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19 条记录 (耗时 0.022 秒)

    Method for the preparation of oxide microcapsules loaded with functional molecules and the products obtained thereof
    5.
    发明授权
    Method for the preparation of oxide microcapsules loaded with functional molecules and the products obtained thereof 有权
    制备负载有功能分子的氧化物微胶囊的方法及其获得的产品

    公开(公告)号：US06303149B1

    公开(公告)日：2001-10-16

    申请号：US09372176

    申请日：1999-08-11

    申请人： Shlomo Magdassi ,  David Avnir ,  Alon Seri-Levy ,  Noa Lapidot ,  Claudio Rottman ,  Yoram Sorek ,  Orit Gans

    发明人： Shlomo Magdassi ,  David Avnir ,  Alon Seri-Levy ,  Noa Lapidot ,  Claudio Rottman ,  Yoram Sorek ,  Orit Gans

    IPC分类号： A61K914

    CPC分类号： A61K8/042 ,  A23L27/72 ,  A61K8/11 ,  A61K8/35 ,  A61K8/37 ,  A61K9/5146 ,  A61K2800/412 ,  A61Q17/04 ,  Y10S514/937 ,  Y10S514/951 ,  Y10T428/2984

    摘要： The present invention relates to a novel process for preparing sol-gel microcapsules loaded with up to 95% (w/w) functional molecules or substances and to the products obtained by said process. Said process is conducted in two steps: (a) creating an oil-in-water emulsion by emulsification of a water insoluble solution comprising the sol-gel precursors and the molecules to be loaded, in an aqueous solution under appropriate shear forces; (b) mixing and stirring said emulsion with an aqueous solution at a suitably selected pH to obtain loaded sol-gel microcapsules in suspension. The microcapsules so obtained can further be subjected to cycles of isolation and rinsing. Incorporation of the final product, either in the form of a suspension or a powder, in cosmetic formulations affords a transparent cream when applying to skin and has a smooth and pleasant contact.

    摘要翻译： 本发明涉及一种制备负载高达95％（w / w）功能分子或物质的溶胶 - 凝胶微胶囊以及通过所述方法获得的产品的新方法。 所述方法分两步进行：（a）通过在适当的剪切力下在水溶液中乳化包含溶胶 - 凝胶前体和待加载的分子的水不溶性溶液来产生水包油乳液; （b）在适当选择的pH下用水溶液混合和搅拌所述乳液，以得到负载的溶胶 - 凝胶微胶囊悬浮液。 如此获得的微胶囊可以进一步进行分离和漂洗的循环。 在化妆品配方中以悬浮液或粉末的形式加入最终产品，当应用于皮肤并具有光滑和愉快的接触时，可提供透明的乳膏。

    Sunscreen composition containing sol-gel microcapsules
    7.
    发明授权
    Sunscreen composition containing sol-gel microcapsules 有权
    含有溶胶 - 凝胶微胶囊的防晒组合物

    公开(公告)号：US06238650B1

    公开(公告)日：2001-05-29

    申请号：US09318828

    申请日：1999-05-26

    申请人： Noa Lapidot ,  Shlomo Magdassi ,  David Avnir ,  Claudio Rottman ,  Orit Gans ,  Alon Seri-Levy

    发明人： Noa Lapidot ,  Shlomo Magdassi ,  David Avnir ,  Claudio Rottman ,  Orit Gans ,  Alon Seri-Levy

    IPC分类号： A61K742

    CPC分类号： A61K8/042 ,  A61K8/11 ,  A61K8/25 ,  A61K8/35 ,  A61K8/37 ,  A61K8/40 ,  A61K8/445 ,  A61K2800/412 ,  A61Q17/04 ,  Y10S514/962

