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    Polynucleotide encoding a novel TRP channel family member, LTRPC3, and splice variants thereof
    1.
    发明申请
    Polynucleotide encoding a novel TRP channel family member, LTRPC3, and splice variants thereof 有权
    编码新型TRP通道家族成员的多核苷酸，LTRPC3及其剪接变体

    公开(公告)号：US20080274505A1

    公开(公告)日：2008-11-06

    申请号：US12152547

    申请日：2008-05-15

    申请人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Liana M. Lee ,  Michael A. Blanar ,  David Bol ,  Paul C. Lavesque ,  Lucy Sun

    发明人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Liana M. Lee ,  Michael A. Blanar ,  David Bol ,  Paul C. Lavesque ,  Lucy Sun

    IPC分类号： C12N15/12 ,  C12N15/63 ,  C12P21/00 ,  C12N5/10

    CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K2319/00

    摘要： The present invention provides novel polynucleotides encoding LTRPC3 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of LTRPC3 polypeptides, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码LTRPC3多肽的新型多核苷酸，其片段及其同源物。 本发明还提供了分别编码LTRPC3多肽，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f的变体和剪接变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型LTRPC3，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotide encoding a novel TRP channel family member, LTRPC3, and splice variants thereof
    2.
    发明授权
    Polynucleotide encoding a novel TRP channel family member, LTRPC3, and splice variants thereof 有权
    编码新型TRP通道家族成员的多核苷酸，LTRPC3及其剪接变体

    公开(公告)号：US07767418B2

    公开(公告)日：2010-08-03

    申请号：US12152547

    申请日：2008-05-15

    申请人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Liana M. Lee ,  Michael A. Blanar

    发明人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Liana M. Lee ,  Michael A. Blanar

    IPC分类号： C12P21/06 ,  C12N15/00 ,  C07K1/00 ,  C07H21/02

    CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K2319/00

    摘要： The present invention provides novel polynucleotides encoding LTRPC3 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of LTRPC3 polypeptides, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f, respectively. Also provided are vectors, host cells, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码LTRPC3多肽的新型多核苷酸，其片段及其同源物。 本发明还提供了分别编码LTRPC3多肽，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f的变体和剪接变体的多核苷酸。 还提供载体，宿主细胞，以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型LTRPC3，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    TRP channel family member, LTRPC3 polypeptides
    3.
    发明授权
    TRP channel family member, LTRPC3 polypeptides 有权
    TRP频道家庭成员，LTRPC3e

    公开(公告)号：US07504481B2

    公开(公告)日：2009-03-17

    申请号：US10405793

    申请日：2003-03-28

    申请人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Liana M. Lee ,  Michael A. Blanar

    发明人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Liana M. Lee ,  Michael A. Blanar

    IPC分类号： C07K1/00 ,  C12P21/06 ,  C12P21/04 ,  C12N15/00 ,  A61K39/00

    CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K2319/00

    摘要： The present invention provides novel polynucleotides encoding LTRPC3 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of LTRPC3 polypeptides, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing the novel LTRPC3, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码LTRPC3多肽的新型多核苷酸，其片段及其同源物。 本发明还提供了分别编码LTRPC3多肽，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f的变体和剪接变体的多核苷酸。 还提供了用于产生新型LTRPC3，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f多肽的载体，宿主细胞，抗体以及重组和合成方法。 本发明还涉及将这些新型LTRPC3，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotide encoding a TRP channel family member, TRP-PLIK2
    4.
    发明授权
    Polynucleotide encoding a TRP channel family member, TRP-PLIK2 有权
    编码TRP通道家族成员的多核苷酸TRP-PLIK2

    公开(公告)号：US07223557B2

    公开(公告)日：2007-05-29

    申请号：US10153244

    申请日：2002-05-22

    申请人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Han Chang ,  Liana M. Le ,  Michael A. Blanar ,  David Bol

    发明人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Han Chang ,  Liana M. Le ,  Michael A. Blanar ,  David Bol

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/02 ,  C12N5/06 ,  C07K14/705

    CPC分类号： C07K14/705

    摘要： The present invention provides novel polynucleotides encoding TRP-PLIK2 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of TRP-PLIK2 polypeptides, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel TRP-PLIK2, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码TRP-PLIK2多肽的新型多核苷酸，其片段和同源物。 本发明还提供分别编码TRP-PLIK2多肽，TRP-PLIK2b，TRP-PLIK2c和TRP-PLIK2d的变体和剪接变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型TRP-PLIK2，TRP-PLIK2b，TRP-PLIK2c和TRP-PLIK2d多肽应用于诊断，治疗和/或预防与这些相关的各种疾病和/或病症的诊断和治疗方法 多肽。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Variants of the TRP channel family member, LTRPC3G
    6.
    发明授权
    Variants of the TRP channel family member, LTRPC3G 有权
    TRP通道家族成员LTRPC3G的变体

    公开(公告)号：US07459532B2

    公开(公告)日：2008-12-02

    申请号：US11985981

    申请日：2007-11-19

    申请人： Ning Lee ,  Jian Chen ,  Shujian Wu ,  Michael A. Blanar ,  Paul C. Levesque ,  Lucy Sun

    发明人： Ning Lee ,  Jian Chen ,  Shujian Wu ,  Michael A. Blanar ,  Paul C. Levesque ,  Lucy Sun

