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公开(公告)号:US5750906A
公开(公告)日:1998-05-12
申请号:US739249
申请日:1996-10-29
申请人: Norman K. Parker , James E. Rasmussen , Richard L. Schulkind , Kevin J. Sullivan , Robert B. Green
发明人: Norman K. Parker , James E. Rasmussen , Richard L. Schulkind , Kevin J. Sullivan , Robert B. Green
CPC分类号: G01N35/1097
摘要: The invention features a sample probe and reagent selector valve that enables selection among multiple functions of withdrawing a biological sample from a syringe or capillary into a fluid parameter sensor module, providing calibration and quality control reagents to the sensor module, and flowing a washing fluid through intake passages to prevent cross-contamination and clogging. The valve and sensor module are used in conjunction with an automated analytical instrument, such as an automated blood analyzer, to increase the speed of the analysis, minimize cross contamination between samples, and to overcome the inherent dangers of using the conventional needle/syringe or capillary methods of withdrawing fluids to be tested. The design of the valve provides performance benefits in the form of lower sample and reagent waste volumes, elimination of auxiliary valves and manifolds, and superior performance and reduced cost.
摘要翻译: 本发明的特征在于一种样本探针和试剂选择阀,其能够选择将生物样品从注射器或毛细管抽出到流体参数传感器模块中的多种功能,向传感器模块提供校准和质量控制试剂,以及使洗涤液流过 进气通道,以防止交叉污染和堵塞。 阀和传感器模块与诸如自动血液分析仪之类的自动分析仪器一起使用,以提高分析速度,最小化样品之间的交叉污染,并克服使用常规针头/注射器的固有危险 抽出待测试液体的毛细管法。 阀门的设计以较低的样品和试剂废物量,减少辅助阀门和歧管的形式提供了性能优势,并具有出色的性能和降低的成本。
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公开(公告)号:US5372782A
公开(公告)日:1994-12-13
申请号:US891553
申请日:1992-05-29
申请人: Peter N. Karkantis , Beat R. Degen , Richard A. Dussault , Richard L. Schulkind , Norman K. Parker
发明人: Peter N. Karkantis , Beat R. Degen , Richard A. Dussault , Richard L. Schulkind , Norman K. Parker
CPC分类号: G01N35/10 , G01N2030/185 , G01N2035/00237 , G01N2035/00277 , G01N30/24 , G01N35/1004 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要: A novel fluid sampling device has been developed. This device provides for sample entry to be handled automatically by the instrument, thus allowing the operator to be involved in other activities while the sampling process is underway. It also assures reproduceable sample size, automatically cleans the sampling device between samples, and reduces the risk of user injury. Furthermore, the sampling system allows for the use of any forseeable collection mechanism.
摘要翻译: 已经开发了一种新颖的流体取样装置。 该设备提供样品输入,由仪器自动处理,从而允许操作人员在采样过程中参与其他活动。 它还保证可重复的样品量,自动清洗样品之间的取样装置,并降低用户受伤的风险。 此外,采样系统允许使用任何可预见的收集机制。
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公开(公告)号:US5391499A
公开(公告)日:1995-02-21
申请号:US158107
申请日:1993-11-24
申请人: Peter N. Karkantis , Beat R. Degen , Richard A. Dussault , Richard L. Schulkind , Norman K. Parker
发明人: Peter N. Karkantis , Beat R. Degen , Richard A. Dussault , Richard L. Schulkind , Norman K. Parker
CPC分类号: G01N35/10 , G01N2030/185 , G01N2035/00237 , G01N2035/00277 , G01N30/24 , G01N35/1004 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要: A novel fluid sampling device has been developed. This device provides for sample entry to be handled automatically by the instrument, thus allowing the operator to be involved in other activities while the sampling process is underway. It also assures reproduceable sample size, automatically cleans the sampling device between samples, and reduces the risk of user injury. Furthermore, the sampling system allows for the use of any forseeable collection mechanism.
摘要翻译: 已经开发了一种新颖的流体取样装置。 该设备提供样品输入,由仪器自动处理,从而允许操作人员在采样过程中参与其他活动。 它还保证可重复的样品量,自动清洗样品之间的取样装置,并降低用户受伤的风险。 此外,采样系统允许使用任何可预见的收集机制。
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公开(公告)号:US06719888B1
公开(公告)日:2004-04-13
申请号:US08921103
申请日:1997-08-29
申请人: Andy D. C. Chan , Joseph S. Foos , James E. Rasmussen , Richard L. Schulkind , John A. Zalenski
发明人: Andy D. C. Chan , Joseph S. Foos , James E. Rasmussen , Richard L. Schulkind , John A. Zalenski
IPC分类号: G01N27401
CPC分类号: G01N27/401 , G01N27/301
摘要: A reference electrode assembly having a constrained-diffusion liquid junction between a liquid junction solution and a sample solution having separate flow paths, said assembly comprising a flow cell having attached thereto a constraint comprising a region of porous material permeable to water and salts; a remote reservoir for holding said liquid junction solution; a means for moving said liquid junction solution from said reservoir to said constraint; and a reference contact region is provided. This unique configuration provides a reference electrode device of the constrained-diffusion liquid junction type useful in pH and/or ion-selective electrode (ISE) potentiometric sensors and is particularly suitable for use in a mini-integrated electrochemical analyzer.
