与泵送室连通的入口和阀，与泵送室连通的出口和阀，以及适于改变 抽水室的体积。 泵送装置中的流体路径包括入口，泵送室，出口以及位于出口阀下游的下游管线。 泵送装置还包括用于测量通道的阀之间的压力的压力传感器和用于处理来自压力传感器的接收的压力数据的处理装置。 本发明还涉及一种用于检测泵送装置中的功能障碍的方法。

公开(公告)号：US20120237375A1

公开(公告)日：2012-09-20

申请号：US13512463

申请日：2010-11-19

申请人： Niklaus Schneeberger ,  Eric Chappel

发明人： Niklaus Schneeberger ,  Eric Chappel

IPC分类号： F04B45/047

CPC分类号： F04B43/046 ,  F04B19/006 ,  F04B43/043

摘要： A micropump in the form of a stack comprising, in succession, a flexible diaphragm, a pumping chamber and a closing-off plate, said pumping chamber communicating with the outside, for example via the flexible diaphragm; said diaphragm being furthermore secured to an actuator arranged outside the micropump, characterized in that said diaphragm is secured to the actuator by way of at least one element in the form of a strip, which is rigid along its main axis and flexible in the direction perpendicular to its main axis.

摘要翻译： 一种堆叠形式的微型泵，其中包括柔性隔膜，泵送室和关闭板，所述泵送室例如经由柔性隔膜与外部连通; 所述隔膜进一步固定到布置在微型泵的外部的致动器上，其特征在于，所述隔膜通过至少一种沿着其主轴线刚性且在垂直方向上柔性的条带形式的至少一个元件固定到致动器 到其主轴。

公开(公告)号：US20110142688A1

公开(公告)日：2011-06-16

申请号：US13059507

申请日：2008-10-22

申请人： Eric Chappel ,  Niklaus Schneeberger ,  Frederic Neftel

发明人： Eric Chappel ,  Niklaus Schneeberger ,  Frederic Neftel

IPC分类号： F04B45/04 ,  F01B31/12

CPC分类号： F04B51/00 ,  A61M5/14224 ,  A61M5/168 ,  A61M5/16854 ,  A61M5/365 ,  A61M2005/16863 ,  A61M2005/16868 ,  A61M2205/0244 ,  A61M2205/0294 ,  A61M2205/3355 ,  A61M2205/70 ,  F04B43/043

摘要： The invention relates to a pumping device including a pump (1) comprising—a pumping chamber (11) having a variable volume,—an inlet (2) communicating with the pumping chamber (11) and comprising a valve,—an outlet (5) communicating with the pumping chamber and comprising a valve,—an actuator adapted to change the volume of the pumping chamber,—a fluidic pathway comprising said inlet (2), said pumping chamber (11), said outlet (5) and a downstream line (7) situated downstream of the outlet valve,—a pressure sensor (4) for measuring the pressure between the valves of said pathway,—processing means for processing the received pressure data from the pressure sensor (4). The invention also covers a method for detecting a dysfunction in a pumping device as defined above.

摘要翻译： 本发明涉及一种泵送装置，其包括泵（1），泵（1）包括具有可变容积的泵送室（11）， - 与泵送室（11）连通并且包括阀的入口（2）， - 出口（5） 与所述泵送室连通并且包括阀， - 适于改变所述泵送室的容积的致动器， - 包括所述入口（2），所述泵送室（11），所述出口（5）和下游 位于出口阀下游的管线（7）， - 用于测量所述通道的阀之间的压力的压力传感器（4），用于处理来自压力传感器（4）的接收的压力数据的处理装置。 本发明还涉及如上所述的用于检测泵送装置中的功能障碍的方法。

公开(公告)号：US20120316492A1

公开(公告)日：2012-12-13

申请号：US13578711

申请日：2011-02-07

申请人： Eric Chappel

发明人： Eric Chappel

IPC分类号： A61M5/14

CPC分类号： A61M5/16881 ,  A61M5/14276 ,  A61M5/145 ,  A61M5/16813 ,  A61M27/006 ,  A61M2039/2413 ,  A61M2205/0244 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0057 ,  F16K2099/008 ,  F16K2099/0088 ,  G05D7/0635 ,  G05D7/0694 ,  Y10T137/7791 ,  Y10T137/86734

