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1.发明申请Device for the Presentation of Peptides or Proteins, Method for the Preparation and Use Thereof 审中-公开用于表达肽或蛋白质的装置，其制备和使用方法公开(公告)号：US20070243623A1
公开(公告)日：2007-10-18
申请号：US10515190
申请日：2003-05-15
申请人： Oleg Melnyk , Xavier Duburcq , Helene Gras-Masse , Christophe Olivier , Fengling Zhou , Claude Auriault , Ahmed Bouzidi
发明人： Oleg Melnyk , Xavier Duburcq , Helene Gras-Masse , Christophe Olivier , Fengling Zhou , Claude Auriault , Ahmed Bouzidi
CPC分类号： C07K17/14 , C07K1/1077 , Y10T436/25
摘要： The invention relates to a device for the presentation of polypeptides, a method for the preparation and the use thereof, as diagnostic tool (polypeptide chip) for miniaturized and highly parallel detection of structurally or functionally complementary molecules of said polypeptides, i.e. antibodies.
摘要翻译： 本发明涉及用于呈现多肽的装置，其制备方法和用途，作为用于微型化和高度平行检测所述多肽（即抗体）的结构或功能互补分子的诊断工具（多肽芯片）。
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公开(公告)号：US08178474B1
公开(公告)日：2012-05-15
申请号：US10196900
申请日：2002-07-15
IPC分类号： C40B50/18
CPC分类号： C40B99/00 , C07B41/06 , C07B61/00 , C07D307/24 , C07K1/042 , C40B40/04 , C40B40/10 , C40B50/14 , Y02P20/55
摘要： The invention relates to a functionalised solid support for the synthesis of compounds comprising at least one α-oxoaldehyde function, to a process for preparing it and to its applications, in particular for the preparation of a library of organic compounds, of a diagnostic reagent, of a microtitration plate and of a biochip, such as a DNA chip. The present invention also relates to a process for the synthesis of organic compounds comprising at least one α-oxoaldehyde function and to the α-oxoaldehyde peptides obtained using this process.
摘要翻译： 本发明涉及用于合成包含至少一种α-氧代醛官能团的化合物的官能化固体支持物，其制备方法及其应用，特别是用于制备诊断试剂的有机化合物文库， 的微量滴定板和生物芯片，例如DNA芯片。 本发明还涉及一种合成包含至少一种α-氧代醛官能团的有机化合物的方法以及使用该方法得到的α-氧代醛类肽。
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3.发明授权Lipopeptides containing an interferon-&ggr; fragment, and uses thereof in pharmaceutical compositions 失效含有干扰素-γ片段的脂肽及其在药物组合物中的用途公开(公告)号：US06683052B1
公开(公告)日：2004-01-27
申请号：US09601729
申请日：2000-11-20
申请人： Kader Thiam , Claude Auriault , Helene Gras-Masse , Estelle Loing , Claudie Verwaerde , Jean Gerard Guillet
发明人： Kader Thiam , Claude Auriault , Helene Gras-Masse , Estelle Loing , Claudie Verwaerde , Jean Gerard Guillet
IPC分类号： C07K1457
CPC分类号： C07K14/57 , A61K9/1075 , A61K39/00 , A61K39/39 , A61K47/54 , A61K2039/55516 , A61K2039/55522 , A61K2039/55555 , A61K2039/6018 , Y02A50/412
摘要： The invention concerns any lipopeptide characterized in that it comprises: a peptide part comprising the peptide sequence consisting of about 30 to about 50 of the last contiguous amino acids of the interferon-&ggr; (IFN-&ggr;) C-terminal end of mammals, whereof, if required, the last 3 to 20 amino acids have been suppressed; and one or several lipophilic parts comprising C4-C20 chain of carbon atoms, saturated or unsaturated, linear or branched, or a steroid group. The invention also concerns any lipopeptide such as defined above containing one or several CD8, and/or CD4, and/or B epitopes. The invention further concerns medicines or vaccines containing any polypeptide such as defined above.
