公开(公告)号：US07807844B2

公开(公告)日：2010-10-05

申请号：US10570159

申请日：2004-09-03

申请人： Noboru Fukuda ,  Hirofumi Kishioka ,  Hiroshi Sugiyama

发明人： Noboru Fukuda ,  Hirofumi Kishioka ,  Hiroshi Sugiyama

IPC分类号： C00D403/02 ,  C07D233/00 ,  C07D487/04 ,  C07D233/34

CPC分类号： C07D403/14

摘要： A TGF-β gene expression inhibitor containing a pyrrole-imidazole polyamide having N-methylimidazole unit (hereinafter also referred to as Py), N-methylimidazole unit (hereinafter also referred to as Im) and γ-aminobutyrate unit which can be holded into an U-shaped conformation at the γ-aminobutyrate unit in the minor groove in a double helix region (hereinafter referred to as the target region) containing a complementary chain corresponding to the sequence at the −557 to −536 in the base sequence of a human transforming growth factor β1 (hereinafter also referred to as hTGF-β1) promoter, either as a whole or a part thereof: TAAAGGAGAGCAATTCT-TACAG (SEQ ID NO: 1) wherein a Py/Im pair corresponds to a C-G base pair, an Im/Py pair corresponds to a G-C base pair, and Py/Py pairs correspond respectively to an A-A base pair and a T-A base pair.

摘要翻译： 转化生长因子 含有具有N-甲基咪唑单元（以下也称为Py）的吡咯 - 咪唑聚酰胺，N-甲基咪唑单元（以下也称为Im）和γ-氨基丁酸酯单元的基因表达抑制剂，其可以被保持为U形构象 在双螺旋区域（以下称为靶区域）的小沟槽中的γ-氨基丁酸酯单元中含有对应于人转化生长因子碱基序列中的-557至-536处的序列的互补链 ; 1（以下也称为hTGF-＆bgr; 1）启动子，其全部或部分：TAAAGGAGAGCAATTCT-TACAG（SEQ ID NO：1），其中Py / Im对对应于CG碱基对， / Py对对应于GC碱基对，Py / Py对分别对应于AA碱基对和TA碱基对。

公开(公告)号：US20080103187A1

公开(公告)日：2008-05-01

申请号：US10570159

申请日：2004-09-03

申请人： Noboru Fukuda ,  Hirofumi Kishioka ,  Hiroshi Sugiyama

发明人： Noboru Fukuda ,  Hirofumi Kishioka ,  Hiroshi Sugiyama

IPC分类号： A61K31/4178 ,  C07D403/14

CPC分类号： C07D403/14

摘要： A TGF-β gene expression inhibitor containing a pyrrole-imidazole polyamide having N-methylimidazole unit (hereinafter also referred to as Py), N-methylimidazole unit (hereinafter also referred to as Im) and γ-aminobutyrate unit which can be holded into an U-shaped conformation at the γ-aminobutyrate unit in the minor groove in a double helix region (hereinafter referred to as the target region) containing a complementary chain corresponding to the sequence at the -557 to -536 in the base sequence of a human transforming growth factor β1 (hereinafter also referred to as hTGF-β1) promoter, either as a whole or a part thereof: TAAAGGAGAGCAATTCT-TACAG (SEQ ID NO: 1) wherein a Py/Im pair corresponds to a C-G base pair, an Im/Py pair corresponds to a G-C base pair, and Py/Py pairs correspond respectively to an A-A base pair and a T-A base pair.

摘要翻译： 含有具有N-甲基咪唑单元（以下也称为Py）的吡咯 - 咪唑聚酰胺，N-甲基咪唑单元（以下也称为Im）和γ-氨基丁酸酯单元的TGF-β基因表达抑制剂，其可以保持在 在双螺旋区域（以下称为靶区域）的小沟槽中的γ-氨基丁酸酯单元处的U型构象，其含有对应于人类碱基序列中-557至-536处的序列的互补链 作为整体或其一部分的转化生长因子β1（以下也称为hTGF-β1）启动子：TAAAGGAGAGCAATTCT-TACAG（SEQ ID NO：1），其中Py / Im对对应于CG碱基对，Im / Py对对应于GC碱基对，Py / Py对分别对应于AA碱基对和TA碱基对。

