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    Polynucelotides encoding novel variants of the TRP channel family member, LTRPC3
    1.
    发明申请
    Polynucelotides encoding novel variants of the TRP channel family member, LTRPC3 有权
    Polynucelotides编码TRP通道家族成员LTRPC3的新型变体

    公开(公告)号：US20080118952A1

    公开(公告)日：2008-05-22

    申请号：US11985981

    申请日：2007-11-19

    申请人： Ning Lee ,  Jian Chen ,  John Feder ,  Shujian Wu ,  Michael Blanar ,  David Bol ,  Paul Levesque ,  Lucy Sun

    发明人： Ning Lee ,  Jian Chen ,  John Feder ,  Shujian Wu ,  Michael Blanar ,  David Bol ,  Paul Levesque ,  Lucy Sun

    IPC分类号： C12P21/04 ,  C07K16/00

    CPC分类号： C07K14/705 ,  C07H21/04 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/622

    摘要： The present invention provides novel polynucleotides encoding LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供编码LTRPC3g，LTRPC3h，LTRPC3i，LTRPC3j，LTRPC3k或LTRPC3l多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型LTRPC3g，LTRPC3h，LTRPC3i，LTRPC3j，LTRPC3k或LTRPC3l多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotide encoding a novel TRP channel family member, TRP-PLIK2, and splice variants thereof
    2.
    发明申请
    Polynucleotide encoding a novel TRP channel family member, TRP-PLIK2, and splice variants thereof 有权
    编码新型TRP通道家族成员的多核苷酸，TRP-PLIK2及其剪接变体

    公开(公告)号：US20070172880A1

    公开(公告)日：2007-07-26

    申请号：US11726234

    申请日：2007-03-21

    申请人： Ning Lee ,  Jian Chen ,  John Feder ,  Shujian Wu ,  Han Chang ,  Liana Lee ,  Michael Blanar ,  David Bol

    发明人： Ning Lee ,  Jian Chen ,  John Feder ,  Shujian Wu ,  Han Chang ,  Liana Lee ,  Michael Blanar ,  David Bol

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  A61K38/17 ,  C07K14/705 ,  C07K16/28 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C07K14/705

    摘要： The present invention provides novel polynucleotides encoding TRP-PLIK2 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of TRP-PLIK2 polypeptides, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel TRP-PLIK2, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码TRP-PLIK2多肽的新型多核苷酸，其片段和同源物。 本发明还提供分别编码TRP-PLIK2多肽，TRP-PLIK2b，TRP-PLIK2c和TRP-PLIK2d的变体和剪接变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型TRP-PLIK2，TRP-PLIK2b，TRP-PLIK2c和TRP-PLIK2d多肽应用于诊断，治疗和/或预防与这些相关的各种疾病和/或病症的诊断和治疗方法 多肽。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotide encoding a novel TRP channel family member, LTRPC3, and splice variants thereof
    3.
    发明申请
    Polynucleotide encoding a novel TRP channel family member, LTRPC3, and splice variants thereof 有权
    编码新型TRP通道家族成员的多核苷酸，LTRPC3及其剪接变体

    公开(公告)号：US20080274505A1

    公开(公告)日：2008-11-06

    申请号：US12152547

    申请日：2008-05-15

    申请人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Liana M. Lee ,  Michael A. Blanar ,  David Bol ,  Paul C. Lavesque ,  Lucy Sun

    发明人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Liana M. Lee ,  Michael A. Blanar ,  David Bol ,  Paul C. Lavesque ,  Lucy Sun

    IPC分类号： C12N15/12 ,  C12N15/63 ,  C12P21/00 ,  C12N5/10

    CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K2319/00

    摘要： The present invention provides novel polynucleotides encoding LTRPC3 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of LTRPC3 polypeptides, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码LTRPC3多肽的新型多核苷酸，其片段及其同源物。 本发明还提供了分别编码LTRPC3多肽，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f的变体和剪接变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型LTRPC3，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Variants of the TRP channel family member, LTRPC3G
    4.
    发明授权
    Variants of the TRP channel family member, LTRPC3G 有权
    TRP通道家族成员LTRPC3G的变体

