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53 条记录 (耗时 0.04 秒)

    Imidazo-pyridazinyl compounds and uses thereof
    1.
    发明授权
    Imidazo-pyridazinyl compounds and uses thereof 有权
    咪唑并哒嗪化合物及其用途

    公开(公告)号：US08273741B2

    公开(公告)日：2012-09-25

    申请号：US12263949

    申请日：2008-11-03

    申请人： Nozomu Sakai ,  Shinichi Imamura ,  Naoki Miyamoto ,  Takaharu Hirayama

    发明人： Nozomu Sakai ,  Shinichi Imamura ,  Naoki Miyamoto ,  Takaharu Hirayama

    IPC分类号： C07D487/04 ,  A01N43/58 ,  A61P35/00

    CPC分类号： C07D487/04

    摘要： The present invention provides a fused heterocyclic derivative having a potent kinase inhibitory activity and use thereof.A compound represented by the formula (I): wherein each symbol is as defined in the specification, except a particular compound, or a salt thereof, and a pharmaceutical agent containing the compound or a prodrug thereof, which is a kinase (VEGFR, VEGFR2, PDGFR, Raf) inhibitor, an angiogenesis inhibitor, an agent for the prophylaxis or treatment of cancer, a cancer growth inhibitor or a cancer metastasis suppressor.

    摘要翻译： 本发明提供具有强激酶抑制活性的稠合杂环衍生物及其应用。 由式（I）表示的化合物：其中每个符号如说明书中所定义，除了特定化合物或其盐，以及含有作为激酶的化合物或其前药的药物（VEGFR，VEGFR2 ，PDGFR，Raf）抑制剂，血管发生抑制剂，用于预防或治疗癌症的药物，癌症生长抑制剂或癌症转移抑制剂。

    Fused heterocyclic derivative and use thereof
    2.
    发明授权
    Fused heterocyclic derivative and use thereof 有权
    熔融杂环衍生物及其用途

    公开(公告)号：US08044049B2

    公开(公告)日：2011-10-25

    申请号：US12064903

    申请日：2007-08-03

    申请人： Nozomu Sakai ,  Shinichi Imamura ,  Naoki Miyamoto ,  Takaharu Hirayama

    发明人： Nozomu Sakai ,  Shinichi Imamura ,  Naoki Miyamoto ,  Takaharu Hirayama

    IPC分类号： C07D487/04 ,  A61K31/5025 ,  A61P35/00

    CPC分类号： C07D487/04

    摘要： The present invention provides a fused heterocyclic derivative having a potent kinase inhibitory activity and use thereof.A compound represented by the formula (I): wherein each symbol is as defined in the specification, except a particular compound, or a salt thereof, and a pharmaceutical agent containing the compound or a prodrug thereof, which is a kinase (VEGFR, VEGFR2, PDGFR, Raf) inhibitor, an angiogenesis inhibitor, an agent for the prophylaxis or treatment of cancer, a cancer growth inhibitor or a cancer metastasis suppressor.

    摘要翻译： 本发明提供具有强激酶抑制活性的稠合杂环衍生物及其应用。 由式（I）表示的化合物：其中每个符号如说明书中所定义，除了特定化合物或其盐，以及含有作为激酶的化合物或其前药的药物（VEGFR，VEGFR2 ，PDGFR，Raf）抑制剂，血管发生抑制剂，用于预防或治疗癌症的药物，癌症生长抑制剂或癌症转移抑制剂。

    Imidazopyridazine derivative having kinase inhibitory activity and pharmaceutical agent thereof
    4.
    发明授权
    Imidazopyridazine derivative having kinase inhibitory activity and pharmaceutical agent thereof 有权
    具有激酶抑制活性的咪唑并哒嗪衍生物及其药剂

    公开(公告)号：US08034812B2

    公开(公告)日：2011-10-11

    申请号：US12263884

    申请日：2008-11-03

    申请人： Nozomu Sakai ,  Shinichi Imamura ,  Naoki Miyamoto ,  Takaharu Hirayama

    发明人： Nozomu Sakai ,  Shinichi Imamura ,  Naoki Miyamoto ,  Takaharu Hirayama

    IPC分类号： C07D487/04 ,  A61K31/4985 ,  A61P35/00

    CPC分类号： C07D487/04

    摘要： The present invention provides an imidazopyridazine derivative compound having a potent kinase inhibitory activity and a pharmaceutical agent thereof useful for treatment or prevention of cancer and the like. One such compound is represented by the formula: or a salt thereof or a prodrug thereof. The pharmaceutical agent contains the imidazopyridazine derivative compound or a prodrug thereof, which is a kinase (VEGFR, VEGFR2, PDGFR, Raf) inhibitor, an angiogenesis inhibitor, an agent for the prophylaxis or treatment of cancer, a cancer growth inhibitor, or a cancer metastasis suppressor.