摘要翻译: 一种参考电极组件,其具有在液体接合溶液和具有分离的流动路径的样品溶液之间的约束扩散液体接合点,所述组件包括流动池,所述流动池附着有包含可透过水和盐的多孔材料区域的约束; 用于保持所述液体接合溶液的远程储存器; 用于将所述液体接合溶液从所述储存器移动到所述约束的装置; 并提供参考接触区域。 这种独特的配置提供了用于pH和/或离子选择性电极(ISE)电位传感器的约束扩散液体接合型的参考电极装置,并且特别适用于微型集成电化学分析仪。
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公开(公告)号:US5340715A
公开(公告)日:1994-08-23
申请号:US711783
申请日:1991-06-07
IPC分类号: G01N21/64 , G01N21/27 , G01N21/55 , G01N21/77 , G01N33/552
CPC分类号: G01N21/7703 , G01N21/648 , Y10S435/808 , Y10S436/805 , Y10S436/807
摘要: An evanescent wave sensor and method for use in analyzing one or more media, the sensor including a waveguide having first and second wave propagating surfaces. The waveguide propagates an input signal along the waveguide between the first and second surfaces. The first surface receives a first radiation signal which indicates the presence of a first analyte, and the second surface receives a second radiation signal representing one or both of a second analyte and a reference. The first and second surfaces can both be contacted with a single medium, or with two separate media, and one or more output signals can be detected.
摘要翻译: 一种用于分析一种或多种介质的ev逝波传感器和方法,所述传感器包括具有第一和第二波传播表面的波导。 波导在第一和第二表面之间沿着波导传播输入信号。 第一表面接收指示第一分析物的存在的第一辐射信号,并且第二表面接收表示第二分析物和参考物中的一个或两者的第二辐射信号。 第一和第二表面都可以与单个介质或两个单独的介质接触,并且可以检测一个或多个输出信号。
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公开(公告)号:US5738992A
公开(公告)日:1998-04-14
申请号:US629595
申请日:1996-04-09
IPC分类号: G01N21/64 , G01N21/27 , G01N21/55 , G01N21/77 , G01N33/543 , G01N33/552
CPC分类号: G01N21/648 , G01N21/7703 , G01N2021/6439 , G01N2021/7709 , G01N2021/7793 , G01N21/6428 , Y10S435/808 , Y10S436/805
摘要: An evanescent wave system and method including an optical sensor for use in assaying a reference material and at least one molecular species or analyte in a test medium or test sample for diagnostic and other applicable purposes. The sensor includes a waveguide for propagating a radiation input along its length. The radiation input causes evanescent electromagnetic waves that are capable of stimulating output emissions that are indicative of a reference material and of one or more molecular species or analytes. By comparing the emission(s) indicative of the reference material to the emission indicative of the presence of the molecular species or analyte, the presence and concentration of the molecule in the sample can be determined. The reference material provides for normalization and/or calibration of the system.
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公开(公告)号:US5525466A
公开(公告)日:1996-06-11
申请号:US246391
申请日:1994-05-20
IPC分类号: G01N21/64 , G01N21/27 , G01N21/55 , G01N21/77 , G01N33/543 , G01N33/552 , G01N3/68
CPC分类号: G01N21/648 , G01N21/7703 , G01N2021/6439 , G01N2021/7709 , G01N2021/7793 , G01N21/6428 , Y10S435/808 , Y10S436/805
摘要: An evanescent wave system and method including an optical sensor for use in assaying a reference material and at least one molecular species or analyte in a test medium or test sample for diagnostic and other applicable purposes. The sensor includes a waveguide for propagating a radiation input along its length. The radiation input causes evanescent electromagnetic waves that are capable of stimulating output emissions that are indicative of a reference material and of one or more molecular species or analytes. By comparing the emission(s) indicative of the reference material to the emission indicative of the presence of the molecular species or analyte, the presence and concentration of the molecule in the sample can be determined. The reference material provides for normalization and/or calibration of the system.
摘要翻译: 一种ev逝波系统和方法,包括用于测定参考材料的光学传感器和用于诊断和其他适用目的的测试介质或测试样品中的至少一种分子种类或分析物。 传感器包括用于沿其长度传播辐射输入的波导。 辐射输入引起能够刺激指示参考物质和一种或多种分子种类或分析物的输出排放的ev逝电磁波。 通过将指示参考物质的排放与指示分子物质或分析物的存在的排放进行比较,可以确定样品中分子的存在和浓度。 参考资料提供了系统的归一化和/或校准。
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