公开(公告)号：US4565781A

公开(公告)日：1986-01-21

申请号：US583108

申请日：1984-02-24

申请人： Noboru Otake ,  Yoichi Hayakawa ,  Hiroyuki Kawai ,  Masaya Nakagawa ,  Kozo Tanabe ,  Junichiro Mochizuki

发明人： Noboru Otake ,  Yoichi Hayakawa ,  Hiroyuki Kawai ,  Masaya Nakagawa ,  Kozo Tanabe ,  Junichiro Mochizuki

IPC分类号： A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61P31/04 ,  A61P35/00 ,  C07H17/02 ,  C12P1/06 ,  C12P19/28 ,  C12P19/32 ,  C12R1/465 ,  C12P19/40 ,  C07H19/06

CPC分类号： C07H17/02

摘要： An antibiotic, Spicamycin, having the physicochemical properties set forth below is produced by aerobically cultivating a Spicamycin-producing Streptomyces strain in a suitable culture medium, and recovering from the culture the antibiotic, Spicamycin.(1) Color and properties: Weakly acidic white powder(2) Melting point: 215.degree. to 220.degree. C. (decomposed)(3) Specific rotatory power: [.alpha.].sub.D.sup.25 =+15.degree. (C: 0.15, in methanol)(4) Elementary analysis (Found): C: 57.4%, H: 8.3%; N: 15.7%, O: 18.6%(5) Ultraviolet absorption spectrum (maximum):______________________________________ CH.sub.3 OH 264 nm (E.sub.1cm.sup.1% 257) 0.01N NaOH + CH.sub.3 OH 272 nm (E.sub.1cm.sup.1% 226) 0.01N HCl + CH.sub.3 OH 273 nm (E.sub.1cm.sup.1% 258) ______________________________________ (6) Infrared absorption spectrum (as measured by the potassium bromide method): As shown in FIG. 2.(7) Solubility in Solvent: Soluble in basic water, dimethyl sulfoxide, methanol, ethanol, n-propanol, and n-butanol. Sparingly soluble in water, acetone, ethyl acetate, and chloroform. Insoluble in benzene, ethyl ether, and hexane.(8) Thin layer chromatography (using "Silica Gel 60F.sub.254 " plate supplied by Merck & Co., Inc.):______________________________________ Developing solvent Rf value ______________________________________ Chloroform:Methanol (1:1) 0.34 ______________________________________ (9) NMR spectrum (400 MHz, in deuteromethanol): As shown in FIG. 3.

摘要翻译： 具有下述物理化学性质的抗生素Spicamycin通过在合适的培养基中有条不紊地培养产生Spicamycin的链霉菌菌株产生，并从培养物中回收抗生素Spicamycin。 （1）颜色和性质：弱酸性白色粉末（2）熔点：215〜220℃（分解）（3）比旋光度：αD25= + 15℃（甲醇中C：0.15） （4）元素分析（实测值）：C：57.4％，H：8.3％ N：15.7％，O：18.6％（5）紫外吸收光谱（最大）：-CH 3 OH 264nm（E1cm1％257）-0.01N NaOH + CH3OH 272nm（E1cm1％226）-0.01N HCl + CH3OH 273nm E1cm1％258） - （6）红外吸收光谱（通过溴化钾法测定）：如图1所示。 （7）溶剂中的溶解度：溶于碱性水，二甲基亚砜，甲醇，乙醇，正丙醇和正丁醇。 微溶于水，丙酮，乙酸乙酯和氯仿。 不溶于苯，乙醚和己烷。 （8）薄层色谱法（使用由Merck＆Co.，Inc。提供的“Silica Gel 60F254”板）：显影溶剂Rf值 - 氯仿：甲醇（1：1）0.34 - （9）NMR谱（400MHz， 在氘甲醇中）： 3。

公开(公告)号：US4598146A

公开(公告)日：1986-07-01

申请号：US583180

申请日：1984-02-24

申请人： Noboru Otake ,  Hiroyuki Kawai ,  Yoichi Hayakawa ,  Masaya Nakagawa ,  Kanji Imamura ,  Kozo Tanabe

