公开(公告)号：US20080274954A1

公开(公告)日：2008-11-06

申请号：US11578324

申请日：2005-04-14

申请人： Osamu Ohara ,  Takahiro Nagase ,  Michio Ohishi ,  Hiroshi Yokota ,  Osamu Kamida

发明人： Osamu Ohara ,  Takahiro Nagase ,  Michio Ohishi ,  Hiroshi Yokota ,  Osamu Kamida

IPC分类号： A61K38/00 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  C07K16/18 ,  A61P31/00 ,  C12P21/04 ,  G01N33/00 ,  C12Q1/68

CPC分类号： G01N33/57446 ,  A61K38/00 ,  C07K14/82 ,  C12Q1/44 ,  G01N33/57407 ,  G01N2500/00 ,  Y10T436/143333

摘要： A gene encoding a novel protein having a guanine nucleotide exchange factor (GEF) activity for a Rho family protein being one group of small GTP binding proteins, namely, a polynucleotide shown by the nucleotide sequence set forth in SEQ ID NO: 1, SEQ ID NO: 3, or SEQ ID NO: 5, or the complementary strand, the equivalents of the polynucleotide, a protein encoded by the polynucleotide, a vector containing the polynucleotide, a transformant containing the vector, an antibody against the protein encoded by the polynucleotide, a method of identifying a compound that inhibits the function of the protein encoded by the polynucleotide and/or the expression of the polynucleotide, a method of determining a disease, a pharmaceutical composition, and a reagent kit are provided.

摘要翻译： 编码具有Rho家族蛋白质的鸟嘌呤核苷酸交换因子（GEF）活性的新蛋白质的基因是一组小GTP结合蛋白，即由SEQ ID NO：1，SEQ ID NO：1所示的核苷酸序列所示的多核苷酸 SEQ ID NO：3或SEQ ID NO：5，或互补链，多核苷酸的等同物，由多核苷酸编码的蛋白质，含有多核苷酸的载体，含有该载体的转化体，由该多核苷酸编码的蛋白质的抗体 提供了鉴定抑制多核苷酸编码的蛋白质的功能和/或多核苷酸表达的化合物的方法，确定疾病的方法，药物组合物和试剂盒的方法。

公开(公告)号：US20080045608A1

公开(公告)日：2008-02-21

申请号：US11578326

申请日：2005-04-20

申请人： Osamu Ohara ,  Takahiro Nagase ,  Michio Ohishi ,  Hiroshi Yokota ,  Osamu Kamida

发明人： Osamu Ohara ,  Takahiro Nagase ,  Michio Ohishi ,  Hiroshi Yokota ,  Osamu Kamida

IPC分类号： A61K35/00 ,  A61P35/00 ,  C07H21/00 ,  C07K14/00 ,  C07K16/00 ,  C12N1/00 ,  C12N15/63 ,  C12N5/00 ,  C12P21/00 ,  C12Q1/68 ,  G01N33/68

CPC分类号： C07K14/82 ,  A61K38/00 ,  C12Q1/44 ,  G01N2500/00 ,  Y10T436/143333

摘要： A gene encoding a novel protein that binds to a Rho family protein being one group of small GTP binding proteins and is capable of exhibiting a GEF activity, namely, a polynucleotide shown by the nucleotide sequence set forth in SEQ ID NO: 1, or SEQ ID NO: 3, or the complementary strand, the equivalents of the polynucleotide, a protein encoded by the polynucleotide, a vector containing the polynucleotide, a transformant containing the vector, an antibody against the protein encoded by the polynucleotide, a method of identifying a compound that inhibits the function of the protein encoded by the polynucleotide and/or the expression of the polynucleotide, a method of determining a disease, a pharmaceutical composition, and a reagent kit are provided.

