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公开(公告)号:US08703117B2
公开(公告)日:2014-04-22
申请号:US13555656
申请日:2012-07-23
申请人: Orahn Preiss Bloom , Ishay Attar , Natalie Iram , Chagai Komlos , Meir Haber
发明人: Orahn Preiss Bloom , Ishay Attar , Natalie Iram , Chagai Komlos , Meir Haber
CPC分类号: A61K38/39 , A61K8/042 , A61K8/20 , A61K8/36 , A61K8/365 , A61K8/60 , A61K8/65 , A61K8/66 , A61K9/0014 , A61K9/19 , A61K47/02 , A61K47/10 , A61K47/18 , A61K47/183 , A61K47/20 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/46 , A61L15/24 , A61L15/26 , A61L15/32 , A61L26/0014 , A61L26/0019 , A61L26/0038 , A61Q19/00 , C08H1/06 , C08L89/06 , C08L29/04 , C08L71/02
摘要: Improved compositions comprising a cross-linkable protein or polypeptide, and a non-toxic material which induces cross-linking of the cross-linkable protein. The compositions are optionally and preferably prepared in a non-phosphate buffer solvent. Optionally and preferably, the cross-linkable protein includes gelatin and any gelatin variant or variant protein as described herein. Optionally and preferably, the non-toxic material comprises transglutaminase (TG), which may optionally comprise any type of calcium dependent or independent transglutaminase, which may for example optionally be a microbial transglutaminase (mTG).
摘要翻译: 包含可交联蛋白质或多肽的改进的组合物和诱导可交联蛋白质交联的无毒材料。 组合物任选且优选在非磷酸缓冲溶剂中制备。 任选且优选地,可交联蛋白质包括本文所述的明胶和任何明胶变体或变体蛋白质。 任选且优选地,无毒材料包含转谷氨酰胺酶(TG),其可以任选地包含任何类型的钙依赖性或独立的转谷氨酰胺酶,其可以例如任选地是微生物转谷氨酰胺酶(mTG)。
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公开(公告)号:US20120329132A1
公开(公告)日:2012-12-27
申请号:US13555656
申请日:2012-07-23
申请人: Orahn Preiss BLOOM , Ishay Attar , Natalie Iram , Chagai Komlos , Meir Haber
发明人: Orahn Preiss BLOOM , Ishay Attar , Natalie Iram , Chagai Komlos , Meir Haber
IPC分类号: C12N9/10
CPC分类号: A61K38/39 , A61K8/042 , A61K8/20 , A61K8/36 , A61K8/365 , A61K8/60 , A61K8/65 , A61K8/66 , A61K9/0014 , A61K9/19 , A61K47/02 , A61K47/10 , A61K47/18 , A61K47/183 , A61K47/20 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/46 , A61L15/24 , A61L15/26 , A61L15/32 , A61L26/0014 , A61L26/0019 , A61L26/0038 , A61Q19/00 , C08H1/06 , C08L89/06 , C08L29/04 , C08L71/02
摘要: Improved compositions comprising a cross-linkable protein or polypeptide, and a non-toxic material which induces cross-linking of the cross-linkable protein. The compositions are optionally and preferably prepared in a non-phosphate buffer solvent. Optionally and preferably, the cross-linkable protein includes gelatin and any gelatin variant or variant protein as described herein. Optionally and preferably, the non-toxic material comprises transglutaminase (TG), which may optionally comprise any type of calcium dependent or independent transglutaminase, which may for example optionally be a microbial transglutaminase (mTG).
摘要翻译: 包含可交联蛋白质或多肽的改进的组合物和诱导可交联蛋白质交联的无毒材料。 组合物任选且优选在非磷酸缓冲溶剂中制备。 任选且优选地,可交联蛋白质包括本文所述的明胶和任何明胶变体或变体蛋白质。 任选且优选地,无毒材料包含转谷氨酰胺酶(TG),其可以任选地包含任何类型的钙依赖性或独立的转谷氨酰胺酶,其可以例如任选地是微生物转谷氨酰胺酶(mTG)。
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公开(公告)号:US20110110882A1
公开(公告)日:2011-05-12
申请号:US13000021
申请日:2009-06-18
申请人: Orahn Preiss-Bloom , Ishay Attar , Natalie Iram , Chagai Komlos , Meir Haber
发明人: Orahn Preiss-Bloom , Ishay Attar , Natalie Iram , Chagai Komlos , Meir Haber
IPC分类号: A61K31/785 , A61K38/45 , A61P3/00
CPC分类号: A61K38/39 , A61K8/042 , A61K8/20 , A61K8/36 , A61K8/365 , A61K8/60 , A61K8/65 , A61K8/66 , A61K9/0014 , A61K9/19 , A61K47/02 , A61K47/10 , A61K47/18 , A61K47/183 , A61K47/20 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/46 , A61L15/24 , A61L15/26 , A61L15/32 , A61L26/0014 , A61L26/0019 , A61L26/0038 , A61Q19/00 , C08H1/06 , C08L89/06 , C08L29/04 , C08L71/02
摘要: Improved compositions comprising a cross-linkable protein or polypeptide, and a non-toxic material which induces cross-linking of the cross-linkable protein. The compositions are optionally and preferably prepared in a non-phosphate buffer solvent. Optionally and preferably, the cross-linkable protein includes gelatin and any gelatin variant or variant protein as described herein. Optionally and preferably, the non-toxic material comprises transglutaminase (TG), which may optionally comprise any type of calcium dependent or independent transglutaminase, which may for example optionally be a microbial transglutaminase (mTG).
