公开(公告)号：US07220878B2

公开(公告)日：2007-05-22

申请号：US10490432

申请日：2001-09-27

申请人： Norihisa Kondo ,  Hideyuki Mimura ,  Kosuke Kawada ,  Shoji Arai

发明人： Norihisa Kondo ,  Hideyuki Mimura ,  Kosuke Kawada ,  Shoji Arai

IPC分类号： C07C69/66

CPC分类号： C07C67/54 ,  C07C69/716

摘要： The present invention concerns a method for purifying/separating a 2-fluoro-3-oxoalkylcarboxylic acid ester from a reaction mixture resulting from the fluorination of a 3-oxoalkylcarboxylic acid ester. The method involves depleting the reaction mixture of a hydrogen fluoride byproduct; and subsequently, separating the 2-fluoro-3-oxoalkylcarboxylic acid ester by distillation. The 2-fluoro-3-oxoalkylcarboxylic acid ester obtained by the method of the invention is highly pure and is thus suitable for use as an intermediate for the production of pharmacological products or agricultural chemicals.

摘要翻译： 本发明涉及从3-氧代烷基羧酸酯氟化得到的反应混合物中纯化/分离2-氟-3-氧代烷基羧酸酯的方法。 该方法涉及耗尽氟化氢副产物的反应混合物; 随后通过蒸馏分离2-氟-3-氧代烷基羧酸酯。 通过本发明方法获得的2-氟-3-氧代烷基羧酸酯是高纯度的，因此适合用作生产药物产品或农药的中间体。

公开(公告)号：US07019162B2

公开(公告)日：2006-03-28

申请号：US10451814

申请日：2001-12-25

申请人： Norihisa Kondo ,  Hideyuki Mimura ,  Kazunori Nukui ,  Kosuke Kawada ,  Shoji Arai

发明人： Norihisa Kondo ,  Hideyuki Mimura ,  Kazunori Nukui ,  Kosuke Kawada ,  Shoji Arai

IPC分类号： C07C69/66

CPC分类号： C07C67/58 ,  C07C67/307 ,  C07C69/738 ,  C07C69/716

摘要： A process for producing a 2-fluoro-3-oxoalkylcarboxylic acid ester by fluorinating 3-oxoalkylcarboxylic acid ester with a fluorine gas is provided. The process is characterized in that the concentration of 3-oxoalkylcarboxylic acid ester in the reaction mixture for fluorination is maintained at 3 wt % or higher. Also provided is a process for purifying 2-fluoro-3-oxoalkylcarboxylic acid ester characterized in that 2-fluoro-3-oxoalkylcarboxylic acid ester is produced at high yield and with less impurities by washing fluorinated 3-oxoalkylcarboxylic acid ester with 3 or more times as much water as the amount of reaction mixture. According to the processes of the present invention, not only is the generation of unwanted by-products minimized, but fluorinated 3-oxoalkylcarboxylic acid ester can be purified in an efficient manner. Thus, the present invention permits efficient production of considerably pure 2-fluoro-3-oxoalkylcarboxylic acid ester, a useful intermediate material in the production of various medical and agricultural agents.

摘要翻译： 提供了通过用氟气氟化3-氧代烷基羧酸酯来制备2-氟-3-氧代烷基羧酸酯的方法。 该方法的特征在于用于氟化的反应混合物中3-氧代烷基羧酸酯的浓度保持在3重量％以上。 还提供了一种纯化2-氟-3-氧代烷基羧酸酯的方法，其特征在于2-氟-3-氧代烷基羧酸酯以高产率制备，通过用氟化3-氧代烷基羧酸酯洗涤3次或更多次而得到较少的杂质 与反应混合物的量一样多的水。 根据本发明的方法，不仅产生不想要的副产物最小化，而且氟化的3-氧代烷基羧酸酯可以以有效的方式被纯化。 因此，本发明允许有效地生产相当纯的2-氟-3-氧代烷基羧酸酯，这是生产各种医药和农药的有用的中间体材料。

公开(公告)号：US06894197B2

公开(公告)日：2005-05-17

申请号：US10476540

申请日：2002-07-01

申请人： Hideyuki Mimura ,  Kosuke Kawada ,  Shoji Arai

发明人： Hideyuki Mimura ,  Kosuke Kawada ,  Shoji Arai

IPC分类号： C07C29/124 ,  C07C31/38 ,  C07C31/42 ,  C07C31/44 ,  C07C205/43 ,  C07C233/10 ,  C07C233/28 ,  C07C233/33 ,  C07C233/44 ,  C07C233/55 ,  C07F9/12 ,  C07C31/34