发明人： Noboru Otake ,  Hiroyuki Kawai ,  Yoichi Hayakawa ,  Masaya Nakagawa ,  Kanji Imamura ,  Kozo Tanabe

IPC分类号： C07G11/00 ,  A61K35/74 ,  A61P35/00 ,  C07H15/252 ,  C12P1/06 ,  C12P19/56 ,  C12R1/465 ,  C07H15/24

CPC分类号： C07H15/252 ,  C12P19/56 ,  C12R1/465

摘要： An anthracycline compound, Arugomycin, having the physicochemical properties set forth below is produced by aerobically cultivating an Arugomycin-producing Streptomyces strain in a suitable culture medium, and recovering from the culture the anthracycline compound, Arugomycin.(1) Color and form:Orange powder(2) Melting point:207.degree. to 213.degree. C. (decomposed)(3) Specific rotatory power:[.alpha.].sub.D.sup.25 =+112.degree.(C: 0.1, chloroform:methanol=9:1)(4) Elementary analysis (%):______________________________________ C H O N ______________________________________ Found 56.2 6.9 35.1 1.8 Calcd. 56.7 6.7 34.9 1.7 ______________________________________ (5) Ultraviolet and visible absorption spectrum: as shown in FIG. 1.______________________________________ .lambda..sub.max (E.sup.1% .sub.1cm) ______________________________________ CH.sub.3 OH 235(363), 258(167), 292(61), 476(104) 0.1N HCl + CH.sub.3 OH 235(387), 258(159), 292(61), 468(110) 0.1N NaOH + CH.sub.3 OH 239(302), 294(41), 543(88) ______________________________________ (6) Infrared absorption spectrum (as measured by the potassium bromide method): as shown in FIG. 2.(7) Solubility in solvent:Easily soluble in a chloroform-methanol mixture, dimethyl sulfoxide, pyridine, and basic water.Soluble in chloroform, methanol, ethyl acetate, methyl ethyl ketone, butanol, butyl acetate, ethanol, acetone, and acidic water.Sparingly soluble in water.(8) Thin layer chromatography (using "Silica Gel 60F.sub.254 " plate supplied by Merck & Co., Inc.):______________________________________ Developing solvent Rf value ______________________________________ Chloroform:Methanol (8:1) 0.20 Chloroform:Methanol:29% Aqueous 0.25 ammonia (8:1:0.1) Chloroform:Methanol:Acetic acid 0.30 (8:1:0.1) Chloroform:Benzene:Methanol 0.26 (7:2:2) ______________________________________ (9) NMR spectrum (400 MHz, in deuterochloroform-deuteromethanol): as shown in FIG. 3.(10) Molecular weight (SIMS):m/z 1694 (M+H).

摘要翻译： 具有下述物理化学性质的蒽环霉素化合物阿鲁木霉是通过在合适的培养基中有条不紊地培养产阿霉素霉素链霉菌菌株产生的，并从培养物中回收蒽环类化合物阿鲁霉素。 （1）颜色和形式：橙色粉末（2）熔点：207〜213℃（分解）（3）比旋光度：αD25= + 112°（C：0.1，氯仿：甲醇= 9 ：1）（4）元素分析（％）：-CHON-发现56.2 6.9 35.1 1.8 - 56.7 6.7 34.9 1.7 - （5）紫外和可见吸收光谱：如图1所示。 - λmax（E1％1cm）-CH 3 OH 235（363），258（167），292（61）， - 476（104）-0.1N HCl + CH3OH 235（387），258（159） 61）， - 468（110）-0.1N NaOH + CH3OH 239（302），294（41），543（88） - （6）红外吸收光谱（通过溴化钾法测量）： （7）溶剂中的溶解性：易溶于氯仿 - 甲醇混合物，二甲基亚砜，吡啶和碱性水。 溶于氯仿，甲醇，乙酸乙酯，甲基乙基酮，丁醇，乙酸丁酯，乙醇，丙酮和酸性水。 微溶于水。 （8）薄层色谱法（使用由Merck＆Co.，Inc。提供的“Silica Gel 60F254”板）： - 显影溶剂Rf值 - 氯仿：甲醇（8:1）0.20-氯仿：甲醇：29％ 氨（8：1：0.1） - 氯仿：甲醇：乙酸0.30 - （8：1：0.1） - 氯仿：苯：甲醇0.26 - （7：2：2） - （9）NMR谱（400MHz， 氘氯仿 - 氘代甲醇）：如图1所示。 （10）分子量（SIMS）：m / z 1694（M + H）。

