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公开(公告)号：US20100190788A1
公开(公告)日：2010-07-29
申请号：US11988614
申请日：2006-07-11
申请人： Olivier Defert , Philippe Van Rompaey , Petra Blom , Dirk Leysen , Gert De Wilde , Thomas Brown
发明人： Olivier Defert , Philippe Van Rompaey , Petra Blom , Dirk Leysen , Gert De Wilde , Thomas Brown
IPC分类号： A61K31/5377 , C07D213/74 , A61K31/4409 , A61K31/444 , C07D401/12 , C07D405/12 , A61K31/443 , C07D409/12 , A61K31/4439 , C07D413/12 , A61K31/496 , C07D471/04 , A61K31/437 , C07D473/34 , A61K31/52 , A61P27/06 , A61P15/10 , A61P29/00 , A61P11/06 , A61P19/10 , A61P13/12 , A61P9/10 , A61P9/12 , A61P7/02 , A61P25/28 , A61P35/00 , A61P35/02 , A61P17/06 , A61P1/04 , C12N9/99
CPC分类号： C07D409/14 , C07D213/75 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04
摘要： The present invention relates to new AGC kinase inhibitors, in particular to compounds of Formula (I) or (II) or a stereoisomer, tautomer, racemic, metabolite, pro- or predrug, salt, hydrate, or solvate thereof, wherein Ar1, Ar2, R1, R3, p and n have the meaning defined in the claims. In particular, the present invention relates to more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease.
摘要翻译： 本发明涉及新的AGC激酶抑制剂，特别是涉及式（I）或（II）的化合物或其立体异构体，互变异构体，外消旋，代谢物，前体或前药，盐，水合物或溶剂合物，其中Ar1，Ar2 ，R1，R3，p和n具有权利要求中限定的含义。 特别地，本发明更具体地涉及包含这种抑制剂的ROCK抑制剂，组合物，特别是药物，以及这些抑制剂在治疗和预防疾病中的用途。
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公开(公告)号：US20110262438A1
公开(公告)日：2011-10-27
申请号：US13073044
申请日：2011-03-28
申请人： Francis Descamps , Maria Gonzalez Pajuelo , Pascal Gerard Merchiers , Catelijne Stortelers , Peter Vanlandschoot , Philippe Van Rompaey , Martine Smit , Regorius Leurs , David Andre Baptiste Maussang Detaille
发明人： Francis Descamps , Maria Gonzalez Pajuelo , Pascal Gerard Merchiers , Catelijne Stortelers , Peter Vanlandschoot , Philippe Van Rompaey , Martine Smit , Regorius Leurs , David Andre Baptiste Maussang Detaille
IPC分类号： A61K39/395 , C12N15/13 , C12P21/08 , A61P35/00 , A61P17/06 , A61P25/00 , A61P29/00 , A61P11/06 , A61P9/10 , A61P37/06 , C07K16/28 , A61P25/28
CPC分类号： C07K16/2866 , A61K39/39558 , A61K2039/505 , C07K2317/22 , C07K2317/33 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes.
摘要翻译： 本发明涉及特定的多肽，编码这种多肽的核酸; 制备这种多肽的方法; 以宿主表达或能够表达这种多肽的细胞; 组合物，特别是涉及用于预防，治疗或诊断目的的包含这种多肽的药物组合物。
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公开(公告)号：US20150158948A9
公开(公告)日：2015-06-11
申请号：US14008011
申请日：2012-03-28
申请人： Francis Descamps , David André Baptiste Maussang-Detaille , Maarten Van Roy , Regorius Leurs , Maria Gonzalez Pajuelo , Pascal Gerard Merchiers , Martine Smit , Catelijne Stortelers , Philippe Van Rompaey , Peter Vanlandschoot
发明人： Francis Descamps , David André Baptiste Maussang-Detaille , Maarten Van Roy , Regorius Leurs , Maria Gonzalez Pajuelo , Pascal Gerard Merchiers , Martine Smit , Catelijne Stortelers , Philippe Van Rompaey , Peter Vanlandschoot
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K2039/507 , C07K2317/22 , C07K2317/31 , C07K2317/33 , C07K2317/569 , C07K2317/76 , C07K2319/31
摘要： The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the present invention provides immunoglobulin single variable domains inhibiting CXCR7 mediated tumour growth.
