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公开(公告)号：US20110083667A1
公开(公告)日：2011-04-14
申请号：US12809155
申请日：2008-12-18
申请人： John Briant , Orest Lastow , Johan Remmelgas
发明人： John Briant , Orest Lastow , Johan Remmelgas
IPC分类号： A61M15/00
CPC分类号： A61M15/0065 , A61M15/0025 , A61M15/0045 , A61M15/0048 , A61M2202/064 , A61M2206/10
摘要： The invention relates to a method for entraining in an airflow a medicament powder contained in a cavity having a cavity opening. Large airflow vortices are provided, for instance, by means of an obstacle in a flow passage. The airflow with large vortices is arranged to by-pass the cavity opening, thereby generating an eddy in the cavity which contributes to entraining the powder in said airflow. The invention also relates to a medical dispenser, for instance an inhaler, in which said method may be performed.
摘要翻译： 本发明涉及一种在气流中夹带药物粉末的方法，所述药物粉末包含在具有空腔开口的空腔中。 例如，通过流动通道中的障碍物提供大气流涡流。 具有大涡流的气流布置成绕过空腔开口，从而在空腔中产生涡流，这有助于将粉末夹带在所述气流中。 本发明还涉及一种医疗分配器，例如吸入器，其中可以执行所述方法。
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公开(公告)号：US09283337B2
公开(公告)日：2016-03-15
申请号：US12809155
申请日：2008-12-18
申请人： Orest Lastow , Johan Remmelgas , John Briant
发明人： Orest Lastow , Johan Remmelgas , John Briant
IPC分类号： A61M15/00
CPC分类号： A61M15/0065 , A61M15/0025 , A61M15/0045 , A61M15/0048 , A61M2202/064 , A61M2206/10
摘要： The present disclosure relates to a method for entraining in an airflow a medicament powder contained in a cavity having a cavity opening. Large airflow vortices are provided, for instance, by use of an obstacle in a flow passage, The airflow with large vortices is arranged to by-pass the cavity opening, thereby generating an eddy in the cavity which contributes to entraining the powder in said airflow. The present disclosure also relates to a medical dispenser, for instance an inhaler, in which the method may be performed.
摘要翻译： 本公开内容涉及一种用于夹带在具有空腔开口的空腔中的药物粉末的气流中的方法。 例如，通过使用流动通道中的障碍物来提供大气流涡流。具有大涡流的气流被布置成绕过空腔开口，从而在空腔中产生涡流，这有助于将粉末夹带在所述空气流中 。 本公开还涉及可以执行该方法的医疗分配器，例如吸入器。
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公开(公告)号：US20110226243A1
公开(公告)日：2011-09-22
申请号：US12809157
申请日：2008-12-18
申请人： Orest Lastow , Johan Remmelgas
发明人： Orest Lastow , Johan Remmelgas
IPC分类号： A61M15/00
CPC分类号： A61M15/0065 , A61M15/0025 , A61M15/0045 , A61M15/0048 , A61M2202/064 , A61M2206/10
摘要： The present disclosure relates to a device for inhalation of at least one air stream carrying a dose of medicament powder. The device comprises a flow passage passing a powder-containing cavity. A part of said flow passage propagates along a generally flat surface region. The flat surface region comprises a cavity opening into said powder-containing cavity. The passing of an air stream along said flat surface region and outside said cavity generates an eddy in the cavity and the generated eddy contributes to deaggregation of the powder in said cavity and emptying of the powder from said cavity. Furthermore, the present disclosure relates to the use of a shear driven cavity principle on such a device and a method of releasing medicament powder.
摘要翻译： 本公开涉及用于吸入携带一定剂量的药物粉末的至少一种气流的装置。 该装置包括通过含粉末的腔的流动通道。 所述流动通道的一部分沿着大致平坦的表面区域传播。 平坦表面区域包括通向所述含粉末的空腔的空腔。 沿着所述平坦表面区域和所述空腔外部的空气流的通过在空腔中产生涡流，并且产生的涡流有助于粉末在所述空腔中的解聚和从所述空腔排空粉末。 此外，本公开涉及在这种装置上使用剪切驱动腔原理以及释放药物粉末的方法。
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公开(公告)号：US20120298106A1
公开(公告)日：2012-11-29
申请号：US13380055
申请日：2010-06-30
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61M15/0003 , A61M15/0025 , A61M15/0043 , A61M15/0048 , A61M2202/064 , A61M2206/10 , A61M2206/14 , A61M2206/16 , A61M2209/02
摘要： The disclosure relates to a device for inhalation of at least one air stream carrying a dose of medicament powder. The device comprises a powder-containing cavity which opens into a flow passage. The flow passage is arranged to direct an inhalation air flow across the cavity opening. A circulating flow is thereby induced in the cavity by the phenomenon of shear driven cavity flow. Powder is entrained in the circulating flow and deaggregated before exiting the cavity and becoming entrained in the flow of air along the flow passage.