CPC分类号： C07C29/124 ,  C07C31/38

摘要： A method for producing fluorinated alcohols from fluorinated alkyl halides can produce fluorinated alcohols at high product yield and at high selectivity in a single-step reaction. The method eliminates the need to use heavy metals and other toxic compounds that are difficult to handle or process.Specifically, the method produces a fluorinated alcohol represented by the following general formula (2): Rf(A)OH  (2) wherein Rf represents a perfluoroalkyl group having 1 to 10 carbon atoms; and A represents a straight-chained or branched saturated hydrocarbon group having 3 to 10 carbon atoms. The method is characterized in that it allows a fluorinated alkyl halide represented by the following general formula (1) to react with an alkali metal salt of 4-hydroxybutyrate in a gamma-butyrolactone solvent: Rf(A)X  (1) wherein Rf and A are as defined above; and X represents a halogen atom.

摘要翻译： 从氟化烷基卤化物制备氟化醇的方法可以以高产率和在一步反应中以高选择性产生氟化醇。 该方法无需使用难处理或加工的重金属和其他有毒化合物。 具体地说，该方法产生由以下通式（2）表示的氟化醇：<？in-line-formula description =“In-line formula”end =“lead”？> Rf（A）OH（2） 在线公式描述=“In-line Formula”end =“tail”？>其中Rf表示具有1-10个碳原子的全氟烷基; A表示碳原子数3〜10的直链状或支链状的饱和烃基。 该方法的特征在于，其允许由以下通式（1）表示的氟化烷基卤在γ-丁内酯溶剂中与4-羟基丁酸的碱金属盐反应：<？在线配方说明=“In 线型公式“end =”lead“？> Rf（A）X（1）<？in-line-formula description =”In-line Formulas“end =”tail“？>其中Rf和A如上所定义; X表示卤素原子。

公开(公告)号：US20060183937A1

公开(公告)日：2006-08-17

申请号：US10550066

申请日：2004-03-24

申请人： Kenji Tokuhisa ,  Hideyuki Mimura ,  Kosuke Kawada ,  Shoji Arai

发明人： Kenji Tokuhisa ,  Hideyuki Mimura ,  Kosuke Kawada ,  Shoji Arai

IPC分类号： C07C69/62

CPC分类号： C07C57/54 ,  C07C57/52

摘要： An α-pentafluoroethyl acrylic acid derivative represented by the general formula [I]: [wherein R represents a hydrogen atom, a non-substituted or substituted aromatic ring, or a straight or branched alkyl group having 1 to 20 carbon(s) which may have a cyclic moiety optionally substituted with at least one substituent (halogen atom, hydroxyl group, straight or branched alkoxy group having 1 to 10 carbon(s) which may have a cyclic moiety, non-substituted or substituted aromatic group)].

摘要翻译： 由通式[I]表示的α-五氟乙基丙烯酸衍生物：[其中R表示氢原子，未取代或取代的芳环，或具有1至20个碳的直链或支链烷基，其可以 具有任选被至少一个取代基（卤素原子，羟基，具有1至10个碳原子的直链或支链烷氧基，可以具有环状部分，未取代或取代的芳族基团）取代的环状部分]。

公开(公告)号：US07476768B2

公开(公告)日：2009-01-13

申请号：US11792255

申请日：2005-11-29

申请人： Hideyuki Mimura ,  Akio Watanabe ,  Noritaka Nagasaki ,  Kosuke Kawada

发明人： Hideyuki Mimura ,  Akio Watanabe ,  Noritaka Nagasaki ,  Kosuke Kawada

IPC分类号： C07C45/29

CPC分类号： C07C47/14 ,  B01J21/066 ,  B01J23/14 ,  B01J23/18 ,  B01J23/22 ,  B01J23/24 ,  B01J35/1014 ,  B01J35/1019 ,  C07C45/38

摘要： A catalyst for oxidizing 2,2,2-trifluoroethanol to form trifluoroacetaldehyde. The catalyst has a long life and achieves high conversion and selectivity.The catalyst of the present invention comprises one or more metal oxides, including at least vanadium oxide, and zirconia as a carrier.

摘要翻译： 用于氧化2,2,2-三氟乙醇以形成三氟乙醛的催化剂。 催化剂寿命长，转化率高，选择性高。 本发明的催化剂包含一种或多种金属氧化物，至少包含氧化钒和氧化锆作为载体。

公开(公告)号：US20080132727A1

公开(公告)日：2008-06-05

申请号：US11792255

申请日：2005-11-29

申请人： Hideyuki Mimura ,  Akio Watanabe ,  Noritaka Nagasaki ,  Kosuke Kawada

发明人： Hideyuki Mimura ,  Akio Watanabe ,  Noritaka Nagasaki ,  Kosuke Kawada

IPC分类号： B01J23/22 ,  C07C45/32 ,  B01J23/28 ,  B01J23/30

CPC分类号： C07C47/14 ,  B01J21/066 ,  B01J23/14 ,  B01J23/18 ,  B01J23/22 ,  B01J23/24 ,  B01J35/1014 ,  B01J35/1019 ,  C07C45/38

摘要： A catalyst for oxidizing 2,2,2-trifluoroethanol to form trifluoroacetaldehyde. The catalyst has a long life and achieves high conversion and selectivity.The catalyst of the present invention comprises one or more metal oxides, including at least vanadium oxide, and zirconia as a carrier.