摘要翻译： 本发明涉及特定的多肽，编码这种多肽的核酸; 制备这种多肽的方法; 以宿主表达或能够表达这种多肽的细胞; 组合物，特别是涉及用于预防，治疗或诊断目的的包含这种多肽的药物组合物。 特别地，本发明提供了抑制CXCR7介导的肿瘤生长的免疫球蛋白单可变结构域。
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公开(公告)号：US20140227270A1
公开(公告)日：2014-08-14
申请号：US14008011
申请日：2012-03-28
申请人： Francis Descamps , David André Baptiste Maussang-Detaille , Maarten Van Roy , Regorius Leurs , Maria Gonzalez Pajuelo , Pascal Gerard Merchiers , Martine Smit , Catelijne Stortelers , Philippe Van Rompaey , Peter Vanlandschoot
发明人： Francis Descamps , David André Baptiste Maussang-Detaille , Maarten Van Roy , Regorius Leurs , Maria Gonzalez Pajuelo , Pascal Gerard Merchiers , Martine Smit , Catelijne Stortelers , Philippe Van Rompaey , Peter Vanlandschoot
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K2039/507 , C07K2317/22 , C07K2317/31 , C07K2317/33 , C07K2317/569 , C07K2317/76 , C07K2319/31
摘要： The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the present invention provides immunoglobulin single variable domains inhibiting CXCR7 mediated tumour growth.
摘要翻译： 本发明涉及特定的多肽，编码这种多肽的核酸; 制备这种多肽的方法; 以宿主表达或能够表达这种多肽的细胞; 组合物，特别是涉及用于预防，治疗或诊断目的的包含这种多肽的药物组合物。 特别地，本发明提供了抑制CXCR7介导的肿瘤生长的免疫球蛋白单可变结构域。
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公开(公告)号：US20100173799A1
公开(公告)日：2010-07-08
申请号：US12643286
申请日：2009-12-21
申请人： Toon Laeremans , Catelijne Stortelers , Friedrich Nolte , Maria Gonzalez Pajuelo , Joana Assunção , Philippe Van Rompaey
发明人： Toon Laeremans , Catelijne Stortelers , Friedrich Nolte , Maria Gonzalez Pajuelo , Joana Assunção , Philippe Van Rompaey
IPC分类号： C40B30/04
CPC分类号： C07K16/28 , A61K2039/505 , A61K2039/53 , C07K16/00 , C07K16/2866 , C07K2317/22 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/75 , C07K2317/92
摘要： The present invention relates to a method for generating immunoglobulin sequences against cell-associated antigens, more particularly, antigens that are membrane-anchored. The invention also provides immunoglobulin sequences obtainable by the method of the invention. Specifically, the present invention relates to the generation of immunoglobulin sequences by use of DNA vaccination. More specifically, the present invention relates to generation of immunoglobulin sequences in camelids, preferably directed against cell-associated antigens, in particular antigens with multiple transmembrane spanning domains, including GPCRs and ion channels, by DNA vaccination. Furthermore, the present invention relates to said immunoglobulin sequences against cell-associated antigens, more particularly, antigens that are membrane-anchored, such as e.g. GPCRs and ion channels, more preferably ion channels.