公开(公告)号：US07888516B2

公开(公告)日：2011-02-15

申请号：US11658475

申请日：2005-08-02

申请人： Noboru Fukuda ,  Takahiro Ueno ,  Hiroshi Sugiyama

发明人： Noboru Fukuda ,  Takahiro Ueno ,  Hiroshi Sugiyama

IPC分类号： C07D233/00

CPC分类号： C07D403/12

摘要： A TGF-β gene expression inhibitor containing a pyrrole-immidazole polyamide comprising an N-methylpyrrole unit (hereinafter also referred to as Py), an N-methylimidazole unit (hereinafter also referred to as Im) and a γ-aminobutyric acid unit which can be folded into an U-shaped conformation at the above-described γ-aminobutyric acid unit site in a minor groove of a double-stranded region (hereinafter referred to as the target region) containing a part or the whole of the following base sequence (SEQ ID NO: 2) corresponding to −450 to −310 of human transforming growth factor β1 (hereinafter also referred to as h TGF-β1) promoter and a strand complementary thereto and in which a Py/Im pair, an Im/Py pair and a PY/Py pair correspond respectively to a C-G base pair, a G-C base pair and an A-T base pair and a T-A base pair.

摘要翻译： 转化生长因子 含有N-甲基吡咯单元（以下也称为Py）的吡咯 - 咪唑聚酰胺，N-甲基咪唑单元（以下也称为Im）和γ-氨基丁酸单元的基因表达抑制剂，其可以折叠成 在上述γ-氨基丁酸单元位置的双链区（以下称为靶区）的小槽中的U型构象，其含有部分或全部以下碱基序列（SEQ ID NO： 2）对应于-450至-310的人转化生长因子＆bgr; 1（以下也称为h TGF-β1）启动子和与其互补的链，并且其中Py / Im对，Im / Py对 并且PY / Py对分别对应于CG碱基对，GC碱基对和AT碱基对和TA碱基对。

公开(公告)号：US20090171097A1

公开(公告)日：2009-07-02

申请号：US12093651

申请日：2006-11-14

申请人： Hiroshi Sugiyama ,  Chikara Dohno ,  Noboru Fukuda

发明人： Hiroshi Sugiyama ,  Chikara Dohno ,  Noboru Fukuda

IPC分类号： C07D403/14

CPC分类号： C07D403/14 ,  C07D409/14

摘要： A synthesis method for pyrrole-imidazole polyamide is automated at a higher level and can produce a product with a high yield in a more stable manner. In a solid phase synthesis method, the automated synthesis of a polyimide can be promoted by using HCTU as a condensation-activator, the yield of a product can be increased by charging a monomer in a solid form, and a pyrrole-imidazole polyamide having any sequence can be synthesis by combining the synthesis method with a manual synthesis with an acid chloride.

摘要翻译： 吡咯 - 咪唑聚酰胺的合成方法在更高的水平上自动化，并且可以以更稳定的方式产生高产率的产物。 在固相合成方法中，通过使用HCTU作为缩合活化剂可以促进聚酰亚胺的自动合成，通过加入固体形式的单体可以提高产物的产率，并且可以使用具有任意形式的吡咯 - 咪唑聚酰胺 可以通过将合成方法与手性合成与酰氯组合来合成序列。

公开(公告)号：US20110160399A1

公开(公告)日：2011-06-30

申请号：US13000950

申请日：2009-07-01

申请人： Hiroki Nagase ,  Hiroshi Sugiyama ,  Tukasa Suzuki ,  Toshikazu Bando ,  Makoto Kimura ,  Akimichi Ohtsuki

发明人： Hiroki Nagase ,  Hiroshi Sugiyama ,  Tukasa Suzuki ,  Toshikazu Bando ,  Makoto Kimura ,  Akimichi Ohtsuki

IPC分类号： C08G69/48

CPC分类号： C07D403/14 ,  A61K45/06 ,  A61K47/595 ,  A61K47/60 ,  A61K47/62

摘要： The present invention provides a target gene-specific histone modification regulator, which comprises a conjugate between a histone modification regulator and a polyamide capable of recognizing a regulatory region in a target gene. This enables the provision of a target gene-specific histone modification regulator.