摘要翻译： 编码结合Rho家族蛋白的新蛋白质的基因是一组小GTP结合蛋白，并且能够显示GEF活性，即由SEQ ID NO：1所示的核苷酸序列显示的多核苷酸或SEQ ID NO： SEQ ID NO：3或互补链，多核苷酸的等同物，由多核苷酸编码的蛋白质，含有多核苷酸的载体，含有载体的转化体，针对由多核苷酸编码的蛋白质的抗体，鉴定 提供抑制多核苷酸编码的蛋白质的功能和/或多核苷酸的表达的化合物，确定疾病的方法，药物组合物和试剂盒。

公开(公告)号：US08173778B2

公开(公告)日：2012-05-08

申请号：US12651145

申请日：2009-12-31

申请人： Osamu Ohara ,  Takahiro Nagase ,  Michio Oishi ,  Hiroshi Yokota ,  Osamu Kamida

发明人： Osamu Ohara ,  Takahiro Nagase ,  Michio Oishi ,  Hiroshi Yokota ,  Osamu Kamida

IPC分类号： C07K16/00

CPC分类号： A61K31/7088 ,  C07K14/4702 ,  C07K14/82 ,  G01N33/57446 ,  G01N33/57484 ,  G01N2333/4703 ,  Y10S435/81 ,  Y10S435/975

摘要： A gene encoding a novel protein that works as a guanine nucleotide exchange factor (GEF) for a Rho family protein being one group of small GTP-binding proteins, namely, a polynucleotide shown by the nucleotide sequence set forth in SEQ ID NO: 1, SEQ ID NO: 3, or SEQ ID NO: 5, or the complementary strand, the equivalents of the polynucleotide, a protein encoded by the polynucleotide, a vector containing the polynucleotide, a transformant containing the vector, an antibody against the protein encoded by the polynucleotide, a method of identifying a compound that inhibits the function of the protein encoded by the polynucleotide and/or the expression of the polynucleotide, a method of determining a disease, a pharmaceutical composition, and a reagent kit are provided.

摘要翻译： 编码作为Rho家族蛋白质的鸟嘌呤核苷酸交换因子（GEF）的新型蛋白质的基因是一组小的GTP结合蛋白，即由SEQ ID NO：1所示的核苷酸序列显示的多核苷酸， SEQ ID NO：3或SEQ ID NO：5，或互补链，多核苷酸的等同物，由多核苷酸编码的蛋白质，含有多核苷酸的载体，含有该载体的转化体， 提供多核苷酸，鉴定抑制多核苷酸编码的蛋白质的功能的化合物的方法和/或多核苷酸的表达，确定疾病的方法，药物组合物和试剂盒的方法。

公开(公告)号：US20100125131A1

公开(公告)日：2010-05-20

申请号：US12651145

申请日：2009-12-31

申请人： Osamu Ohara ,  Takahiro Nagase ,  Michio Oishi ,  Hiroshi Yokota ,  Osamu Kamida

发明人： Osamu Ohara ,  Takahiro Nagase ,  Michio Oishi ,  Hiroshi Yokota ,  Osamu Kamida

IPC分类号： C07K16/00

CPC分类号： A61K31/7088 ,  C07K14/4702 ,  C07K14/82 ,  G01N33/57446 ,  G01N33/57484 ,  G01N2333/4703 ,  Y10S435/81 ,  Y10S435/975

摘要： A gene encoding a novel protein that works as a guanine nucleotide exchange factor (GEF) for a Rho family protein being one group of small GTP-binding proteins, namely, a polynucleotide shown by the nucleotide sequence set forth in SEQ ID NO: 1, SEQ ID NO: 3, or SEQ ID NO: 5, or the complementary strand, the equivalents of the polynucleotide, a protein encoded by the polynucleotide, a vector containing the polynucleotide, a transformant containing the vector, an antibody against the protein encoded by the polynucleotide, a method of identifying a compound that inhibits the function of the protein encoded by the polynucleotide and/or the expression of the polynucleotide, a method of determining a disease, a pharmaceutical composition, and a reagent kit are provided.