摘要翻译： 本公开涉及用于吸入携带一定剂量的药物粉末的至少一种气流的装置。 该装置包括通向流动通道的含粉末的空腔。 流动通道布置成将吸入空气流引导通过腔开口。 由此，通过剪切驱动的空腔流动的现象在空腔中引起循环流动。 粉末被夹带在循环流中，并在离开空腔之前解聚，并被夹带在沿着流动通道的空气流中。
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公开(公告)号：US08151793B2
公开(公告)日：2012-04-10
申请号：US12940683
申请日：2010-11-05
申请人： Orest Lastow , Johan Remmelgas
发明人： Orest Lastow , Johan Remmelgas
CPC分类号： A61M15/0065 , A61M15/0025 , A61M15/0045 , A61M15/0048 , A61M2202/064 , A61M2206/10
摘要： A device for inhalation of at least one air stream carrying a dose of medicament powder is provided. The device includes a flow passage passing a powder-containing cavity. A part of said flow passage propagates along a generally flat surface region. The flat surface region includes a cavity opening into said powder-containing cavity. The passing of an air stream along said flat surface region and outside said cavity generates an eddy in the cavity and the generated eddy contributes to deaggregation of the powder in said cavity and emptying of the powder from said cavity. Furthermore, a shear driven cavity principle is used in conjunction with such a device and a method of releasing medicament powder.
摘要翻译： 提供了用于吸入至少一个携带一定剂量的药物粉末的气流的装置。 该装置包括通过含粉末的空腔的流动通道。 所述流动通道的一部分沿着大致平坦的表面区域传播。 平坦表面区域包括通向所述含粉末的腔体的空腔。 沿着所述平坦表面区域和所述空腔外部的空气流的通过在空腔中产生涡流，并且产生的涡流有助于粉末在所述空腔中的解聚和从所述空腔排空粉末。 此外，剪切驱动腔原理与这种装置和释放药物粉末的方法结合使用。
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公开(公告)号：US09211383B2
公开(公告)日：2015-12-15
申请号：US13380055
申请日：2010-06-30
CPC分类号： A61M15/0045 , A61M15/0003 , A61M15/0025 , A61M15/0043 , A61M15/0048 , A61M2202/064 , A61M2206/10 , A61M2206/14 , A61M2206/16 , A61M2209/02
摘要： A device for inhalation of at least one air stream carrying a dose of medicament powder having a powder-containing cavity which opens into a flow passage. The flow passage is arranged to direct an inhalation air flow across the cavity opening. A circulating flow is thereby induced in the cavity by the phenomenon of shear driven cavity flow. Powder is entrained in the circulating flow and deaggregated before exiting the cavity and becoming entrained in the flow of air along the flow passage.
摘要翻译： 用于吸入至少一个携带一定剂量的药物粉末的空气流的装置，其具有通向流动通道的含有粉末的空腔。 流动通道布置成将吸入空气流引导通过腔开口。 由此，通过剪切驱动的空腔流动的现象在空腔中引起循环流动。 粉末被夹带在循环流中，并在离开空腔之前解聚，并被夹带在沿着流动通道的空气流中。
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公开(公告)号：US08578933B2
公开(公告)日：2013-11-12
申请号：US12496525
申请日：2009-07-01
CPC分类号： A61M15/0065 , A61M15/0025 , A61M15/0045 , A61M15/0048 , A61M2202/064 , A61M2206/10
摘要： A device for inhalation of at least one air stream carrying a dose of medicament powder. The device comprises a powder-containing cavity which opens into a flow passage. The flow passage is arranged to direct an inhalation air flow across the cavity opening. A circulating flow is thereby induced in the cavity by the phenomenon of shear driven cavity flow. Powder is entrained in the circulating flow and deaggregated before exiting the cavity and becoming entrained in the flow of air along the flow passage.
摘要翻译： 用于吸入携带一定剂量药物粉末的至少一个气流的装置。 该装置包括通向流动通道的含粉末的空腔。 流动通道布置成将吸入空气流引导通过腔开口。 由此，通过剪切驱动的空腔流动的现象在空腔中引起循环流动。 粉末被夹带在循环流中，并在离开空腔之前解聚，并被夹带在沿着流动通道的空气流中。
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公开(公告)号：US08479729B2
公开(公告)日：2013-07-09
申请号：US12809157
申请日：2008-12-18
申请人： Orest Lastow , Johan Remmelgas
发明人： Orest Lastow , Johan Remmelgas
CPC分类号： A61M15/0065 , A61M15/0025 , A61M15/0045 , A61M15/0048 , A61M2202/064 , A61M2206/10
摘要： A device for inhalation of at least one air stream carrying a dose of medicament powder is provided. The device includes a flow passage passing a powder-containing cavity. A part of said flow passage propagates along a generally flat surface region. The flat surface region includes a cavity opening into said powder-containing cavity. The passing of an air stream along said flat surface region and outside said cavity generates an eddy in the cavity and the generated eddy contributes to deaggregation of the powder in said cavity and emptying of the powder from said cavity. Furthermore, a shear driven cavity principle is used in conjunction with such a device and a method of releasing medicament powder.
