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公开(公告)号：US20110294819A1
公开(公告)日：2011-12-01
申请号：US12974069
申请日：2010-12-21
申请人： Omar D. Lopez , Denis R. St. Laurent , Jason Goodrich , Jeffrey Lee Romine , Michael Serrano-Wu , Fukang Yang , Ramesh Kakarla , Xuejie Yang , Yuping Qiu , Lawrence B. Snyder
发明人： Omar D. Lopez , Denis R. St. Laurent , Jason Goodrich , Jeffrey Lee Romine , Michael Serrano-Wu , Fukang Yang , Ramesh Kakarla , Xuejie Yang , Yuping Qiu , Lawrence B. Snyder
IPC分类号： A61K31/421 , C07D413/14 , C07D471/04 , C07D403/14 , C07D417/14 , C07D401/14 , C07D231/12 , C07D249/08 , C07D249/12 , C07D249/06 , C07D409/14 , C07D405/14 , A61K31/422 , A61K31/496 , A61K31/427 , A61K31/438 , A61K31/444 , A61K31/4545 , A61K31/4178 , A61K31/4725 , A61P31/14 , C07D263/32
CPC分类号： A61K31/415 , A61K31/4196 , A61K31/4245 , C07D231/12 , C07D233/58 , C07D233/64 , C07D249/06 , C07D249/08 , C07D249/12 , C07D263/32 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The present disclosure is generally directed to antiviral compounds, and more specifically directed to compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such compounds, and methods for inhibiting the function of the NS5A protein.
摘要翻译： 本公开一般涉及抗病毒化合物，更具体地涉及可以抑制由丙型肝炎病毒（HCV）编码的NS5A蛋白的功能的化合物，包含这些化合物的组合物，以及用于抑制NS5A蛋白功能的方法。
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公开(公告)号：US08362020B2
公开(公告)日：2013-01-29
申请号：US12974069
申请日：2010-12-21
申请人： Omar D. Lopez , Denis R. St. Laurent , Jason Goodrich , Jeffrey Lee Romine , Michael Serrano-Wu , Fukang Yang , Ramesh Kakarla , Xuejie Yang , Yuping Qiu , Lawrence B. Snyder
发明人： Omar D. Lopez , Denis R. St. Laurent , Jason Goodrich , Jeffrey Lee Romine , Michael Serrano-Wu , Fukang Yang , Ramesh Kakarla , Xuejie Yang , Yuping Qiu , Lawrence B. Snyder
IPC分类号： A61K31/422 , A61K31/4025 , A61K31/496 , A61K31/427 , A61K31/438 , A61K31/444 , A61K31/4545 , C07D263/32 , C07D207/09 , C07D413/14 , C07D471/04 , C07D417/14
CPC分类号： A61K31/415 , A61K31/4196 , A61K31/4245 , C07D231/12 , C07D233/58 , C07D233/64 , C07D249/06 , C07D249/08 , C07D249/12 , C07D263/32 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The present disclosure is generally directed to antiviral compounds, and more specifically directed to compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such compounds, and methods for inhibiting the function of the NS5A protein.
摘要翻译： 本公开一般涉及抗病毒化合物，更具体地涉及可以抑制由丙型肝炎病毒（HCV）编码的NS5A蛋白的功能的化合物，包含这些化合物的组合物，以及用于抑制NS5A蛋白功能的方法。
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公开(公告)号：US20100068176A1
公开(公告)日：2010-03-18
申请号：US12536362
申请日：2009-08-05
申请人： Makonen Belema , Andrew C. Good , Jason Goodrich , Ramesh Kakarla , Guo Li , Omar D. Lopez , Van N. Nguyen , Jayne Kapur , Yuping Qiu , Jeffrey Lee Romine , Denis R. St. Laurent , Michael Serrano-Wu , Lawrence B. Snyder , Fukang Yang
发明人： Makonen Belema , Andrew C. Good , Jason Goodrich , Ramesh Kakarla , Guo Li , Omar D. Lopez , Van N. Nguyen , Jayne Kapur , Yuping Qiu , Jeffrey Lee Romine , Denis R. St. Laurent , Michael Serrano-Wu , Lawrence B. Snyder , Fukang Yang
IPC分类号： A61K38/20 , C07D403/14 , A61K31/4184 , A61K31/497 , A61K38/21 , A61K31/7088 , A61P31/12
CPC分类号： C07D235/20 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
摘要翻译： 本公开涉及用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。
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公开(公告)号：US07906655B2
公开(公告)日：2011-03-15
申请号：US12536362
申请日：2009-08-05
申请人： Makonen Belema , Andrew C. Good , Jason Goodrich , Ramesh Kakarla , Guo Li , Omar D. Lopez , Van N. Nguyen , Jayne Kapur , Yuping Qiu , Jeffrey Lee Romine , Denis R. St. Laurent , Michael Serrano-Wu , Lawrence B. Snyder , Fukang Yang
发明人： Makonen Belema , Andrew C. Good , Jason Goodrich , Ramesh Kakarla , Guo Li , Omar D. Lopez , Van N. Nguyen , Jayne Kapur , Yuping Qiu , Jeffrey Lee Romine , Denis R. St. Laurent , Michael Serrano-Wu , Lawrence B. Snyder , Fukang Yang
IPC分类号： C07D403/14 , C07D217/08 , C07D211/32 , C07D239/04 , C07D413/14 , A61K31/47 , A61K31/497 , A61K31/445 , A61K31/5355 , A01N43/60
CPC分类号： C07D235/20 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
摘要翻译： 本公开涉及用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。