公开(公告)号：US07661887B2

公开(公告)日：2010-02-16

申请号：US12143336

申请日：2008-06-20

申请人： Masaya Nakagawa

发明人： Masaya Nakagawa

IPC分类号： G02B6/38 ,  G02B6/36

CPC分类号： G02B6/4296 ,  G02B6/4246 ,  G02B6/4292 ,  G02B2006/4297

摘要： According to the shutter assembly of the present invention, since the guide groove for facilitating the insertion of the pivot shaft into the bearing hole of the second bearing part of the shutter member is formed at the opposing end surface of the second bearing part that faces to the first bearing part of the shutter member so that the guide groove is opened to the opposing end surface and is along the direction orthogonal to the axial-line direction of the pivot shaft, it is possible to easily and accurately form the guide groove.

摘要翻译： 根据本发明的闸门组件，由于用于便于将枢轴插入活门构件的第二轴承部分的轴承孔中的导槽形成在第二轴承部分的相对端面上， 活门构件的第一承载部分，使得导向槽朝向相对的端面开口并且沿着与枢转轴的轴线方向正交的方向，可以容易且精确地形成导向槽。

公开(公告)号：US07648286B2

公开(公告)日：2010-01-19

申请号：US12143277

申请日：2008-06-20

申请人： Masaya Nakagawa

发明人： Masaya Nakagawa

IPC分类号： G02B6/38 ,  G02B6/36

CPC分类号： G02B6/4296 ,  G02B6/4201 ,  G02B6/424 ,  G02B6/4246 ,  G02B6/4255 ,  G02B6/4256 ,  G02B6/4261 ,  G02B6/4292 ,  G02B2006/4297

摘要： According to the shutter assembly of the present invention, since the shutter member is connected in a swingable manner with the shutter housing that could be mounted on the optical adapter so as to surround the optical adapter, it is possible to easily provide the shutter member in either of the SC or LC optical adapter only by mounting the shutter housing on the SC or LC type optical adapter.

摘要翻译： 根据本发明的活门组件，由于活门构件与可安装在光学适配器上的遮光罩外壳以可摆动的方式连接，以便围绕光学适配器，因此可以容易地将遮光构件 只有通过将快门外壳安装在SC或LC型光学适配器上，才能使用SC或LC光纤适配器。

公开(公告)号：US08506174B2

公开(公告)日：2013-08-13

申请号：US13150567

申请日：2011-06-01

申请人： Masaya Nakagawa

发明人： Masaya Nakagawa

IPC分类号： G02B6/36

CPC分类号： G02B6/3897 ,  G02B6/3825 ,  G02B6/3893

摘要： An optical connector includes a second operation lever extending rearward from a first operation lever. By pressing a rear end portion of the second operation lever up, or pressing the second operation lever forward, the first operation lever can be inclined forward. In this way, a front end portion of the first operation lever presses a rear end portion of a locking lever down, and disengages the locking lever and an optical adapter from each other. Thus, the optical connector can be detached from the optical adapter.

摘要翻译： 光学连接器包括从第一操作杆向后延伸的第二操作杆。 通过向上按压第二操作杆的后端部或向前按压第二操作杆，第一操作杆可以向前倾斜。 以这种方式，第一操作杆的前端部向下按压锁定杆的后端部，并且使锁定杆和光学适配器彼此脱离。 因此，光学连接器可以从光学适配器拆下。

公开(公告)号：US20070165984A1

公开(公告)日：2007-07-19

申请号：US11643083

申请日：2006-12-21

申请人： Masaya Nakagawa

发明人： Masaya Nakagawa

IPC分类号： G02B6/38

CPC分类号： G02B6/3825 ,  G02B6/3897

摘要： There is provided optical adaptor mounting metal fittings for mounting an optical adaptor on a panel through it without wobbling and an optical adaptor with the mounting metal fittings attached thereto. An optical adaptor mounting metal fittings to be attached to the outer surface of an optical adaptor comprises a joining plate and a pair of facing side plates extending from either side of the joining plate nearly at a right angle, the side plates each comprise an elastic click engagement formed by cutting out and raising the middle part of the side plate so that the front end thereof closely faces the panel. A first side plate piece that is on the joining plate side of the elastic click engagement, and a second side plate piece that is on the opposite side of the elastic click engagement to the first side plate piece, and first elastic engagements each obliquely extending from the front end of the second side plate piece toward the joining plate and the optical adaptor are provided.

