公开(公告)号：US06784999B1

公开(公告)日：2004-08-31

申请号：US10031659

申请日：2001-11-13

申请人： Nongjian Tao ,  Salah Boussaad ,  Wenlue Huang

发明人： Nongjian Tao ,  Salah Boussaad ,  Wenlue Huang

IPC分类号： G01N2100

CPC分类号： G01N21/553

摘要： A device and method of detecting surface plasmon resonance for sensing molecules or conformational changes in molecules with high resolution and fast response time is disclosed. Light from a light source (14) is focused through a prism onto a metal thin film (15) on which sample molecules to be detected are adsorbed. The total internal reflection of the laser/incident light is collected with a differential position or intensity sensitive photo-detecting device instead of a single cell or an array of photo-detectors (12) that are widely used in previous works. The ratio of the differential signal to the sum signal of the differential position or intensity sensitive photo-detecting device (12) provides an accurate measurement of the shift in the surface plasmon resonance angle caused by the adsorption of molecules onto the metal films (15) or by conformational changes in the adsorbed molecules. The present invention requires no numerical fitting to determine the resonant angle and the setup is compact and immune to background light, The methods and sensors of this invention can be used in numerous biological, biochemical, and chemical applications such as measuring subtle conformational changes in molecules and electron transfer reactions can be studied.

摘要翻译： 公开了一种用于检测表面等离子体共振以用于感测分子的分子或构象变化的装置和方法，其具有高分辨率和快速响应时间。 来自光源（14）的光通过棱镜聚焦到金属薄膜（15）上，待测样品分子被吸附在其上。 激光/入射光的全部内部反射是用差分位置或强度敏感的光检测装置代替在以前的工作中广泛使用的单个电池或光电检测器阵列（12）来收集的。 微分信号与差分位置或强度敏感光检测装置（12）的和信号的比率提供了由分子吸附到金属膜（15）上引起的表面等离子体共振角的偏移的精确测量， 或通过吸附分子的构象变化。 本发明不需要数值拟合来确定共振角，并且设置是紧凑的并且不受背景光的影响。本发明的方法和传感器可用于许多生物学，生物化学和化学应用，例如测量分子中微妙的构象变化 并可以研究电子转移反应。

公开(公告)号：US08215170B2

公开(公告)日：2012-07-10

申请号：US11568209

申请日：2006-10-23

申请人： Nongjian Tao ,  Salah Boussaad

发明人： Nongjian Tao ,  Salah Boussaad

IPC分类号： G01N29/12

CPC分类号： G01N29/036 ,  G01N29/022 ,  G01N2291/014 ,  G01N2291/0257 ,  Y10T29/49117 ,  Y10T29/49574

摘要： A device for sensing a chemical analyte is disclosed. The device is comprised of a vibrating structure having first and second surfaces and having an associated resonant frequency and a wire coupled between the first and second surfaces of the vibrating structure, wherein the analyte interacts with the wire and causes a change in the resonant frequency of the vibrating structure. The vibrating structure can include a tuning fork. The vibrating structure can be comprised of quartz. The wire can be comprised of polymer. A plurality of vibrating structures are arranged in an array to increase confidence by promoting a redundancy of measurement or to detect a plurality of chemical analytes. A method of making a device for sensing a chemical analyte is also disclosed.

摘要翻译： 公开了用于感测化学分析物的装置。 该装置包括具有第一和第二表面并且具有相关联的谐振频率的振动结构和耦合在振动结构的第一和第二表面之间的导线，其中分析物与导线相互作用并导致谐振频率的变化 振动结构。 振动结构可以包括音叉。 振动结构可以由石英组成。 电线可以由聚合物组成。 多个振动结构被布置成阵列以通过促进测量的冗余或检测多个化学分析物来增加置信度。 还公开了一种制造用于感测化学分析物的装置的方法。

公开(公告)号：US07030452B2

公开(公告)日：2006-04-18

申请号：US10795151

申请日：2004-03-04

申请人： Nongjian Tao ,  Salah Boussaad

发明人： Nongjian Tao ,  Salah Boussaad

IPC分类号： H01L27/14 ,  H01L29/82 ,  H01L29/84

CPC分类号： G01R33/06 ,  B82Y10/00 ,  B82Y15/00 ,  H01L49/006 ,  H01L51/0595

摘要： A method for forming atomic-scale contacts and atomic-scale gaps between two electrodes is disclosed. The method provides for applying a voltage between two electrodes in a circuit with a resistor. The applied voltage etches metal ions off one electrode and deposits the metal ions onto the second electrode. The metal ions are deposited on the sharpest point of the second electrode, causing the second electrode to grow towards the first electrode until an atomic-scale contact is formed. By increasing the magnitude of the resistor, the etching and deposition process will terminate prior to contact, forming an atomic-scale gap. The atomic-scale contacts and gaps formed according to this method are useful as a variety of nanosensors including chemical sensors, biosensors, hydrogen ion sensors, heavy metal ion sensors, magnetoresistive sensors, and molecular switches.