摘要翻译： 本发明涉及任何脂肽，其特征在于其包含：肽部分，其包含由哺乳动物的干扰素-γ（IFN-γ）C-末端的最后连续氨基酸的约30至约50个氨基酸组成的肽序列， 如果需要，最后3〜20个氨基酸被抑制; 和一个或多个亲油部分，其包含饱和或不饱和的直链或支链的碳原子的C 4 -C 20链或类固醇基团。 本发明还涉及包含一种或几种CD8，和/或CD4和/或B表位的任何如上所定义的脂肽。 本发明还涉及含有如上所定义的任何多肽的药物或疫苗。
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公开(公告)号：US6015564A
公开(公告)日：2000-01-18
申请号：US248082
申请日：1999-02-10
申请人： Christophe Boutillon , Frederic Martinon , Christian Sergheraert , Remy Magne , Helene Gras-Masse , Elisabeth Gomard , Andre Tartar , Jean-Paul Levy
发明人： Christophe Boutillon , Frederic Martinon , Christian Sergheraert , Remy Magne , Helene Gras-Masse , Elisabeth Gomard , Andre Tartar , Jean-Paul Levy
IPC分类号： A61K39/00 , A61K47/48 , A61P31/00 , A61P37/04 , C07K14/16 , A61K39/21 , A61K39/12 , C07K1/00
CPC分类号： C07K14/005 , A61K47/48023 , A61K47/48038 , A61K47/48053 , A61K47/48123 , A61K39/00 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322
摘要： Cytotoxic lymphocyte-inducing lipopeptides comprising a peptide part having between 10 and 40 amino acids approximately and comprising at least one tigenic determinant. The lipopeptides also comprise one or more chains derived from fatty acids and one or more modified steroid groups. Said lipopeptides may be used for immunizing the human or animal body against pathogenic agents such as viruses or parasites. The peptide part may, in particular, be a fragment of the protein encoded by the ENV gene, by the NEF gene or by the GAG gene of HIV viruses.
摘要翻译： 细胞毒性淋巴细胞诱导脂肽包含约10至40个氨基酸的肽部分，并且包含至少一个抗原决定簇。 脂肽还包含一种或多种衍生自脂肪酸和一种或多种修饰类固醇基团的链。 所述脂肽可以用于免疫人体或动物体内的病原体如病毒或寄生虫。 肽部分尤其可以是由ENV基因，NEF基因或HIV病毒的GAG基因编码的蛋白质的片段。
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公开(公告)号：US4695562A
公开(公告)日：1987-09-22
申请号：US808214
申请日：1985-12-11
申请人： Edwin H. Beachey , Andre Tartar , Helene Gras-Masse , Michel Jolivet , Francoise Audibert , Louis Chedid
发明人： Edwin H. Beachey , Andre Tartar , Helene Gras-Masse , Michel Jolivet , Francoise Audibert , Louis Chedid
CPC分类号： C07K14/315 , A61K39/00
摘要： Peptide fragment of M protein of S. pyrogenes elecit opsonic antibodies which are type-specific for type 24 streptococci.
摘要翻译： 致热原性电解质抗体的M蛋白的肽片段，其为24型链球菌的特异性。
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6.发明申请Immunogenic Composition and Peptide Sequences for Prevention and Treatment of an Hsv Condition 审中-公开免疫原性组合物和肽序列用于预防和治疗Hsv病症公开(公告)号：US20080299140A1
公开(公告)日：2008-12-04
申请号：US10516035
申请日：2003-05-23
IPC分类号： A61K39/245 , A61P31/12
CPC分类号： A61K39/245 , A61K39/12 , A61K2039/525 , A61K2039/5252 , A61K2039/55566 , A61K2039/57 , C07K14/005 , C12N2710/16622 , C12N2710/16634
摘要： Immunogenic composition comprising at least one Herpes Simplex Virus type 1 (HSV-1) and/or type 2 (HSV-2) peptide sequence hearing at least one epitope from glycoprotein D (gD) and/or glycoprotein B (gB), a pharmaceutical carrier and/or a human compatible adjuvant, peptide sequences and uses thereof for prevention or treatment of an HSV condition.
