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公开(公告)号：US20100173799A1
公开(公告)日：2010-07-08
申请号：US12643286
申请日：2009-12-21
申请人： Toon Laeremans , Catelijne Stortelers , Friedrich Nolte , Maria Gonzalez Pajuelo , Joana Assunção , Philippe Van Rompaey
发明人： Toon Laeremans , Catelijne Stortelers , Friedrich Nolte , Maria Gonzalez Pajuelo , Joana Assunção , Philippe Van Rompaey
IPC分类号： C40B30/04
CPC分类号： C07K16/28 , A61K2039/505 , A61K2039/53 , C07K16/00 , C07K16/2866 , C07K2317/22 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/75 , C07K2317/92
摘要： The present invention relates to a method for generating immunoglobulin sequences against cell-associated antigens, more particularly, antigens that are membrane-anchored. The invention also provides immunoglobulin sequences obtainable by the method of the invention. Specifically, the present invention relates to the generation of immunoglobulin sequences by use of DNA vaccination. More specifically, the present invention relates to generation of immunoglobulin sequences in camelids, preferably directed against cell-associated antigens, in particular antigens with multiple transmembrane spanning domains, including GPCRs and ion channels, by DNA vaccination. Furthermore, the present invention relates to said immunoglobulin sequences against cell-associated antigens, more particularly, antigens that are membrane-anchored, such as e.g. GPCRs and ion channels, more preferably ion channels.
摘要翻译： 本发明涉及产生针对细胞相关抗原的免疫球蛋白序列的方法，更具体地说，涉及膜锚定的抗原。 本发明还提供可通过本发明的方法获得的免疫球蛋白序列。 具体地说，本发明涉及使用DNA疫苗接种产生免疫球蛋白序列。 更具体地，本发明涉及通过DNA疫苗接种在骆驼中产生免疫球蛋白序列，优选针对细胞相关抗原，特别是具有多个跨膜跨越结构域的抗原，包括GPCR和离子通道。 此外，本发明涉及针对细胞相关抗原的所述免疫球蛋白序列，更具体地，涉及膜锚定的抗原，例如抗体。 GPCR和离子通道，更优选离子通道。
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公开(公告)号：US09260508B2
公开(公告)日：2016-02-16
申请号：US12643286
申请日：2009-12-21
申请人： Toon Laeremans , Catelijne Stortelers , Friedrich Nolte , Maria Gonzalez Pajuelo , Joana Assunção , Philippe Van Rompaey
发明人： Toon Laeremans , Catelijne Stortelers , Friedrich Nolte , Maria Gonzalez Pajuelo , Joana Assunção , Philippe Van Rompaey
CPC分类号： C07K16/28 , A61K2039/505 , A61K2039/53 , C07K16/00 , C07K16/2866 , C07K2317/22 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/75 , C07K2317/92
摘要： The present invention relates to a method for generating immunoglobulin sequences against cell-associated antigens, more particularly, antigens that are membrane-anchored. The invention also provides immunoglobulin sequences obtainable by the method of the invention. Specifically, the present invention relates to the generation of immunoglobulin sequences by use of DNA vaccination. More specifically, the present invention relates to generation of immunoglobulin sequences in camelids, preferably directed against cell-associated antigens, in particular antigens with multiple transmembrane spanning domains, including GPCRs and ion channels, by DNA vaccination. Furthermore, the present invention relates to said immunoglobulin sequences against cell-associated antigens, more particularly, antigens that are membrane-anchored, such as e.g. GPCRs and ion channels, more preferably ion channels.
摘要翻译： 本发明涉及产生针对细胞相关抗原的免疫球蛋白序列的方法，更具体地说，涉及膜锚定的抗原。 本发明还提供可通过本发明的方法获得的免疫球蛋白序列。 具体地说，本发明涉及使用DNA疫苗接种产生免疫球蛋白序列。 更具体地，本发明涉及通过DNA疫苗接种在骆驼中产生免疫球蛋白序列，优选针对细胞相关抗原，特别是具有多个跨膜跨越结构域的抗原，包括GPCR和离子通道。 此外，本发明涉及针对细胞相关抗原的所述免疫球蛋白序列，更具体地，涉及膜锚定的抗原，例如抗体。 GPCR和离子通道，更优选离子通道。
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3.发明申请Camelidae single domain antibodies vhh directed against epidermal growth factor receptor and uses therefor 审中-公开骆驼科单结构域抗体vhh针对表皮生长因子受体并用于其公开(公告)号：US20060228355A1
公开(公告)日：2006-10-12
申请号：US10553105
申请日：2003-11-07
CPC分类号： C07K16/2863 , C07K16/18 , C07K2317/22 , C07K2317/31 , C07K2317/77 , C07K2317/80
摘要： The present invention relates to antibodies directed to Epidermal Growth Factor Receptor that are single domain antibodies Camelidae VHHs. It further relates to methods of of use of said polypeptides.