摘要： The invention concerns a flow regulator, made of a stack of 3 plates, respectively a top plate including a flexible membrane (1), a middle plate (2) with pillars and through holes and a bottom plate (3) with fluidic ports, micro channels and through holes (8,9,12). The principle is based on the deformation of the membrane due to the pressure of the liquid. The membrane goes in contact with the pillars of the middle plate, obstructing gradually the through holes of the pillars. The device is designed to keep the flow constant in a predefined range of pressure. The device is dedicated to ultra low flow rate up to 1 ml per day or below, typically for drug infusion. Plastic flow regulators comprise preferably several independent valves coupled in parallel. The membrane plate is therefore made of several flexible membranes obstructing gradually the flow by increasing the pressure. Stress limiters are used to avoid plastic deformation of the membrane. For implanted pump, the use of a flow regulator instead of a flow restrictor has several advantages, including the possibility to reduce significantly the reservoir pressure and to generate directly the pressure during the pump filling by using an elastic drug reservoir.

摘要翻译： 本发明涉及一种流量调节器，由三个板组成，分别是包括柔性膜（1），具有支柱和通孔的中间板（2）和具有流体端口的底板（3）的顶板，微板 通道和通孔（8,9,12）。 该原理是基于液体由于压力引起的膜的变形。 膜与中间板的支柱接触，逐渐阻塞柱的通孔。 设备旨在使流量保持在预定的压力范围内。 该设备专用于每天或以下超过1毫升的超低流速，通常用于药物输注。 塑料流量调节器优选并联连接多个独立的阀。 因此，膜片由几个柔性膜制成，通过增加压力逐渐阻塞流动。 应力限制器用于避免膜的塑性变形。 对于植入式泵，使用流量调节器代替限流器具有若干优点，包括显着降低储层压力并通过使用弹性药物储存器在泵填充期间直接产生压力的可能性。

公开(公告)号：US20140199181A1

公开(公告)日：2014-07-17

申请号：US14235090

申请日：2012-07-27

申请人： Eric Chappel

发明人： Eric Chappel

IPC分类号： F04B19/00

CPC分类号： F04B19/006 ,  A61M5/14224 ,  F04B43/02 ,  F04B43/043 ,  F04B43/046

摘要： The present invention describes the improvements due to alternated actuation cycles to reduce the delivery errors related to the pumping chamber elasticity, the actuator relaxation or hysteresis. The method actuates a pumping device with an optimal driving voltage profile, wherein the pumping device comprises a pumping chamber including a pumping membrane and a voltage controlled actuator connected to said membrane; the movement of said membrane being defined by three positions, namely a rest, a bottom and a top position. The method includes the actuation of the membrane with a pumping pattern including at least two different cycles: Cycle A: rest-bottom-rest-top-rest Cycle B: rest-top-rest-bottom-rest. The invention also relates to a device to carry out the method.

摘要翻译： 本发明描述了由于交替的致动循环引起的改进，以减少与泵室弹性，致动器松弛或滞后有关的输送误差。 该方法致动具有最佳驱动电压分布的泵送装置，其中泵送装置包括泵送室，泵送室包括泵送膜和连接到所述膜的电压控制致动器; 所述膜的运动由三个位置限定，即休息，底部和顶部位置。 该方法包括用包括至少两个不同循环的泵送模式来致动膜：循环A：休息 - 休息 - 休息 - 休息循环B：休息 - 休息 - 休息 - 休息。 本发明还涉及一种用于执行该方法的装置。

