公开(公告)号：US20210373312A1

公开(公告)日：2021-12-02

申请号：US17327891

申请日：2021-05-24

Applicant: OLYMPUS CORPORATION

Inventor： Yoshihiro SHIMADA ,  Chihiro HIRAGA ,  Katsunori OGO ,  Daisuke NISHIWAKI ,  Takashi SUGIYAMA

IPC: G02B21/06 ,  G02B21/00 ,  G02B21/34

Abstract: An observation vessel includes a holding portion configured to hold an observation object and an accommodation portion at least partially formed of a transparent curved surface and configured to position the holding portion. The holding portion is configured to hold the observation object at a set position separated from the curved surface toward a center of curvature of the curved surface in a first state of being positioned at a first position by the accommodation portion.

公开(公告)号：US20180259761A1

公开(公告)日：2018-09-13

申请号：US15872149

申请日：2018-01-16

Applicant: OLYMPUS CORPORATION

Inventor： Brendan BRINKMAN ,  Yoshihiro SHIMADA ,  Daisuke NISHIWAKI

IPC: G02B21/33 ,  G01N21/64 ,  G02B21/24

CPC classification number: G02B21/33 ,  G01N21/6458 ,  G01N2021/6463 ,  G02B21/241

Abstract: An immersion liquid holder 2 is an immersion liquid holder that is used for an observation device 10 for observing sample S by using an immersion method, and includes a supporting member 2b configured to support an absorption member 3 that has absorbed an immersion liquid and a connection unit 2c configured to relatively fix the absorption member 3 that has absorbed the immersion liquid with respect to an optical system, which is an optical system included in the observation device 10, and to fix the absorption member 3 on an optical path of the optical system 1, by fixing the supporting member 2b to the observation device 10.

公开(公告)号：US20220128808A1

公开(公告)日：2022-04-28

申请号：US17511485

申请日：2021-10-26

Applicant: OLYMPUS CORPORATION

Inventor： Yoshiharu SAITO ,  Kentaro IMOTO ,  Daisuke NISHIWAKI

IPC: G02B21/33 ,  G02B21/02 ,  G02B21/24 ,  G02B21/06 ,  G02B21/36

Abstract: Provided is an optical signal detection device that includes: an objective; a holding member provided between the objective and a sample to hold the sample; and a gel member that fills a space between the objective and the holding member. The gel member has ¼ scale penetration indicating a value of 44 to 111, both inclusive, measured based on a penetration test using a ¼ scale cone of JIS K 2220.

公开(公告)号：US20140233094A1

公开(公告)日：2014-08-21

申请号：US14180189

申请日：2014-02-13

Applicant: OLYMPUS CORPORATION

Inventor： Yoshihiro UE ,  Daisuke NISHIWAKI

IPC: G02B21/02

CPC classification number: G02B21/008 ,  G02B21/0072

Abstract: A microscope system includes: an objective; a correction apparatus which corrects a spherical aberration; a controller which obtains a plurality of combinations of a relative position of the objective to a sample and an optimum value, which is a set value of the correction apparatus in a state in which a spherical aberration caused in accordance with the relative position has been corrected, calculates a function expressing the relationship between the relative position and the optimum value on the basis of the obtained plurality of combinations by interpolation, and calculates the optimum value according to an observation target surface of the sample, on the basis of the function and the relative position which is determined from the observation target surface; and a correction apparatus driving apparatus which drives the correction apparatus in accordance with the optimum value, which is calculated by the controller.

Abstract translation: 显微镜系统包括：目标; 校正球面像差的校正装置; 获取目标与样本的相对位置和最佳值的多个组合的控制器，该最佳值是在根据相对位置引起的球面像差已被校正的状态下校正装置的设定值 基于所获得的多个组合，通过插值来计算表示相对位置与最佳值之间的关系的函数，并且根据该函数和该样本计算出根据样本的观察目标表面的最佳值 从观察目标表面确定的相对位置; 以及根据由控制器计算的最佳值驱动校正装置的校正装置驱动装置。

公开(公告)号：US20140126048A1

公开(公告)日：2014-05-08

申请号：US14056765

申请日：2013-10-17

Applicant: OLYMPUS CORPORATION

Inventor： Daisuke NISHIWAKI

IPC: G02B21/06

CPC classification number: G02B21/06 ,  G02B26/0833

Abstract: A illumination apparatus for microscope comprises a light source, a spatial modulation section, a first illumination optical system, a second illumination optical system, and the spatial modulation section includes a spatial modulation element which is of reflecting type, and a polarizing element, and the first illumination optical system is disposed in an optical path from the light source up to the spatial modulation element, and the second illumination optical system is disposed in an optical path from the spatial modulation element up to a specimen position, and a position of the spatial modulation element is conjugate with the specimen position. Moreover, a microscope comprises a illumination apparatus, a main-body section, an observation unit, and a control unit, and the illumination apparatus for microscope is to be used as the illumination apparatus.