摘要翻译： 用于氧化2,2,2-三氟乙醇以形成三氟乙醛的催化剂。 催化剂寿命长，转化率高，选择性高。 本发明的催化剂包含一种或多种金属氧化物，至少包含氧化钒和氧化锆作为载体。

公开(公告)号：US20060122423A1

公开(公告)日：2006-06-08

申请号：US10550387

申请日：2004-03-24

申请人： Takamasa Fuchikami ,  Noriko Wakasa ,  Kenji Tokuhisa ,  Hideyuki Mimura ,  Shoji Arai

发明人： Takamasa Fuchikami ,  Noriko Wakasa ,  Kenji Tokuhisa ,  Hideyuki Mimura ,  Shoji Arai

IPC分类号： C07C51/14

CPC分类号： C07C67/36 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2603/74 ,  C07C69/653

摘要： A process for producing a fluorine-containing acrylic acid ester represented by CH2═C(Rf)(COOR) characterized in that 1-bromo-1-perfluoroalkylethene represented by CH2═CBr—Rf, or 1,2-dibromo-1-perfluoroalkylethane represented by CH2CBr—CHBr—Rf is allowed to react with an alcohol represented by ROH in the presence of a palladium catalyst, carbon monoxide, and two or more kinds of bases. The fluorine-containing acrylic acid ester is a useful compound having wide applications in materials for pharmaceuticals and functional polymers.

摘要翻译： 一种由CH 2 -C（Rf）（COOR）表示的含氟丙烯酸酯的制备方法，其特征在于由CH 2表示的1-溴-1-全氟烷基乙烯基 将由CH 2 CO 2 CBr-CHBr-Rf表示的-CBr-Rf或1,2-二溴-1-全氟烷基乙烷与由ROH表示的醇在钯催化剂存在下反应， 一氧化碳和两种或更多种碱。 含氟丙烯酸酯是广泛用于药物和功能聚合物的材料的有用化合物。

公开(公告)号：US07470808B2

公开(公告)日：2008-12-30

申请号：US10550387

申请日：2004-03-24

申请人： Takamasa Fuchikami ,  Noriko Wakasa ,  Kenji Tokuhisa ,  Hideyuki Mimura ,  Shoji Arai

发明人： Takamasa Fuchikami ,  Noriko Wakasa ,  Kenji Tokuhisa ,  Hideyuki Mimura ,  Shoji Arai

IPC分类号： C07C69/63 ,  C07C67/36 ,  C07C69/66

CPC分类号： C07C67/36 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2603/74 ,  C07C69/653

摘要： A process for producing a fluorine-containing acrylic acid ester represented by CH2═C(Rf)(COOR) characterized in that 1-bromo-1-perfluoroalkylethene represented by CH2═CBr—Rf, or 1,2-dibromo-1-perfluoroalkylethane represented by CH2CBr—CHBr—Rf is allowed to react with an alcohol represented by ROH in the presence of a palladium catalyst, carbon monoxide, and two or more kinds of bases. The fluorine-containing acrylic acid ester is a useful compound having wide applications in materials for pharmaceuticals and functional polymers.

摘要翻译： 一种由CH2-C（Rf）（COOR）表示的含氟丙烯酸酯的制备方法，其特征在于由CH2-CBr-Rf表示的1-溴-1-全氟烷基烯或1,2-二溴-1-全氟烷基乙烷 由二氯甲烷CH 2 Cl-Rf表示的化合物与钯催化剂，一氧化碳和两种或更多种碱的存在下与ROH表示的醇进行反应。 含氟丙烯酸酯是广泛用于药物和功能聚合物的材料的有用化合物。

公开(公告)号：US06337297B1

公开(公告)日：2002-01-08

申请号：US09457522

申请日：1999-12-09

申请人： Hideyuki Mimura ,  Motohiro Oguri ,  Toshihide Yamamoto ,  Hideyuki Murakita ,  Hisanori Okada ,  Toru Yoshida

发明人： Hideyuki Mimura ,  Motohiro Oguri ,  Toshihide Yamamoto ,  Hideyuki Murakita ,  Hisanori Okada ,  Toru Yoshida