摘要翻译： 公开了一种在两个电极之间形成原子尺度接触和原子尺度间隙的方法。 该方法提供了在具有电阻器的电路中的两个电极之间施加电压。 施加的电压将金属离子从一个电极上除去并将金属离子沉积到第二电极上。 金属离子沉积在第二电极的最尖点上，导致第二电极朝着第一电极生长，直到形成原子级接触。 通过增加电阻的大小，蚀刻和沉积过程将在接触之前终止，形成原子尺度间隙。 根据该方法形成的原子尺度接触和间隙可用作各种包括化学传感器，生物传感器，氢离子传感器，重金属离子传感器，磁阻传感器和分子开关的纳米传感器。

公开(公告)号：US06737286B2

公开(公告)日：2004-05-18

申请号：US10305708

申请日：2002-11-27

申请人： Nongjian Tao ,  Salah Boussaad

发明人： Nongjian Tao ,  Salah Boussaad

IPC分类号： H01L2166

CPC分类号： G01R33/06 ,  B82Y10/00 ,  B82Y15/00 ,  H01L49/006 ,  H01L51/0595

摘要： A method for forming atomic-scale contacts and atomic-scale gaps between two electrodes is disclosed. The method provides for applying a voltage between two electrodes in a circuit with a resistor. The applied voltage etches metal ions off one electrode and deposits the metal ions onto the second electrode. The metal ions are deposited on the sharpest point of the second electrode, causing the second electrode to grow towards the first electrode until an atomic-scale contact is formed. By increasing the magnitude of the resistor, the etching and deposition process will terminate prior to contact, forming an atomic-scale gap. The atomic-scale contacts and gaps formed according to this method are useful as a variety of nanosensors including chemical sensors, biosensors, hydrogen ion sensors, heavy metal ion sensors, magnetoresistive sensors, and molecular switches.

摘要翻译： 公开了一种在两个电极之间形成原子尺度接触和原子尺度间隙的方法。 该方法提供了在具有电阻器的电路中的两个电极之间施加电压。 施加的电压将金属离子从一个电极上除去并将金属离子沉积到第二电极上。 金属离子沉积在第二电极的最尖点上，导致第二电极朝着第一电极生长，直到形成原子级接触。 通过增加电阻的大小，蚀刻和沉积过程将在接触之前终止，形成原子尺度间隙。 根据该方法形成的原子尺度接触和间隙可用作各种包括化学传感器，生物传感器，氢离子传感器，重金属离子传感器，磁阻传感器和分子开关的纳米传感器。

公开(公告)号：US20200156074A1

公开(公告)日：2020-05-21

申请号：US16689530

申请日：2019-11-20

申请人： Nongjian Tao ,  Wenwen Jing

发明人： Nongjian Tao ,  Wenwen Jing

IPC分类号： B01L3/00 ,  G01N1/38 ,  G01N33/543

摘要： A method for detecting biomarkers with shortened test time and maximized precision. A sample from the body fluid is made to flow over a sensor surface coated with a capture antibody to allow binding of a biomarker in the sample to the capture body. An optical method detects and counts the individual binding events along the sensor surface with single molecule resolution, and difference in the binding events along the sensor surface is detected in real time and analyzed to determine the biomarker concentration.

公开(公告)号：US10143401B2

公开(公告)日：2018-12-04

申请号：US13493552

申请日：2012-06-11

申请人： Nongjian Tao ,  Erica Forzani

发明人： Nongjian Tao ,  Erica Forzani

IPC分类号： A61B5/08 ,  A61B5/083 ,  G06Q50/22

摘要： A method for weight and/or fitness management using a metabolic analyzer that measures metabolic data including oxygen and carbon dioxide. The metabolic analyzer includes integrated collection-detection sensors with for high efficiency and collection, high specificity and simultaneous detection of at least two metabolic signatures, including at least oxygen and carbon dioxide, in breath via a porous membrane with high density of sensing binding sites, where the porous membrane includes sensing materials such that the sensing binding sites are specific to the metabolic signatures, and change colors upon interactions with the metabolic signatures. Weight of the subject is measured using a weight measurement device and a recommendation for food intake and/or physical activity is based on at least the readings of the metabolic analyzer and weight of the subject.

公开(公告)号：US09581561B2

公开(公告)日：2017-02-28

申请号：US14160035

申请日：2014-01-21

申请人： Nongjian Tao ,  Erica Forzani ,  Rodrigo A Iglesias

发明人： Nongjian Tao ,  Erica Forzani ,  Rodrigo A Iglesias

IPC分类号： G01N15/06 ,  G01N33/00 ,  G01N33/48 ,  G01N27/27 ,  G01N21/78 ,  G01N31/22 ,  G01N21/05

CPC分类号： G01N27/27 ,  G01N21/05 ,  G01N21/783 ,  G01N31/223 ,  G01N33/0037 ,  Y02A50/245 ,  Y10T436/173845

摘要： A gas-phase detection system based on detecting optochemical and optoelectrochemical signals. The sensing platform is particularly powerful for detection of nitrogen oxides at low ppbV concentrations. The optochemical analysis is based on the color development due to a chemical reaction taking place in an optimized material. The electrochemical analysis can be based on the doping level or redox potential changes of an electrochemical sensor; and optoelectrochemical detection can be based on a combination of the electrochemical and optoelectrochemical methodologies. Each independent signal can be simultaneously detected, increasing the reliability of detection.