摘要翻译： 本发明涉及针对表皮生长因子受体的抗体，其是单结构域抗体骆驼科VHH。 它还涉及使用所述多肽的方法。
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公开(公告)号：US09695227B2
公开(公告)日：2017-07-04
申请号：US14129100
申请日：2012-06-21
申请人： Jan Steyaert , Els Pardon , Toon Laeremans , Brian Kobilka , Søren Rasmussen , Sebastian Granier , Roger K. Sunahara
发明人： Jan Steyaert , Els Pardon , Toon Laeremans , Brian Kobilka , Søren Rasmussen , Sebastian Granier , Roger K. Sunahara
IPC分类号： C07K16/28 , C07K14/705 , C07K14/47 , C07K14/435 , G01N33/74
CPC分类号： C07K14/705 , C07K14/435 , C07K14/4722 , C07K14/70571 , C07K16/28 , C07K2317/22 , C07K2317/569 , C12N2799/026 , G01N33/74 , G01N2333/726 , G01N2500/02
摘要： The present invention relates to the field of G protein coupled receptor (GPCR) structural biology and signaling. In particular, the present invention relates to binding domains directed against and/or specifically binding to GPCR:G protein complexes. Also provided are nucleic acid sequences encoding such binding domains and cells expressing or capable of expressing such binding domains. The binding domains of the present invention can be used as universal tools for the structural and functional characterization of G-protein coupled receptors in complex with downstream heterotrimeric G proteins and bound to various natural or synthetic ligands, for investigating the dynamic features of G protein activation, as well as for screening and drug discovery efforts that make use of GPCR:G protein complexes.
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5.发明授权CX3CR1-binding polypeptides comprising immunoglobulin single variable domains 有权包含免疫球蛋白单可变结构域的CX3CR1结合多肽公开(公告)号：US09035029B2
公开(公告)日：2015-05-19
申请号：US13775307
申请日：2013-02-25
申请人： Sanjaya Singh , Alisa K. Waterman , Erik Depla , Toon Laeremans , Diane Van Hoorick , Cedric Jozef Néotère Ververken
发明人： Sanjaya Singh , Alisa K. Waterman , Erik Depla , Toon Laeremans , Diane Van Hoorick , Cedric Jozef Néotère Ververken
IPC分类号： C07K16/28 , A61K39/395 , A61K39/00
CPC分类号： C07K16/2866 , A61K39/3955 , A61K2039/505 , C07H21/04 , C07K16/28 , C07K2317/22 , C07K2317/24 , C07K2317/30 , C07K2317/35 , C07K2317/52 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/30 , C12N15/09 , C12N15/11 , C12N15/63
摘要： The present invention relates to CX3CR1-binding polypeptides, in particular polypeptides comprising specific immunoglobulin domains. The invention also relates to nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions comprising such polypeptides; and to uses of such polypeptides or such compositions, in particular for prophylactic, therapeutic and diagnostic purposes.
摘要翻译： 本发明涉及CX3CR1结合多肽，特别是涉及包含特异性免疫球蛋白结构域的多肽。 本发明还涉及编码这种多肽的核酸; 制备这种多肽的方法; 以宿主表达或能够表达这种多肽的细胞; 包含这样的多肽的组合物; 以及这些多肽或这种组合物的用途，特别是用于预防，治疗和诊断目的。
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6.发明申请公开(公告)号：US20110123529A1
公开(公告)日：2011-05-26
申请号：US13016709
申请日：2011-01-28
IPC分类号： A61K39/395 , C07K16/00 , C07H21/00 , C07K2/00 , C12N15/63 , C12N5/10 , C12P21/00 , C12N5/071
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/241 , C07K16/249 , C07K16/2863 , C07K16/40 , C07K16/4291 , C07K2317/22 , C07K2317/31 , C07K2317/569 , C07K2317/76 , C07K2317/77 , C07K2317/80
摘要： The present invention relates to polypeptides derived from single domain heavy chain antibodies directed to Epidermal Growth Factor Receptor. It further relates to single domain antibodies that are Camelidae VHHs. It further relates to methods of administering said polypeptides orally, sublingually, topically, intravenously, subcutaneously, nasally, vaginally, rectally or by inhalation. It further relates to protocols for screening for agents that modulate the Epidermal Growth Factor Receptor, and the agents resulting from said screening. The invention further a method for delivering therapeutic molecules to the interior of cells.
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7.发明申请SINGLE DOMAIN ANTIBODIES DIRECTED AGAINST EPIDERMAL GROWTH FACTOR RECEPTOR AND USES THEREFOR 审中-公开针对抗生殖因子受体的单抗抗体及其用途公开(公告)号：US20110184151A1
公开(公告)日：2011-07-28
申请号：US13078703
申请日：2011-04-01
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/241 , C07K16/249 , C07K16/2863 , C07K16/40 , C07K16/4291 , C07K2317/22 , C07K2317/31 , C07K2317/569 , C07K2317/76 , C07K2317/77 , C07K2317/80
摘要： The present invention relates to polypeptides derived from single domain heavy chain antibodies directed to Epidermal Growth Factor Receptor. It further relates to single domain antibodies that are Camelidae VHHs. It further relates to methods of administering said polypeptides orally, sublingually, topically, intravenously, subcutaneously, nasally, vaginally, rectally or by inhalation. It further relates to protocols for screening for agents that modulate the Epidermal Growth Factor Receptor, and the agents resulting from said screening. The invention further a method for delivering therapeutic molecules to the interior of cells.