摘要翻译： 本发明提供了靶基因特异性组蛋白修饰调节剂，其包含组蛋白修饰调节剂和能够识别靶基因中调节区的聚酰胺之间的缀合物。 这使得能够提供靶基因特异性组蛋白修饰调节剂。

公开(公告)号：US20090240496A1

公开(公告)日：2009-09-24

申请号：US12404505

申请日：2009-03-16

申请人： Daisuke Yamamoto ,  Hiroshi Sugiyama ,  Toshiyuki Koga ,  Kaoru Suzuki

发明人： Daisuke Yamamoto ,  Hiroshi Sugiyama ,  Toshiyuki Koga ,  Kaoru Suzuki

IPC分类号： G10L15/20 ,  G10L15/00

CPC分类号： G10L15/20 ,  G10L21/0208 ,  G10L25/78

摘要： According to one aspect of the invention, a speech recognizer includes: an audio data acquiring portion configured to acquire audio data via a microphone; a speech section detecting portion configured to detect a talking start time and a talking end time based on the audio data; a spoken word identifying portion configured to identify the audio in a speech section from the talking start time to the talking end time; and a noise suppressing portion configured to suppress a generation of a noise from an electrical noise source for the speech section.

摘要翻译： 根据本发明的一个方面，语音识别器包括：音频数据获取部分，经配置以通过麦克风获取音频数据; 语音部分检测部分，被配置为基于音频数据检测通话开始时间和通话结束时间; 口语单词识别部分，被配置为从通话开始时间到通话结束时间识别话音部分中的音频; 以及噪声抑制部，被配置为抑制来自语音部分的电噪声源的噪声的产生。

公开(公告)号：US07456294B2

公开(公告)日：2008-11-25

申请号：US10507004

申请日：2003-03-03

申请人： Hiroshi Sugiyama ,  Toshikazu Bando ,  Isao Saito

发明人： Hiroshi Sugiyama ,  Toshikazu Bando ,  Isao Saito

IPC分类号： A61K31/407 ,  C07D403/14

CPC分类号： C07D487/04 ,  C07D403/14

摘要： It is intended to provide a pyrrole-imidazole polyamide type functional molecule having enhanced abilities of alkylating DNA and recognizing a sequence, compared with the existing functional molecules of this type, for a specific base sequence occurring on DNA. A hairpin polyamide having an alkylation site via a vinyl linker at the end of a pyrrole-imidazole polyamide. Drugs for inhibiting the expression of a specific gene and anticancer agents containing the above hairpin polyamide.

摘要翻译： 旨在提供一种吡咯 - 咪唑聚酰胺型功能分子，其与DNA上存在的特定碱基序列相比，具有增强的DNA烷基化能力和识别序列，与此类型的现有功能分子相比。 在吡咯 - 咪唑聚酰胺末端通过乙烯基接头具有烷基化位点的发夹聚酰胺。 用于抑制特定基因表达的药物和含有上述发夹聚酰胺的抗癌剂。