    摘要翻译： 本发明提供了可用于治疗或预防癌症等的具有强激酶抑制活性的咪唑并哒嗪衍生化合物及其药剂。 一种这样的化合物由下式表示：或其盐或其前药。 药剂含有作为激酶（VEGFR，VEGFR2，PDGFR，Raf）抑制剂，血管发生抑制剂，癌症预防或治疗剂，癌症生长抑制剂或癌症的咪唑并哒嗪衍生物化合物或其前药 转移抑制因子

    CONTROL DEVICE AND CONTROL METHOD FOR LASER PROCESSING MACHINE
    8.
    发明申请
    CONTROL DEVICE AND CONTROL METHOD FOR LASER PROCESSING MACHINE 有权
    激光加工机控制装置及控制方法

    公开(公告)号：US20130220981A1

    公开(公告)日：2013-08-29

    申请号：US13880136

    申请日：2011-09-13

    申请人： Mototoshi Kumaoka ,  Tomohiro Kyoto ,  Naoki Miyamoto

    发明人： Mototoshi Kumaoka ,  Tomohiro Kyoto ,  Naoki Miyamoto

    IPC分类号： B23K26/00

    CPC分类号： B23K26/00 ,  B23K26/128 ,  H01S3/02 ,  H01S3/036 ,  H01S3/0401 ,  H01S3/0407 ,  H01S3/2232

    摘要： In a laser processing machine 100 including a plurality of element units containing at least a laser blower unit 3, an optical-path purge unit 24, and a temperature controlling unit 8, a measurement unit and a control unit 10 are provided. The measurement unit measures an elapsed time from a final trigger at which a laser processing operation of the laser processing machine has stopped and no user operation is applied with respect to the laser processing machine. The control unit 10 stops the element units based on the elapsed time after the final trigger, when a condition specified for each of the element units is satisfied.

    摘要翻译： 在包括至少包含激光鼓风机单元3的多个元件单元的激光加工机100中，设置有光路吹扫单元24和温度控制单元8，测量单元和控制单元10。 测量单元测量从激光加工机的激光加工操作停止的最终触发器的经过时间，并且不对激光加工机器施加用户操作。 当满足为每个元件单元指定的条件时，控制单元10基于最终触发之后的经过时间来停止元件单元。

    Transfusion Safety Device
    9.
    发明申请
    Transfusion Safety Device 审中-公开
    输血安全装置

    公开(公告)号：US20070265559A1

    公开(公告)日：2007-11-15

    申请号：US11662338

    申请日：2005-12-19

    申请人： Takahiko Kunishige ,  Naoki Miyamoto

    发明人： Takahiko Kunishige ,  Naoki Miyamoto

    IPC分类号： A61M5/00

    CPC分类号： A61M39/281 ,  A61M5/14228 ,  A61M5/16831 ,  A61M2205/14

    摘要： A first object is to offer a safety device that allows to effectively solve problems regarding transfusion including free-flow issues in the case where the transfusion tube comes off from the transfusion pump, by employing a comparatively simple structure constructed at a low cost. A second object is to offer a safety device that can be newly added to an existing transfusion pump having no safety device. Specifically speaking, the case 100 in a tubular shape having a base, the compression spring 130, and the clamp 10 having the movable body 120 are set in the socket 20 having a cross-sectional shape of a square bracket. When the clamp 10 is set in the socket 20, the through-holes 101 and 121 become open, which allows distribution of fluid in the transfusion tube. On the other hand, when the clamp 10 becomes detached from the socket 20, the tension of the compression spring 130 causes the movable body 120 to slide, and the through-holes 101 and 121 are closed. As a result, the transfusion tube is blocked off, preventing the occurrence of a free flow.

    摘要翻译： 第一个目的是提供一种安全装置，通过采用以较低成本构造的比较简单的结构，能够有效地解决在输血管从输血泵中脱出的情况下的输血问题，包括自由流动问题。 第二个目的是提供一种可以新添加到没有安全装置的现有输液泵中的安全装置。 具体来说，具有底座的管状形状的壳体100，具有可移动体120的压缩弹簧130和夹具10设置在具有正方形支架的横截面形状的插座20中。 当夹具10设置在插座20中时，通孔101和121变得开放，这允许流体在输液管中分配。 另一方面，当夹具10从插座20脱离时，压缩弹簧130的张力使可动体120滑动，并且通孔101和121被关闭。 结果，输血管堵塞，防止自由流动的发生。