    IPC分类号： C07K14/435 ,  C07K14/705 ,  C12P21/02 ,  A61K38/17

    CPC分类号： C07K14/705 ,  C07H21/04 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/622

    摘要： The present invention provides novel polynucleotides encoding LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供编码LTRPC3g，LTRPC3h，LTRPC3i，LTRPC3j，LTRPC3k或LTRPC3l多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型LTRPC3g，LTRPC3h，LTRPC3i，LTRPC3j，LTRPC3k或LTRPC3l多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotides encoding variants of the TRP channel family member, LTRPC3
    7.
    发明授权
    Polynucleotides encoding variants of the TRP channel family member, LTRPC3 有权
    编码TRP通道家族成员LTRPC3变体的多核苷酸

    公开(公告)号：US07344882B2

    公开(公告)日：2008-03-18

    申请号：US10842313

    申请日：2004-05-10

    申请人： Ning Lee ,  Jian Chen ,  Shujian Wu ,  Michael A. Blanar ,  Paul C. Levesque ,  Lucy Sun

    发明人： Ning Lee ,  Jian Chen ,  Shujian Wu ,  Michael A. Blanar ,  Paul C. Levesque ,  Lucy Sun

    IPC分类号： C12N5/10 ,  C12N15/12 ,  C12N15/63 ,  C12N1/21

    CPC分类号： C07K14/705 ,  C07H21/04 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/622

    摘要： The present invention provides novel polynucleotides encoding LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides, fragments and homologues thereof Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供编码LTRPC3g，LTRPC3h，LTRPC3i，LTRPC3j，LTRPC3k或LTRPC3l多肽的新型多核苷酸，其片段和同系物。还提供了用于产生所述多肽的载体，宿主细胞，抗体以及重组和合成方法。 本发明还涉及将这些新型LTRPC3g，LTRPC3h，LTRPC3i，LTRPC3j，LTRPC3k或LTRPC3l多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Antibodies which bind variants of the TRP channel family member, LTRPC3
    8.
    发明授权
    Antibodies which bind variants of the TRP channel family member, LTRPC3 有权
    结合TRP通道家族成员LTRPC3的变体的抗体

    公开(公告)号：US07705133B2

    公开(公告)日：2010-04-27

    申请号：US12220155

    申请日：2008-07-22

    申请人： Ning Lee ,  Jian Chen ,  Shujian Wu ,  Michael A. Blanar ,  Paul C. Levesque ,  Lucy Sun

    发明人： Ning Lee ,  Jian Chen ,  Shujian Wu ,  Michael A. Blanar ,  Paul C. Levesque ,  Lucy Sun

    IPC分类号： C07K16/28 ,  C07K16/18 ,  A61K39/395

    CPC分类号： C07K14/705 ,  C07H21/04 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/622

    摘要： The present invention provides novel polynucleotides encoding LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供编码LTRPC3g，LTRPC3h，LTRPC3i，LTRPC3j，LTRPC3k或LTRPC3l多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型LTRPC3g，LTRPC3h，LTRPC3i，LTRPC3j，LTRPC3k或LTRPC3l多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucelotides encoding novel variants of the TRP channel family member, LTRPC3
    9.
    发明申请
    Polynucelotides encoding novel variants of the TRP channel family member, LTRPC3 有权
    Polynucelotides编码TRP通道家族成员LTRPC3的新型变体

    公开(公告)号：US20080118952A1

    公开(公告)日：2008-05-22

    申请号：US11985981

    申请日：2007-11-19

    申请人： Ning Lee ,  Jian Chen ,  John Feder ,  Shujian Wu ,  Michael Blanar ,  David Bol ,  Paul Levesque ,  Lucy Sun

    发明人： Ning Lee ,  Jian Chen ,  John Feder ,  Shujian Wu ,  Michael Blanar ,  David Bol ,  Paul Levesque ,  Lucy Sun

    IPC分类号： C12P21/04 ,  C07K16/00

    CPC分类号： C07K14/705 ,  C07H21/04 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/622

    摘要： The present invention provides novel polynucleotides encoding LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供编码LTRPC3g，LTRPC3h，LTRPC3i，LTRPC3j，LTRPC3k或LTRPC3l多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型LTRPC3g，LTRPC3h，LTRPC3i，LTRPC3j，LTRPC3k或LTRPC3l多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotides encoding a human cell surface protein with immunoglobulin folds, BGS-19
    10.
    发明授权
    Polynucleotides encoding a human cell surface protein with immunoglobulin folds, BGS-19 有权
    编码具有免疫球蛋白折叠的人细胞表面蛋白的多核苷酸，BGS-19

    公开(公告)号：US07202056B2

    公开(公告)日：2007-04-10

    申请号：US10403938

    申请日：2003-03-28

    申请人： Liana M. Lee ,  John N. Feder ,  Shujian Wu ,  Jian Chen

    发明人： Liana M. Lee ,  John N. Feder ,  Shujian Wu ,  Jian Chen

    IPC分类号： C12P21/06 ,  C12N15/87 ,  C12N1/20 ,  C12N15/74 ,  C07H21/04

    CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K14/70503

    摘要： The present invention provides novel polynucleotides encoding BGS-19 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying the novel BGS-19 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码BGS-19多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将新型BGS-19多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。