摘要翻译： 包含至少一种从糖蛋白D（gD）和/或糖蛋白B（gB）至少检测一个表位的一种单克隆单克隆病毒1型（HSV-1）和/或2型（HSV-2）肽序列的免疫原性组合物， 载体和/或人类相容的佐剂，肽序列及其用于预防或治疗HSV病症的用途。
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公开(公告)号：US5993823A
公开(公告)日：1999-11-30
申请号：US477420
申请日：1995-06-07
申请人： Christophe Boutillon , Frederic Martinon , Christian Sergheraert , Remy Magne , Helene Gras-Masse , Elisabeth Gomard , Andre Tartar , Jean-Paul Levy
发明人： Christophe Boutillon , Frederic Martinon , Christian Sergheraert , Remy Magne , Helene Gras-Masse , Elisabeth Gomard , Andre Tartar , Jean-Paul Levy
CPC分类号： C07K14/005 , A61K47/48038 , A61K47/48053 , A61K47/48123 , A61K39/00 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322
摘要： Cytotoxic lymphocyte-inducing lipopeptides comprising a peptide fragment having approximately between 10 and 40 amino acids and comprising at least one antigenic determinant and also comprising one or more chains derived from fatty acids and one or more modified steroid groups useful for immunizing a human or animal body against pathogenic agents such as viruses or parasites which fragment is preferably a fragment of the protein encoded by the ENV gene, by the NEF gene or by the GAG gene of HIV viruses.
摘要翻译： 包含具有约10至40个氨基酸并且包含至少一个抗原决定簇的肽片段的细胞毒性淋巴细胞诱导性脂肽，并且还包含一种或多种衍生自脂肪酸的链和用于免疫人或动物体的一种或多种修饰类固醇基团 针对诸如病毒或寄生虫的病原体，其片段优选是由ENV基因编码的蛋白质的片段，NEF基因或HIV病毒的GAG基因。
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公开(公告)号：US5871746A
公开(公告)日：1999-02-16
申请号：US251472
申请日：1994-05-31
申请人： Christophe Boutillon , Frederic Martinon , Christian Sergheraert , Remy Magne , Helene Gras-Masse , Elisabeth Gomard , Andre Tartar , Jean-Paul Levy
发明人： Christophe Boutillon , Frederic Martinon , Christian Sergheraert , Remy Magne , Helene Gras-Masse , Elisabeth Gomard , Andre Tartar , Jean-Paul Levy
IPC分类号： A61K39/00 , A61K47/48 , A61P31/00 , A61P37/04 , C07K14/16 , A61K39/21 , A61K39/38 , C07K1/00
CPC分类号： C07K14/005 , A61K47/48023 , A61K47/48038 , A61K47/48053 , A61K47/48123 , A61K39/00 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322
摘要： Cytotoxic lymphocyte-inducing lipopeptides comprising a peptide part having between 10 and 40 amino acids approximately and comprising at least one antigenic determinant. The lipopeptides also comprise one or more chains derived from fatty acids and one or more modified steroid groups.Said lipopeptides may be used for immunizing the human or animal body against pathogenic agents such as viruses or parasites. The peptide part may, in particular, be a fragment of the protein encoded by the ENV gene, by the NEF gene or by the GAG gene of HIV viruses. DA.
摘要翻译： 细胞毒性淋巴细胞诱导脂肽包含约10至40个氨基酸的肽部分，并且包含至少一个抗原决定簇。 脂肽还包含一种或多种衍生自脂肪酸和一种或多种修饰类固醇基团的链。 所述脂肽可以用于免疫人体或动物体内的病原体如病毒或寄生虫。 肽部分尤其可以是由ENV基因，NEF基因或HIV病毒的GAG基因编码的蛋白质的片段。 DA。
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