公开(公告)号：US20130272902A1

公开(公告)日：2013-10-17

申请号：US13997523

申请日：2011-12-19

申请人： André Noth ,  Eric Chappel

发明人： André Noth ,  Eric Chappel

IPC分类号： F04B49/00

CPC分类号： F04B49/00 ,  F04B43/0081 ,  F04B43/046 ,  F04B49/065

摘要： A method for actuating a pumping device with an optimal driving voltage, wherein the pumping device comprises a pumping chamber (4) having a pumping membrane (1), an inlet (3) and an outlet chamber (5), a voltage controlled actuator (6) connected to said pumping membrane (1), said pumping membrane reaching a stop position defined by a mechanical stop (2) a sensor for determining whether the pumping membrane has reached said mechanical stop (2); said method comprising a learning and working phase, wherein the learning phase comprises the following steps actuation of the pumping membrane (1) by applying a predetermined actuation voltage Vact to the actuator (6) said pumping membrane (1) reaching said position in an over-actuation step or not reaching said mechanical stop (2) position in an under-actuation process; after the over-actuation step, decreasing the voltage so that the pumping membrane (1) has left said mechanical stop (2) position and storing as the optimal voltage Vact optimal or in the under-actuation step, increasing the voltage so that the pumping membrane (1) reaches said mechanical stop (2) position and storing as the optimal voltage Vact optimal actuating the pumping device in the working phase with the determined optimal voltage value Vact optimal.

摘要翻译： 一种用于以最佳驱动电压致动泵送装置的方法，其中所述泵送装置包括具有泵送膜（1），入口（3）和出口室（5）的泵送室（4），电压控制致动器 6）连接到所述泵送膜（1），所述泵送膜达到由机械止动件（2）限定的停止位置，传感器用于确定泵膜是否到达所述机械止动件（2）; 所述方法包括学习和工作阶段，其中所述学习阶段包括以下步骤：通过将预定的致动电压Vact施加到所述致动器（6）来致动所述泵送膜（1），所述泵送膜（1）到达所述位置 在未致动过程中没有达到所述机械止挡（2）位置; 在过度致动步骤之后，降低电压使得泵膜（1）已经离开所述机械停止（2）位置并且存储为最佳电压Vact最佳或者在低致动步骤中，增加电压使得泵送 膜（1）到达所述机械停止位置（2）并且存储为在确定的最佳电压值Vact最优的工作阶段中使泵送装置致动的最佳电压Vact。

公开(公告)号：US20110132480A1

公开(公告)日：2011-06-09

申请号：US13058255

申请日：2009-06-26

申请人： Eric Chappel

发明人： Eric Chappel

IPC分类号： A61M5/168

CPC分类号： A61M5/16881 ,  A61M5/145 ,  A61M27/006 ,  A61M37/00 ,  A61M2205/0244 ,  F16K99/0001 ,  F16K99/0013 ,  F16K99/0015 ,  F16K99/0026 ,  F16K99/0057 ,  F16K2099/0088 ,  Y10T137/86718 ,  Y10T137/87306

摘要： A fluid flow regulator (1) of the passive type is disclosed which has a fluid inlet adapted to be connected to a fluid reservoir and a fluid outlet (13) adapted to be connected to a patient's body. The regulator comprises a rigid substrate (2) and a resilient membrane (3) tightly linked together so as to define a cavity (6) there between which is disconnected to the fluid outlet while the membrane has a first surface (12) opposite the cavity which is connected to the fluid inlet. The membrane has a plurality of through holes (15) contiguous with the cavity, to define a pathway for a fluid from the fluid inlet to the fluid outlet, and is flexible so as to be able to come into contact with the substrate as a fluid applies a sufficient pressure on the first surface. The through holes are arranged such that, when the fluid pressure increases, they close one after the other to increase the regulator fluidic resistance so that a fluid flow rate would be substantially constant as a function of the pressure applied on the first surface within a predefined pressure range.

摘要翻译： 公开了一种无源型流体流量调节器（1），其具有适于连接到流体储存器的流体入口和适于连接到患者身体的流体出口（13）。 调节器包括刚性基板（2）和紧密连接在一起的弹性膜（3），以便限定一个空腔（6），在该空腔之间与流体出口断开，而膜具有与空腔相对的第一表面（12） 其连接到流体入口。 膜具有多个与空腔邻接的通孔（15），以限定用于流体从流体入口到流体出口的路径，并且是柔性的，以便能够作为流体与基底接触 在第一表面施加足够的压力。 通孔布置成使得当流体压力增加时，它们一个接一个地关闭以增加调节器流体阻力，使得流体流速基本上恒定，这是在预定义的范围内施加在第一表面上的压力的函数 压力范围。