    公开(公告)号：US07459532B2

    公开(公告)日：2008-12-02

    申请号：US11985981

    申请日：2007-11-19

    申请人： Ning Lee ,  Jian Chen ,  Shujian Wu ,  Michael A. Blanar ,  Paul C. Levesque ,  Lucy Sun

    发明人： Ning Lee ,  Jian Chen ,  Shujian Wu ,  Michael A. Blanar ,  Paul C. Levesque ,  Lucy Sun

    IPC分类号： C07K14/435 ,  C07K14/705 ,  C12P21/02 ,  A61K38/17

    CPC分类号： C07K14/705 ,  C07H21/04 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/622

    摘要： The present invention provides novel polynucleotides encoding LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供编码LTRPC3g，LTRPC3h，LTRPC3i，LTRPC3j，LTRPC3k或LTRPC3l多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型LTRPC3g，LTRPC3h，LTRPC3i，LTRPC3j，LTRPC3k或LTRPC3l多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotides encoding variants of the TRP channel family member, LTRPC3
    5.
    发明授权
    Polynucleotides encoding variants of the TRP channel family member, LTRPC3 有权
    编码TRP通道家族成员LTRPC3变体的多核苷酸

    公开(公告)号：US07344882B2

    公开(公告)日：2008-03-18

    申请号：US10842313

    申请日：2004-05-10

    申请人： Ning Lee ,  Jian Chen ,  Shujian Wu ,  Michael A. Blanar ,  Paul C. Levesque ,  Lucy Sun

    发明人： Ning Lee ,  Jian Chen ,  Shujian Wu ,  Michael A. Blanar ,  Paul C. Levesque ,  Lucy Sun

    IPC分类号： C12N5/10 ,  C12N15/12 ,  C12N15/63 ,  C12N1/21

    CPC分类号： C07K14/705 ,  C07H21/04 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/622

    摘要： The present invention provides novel polynucleotides encoding LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides, fragments and homologues thereof Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供编码LTRPC3g，LTRPC3h，LTRPC3i，LTRPC3j，LTRPC3k或LTRPC3l多肽的新型多核苷酸，其片段和同系物。还提供了用于产生所述多肽的载体，宿主细胞，抗体以及重组和合成方法。 本发明还涉及将这些新型LTRPC3g，LTRPC3h，LTRPC3i，LTRPC3j，LTRPC3k或LTRPC3l多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotide encoding a TRP channel family member, TRP-PLIK2
    6.
    发明授权
    Polynucleotide encoding a TRP channel family member, TRP-PLIK2 有权
    编码TRP通道家族成员的多核苷酸TRP-PLIK2

    公开(公告)号：US07223557B2

    公开(公告)日：2007-05-29

    申请号：US10153244

    申请日：2002-05-22

    申请人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Han Chang ,  Liana M. Le ,  Michael A. Blanar ,  David Bol

    发明人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Han Chang ,  Liana M. Le ,  Michael A. Blanar ,  David Bol

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/02 ,  C12N5/06 ,  C07K14/705

    CPC分类号： C07K14/705

    摘要： The present invention provides novel polynucleotides encoding TRP-PLIK2 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of TRP-PLIK2 polypeptides, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel TRP-PLIK2, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码TRP-PLIK2多肽的新型多核苷酸，其片段和同源物。 本发明还提供分别编码TRP-PLIK2多肽，TRP-PLIK2b，TRP-PLIK2c和TRP-PLIK2d的变体和剪接变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型TRP-PLIK2，TRP-PLIK2b，TRP-PLIK2c和TRP-PLIK2d多肽应用于诊断，治疗和/或预防与这些相关的各种疾病和/或病症的诊断和治疗方法 多肽。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Antibodies which bind variants of the TRP channel family member, LTRPC3
    7.
    发明授权
    Antibodies which bind variants of the TRP channel family member, LTRPC3 有权
    结合TRP通道家族成员LTRPC3的变体的抗体

    公开(公告)号：US07705133B2

    公开(公告)日：2010-04-27

    申请号：US12220155

    申请日：2008-07-22

    申请人： Ning Lee ,  Jian Chen ,  Shujian Wu ,  Michael A. Blanar ,  Paul C. Levesque ,  Lucy Sun

    发明人： Ning Lee ,  Jian Chen ,  Shujian Wu ,  Michael A. Blanar ,  Paul C. Levesque ,  Lucy Sun