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公开(公告)号：US08143288B2
公开(公告)日：2012-03-27
申请号：US11446788
申请日：2006-06-05
申请人： Michael Serrano-Wu , Makonen Belema , Lawrence B. Snyder , Nicholas A. Meanwell , Denis R. St. Laurent , Ramesh Kakarla , Van N. Nguyen , Yuping Qiu , Xuejie Yang , John E. Leet , Min Gao , Donald R. O'Boyle, II , Julie A. Lemm , Fukang Yang
发明人： Michael Serrano-Wu , Makonen Belema , Lawrence B. Snyder , Nicholas A. Meanwell , Denis R. St. Laurent , Ramesh Kakarla , Van N. Nguyen , Yuping Qiu , Xuejie Yang , John E. Leet , Min Gao , Donald R. O'Boyle, II , Julie A. Lemm , Fukang Yang
IPC分类号： A61K31/444 , A61K31/4439 , A61K31/42 , A61K31/416 , A61K31/4025 , C07D413/14 , C07D403/14 , C07D409/14
CPC分类号： C07D207/16 , C07D207/22 , C07D207/277 , C07D209/42 , C07D211/60 , C07D263/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Compounds having the structure of formula I are described. The compounds can inhibit hepatitis C virus (HCV) replication, and in particular can inhibit the function of the HCV NS5A protein.
摘要翻译： 描述具有式I结构的化合物。 该化合物可以抑制丙型肝炎病毒（HCV）复制，特别是可以抑制HCV NS5A蛋白的功能。
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公开(公告)号：US20080299075A1
公开(公告)日：2008-12-04
申请号：US12029680
申请日：2008-02-12
申请人： Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
发明人： Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
IPC分类号： C07D403/14 , A61K31/4178 , A61K38/20 , A61K38/21 , A61K38/43 , A61K38/48 , A61K31/7088 , A61K38/16 , A61P31/12
CPC分类号： C07D403/14
摘要： The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
摘要翻译： 本公开涉及用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。
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公开(公告)号：US20080044379A1
公开(公告)日：2008-02-21
申请号：US11835485
申请日：2007-08-08
申请人： Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
发明人： Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
IPC分类号： A61K38/20 , A61K31/4178 , A61K31/4196 , A61K31/4245 , A61K31/426 , A61K31/4353 , A61K31/4427 , A61K38/21 , C07D213/02 , C07D295/00 , C07D277/02 , C07D249/08 , C07D241/02 , C07D239/02 , C07D237/02 , C07D233/54 , C07D221/00 , A61P31/12 , A61K31/4523 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/7052
CPC分类号： C07D401/14 , C07D403/14
摘要： The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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公开(公告)号：US20130004457A1
公开(公告)日：2013-01-03
申请号：US13609957
申请日：2012-09-11
申请人： Carol Bachand , Makonen Bekema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
发明人： Carol Bachand , Makonen Bekema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
IPC分类号： C07D403/14 , A61K31/506 , C07D417/14 , A61K31/427 , C07D405/14 , A61P31/16 , A61K31/4545 , A61K38/21 , A61K31/7056 , A61K38/20 , A61K31/7105 , A61K31/4745 , A61K31/4178 , C07D401/14
CPC分类号： A61K31/506 , A61K31/13 , A61K31/4178 , A61K31/427 , A61K31/4745 , A61K31/7056 , A61K31/7105 , A61K38/2013 , A61K38/204 , A61K38/208 , A61K38/21 , A61K38/212 , C07D401/14 , C07D403/14 , C07D405/14 , C07D417/14
摘要： The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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公开(公告)号：US20120328570A1
公开(公告)日：2012-12-27
申请号：US13606231
申请日：2012-09-07
申请人： Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
发明人： Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
IPC分类号： A61K31/4178 , C07D401/14 , A61K31/4545 , C07D413/14 , A61K31/5377 , A61P31/14 , A61K31/695 , A61K38/21 , A61K31/7056 , A61K38/20 , A61K31/713 , C07D403/14 , C07F7/10
CPC分类号： C07D403/14 , A61K31/4178 , A61K31/4545 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D401/14 , C07F7/10
摘要： The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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公开(公告)号：US07759495B2
公开(公告)日：2010-07-20
申请号：US11835524
申请日：2007-08-08
申请人： Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
发明人： Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
IPC分类号： C07D233/02 , A01N43/50
CPC分类号： C07D403/14 , A61K31/4178 , A61K31/4545 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D401/14 , C07F7/10
摘要： The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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