    摘要： The present invention generally relates to safe and stable sunscreen compositions comprising of at least one sunscreen active ingredient in the form of an inert sol-gel microcapsules encapsulating ultraviolet absorbing compounds in any acceptable cosmetic vehicle. The composition according to the present invention can comprise several ultraviolet absorbers that may be encapsulated in the same sol-gel microcapsule or in different capsules. The encapsulation of the ultraviolet absorbers reduces or even prevents the contact between the sunscreen compounds and the human tissue, thus reducing various adverse effects that are associated with the use of sunscreens, such as photoallergy and phototoxicity, and makes the composition safer for use. The encapsulation also reduces or even prevents cross reactivity between the sunscreen compounds and the packaging material and between the sunscreen compounds and any other component present in the composition, thus enhance the compositions stability. The hydophobicity/hydrophilicity character of the sol-gel microcapsules can be controlled by selecting suitable sol-gel precursors and suitable reaction conditions and can be chosen to be compatible with the cosmetic vehicle to be used in the sunscreen composition, thus, the present invention facilitates an easy incorporation of the composite sol-gel encapsulated sunscreen in all types of cosmetic vehicles including oil free compositions, with no necessary steps of heating or high shear forces. The sunscreen compositions of the present invention can comprise any acceptable UVA and/or UVB absorbing compounds at any desired ratio to obtain a desired accumulative ultraviolet screening spectrum.

    摘要翻译： 本发明一般涉及安全和稳定的防晒组合物，其包含至少一种防霉活性成分，其形式为在任何可接受的化妆品载体中包封紫外线吸收化合物的惰性溶胶 - 凝胶微胶囊形式。 根据本发明的组合物可以包含几种可以包封在相同溶胶 - 凝胶微胶囊或不同胶囊中的紫外线吸收剂。 紫外线吸收剂的封装减少或甚至防止防晒化合物与人体组织之间的接触，从而减少与防晒剂的使用相关的各种不利影响，例如光过敏和光毒性，并使组合物更安全地使用。 封装还降低或甚至防止防晒化合物和包装材料之间以及防晒化合物和组合物中存在的任何其它组分之间的交叉反应性，从而增强组合物的稳定性。 可以通过选择合适的溶胶 - 凝胶前体和合适的反应条件来控制溶胶 - 凝胶微胶囊的疏水性/亲水性，并且可以选择与化妆品相容以用于防晒组合物，因此本发明有利于 将复合溶胶 - 凝胶包胶的防晒剂容易地并入包括无油组合物的所有类型的化妆品载体中，没有必要的加热步骤或高剪切力。 本发明的防晒组合物可以以任何所需的比例包含任何可接受的UVA和/或UVB吸收化合物，以获得所需的累积紫外线屏蔽谱。

    Method for obtaining photostable sunscreen compositions
    9.
    发明授权
    Method for obtaining photostable sunscreen compositions 失效
    获得耐光防晒组合物的方法

    公开(公告)号：US06436375B1

    公开(公告)日：2002-08-20

    申请号：US09576962

    申请日：2000-05-24

    申请人： Noa Lapidot ,  Shlomo Magdassi ,  David Avnir ,  Claudio Rottman ,  Orit Gans ,  Alon Seri-Levy

    发明人： Noa Lapidot ,  Shlomo Magdassi ,  David Avnir ,  Claudio Rottman ,  Orit Gans ,  Alon Seri-Levy

    IPC分类号： A61K742

    CPC分类号： A61K8/042 ,  A61K8/11 ,  A61K8/25 ,  A61K8/29 ,  A61K8/35 ,  A61K8/37 ,  A61K8/375 ,  A61K2800/412 ,  A61K2800/52 ,  A61Q17/04 ,  Y10S514/844 ,  Y10S514/944 ,  Y10S514/945 ,  Y10S514/972

    摘要： The present invention relates to a method for obtaining improved photostability of a sunscreen composition that contains at least two sunscreen active ingredients, which are photo-unstable when formulated together, by microencapsulating at least one of said active ingredients in an encapsulating material suitable for holding the encapsulated active ingredient material, thus reducing or preventing its leaching out of the capsules; and adding other acceptable components and additives needed for the preparation of said composition. The sunscreen active ingredients can be selected from UVA and UVB absorbers, preferably a combination thereof. In a preferred embodiment of the present invention said active ingredients are encapsulated in separate sol-gel microcapsules.

    摘要翻译： 说，当配制在一起，通过微胶囊化中的至少一个在封装材料的活性成分适合用于保持本发明涉及用于获得改进的包含至少两种防晒活性成分，其是光不稳定的防晒组合物的光稳定性的方法 包封的活性成分材料，从而减少或防止其从胶囊中浸出; 并加入制备所述组合物所需的其它可接受的组分和添加剂。 防晒活性成分可以选自UVA和UVB吸收剂，优选其组合。 在本发明的优选实施方案中，所述活性成分被包封在单独的溶胶 - 凝胶微胶囊中。