    IPC分类号： C07K16/28 ,  C07K16/18 ,  A61K39/395

    CPC分类号： C07K14/705 ,  C07H21/04 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/622

    摘要： The present invention provides novel polynucleotides encoding LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供编码LTRPC3g，LTRPC3h，LTRPC3i，LTRPC3j，LTRPC3k或LTRPC3l多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型LTRPC3g，LTRPC3h，LTRPC3i，LTRPC3j，LTRPC3k或LTRPC3l多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotides encoding novel adiponectin receptor variants
    9.
    发明申请
    Polynucleotides encoding novel adiponectin receptor variants 有权
    编码新型脂联素受体变体的多核苷酸

    公开(公告)号：US20050032166A1

    公开(公告)日：2005-02-10

    申请号：US10874923

    申请日：2004-06-23

    申请人： Jian Chen ,  Shujian Wu ,  Ning Lee

    发明人： Jian Chen ,  Shujian Wu ,  Ning Lee

    IPC分类号： C07H21/04 ,  C07K14/705 ,  C07K14/72 ,  C12N20060101 ,  C12P21/04

    CPC分类号： C07K14/72

    摘要： The present invention provides novel polynucleotides encoding human AdipoR2v1 polypeptides, mouse AdipoR2v1 polypeptides, human AdipoR3 polypeptides, human AdipoR2v2 polypeptides, human AdipoR3v1 polypeptides, rat AdipoR1 polypeptides, rat AdipoR2 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human AdipoR2v1 polypeptides, mouse AdipoR2v1 polypeptides, human AdipoR3 polypeptides, human AdipoR2v2 polypeptides, human AdipoR3v1 polypeptides, rat AdipoR1 polypeptides, rat AdipoR2 polypeptides, to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供编码人AdipoR2v1多肽，小鼠AdipoR2v1多肽，人AdipoR3多肽，人AdipoR2v2多肽，人AdipoR3v1多肽，大鼠AdipoR1多肽，大鼠AdipoR2多肽，其片段及其同源物的新型多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新的人AdipoR2v1多肽，小鼠AdipoR2v1多肽，人AdipoR3多肽，人AdipoR2v2多肽，人AdipoR3v1多肽，大鼠AdipoR1多肽，大鼠AdipoR2多肽应用于诊断，治疗和/或治疗的诊断和治疗方法。 预防与这些多肽相关的各种疾病和/或病症。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotides encoding novel adiponectin receptor variants
    10.
    发明申请
    Polynucleotides encoding novel adiponectin receptor variants 有权
    编码新型脂联素受体变体的多核苷酸

    公开(公告)号：US20080221305A1

    公开(公告)日：2008-09-11

    申请号：US12148669

    申请日：2008-04-21

    申请人： Jian Chen ,  Shujian Wu ,  Ning Lee ,  Dong Cheng

    发明人： Jian Chen ,  Shujian Wu ,  Ning Lee ,  Dong Cheng

    IPC分类号： C07K14/00

    CPC分类号： C07K14/72

    摘要： The present invention provides novel polynucleotides encoding human AdipoR2v1 polypeptides, mouse AdipoR2v1 polypeptides, human AdipoR3 polypeptides, human AdipoR2v2 polypeptides, human AdipoR3v1 polypeptides, rat AdipoR1 polypeptides, rat AdipoR2 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human AdipoR2v1 polypeptides, mouse AdipoR2v1 polypeptides, human AdipoR3 polypeptides, human AdipoR2v2 polypeptides, human AdipoR3v1 polypeptides, rat AdipoR1 polypeptides, rat AdipoR2 polypeptides, to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供编码人AdipoR2v1多肽，小鼠AdipoR2v1多肽，人AdipoR3多肽，人AdipoR2v2多肽，人AdipoR3v1多肽，大鼠AdipoR1多肽，大鼠AdipoR2多肽，其片段及其同源物的新型多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新的人AdipoR2v1多肽，小鼠AdipoR2v1多肽，人AdipoR3多肽，人AdipoR2v2多肽，人AdipoR3v1多肽，大鼠AdipoR1多肽，大鼠AdipoR2多肽应用于诊断，治疗和/或治疗的诊断和治疗方法。 预防与这些多肽相关的各种疾病和/或病症。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。