摘要翻译: 包含可交联蛋白质或多肽的改进的组合物和诱导可交联蛋白质交联的无毒材料。 组合物任选且优选在非磷酸缓冲溶剂中制备。 任选且优选地,可交联蛋白包括本文所述的明胶和任何明胶变体或变体蛋白质。 任选且优选地,无毒材料包含转谷氨酰胺酶(TG),其可以任选地包含任何类型的钙依赖性或独立的转谷氨酰胺酶,其可以例如任选地是微生物转谷氨酰胺酶(mTG)。
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公开(公告)号:US08367388B2
公开(公告)日:2013-02-05
申请号:US13000021
申请日:2009-06-18
申请人: Orahn Preiss Bloom , Ishay Attar , Natalie Iram , Chagai Komlos , Meir Haber
发明人: Orahn Preiss Bloom , Ishay Attar , Natalie Iram , Chagai Komlos , Meir Haber
CPC分类号: A61K38/39 , A61K8/042 , A61K8/20 , A61K8/36 , A61K8/365 , A61K8/60 , A61K8/65 , A61K8/66 , A61K9/0014 , A61K9/19 , A61K47/02 , A61K47/10 , A61K47/18 , A61K47/183 , A61K47/20 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/46 , A61L15/24 , A61L15/26 , A61L15/32 , A61L26/0014 , A61L26/0019 , A61L26/0038 , A61Q19/00 , C08H1/06 , C08L89/06 , C08L29/04 , C08L71/02
摘要: Improved compositions comprising a cross-linkable protein or polypeptide, and a non-toxic material which induces cross-linking of the cross-linkable protein. The compositions are optionally and preferably prepared in a non-phosphate buffer solvent. Optionally and preferably, the cross-linkable protein includes gelatin and any gelatin variant or variant protein as described herein. Optionally and preferably, the non-toxic material comprises transglutaminase (TG), which may optionally comprise any type of calcium dependent or independent transglutaminase, which may for example optionally be a microbial transglutaminase (mTG).
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公开(公告)号:US5859198A
公开(公告)日:1999-01-12
申请号:US522179
申请日:1995-08-31
申请人: Meir Haber
发明人: Meir Haber
IPC分类号: C07K14/415 , C07K14/405
CPC分类号: C07K14/415
摘要: Adhesive proteins isolated from mature plants selected from the group consisting of macroalgae and microalgae, said proteins being characterized by the presence of at least one RGD or RGD-like or other adhesive recognition sequence, the absence of DOPA and hydroxyproline units, and by the fact that the proteins may be used by the plants in their natural state, for the purpose of adhesion to substrates.
摘要翻译: 从从大藻和微藻组成的组中分离的成熟植物分离的粘合蛋白,所述蛋白的特征在于存在至少一种RGD或RGD样或其他粘合剂识别序列,不存在DOPA和羟脯氨酸单位, 这些蛋白质可以被植物以其天然状态使用,用于粘附到底物上。
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公开(公告)号:US08840935B2
公开(公告)日:2014-09-23
申请号:US12226879
申请日:2007-04-30
IPC分类号: A61K36/00 , A61K36/534 , A61K9/00
CPC分类号: A61K9/006
摘要: The invention relates to an orally administrable mucoadhesive film which comprises one or more bioactive ingredients and, as a major film-forming polymer, at least one alginate which is capable of forming a low viscosity aqueous solution. Also provided is a process for preparing such films.
摘要翻译: 本发明涉及一种口服给药的粘膜粘附膜,其包含一种或多种生物活性成分,以及作为主要成膜聚合物的至少一种能够形成低粘度水溶液的藻酸盐。 还提供了制备这种膜的方法。
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公开(公告)号:US20090186107A1
公开(公告)日:2009-07-23
申请号:US12226879
申请日:2007-04-30
IPC分类号: A61K36/534 , A61K31/519 , A61K31/18 , A61K31/343 , A61K31/13 , A61K31/4353 , A61K31/01 , A61K36/484 , A61K31/015
CPC分类号: A61K9/006
摘要: The invention relates to an orally administrable mucoadhesive film which comprises one or more bioactive ingredients and, as a major film-forming polymer, at least one alginate which is capable of forming a low viscosity aqueous solution. Also provided is a process for preparing such films.
摘要翻译: 本发明涉及一种口服给药的粘膜粘附膜,其包含一种或多种生物活性成分,以及作为主要成膜聚合物的至少一种能够形成低粘度水溶液的藻酸盐。 还提供了制备这种膜的方法。
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