公开(公告)号：US20080170653A1

公开(公告)日：2008-07-17

申请号：US11885069

申请日：2006-02-28

申请人： Masami Ando ,  Anton Maksimenko ,  Hiroshi Sugiyama ,  Tetsuya Yuasa

发明人： Masami Ando ,  Anton Maksimenko ,  Hiroshi Sugiyama ,  Tetsuya Yuasa

IPC分类号： G01N23/04 ,  G06K9/00

CPC分类号： A61B6/466 ,  A61B6/4092 ,  A61B6/483 ,  A61B6/502 ,  G01N23/04

摘要： A method and apparatus for constructing a 3-dimensional image of the internal organs invisible by the conventional method is provided. The apparatus comprises: generating means for generating a monochromatic and parallel X-ray beam from an X-ray beam; a reflection-type angle analyzer for reflecting the monochromatic and parallel X-ray beam at reflecting points on both slopes of a reflection curve of the reflection-type analyzer, angle information being extracted to a maximum extent at the reflecting points, the monochromatic and parallel X-ray beam including an X-ray beam which passed through the object when the object is positioned on a rotatable goniometer in the monochromatic and parallel X-ray beam and an X-ray beam from the generating means when the object is not positioned in the monochromatic and parallel X-ray beam; an imaging device for generating a refraction angle data by receiving the monochromic and parallel X-ray beam reflected on the reflection-type angle analyzer to detect the intensity thereof, and output a refraction angle data; andan arithmetic device for constructing the 3-dimensional image by carrying out au arithmetical operation for the refraction angle data from the imaging device.

摘要翻译： 提供了一种通过常规方法构建不可见的内脏的三维图像的方法和装置。 该装置包括：用于从X射线束产生单色和平行X射线束的产生装置; 反射型角度分析仪，用于在反射型分析仪的反射曲线的两个斜率上的反射点处反射单色平行X射线束，在反射点最大程度地提取角度信息，单色和平行 X射线束包括当物体位于单色和平行X射线束中的可旋转角度计上时穿过物体的X射线束，以及当物体未定位在来自发生装置的X射线束时 单色和平行的X射线束; 用于通过接收在反射型角度分析仪上反射的单色和平行X射线束来产生折射角数据以检测其强度并输出折射角数据的成像装置; 以及用于通过对来自成像装置的折射角数据执行自动运算来构造3维图像的运算装置。

公开(公告)号：US20060075021A1

公开(公告)日：2006-04-06

申请号：US11294435

申请日：2005-12-06

申请人： Hiroshi Sugiyama ,  Miwako Doi

发明人： Hiroshi Sugiyama ,  Miwako Doi

IPC分类号： G06F15/16

CPC分类号： H04B1/20

摘要： There is disclosed an information exchange apparatus in which apparatus name information and address information of a display/headphone are transferred to a DVD reproduction apparatus from the display/headphone via a path of an infrared ray or the like different from a radio path for exchanging information. The information are registered in the DVD reproduction apparatus. The DVD reproduction apparatus on a transmission side transmits video and audio information based on information concerning the display/headphone as a reception side registered in the reproduction apparatus, and the display/headphone on the reception side receives the video and audio information transmitted to the display/headphone.

公开(公告)号：US06729711B1

公开(公告)日：2004-05-04

申请号：US09565446

申请日：2000-05-05

申请人： Kenichiro Hashimoto ,  Jiro Moriyama ,  Hiroshi Sugiyama ,  Isao Ebisawa ,  Hisao Yaegashi ,  Toshiharu Inui

发明人： Kenichiro Hashimoto ,  Jiro Moriyama ,  Hiroshi Sugiyama ,  Isao Ebisawa ,  Hisao Yaegashi ,  Toshiharu Inui

IPC分类号： B41J29393

CPC分类号： B41J29/38 ,  B41J2/17503 ,  B41J2/17546 ,  B41J2/17566 ,  B41J25/34 ,  B41J2002/17573 ,  B41J2002/17576

摘要： An ink jet recording apparatus comprises a carriage movable in a given direction with a recording head which is detachably mountable on it and provided with discharge ports for discharging liquid. The apparatus is arranged to include a sensor for detecting the presence or absence of the carriage, the recording head, and at least one of the ink containers. This sensor is provided for the main body of the apparatus and positioned within the movable range of the carriage. With this arrangement, it is possible to simplify the structure required for detecting whether or not these vital elements for recording are installed without any auxiliary power-supply or memory means.

摘要翻译： 一种喷墨记录装置，包括可沿着给定方向移动的托架，其具有可拆卸地安装在其上并具有用于排出液体的排出口的记录头。 该装置被布置成包括用于检测托架，记录头和至少一个墨盒的传感器。 该传感器设置在设备的主体上，并位于滑架的可移动范围内。 利用这种布置，可以简化检测这些用于记录的这些重要元件是否安装在没有任何辅助电源或存储装置的情况下所需的结构。