Abstract translation: 显微镜照明装置包括光源，空间调制部，第一照明光学系统，第二照明光学系统，空间调制部包括反射型的空间调制元件和偏振元件， 第一照明光学系统设置在从光源到空间调制元件的光路中，并且第二照明光学系统设置在从空间调制元件到样本位置的光路中，并且空间 调制元素与样品位置共轭。 此外，显微镜包括照明装置，主体部，观察单元和控制单元，并且用于显微镜的照明装置将用作照明装置。

公开(公告)号：US20150177506A1

公开(公告)日：2015-06-25

申请号：US14552043

申请日：2014-11-24

Applicant: OLYMPUS CORPORATION

Inventor： Daisuke NISHIWAKI

IPC: G02B21/36 ,  G02B21/22 ,  H04N13/02 ,  G02B21/06

CPC classification number: G02B21/367 ,  G02B21/06 ,  G02B21/16 ,  G02B21/22 ,  G02B21/36 ,  H04N13/211 ,  H04N13/221 ,  H04N13/229 ,  H04N13/239

Abstract: A microscope device includes an illumination optical system that illuminates a specimen with a light sheet, and a stereo image capturing device that captures images of the specimen in a plurality of different directions in which a resolution based on a triangulation method in a Z direction orthogonal to a direction of one or a plurality of light sheets formed on the specimen by the illumination optical system is less than a thickness in the Z direction of light sheet illumination that comprises the one or the plurality of light sheets.

Abstract translation: 显微镜装置包括利用光片对样本进行照明的照明光学系统，以及立体图像拍摄装置，其以与Z轴方向正交的基于三角测量方法的分辨率的多个不同方向拍摄样本的图像 通过照明光学系统在样本上形成的一个或多个光片的方向小于包括一个或多个光片的光照明的Z方向上的厚度。

公开(公告)号：US20150022882A1

公开(公告)日：2015-01-22

申请号：US14329388

申请日：2014-07-11

Applicant: OLYMPUS CORPORATION

Inventor： Yoshihiro UE ,  Tetsuya TAJIMA ,  Daisuke NISHIWAKI ,  Kaori HIGUCHI

IPC: G02B21/06

CPC classification number: G02B21/06 ,  G02B7/14 ,  G02B21/0088 ,  G02B21/248

Abstract: A microscope system includes: a main body portion having an optical system for forming an image from at least observation light from a specimen; an objective lens unit having an objective lens for taking in the observation light and having a base portion with an approximately belt shape for holding the objective lens on one end; and a unit attachment portion that is held by the main body portion and is configured to detachably attach the base portion at a position where at least an optical axis of the objective lens coincides with an optical path of the observation light.

Abstract translation: 显微镜系统包括：主体部分，具有用于至少从样本观察光形成图像的光学系统; 物镜单元，具有用于摄取观察光的物镜，具有用于将物镜保持在一端的大致带状的基部; 以及由所述主体部保持并且被构造成将所述基部可拆卸地附接到所述物镜的至少光轴与所述观察光的光路重合的位置的单元附接部。

公开(公告)号：US20170017071A1

公开(公告)日：2017-01-19

申请号：US15205039

申请日：2016-07-08

Applicant: OLYMPUS CORPORATION

Inventor： Yoshihiro UE ,  Daisuke NISHIWAKI ,  Kenya OKAZAKI ,  Osamu ONO ,  Shingo SUZUKI

IPC: G02B21/36 ,  G02B21/02 ,  G06T11/60 ,  G01N21/41 ,  G06T11/20

CPC classification number: G02B21/367 ,  G01N21/41 ,  G01N2201/06113 ,  G01N2201/0638 ,  G01N2201/0697 ,  G01N2201/12 ,  G02B21/02 ,  G02B21/24 ,  G06T11/206 ,  G06T11/60

Abstract: A microscopy system includes a microscope apparatus that has an objective and a correction device correcting for a spherical aberration, and a refractive index calculator that calculates a refractive index of a sample at a target position in the sample on the basis of a plurality of target set values each of which is a set value of the correction device and each of which corresponds to an amount of spherical aberration that occurs in the microscope apparatus when an observation target plane is situated at a different position in the sample in an optical-axis direction of the objective.

Abstract translation: 显微镜系统包括具有物镜的矫正装置和校正球面像差的校正装置，以及折射率计算器，其基于多个目标组计算样本中目标位置处的样本的折射率 其中每个值是校正装置的设定值，并且每个值对应于当观察目标平面位于样品中在光轴方向上的不同位置时在显微镜装置中发生的球面像差量 的目标。

公开(公告)号：US20130193345A1

公开(公告)日：2013-08-01

申请号：US13744750

申请日：2013-01-18

Applicant: OLYMPUS CORPORATION

Inventor： Daisuke NISHIWAKI

IPC: G01N21/64

CPC classification number: G01N21/64 ,  G01N21/6458

Abstract: Fluorescence observation apparatus includes laser scanning fluorescence observation unit and wide field fluorescence observation unit. The former unit includes: lasers; scanning unit that scans sample by laser light; and detector that detects fluorescence from the sample excited by the laser light. The latter unit includes: light source to planar-illuminate the sample; excitation filters that are selectively arranged on light path from the light source, and that correspond to the lasers, respectively; and two-dimensional detector that detects fluorescence from the sample excited by light that has passed through excitation filter arranged on light path from the light source. Each of the excitation filters has optical property in which center wavelength of transmissive band is approximately the same as oscillation wavelength of corresponding laser and bandwidth of transmissive band is approximately the same as tolerance width of oscillation wavelength of corresponding laser.

Abstract translation: 荧光观察装置包括激光扫描荧光观察单元和宽场荧光观察单元。 前一单位包括：激光; 用激光扫描样品的扫描单元; 以及检测由激光激发的样品的荧光的检测器。 后者单元包括：光源平面照射样品; 激励滤光器，其选择性地布置在来自光源的光路上，并且分别对应于激光器; 以及二维检测器，其检测来自已经通过布置在光源的光路上的激发滤光器的光激发的样品的荧光。 每个激发滤光器具有光学性质，其中透射带的中心波长与相应激光器的振荡波长大致相同，并且透射带的带宽与相应激光器的振荡波长的容许宽度大致相同。