公开(公告)号：US20180201899A1

公开(公告)日：2018-07-19

申请号：US15744216

申请日：2016-07-15

Applicant: Northwestern University

Inventor： Guillermo A. Ameer ,  Bin Jiang ,  Michele Jen ,  Jason A. Wertheim

IPC: C12N5/071 ,  A61K35/44 ,  A61K38/50 ,  C12N9/80 ,  G01N33/50

CPC classification number: C12N5/069 ,  A01N1/0226 ,  A61K35/44 ,  A61K38/50 ,  C12N5/0696 ,  C12N9/1077 ,  C12N9/80 ,  C12N15/00 ,  C12N2501/72 ,  C12N2506/45 ,  C12N2510/00 ,  C12N2740/16043 ,  C12Y204/0203 ,  G01N33/5014 ,  G01N33/502

Abstract: Compositions comprising endothelial cells (ECs) differentiated from induced pluripotent stem cells (iPSC)that over-express Sirtuin 1 (SIRT1) are disclosed. Further disclosed are methods of preparation of the compositions, and methods for treating a subject comprising administering transplatanbe cells, tissue, or organ comprising the iPSC-derived ECs overexpressing SIRT1, as well as methods of testing an agent for therapeutic efficacy and toxicity using the compositions.

公开(公告)号：US11529417B2

公开(公告)日：2022-12-20

申请号：US15931262

申请日：2020-05-13

Applicant: Northwestern University

Inventor： Guillermo A. Ameer ,  Michele Jen ,  Jian Yang

IPC: A01N63/00 ,  A61K47/32 ,  A61K48/00 ,  A61K9/00 ,  A61P17/02 ,  A61K38/50 ,  A61K47/10 ,  A61K47/34 ,  A61L15/24 ,  A61L15/44 ,  A61L15/60 ,  A61L15/62 ,  A61L15/64

Abstract: Compositions and methods are provided for improved wound healing. In particular, provided herein are compositions and methods for the direct delivery of Sirtuin-1 (Sirt1) or vectors encoding Sirt1 to the wounds (e.g., of diabetic patients).

公开(公告)号：US10653782B2

公开(公告)日：2020-05-19

申请号：US15529288

申请日：2015-11-25

Applicant: Northwestern University

Inventor： Guillermo A. Ameer ,  Michele Jen

IPC: A01N63/00 ,  A61K47/32 ,  A61K48/00 ,  A61K9/00 ,  A61P17/02 ,  A61K38/50 ,  A61K47/10 ,  A61K47/34 ,  A61L15/24 ,  A61L15/44 ,  A61L15/60 ,  A61L15/62 ,  A61L15/64

Abstract: Compositions and methods are provided for improved wound healing. In particular, provided herein are compositions and methods for the direct delivery of Sirtuin-1 (Sirt1) or vectors encoding Sirt1 to the wounds (e.g., of diabetic patients). In some embodiments, provided herein are therapeutic devices comprising: (a) a vector encoding Sirtuin-1 (Sirt 1); and (b) a hydrogel carrier. In some embodiments, the vector comprises a viral vector comprising a polynucleotide sequence encoding Sirt 1. In some embodiments, the vector comprises a non-viral vector comprising a polynucleotide sequence encoding Sirt1.