IPC分类号： B01J3100

CPC分类号： B01J31/2409 ,  B01J31/16 ,  B01J31/1815 ,  B01J31/20 ,  B01J2231/328 ,  B01J2531/0247 ,  B01J2531/62 ,  C07C2/32 ,  C07C2531/22 ,  Y02P20/52 ,  C07C11/107

摘要： A catalyst for trimerization of ethylene is disclosed which comprises (a) a chromium complex having a neutral multidentate ligand having a tripod structure, represented by the formula, ACrJnQ3-n wherein A is a neutral multidentate ligand having a tripod structure, J is a carbonyl ligand or halogen, n is an integer of 0-3, and Q is at least one member selected from hydrogen, a C1-C10 hydrocarbon group, a C1-C10 carboxylate group, a C3-C10 diketonato group, an amide group, an imide group, an C1-C10 alkoxide group, a C1-C10 thioalkoxide group, an C6-C15 arene ligand, an C2-C10 alkene ligand, an C2-C15 alkyne ligand, an amine ligand, an imine ligand, an isonitrile ligand, a phosphine ligand, a phosphine oxide ligand, a phosphite ligand, an ether ligand, a sulfide ligand, a sulfone ligand and a sulfoxide ligand, and (b) a metal alkyl compound. The catalyst optionally further comprises (c) at least one compound selected from aromatic tertiary amine compounds, except for an imine, and nitrogen-containing heterocyclic compounds, and (d) a radical anion compound.

摘要翻译： 公开了一种用于乙烯三聚的催化剂，其包含（a）具有三角架结构的中性多齿配体的铬络合物，其由式ACrJnQ3-n表示，其中A是具有三脚架结构的中性多齿配体，J是羰基 配体或卤素，n为0-3的整数，Q为选自氢，C1-C10烃基，C1-C10羧酸酯基，C3-C10二酮基，酰胺基，酰胺基， 酰亚胺基，C1-C10烷氧基，C1-C10硫代烷氧基，C6-C15芳烃配体，C2-C10烯配体，C2-C15炔配体，胺配体，亚胺配体，异腈配体， 膦配体，氧化膦配体，亚磷酸酯配体，醚配体，硫化物配体，砜配体和亚砜配体，和（b）金属烷基化合物。 催化剂任选地还包含（c）至少一种选自除了亚胺以外的芳族叔胺化合物和含氮杂环化合物的化合物，和（d）自由基阴离子化合物。

公开(公告)号：US20120094190A1

公开(公告)日：2012-04-19

申请号：US13380658

申请日：2010-07-30

申请人： Hideyuki Mimura ,  Kentaro Kono ,  Hisao Eguchi ,  Kotaro Sakoda ,  Masahiro Aoki

发明人： Hideyuki Mimura ,  Kentaro Kono ,  Hisao Eguchi ,  Kotaro Sakoda ,  Masahiro Aoki

IPC分类号： H01M10/056 ,  C07F9/141

CPC分类号： H01M10/0569 ,  H01M10/052 ,  H01M10/0525 ,  H01M10/4235 ,  Y02T10/7011

摘要： As to a fluorine-containing phosphate used to impart flame retardancy to an electrolyte solution for a non-aqueous secondary battery, a fluorine-containing phosphate having high flame retardancy and providing high battery performance such as high-rate charge-discharge characteristics, and a method for manufacturing the same are provided. Also provided are a non-aqueous electrolyte solution and a non-aqueous secondary battery each containing the fluorine-containing phosphate.Further a fluorine-containing phosphate having a high ability to dissolve an electrolyte and capable of providing the composition of a safer electrolyte solution is provided.The fluorine-containing phosphate for a non-aqueous electrolyte solution is represented by the general formula (1) (wherein R represents an alkyl group having 1 to 10 carbon atoms or a fluorine-containing alkyl group having 1 to 10 carbon atoms, A and B are different from each other and each represent a hydrogen atom or a fluorine atom, and n and m each independently represent an integer from 1 to 8) and contains fluorine atoms in a weight ratio of 30% or higher.

摘要翻译： 对于用于赋予非水二次电池用电解液阻燃性的含氟磷酸盐，具有高阻燃性且具有高电压特性的含氟磷酸盐，例如高倍率充放电特性，以及 提供了制造该方法的方法。 还提供了含有含氟磷酸盐的非水电解液和非水二次电池。 此外，还提供了一种具有高溶解电解质并且能够提供更安全的电解质溶液组成的能力的含氟磷酸盐。 用于非水电解质溶液的含氟磷酸酯由通式（1）表示（其中R表示碳原子数为1〜10的烷基或碳原子数1〜10的含氟烷基，A和 B彼此不同，各自表示氢原子或氟原子，n和m各自独立地表示1〜8的整数），并且含有30重量％以上的氟原子。