摘要翻译： 一种基于光电化学和光电信号检测的气相检测系统。 传感平台对于检测低ppbV浓度的氮氧化物特别强大。 光化学分析是由于化学反应发生在优化材料中的颜色发展。 电化学分析可以基于电化学传感器的掺杂水平或氧化还原电位变化; 光电化学检测可以基于电化学和光电化学方法的组合。 可以同时检测每个独立信号，提高检测的可靠性。

公开(公告)号：US20130248379A1

公开(公告)日：2013-09-26

申请号：US13893181

申请日：2013-05-13

申请人： Nongjian Tao ,  Erica Forzani

发明人： Nongjian Tao ,  Erica Forzani

IPC分类号： G01N27/27

CPC分类号： G01N27/27 ,  G01N27/3277

摘要： An integrated sensing device is capable of detecting analytes using electrochemical (EC) and electrical (E) signals. The device introduces synergetic new capabilities and enhances the sensitivity and selectivity for real-time detection of an analyte in complex matrices, including the presence of high concentration of interferences in liquids and in gas phases.

摘要翻译： 集成的感测装置能够使用电化学（EC）和电（E）信号来检测分析物。 该设备引入了协同的新功能，并增强了对复杂基质中分析物的实时检测的灵敏度和选择性，包​​括在液体和气相中存在高浓度的干扰。

公开(公告)号：US20130150746A1

公开(公告)日：2013-06-13

申请号：US13493552

申请日：2012-06-11

申请人： Nongjian Tao ,  Erica Forzani

发明人： Nongjian Tao ,  Erica Forzani

IPC分类号： A61B5/083

CPC分类号： A61B5/0833 ,  A61B5/08 ,  A61B5/083 ,  A61B5/0836 ,  G06F19/00 ,  G06Q50/22 ,  Y02P90/84 ,  Y02P90/845

摘要： A method for weight and/or fitness management using a metabolic analyzer that measures metabolic data including oxygen and carbon dioxide. The metabolic analyzer includes integrated collection-detection sensors with for high efficiency and collection, high specificity and simultaneous detection of at least two metabolic signatures, including at least oxygen and carbon dioxide, in breath via a porous membrane with high density of sensing binding sites, where the porous membrane includes sensing materials such that the sensing binding sites are specific to the metabolic signatures, and change colors upon interactions with the metabolic signatures. Weight of the subject is measured using a weight measurement device and a recommendation for food intake and/or physical activity is based on at least the readings of the metabolic analyzer and weight of the subject.

摘要翻译： 使用代谢分析仪测量包括氧气和二氧化碳在内的代谢数据的体重和/或健康管理方法。 代谢分析仪包括集成采集检测传感器，通过具有高密度感测结合位点的多孔膜，具有高效率和收集性，高特异度和同时检测至少两种代谢特征（包括至少氧气和二氧化碳） 其中多孔膜包括感测材料，使得感测结合位点对于代谢特征是特异性的，并且在与代谢特征相互作用时改变颜色。 使用体重测量装置测量受试者的体重，并且关于食物摄取和/或身体活动的建议至少基于代谢分析仪的读数和受试者的体重。

公开(公告)号：US20120118045A1

公开(公告)日：2012-05-17

申请号：US13322898

申请日：2010-06-02

申请人： Nongjian Tao ,  Erica Forzani ,  Rodrigo A. Iglesias

发明人： Nongjian Tao ,  Erica Forzani ,  Rodrigo A. Iglesias

IPC分类号： G01N7/00

CPC分类号： G01N27/27 ,  G01N21/05 ,  G01N21/783 ,  G01N31/223 ,  G01N33/0037 ,  Y02A50/245 ,  Y10T436/173845

摘要： A gas-phase detection system based on detecting optochemical and optoelectrochemical signals. The sensing platform is particularly powerful for detection of nitrogen oxides at low ppbV concentrations. The optochemical analysis is based on the color development due to a chemical reaction taking place in an optimized material. The electrochemical analysis can be based on the doping level or redox potential changes of an electrochemical sensor; and optoelectrochemical detection can be based on a combination of the electrochemical and optoelectrochemical methodologies. Each independent signal can be simultaneously detected, increasing the reliability of detection.

摘要翻译： 一种基于光电化学和光电信号检测的气相检测系统。 传感平台对于检测低ppbV浓度的氮氧化物特别强大。 光化学分析是由于化学反应发生在优化材料中的颜色发展。 电化学分析可以基于电化学传感器的掺杂水平或氧化还原电位变化; 光电化学检测可以基于电化学和光电化学方法的组合。 可以同时检测每个独立信号，提高检测的可靠性。