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    LONG-ACTING COAGULATION FACTORS AND METHODS OF PRODUCING SAME
    1.
    发明申请
    LONG-ACTING COAGULATION FACTORS AND METHODS OF PRODUCING SAME 有权

    公开(公告)号：US20220000990A1

    公开(公告)日：2022-01-06

    申请号：US17189653

    申请日：2021-03-02

    申请人： OPKO BIOLOGICS LTD.

    发明人： Udi Eyal FIMA ,  Gili Hart

    IPC分类号： A61K38/48 ,  C12N9/64 ,  A61P7/04 ,  A61K9/00

    摘要： Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions and pharmaceutical formulations comprising the polypeptides and polynucleotides of the disclosure and methods of using and producing same are also disclosed.

    LONG-ACTING COAGULATION FACTORS AND METHODS OF PRODUCING SAME
    7.
    发明申请
    LONG-ACTING COAGULATION FACTORS AND METHODS OF PRODUCING SAME 有权
    长效凝血因子及其生产方法

    公开(公告)号：US20150079063A1

    公开(公告)日：2015-03-19

    申请号：US14274061

    申请日：2014-05-09

    申请人： OPKO Biologics Ltd.

    发明人： Udi Eyal FIMA ,  Gili Hart

    IPC分类号： C12N9/96 ,  C07K14/59 ,  C12N9/64

    CPC分类号： C12N9/96 ,  A61K38/00 ,  C07K14/505 ,  C07K14/59 ,  C07K14/745 ,  C07K2319/31 ,  C12N9/6437 ,  C12N9/644

    摘要： Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.

    摘要翻译： 公开了包含至少一个连接到羧基末端而不是凝固因子的氨基末端的绒毛膜促性腺激素的羧基末端肽（CTP）的多肽和编码其的多核苷酸。 还公开了包含本发明的多肽和多核苷酸的药物组合物及其使用和生产方法。