摘要翻译： 提供了用于吸入至少一个携带一定剂量的药物粉末的气流的装置。 该装置包括通过含粉末的空腔的流动通道。 所述流动通道的一部分沿着大致平坦的表面区域传播。 平坦表面区域包括通向所述含粉末的腔体的空腔。 沿着所述平坦表面区域和所述空腔外部的空气流的通过在空腔中产生涡流，并且产生的涡流有助于粉末在所述空腔中的解聚和从所述空腔排空粉末。 此外，剪切驱动腔原理与这种装置和释放药物粉末的方法结合使用。
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公开(公告)号：US20110036348A1
公开(公告)日：2011-02-17
申请号：US12940683
申请日：2010-11-05
申请人： Orest Lastow , Johan Remmelgas
发明人： Orest Lastow , Johan Remmelgas
IPC分类号： A61M15/00
CPC分类号： A61M15/0065 , A61M15/0025 , A61M15/0045 , A61M15/0048 , A61M2202/064 , A61M2206/10
摘要： The present disclosure relates to a device for inhalation of at least one air stream carrying a dose of medicament powder. The device comprises a flow passage passing a powder-containing cavity. A part of said flow passage propagates along a generally flat surface region. The flat surface region comprises a cavity opening into said powder- containing cavity. The passing of an air stream along said flat surface region and outside said cavity generates an eddy in the cavity and the generated eddy contributes to deaggregation of the powder in said cavity and emptying of the powder from said cavity. Furthermore, the present disclosure relates to the use of a shear driven cavity principle on such a device and a method of releasing medicament powder.
摘要翻译： 本公开涉及用于吸入携带一定剂量的药物粉末的至少一种气流的装置。 该装置包括通过含粉末的腔的流动通道。 所述流动通道的一部分沿着大致平坦的表面区域传播。 平坦表面区域包括通向所述含粉末的空腔的空腔。 沿着所述平坦表面区域和所述空腔外部的空气流的通过在空腔中产生涡流，并且产生的涡流有助于粉末在所述空腔中的解聚和从所述空腔排空粉末。 此外，本公开涉及在这种装置上使用剪切驱动腔原理以及释放药物粉末的方法。
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公开(公告)号：US20120125330A1
公开(公告)日：2012-05-24
申请号：US13129393
申请日：2009-10-07
申请人： John Briant , Patrick Campbell , Charles Cooke , Christopher Groombridge , James Daniel John , Nicholas Smartt , William Bakewell , Nicholas Harrison , Orest Lastow
发明人： John Briant , Patrick Campbell , Charles Cooke , Christopher Groombridge , James Daniel John , Nicholas Smartt , William Bakewell , Nicholas Harrison , Orest Lastow
CPC分类号： A61M15/0091 , A61M15/0003 , A61M15/0026 , A61M15/0043 , A61M15/0045 , A61M15/0048 , A61M15/0093 , A61M15/0096 , A61M2202/064 , A61M2205/073
摘要： The present invention relates to an inhaler, comprising a base having at least one air-tight, foil-sealed cavity containing medicament. An actuator is engagable with a separating element attached to the foil, the actuator having an energized position in which it is biased towards an unloaded position so as to cause the separating element and attached foil to be moved away from the cavity. A latch has a first position, in which it latches the actuator in said energized position, wherein the latch is at least partly arranged in a flow path such that an inhalation flow through the flow path affects the latch to move from the first position to the second position. The invention also relates to a method of dispensing a medicament from a sealed cavity inside an inhaler.
摘要翻译： 吸入器技术领域本发明涉及一种吸入器，其包括具有至少一个包含药物的气密的箔密封空腔的底座。 致动器可接合附接到箔的分离元件，致动器具有通电位置，在该位置中，致动器被朝向卸载位置偏置，以使分离元件和附着的箔片远离腔体移动。 闩锁具有第一位置，其中致动器在所述通电位置中锁定，其中闩锁至少部分地布置在流动路径中，使得通过流动路径的吸入流动影响闩锁从第一位置移动到 第二名 本发明还涉及从吸入器内部的密封空腔分配药物的方法。
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