摘要翻译： 本发明涉及产生针对细胞相关抗原的免疫球蛋白序列的方法，更具体地说，涉及膜锚定的抗原。 本发明还提供可通过本发明的方法获得的免疫球蛋白序列。 具体地说，本发明涉及使用DNA疫苗接种产生免疫球蛋白序列。 更具体地，本发明涉及通过DNA疫苗接种在骆驼中产生免疫球蛋白序列，优选针对细胞相关抗原，特别是具有多个跨膜跨越结构域的抗原，包括GPCR和离子通道。 此外，本发明涉及针对细胞相关抗原的所述免疫球蛋白序列，更具体地，涉及膜锚定的抗原，例如抗体。 GPCR和离子通道，更优选离子通道。
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公开(公告)号：US09260508B2
公开(公告)日：2016-02-16
申请号：US12643286
申请日：2009-12-21
申请人： Toon Laeremans , Catelijne Stortelers , Friedrich Nolte , Maria Gonzalez Pajuelo , Joana Assunção , Philippe Van Rompaey
发明人： Toon Laeremans , Catelijne Stortelers , Friedrich Nolte , Maria Gonzalez Pajuelo , Joana Assunção , Philippe Van Rompaey
CPC分类号： C07K16/28 , A61K2039/505 , A61K2039/53 , C07K16/00 , C07K16/2866 , C07K2317/22 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/75 , C07K2317/92
摘要： The present invention relates to a method for generating immunoglobulin sequences against cell-associated antigens, more particularly, antigens that are membrane-anchored. The invention also provides immunoglobulin sequences obtainable by the method of the invention. Specifically, the present invention relates to the generation of immunoglobulin sequences by use of DNA vaccination. More specifically, the present invention relates to generation of immunoglobulin sequences in camelids, preferably directed against cell-associated antigens, in particular antigens with multiple transmembrane spanning domains, including GPCRs and ion channels, by DNA vaccination. Furthermore, the present invention relates to said immunoglobulin sequences against cell-associated antigens, more particularly, antigens that are membrane-anchored, such as e.g. GPCRs and ion channels, more preferably ion channels.
摘要翻译： 本发明涉及产生针对细胞相关抗原的免疫球蛋白序列的方法，更具体地说，涉及膜锚定的抗原。 本发明还提供可通过本发明的方法获得的免疫球蛋白序列。 具体地说，本发明涉及使用DNA疫苗接种产生免疫球蛋白序列。 更具体地，本发明涉及通过DNA疫苗接种在骆驼中产生免疫球蛋白序列，优选针对细胞相关抗原，特别是具有多个跨膜跨越结构域的抗原，包括GPCR和离子通道。 此外，本发明涉及针对细胞相关抗原的所述免疫球蛋白序列，更具体地，涉及膜锚定的抗原，例如抗体。 GPCR和离子通道，更优选离子通道。
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公开(公告)号：US08937164B2
公开(公告)日：2015-01-20
申请号：US13073044
申请日：2011-03-28
申请人： Francis Descamps , Maria Gonzalez Pajuelo , Pascal Gerard Merchiers , Catelijne Stortelers , Peter Vanlandschoot , Philippe Van Rompaey , Martine Smit , Regorius Leurs , David Andre Baptiste Maussang Detaille
发明人： Francis Descamps , Maria Gonzalez Pajuelo , Pascal Gerard Merchiers , Catelijne Stortelers , Peter Vanlandschoot , Philippe Van Rompaey , Martine Smit , Regorius Leurs , David Andre Baptiste Maussang Detaille
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K39/39558 , A61K2039/505 , C07K2317/22 , C07K2317/33 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes.
摘要翻译： 本发明涉及特定的多肽，编码这种多肽的核酸; 制备这种多肽的方法; 以宿主表达或能够表达这种多肽的细胞; 组合物，特别是涉及用于预防，治疗或诊断目的的包含这种多肽的药物组合物。
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公开(公告)号：US20090233960A1
公开(公告)日：2009-09-17
申请号：US12083408
申请日：2006-10-13
IPC分类号： A61K31/437 , A61K31/44 , C07D471/04 , C07D213/02
CPC分类号： C07D213/40 , C07D401/12 , C07D407/12 , C07D409/12 , C07D471/04
摘要： The present invention relates to new AGC kinase inhibitors, in particular to compounds of Formula I, II, or III or a stereoisomer, tautomer, racemic, metabolite, pro- or predrug, salt, hydrate, or solvate thereof, I II III wherein X, R1, R2, R3, R31, n, and m have the meaning defined in the claims. In particular, the present invention relates more specifically to ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease.
摘要翻译： 本发明涉及新的AGC激酶抑制剂，特别是涉及式I，II或III的化合物或其立体异构体，互变异构体，外消旋，代谢物，前体或前药，盐，水合物或溶剂合物，其中X ，R1，R2，R3，R31，n和m具有权利要求中限定的含义。 特别地，本发明更具体地涉及包含这种抑制剂的ROCK抑制剂，组合物，特别是药物，以及这些抑制剂在治疗和预防疾病中的用途。
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