摘要翻译： 提供了光学适配器安装金属配件，用于通过其将光学适配器安装在面板上而不产生摆动，并且光学适配器具有附接到其上的安装金属配件。 要安装在光学适配器的外表面上的光学适配器安装金属配件包括接合板和一对相对的侧板，几乎以直角从接合板的任一侧延伸，侧板各自包括弹性单击 通过切割和提升侧板的中间部分使得其前端紧密面对面板而形成接合。 第一侧板件，其位于弹性止动卡合的接合板侧，以及第二侧板件，其位于与第一侧板件的弹性止动接合的相对侧上，以及第一弹性接合部， 第二侧板件的前端朝向接合板和光适配器。

公开(公告)号：US20050250843A1

公开(公告)日：2005-11-10

申请号：US10516320

申请日：2003-04-03

申请人： Yasushi Nakada ,  Masaya Nakagawa ,  Satoshi Ono

发明人： Yasushi Nakada ,  Masaya Nakagawa ,  Satoshi Ono

IPC分类号： A61K31/122 ,  A61K31/21 ,  A61K31/381 ,  A61K31/397 ,  A61K31/445 ,  A61K31/473 ,  A61K31/55 ,  A61K45/06 ,  A61P25/28 ,  A61P43/00 ,  A61K31/343 ,  C07D333/72

CPC分类号： A61K45/06 ,  A61K31/122 ,  A61K31/21 ,  A61K31/381 ,  A61K31/397 ,  A61K31/445 ,  A61K31/473 ,  A61K31/55 ,  A61K2300/00

摘要： An alkyl ether derivative represented by the formula: wherein R1, R2, R3, R4, m and n are as defined in the specification, or salts thereof exhibits synergistically improved anti-hypoxic activity when combined with a compound having an acetylcholine esterase inhibitory activity. Therefore, the combination according to the present invention is useful as a method for improving cerebral function. Further, a pharmaceutical composition containing the compound relating to the combination according to the present invention is useful for treatment and prevention of dysfunction of cerebral acetylcholine neurons in the sequelae of cerebrovascular dementia, senile dementia, Alzheimer's disease and ischemic cerebral lesion and in the cerebral apoplexy or the memory impairment caused by selective neuronal death.

摘要翻译： 由下式表示的烷基醚衍生物：其中R 1，R 2，R 3，R 4， m和n如说明书中所定义，或当其与具有乙酰胆碱酯酶抑制活性的化合物组合时，其表现出协同改善的抗缺氧活性。 因此，本发明的组合作为改善脑功能的方法是有用的。 此外，含有本发明组合物的化合物的药物组合物可用于治疗和预防脑血管性痴呆，老年痴呆，老年痴呆症和缺血性脑损伤后遗症中脑乙酰胆碱神经元的功能障碍和脑中风 或由选择性神经元死亡引起的记忆障碍。

公开(公告)号：US07997806B2

公开(公告)日：2011-08-16

申请号：US12372991

申请日：2009-02-18

申请人： Masaya Nakagawa

发明人： Masaya Nakagawa

IPC分类号： G02B6/36

CPC分类号： G02B6/3861 ,  G02B6/3821 ,  G02B6/3825 ,  G02B6/3834

摘要： An optical fiber connector includes a housing, a ferrule, a bias member and a flexible tube. The ferrule is formed with a first axial hole of a first inner diameter larger than an outer diameter of a jacket of an optical fiber and a second axial hole that is communicated to a distal end of the first axial hole and that has a second inner diameter smaller than the first inner diameter and larger than an outer diameter of a fiber wire of the optical fiber. The flexible tube is inserted around the proximal end side of the ferrule so that at least a part thereof is extended toward the proximal end side than the ferrule to form a proximal-end-side extended part. The proximal-end-side extended part has an inner diameter larger than the outer diameter of the jacket and smaller than the first inner diameter.