摘要翻译： 本发明涉及衍生自针对表皮生长因子受体的单结构域重链抗体的多肽。 它还涉及骆驼科VHHs的单结构域抗体。 本发明还涉及口服，舌下，局部，静脉内，皮下，鼻腔，阴道，直肠或吸入所述多肽的方法。 它还涉及用于筛选调节表皮生长因子受体的试剂的方案和由所述筛选产生的试剂。 本发明还提供了一种将治疗分子递送至细胞内部的方法。
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8.发明申请SINGLE DOMAIN ANTIBODIES DIRECTED AGAINST EPIDERMAL GROWTH FACTOR RECEPTOR AND USES THEREFOR 审中-公开针对抗生殖因子受体的单抗抗体及其用途公开(公告)号：US20100003253A1
公开(公告)日：2010-01-07
申请号：US12431403
申请日：2009-04-28
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/241 , C07K16/249 , C07K16/2863 , C07K16/40 , C07K16/4291 , C07K2317/22 , C07K2317/31 , C07K2317/569 , C07K2317/76 , C07K2317/77 , C07K2317/80
摘要： The present invention relates to polypeptides derived from single domain heavy chain antibodies directed to Epidermal Growth Factor Receptor. It further relates to single domain antibodies that are Camelidae VHHs. It further relates to methods of administering said polypeptides orally, sublingually, topically, intravenously, subcutaneously, nasally, vaginally, rectally or by inhalation. It further relates to protocols for screening for agents that modulate the Epidermal Growth Factor Receptor, and the agents resulting from said screening. The invention further a method for delivering therapeutic molecules to the interior of cells
摘要翻译： 本发明涉及衍生自针对表皮生长因子受体的单结构域重链抗体的多肽。 它还涉及骆驼科VHHs的单结构域抗体。 本发明还涉及口服，舌下，局部，静脉内，皮下，鼻腔，阴道，直肠或吸入所述多肽的方法。 它还涉及用于筛选调节表皮生长因子受体的试剂的方案和由所述筛选产生的试剂。 本发明还提供了一种将治疗分子递送至细胞内部的方法
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公开(公告)号：US20090252681A1
公开(公告)日：2009-10-08
申请号：US12083406
申请日：2006-10-11
IPC分类号： A61K39/395 , C07K16/28 , C07K2/00 , C12P21/00 , C07H21/04 , C12N1/21 , C12N5/10 , C12N1/15 , A61K49/00 , A61P35/00 , A61P29/00 , A61P17/00 , G01N33/53
CPC分类号： G01N33/74 , C07K16/00 , C07K16/18 , C07K16/2863 , C07K16/3053 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N2333/61 , G01N2333/62
摘要： The invention relates to polypeptides and Nanobodies against Epidermal Growth Factor Receptor (EGFR) and/or Insulin Growth Factor-I Receptor (IGF-IR). The invention also relates to nucleic acids encoding such Nanobodies and polypeptides; to methods for preparing such Nanobodies and polypeptides; to host cells expressing or capable of expressing such Nanobodies or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such Nanobodies, polypeptides, nucleic acids and/or host cells; and to uses of such Nanobodies, polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.
摘要翻译： 本发明涉及针对表皮生长因子受体（EGFR）和/或胰岛素生长因子-I受体（IGF-1R）的多肽和纳米抗体。 本发明还涉及编码这种纳米抗体和多肽的核酸; 制备这种纳米抗体和多肽的方法; 宿主表达或能够表达这种纳米抗体或多肽的细胞; 包括这样的纳米抗体，多肽，核酸和/或宿主细胞的组合物，特别是药物组合物; 以及这些纳米抗体，多肽，核酸，宿主细胞和/或组合物的用途，特别是用于预防，治疗或诊断目的。
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公开(公告)号：US20240279349A2
公开(公告)日：2024-08-22
申请号：US17836473
申请日：2022-06-09
申请人： Sanjaya Singh , Alisa Waterman , Erik Depla , Toon Laeremans , Diane Van Hoorick , Cedric Ververken
发明人： Sanjaya Singh , Alisa Waterman , Erik Depla , Toon Laeremans , Diane Van Hoorick , Cedric Ververken
IPC分类号： C07K16/28 , C07H21/04 , C12N15/09 , C12N15/11 , C12N15/63 , A61K39/00 , A61K39/395 , A61P13/12 , C07K14/52 , C07K14/715
CPC分类号： C07K16/2866 , C07H21/04 , C07K16/28 , C12N15/09 , C12N15/11 , C12N15/63 , A61K39/3955 , A61K2039/505 , A61P13/12 , C07K14/521 , C07K14/7158 , C07K2317/22 , C07K2317/24 , C07K2317/30 , C07K2317/35 , C07K2317/52 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to CX3CR1-binding polypeptides, in particular polypeptides comprising specific immunoglobulin domains. The invention also relates to nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions comprising such polypeptides; and to uses of such polypeptides or such compositions, in particular for prophylactic, therapeutic and diagnostic purposes.
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