摘要翻译： 光纤连接器包括壳体，套圈，偏置构件和柔性管。 套圈形成有第一内径大于光纤护套外径的第一轴向孔和与第一轴向孔的远端连通的第二轴向孔，并且具有第二内径 小于第一内径并且大于光纤的光纤线的外径。 柔性管插入到套圈的基端侧，使得其至少一部分比套圈向基端侧延伸以形成近端侧延伸部。 近端侧延伸部的内径大于护套的外径，小于第一内径。

公开(公告)号：USRE42327E1

公开(公告)日：2011-05-03

申请号：US12683813

申请日：2003-04-03

申请人： Yasushi Nakada ,  Masaya Nakagawa ,  Satoshi Ono

发明人： Yasushi Nakada ,  Masaya Nakagawa ,  Satoshi Ono

IPC分类号： A61K31/38

CPC分类号： A61K45/06 ,  A61K31/122 ,  A61K31/21 ,  A61K31/381 ,  A61K31/397 ,  A61K31/445 ,  A61K31/473 ,  A61K31/55 ,  A61K2300/00

摘要： An alkyl ether derivative represented by the formula: wherein R1, R2, R3, R4, m and n are as defined in the specification, or salts thereof exhibits synergistically improved anti-hypoxic activity when combined with a compound having an acetylcholine esterase inhibitory activity. Therefore, the combination according to the present invention is useful as a method for improving cerebral function. Further, a pharmaceutical composition containing the compound relating to the combination according to the present invention is useful for treatment and prevention of dysfunction of cerebral acetylcholine neurons in the sequelae of cerebrovascular dementia, senile dementia, Alzheimer's disease and ischemic cerebral lesion and in the cerebral apoplexy or the memory impairment caused by selective neuronal death.

摘要翻译： 由下式表示的烷基醚衍生物：其中R 1，R 2，R 3，R 4，m和n如说明书中所定义，或其盐与具有乙酰胆碱酯酶抑制活性的化合物组合时，表现出协同改善的抗缺氧活性。 因此，本发明的组合作为改善脑功能的方法是有用的。 此外，含有本发明组合物的化合物的药物组合物可用于治疗和预防脑血管性痴呆，老年痴呆，老年痴呆症和缺血性脑损伤后遗症中脑乙酰胆碱神经元的功能障碍和脑中风 或由选择性神经元死亡引起的记忆障碍。

公开(公告)号：US20110045113A1

公开(公告)日：2011-02-24

申请号：US12989667

申请日：2009-05-13

申请人： Takuji Miyasaka ,  Hirohide Sato ,  Ryota Yoshimura ,  Masaya Nakagawa ,  Eiji Doba ,  Hiroyuki Ito ,  Takeo Aridabe

发明人： Takuji Miyasaka ,  Hirohide Sato ,  Ryota Yoshimura ,  Masaya Nakagawa ,  Eiji Doba ,  Hiroyuki Ito ,  Takeo Aridabe

IPC分类号： B29C43/58

CPC分类号： B21D24/02

摘要： In the die cushion device, a shock absorber device relieves shock between a cushion pad and a support section. The shock absorber device includes a damping section and an elastic section. The damping section generates reaction force in accordance with the relative speed of the cushion pad with respect to the support section. The elastic section generates reaction force in accordance with the relative displacement of the cushion pad with respect to the support section. The controller section controls a servomotor so that a speed difference between the speed of the slide member and the speed of the support section is set to be a predetermined target speed difference value that changes over time.

摘要翻译： 在模具缓冲装置中，减震装置减轻缓冲垫和支撑部之间的冲击。 减震装置包括阻尼部和弹性部。 阻尼部根据缓冲垫相对于支撑部的相对速度产生反作用力。 弹性部分根据缓冲垫相对于支撑部的相对位移产生反作用力。 控制器部分控制伺服电动机，使得滑动构件的速度和支撑部分的速度之间的速度差设定为随时间变化的预定目标速度差值。