摘要翻译： 编码作为Rho家族蛋白质的鸟嘌呤核苷酸交换因子（GEF）的新型蛋白质的基因是一组小的GTP结合蛋白，即由SEQ ID NO：1所示的核苷酸序列显示的多核苷酸， SEQ ID NO：3或SEQ ID NO：5，或互补链，多核苷酸的等同物，由多核苷酸编码的蛋白质，含有多核苷酸的载体，含有该载体的转化体， 提供多核苷酸，鉴定抑制多核苷酸编码的蛋白质的功能的化合物的方法和/或多核苷酸的表达，确定疾病的方法，药物组合物和试剂盒的方法。

公开(公告)号：US20070196377A1

公开(公告)日：2007-08-23

申请号：US10594707

申请日：2005-03-29

申请人： Osamu Ohara ,  Takahiro Nagase ,  Michi Oishi ,  Hiroshi Yokota ,  Osamu Kamida

发明人： Osamu Ohara ,  Takahiro Nagase ,  Michi Oishi ,  Hiroshi Yokota ,  Osamu Kamida

IPC分类号： A61K48/00 ,  C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C07K16/40 ,  A61K39/395 ,  C12P21/06 ,  C12N9/10

CPC分类号： A61K31/7088 ,  C07K14/4702 ,  C07K14/82 ,  G01N33/57446 ,  G01N33/57484 ,  G01N2333/4703 ,  Y10S435/81 ,  Y10S435/975

摘要： A gene encoding a novel protein that works as a guanine nucleotide exchange factor (GEF) for a Rho family protein being one group of small GTP-binding proteins, namely, a polynucleotide shown by the nucleotide sequence set forth in SEQ ID NO: 1, SEQ ID NO: 3, or SEQ ID NO: 5, or the complementary strand, the equivalents of the polynucleotide, a protein encoded by the polynucleotide, a vector containing the polynucleotide, a transformant containing the vector, an antibody against the protein encoded by the polynucleotide, a method of identifying a compound that inhibits the function of the protein encoded by the polynucleotide and/or the expression of the polynucleotide, a method of determining a disease, a pharmaceutical composition, and a reagent kit are provided.

摘要翻译： 编码作为Rho家族蛋白质的鸟嘌呤核苷酸交换因子（GEF）的新型蛋白质的基因是一组小的GTP结合蛋白，即由SEQ ID NO：1所示的核苷酸序列显示的多核苷酸， SEQ ID NO：3或SEQ ID NO：5，或互补链，多核苷酸的等同物，由多核苷酸编码的蛋白质，含有多核苷酸的载体，含有该载体的转化体， 提供多核苷酸，鉴定抑制多核苷酸编码的蛋白质的功能的化合物的方法和/或多核苷酸的表达，确定疾病的方法，药物组合物和试剂盒的方法。

公开(公告)号：US07667013B2

公开(公告)日：2010-02-23

申请号：US10594707

申请日：2005-03-29

申请人： Osamu Ohara ,  Takahiro Nagase ,  Michio Oishi ,  Hiroshi Yokota ,  Osamu Kamida

发明人： Osamu Ohara ,  Takahiro Nagase ,  Michio Oishi ,  Hiroshi Yokota ,  Osamu Kamida

IPC分类号： C12N15/11

CPC分类号： A61K31/7088 ,  C07K14/4702 ,  C07K14/82 ,  G01N33/57446 ,  G01N33/57484 ,  G01N2333/4703 ,  Y10S435/81 ,  Y10S435/975

摘要： A gene encoding a novel protein that works as a guanine nucleotide exchange factor (GEF) for a Rho family protein being one group of small GTP-binding proteins, namely, a polynucleotide shown by the nucleotide sequence set forth in SEQ ID NO: 1, SEQ ID NO: 3, or SEQ ID NO: 5, or the complementary strand, the equivalents of the polynucleotide, a protein encoded by the polynucleotide, a vector containing the polynucleotide, a transformant containing the vector, an antibody against the protein encoded by the polynucleotide, a method of identifying a compound that inhibits the function of the protein encoded by the polynucleotide and/or the expression of the polynucleotide, a method of determining a disease, a pharmaceutical composition, and a reagent kit are provided.

摘要翻译： 编码作为Rho家族蛋白质的鸟嘌呤核苷酸交换因子（GEF）的新型蛋白质的基因是一组小的GTP结合蛋白，即由SEQ ID NO：1所示的核苷酸序列显示的多核苷酸， SEQ ID NO：3或SEQ ID NO：5，或互补链，多核苷酸的等同物，由多核苷酸编码的蛋白质，含有多核苷酸的载体，含有该载体的转化体， 提供多核苷酸，鉴定抑制由多核苷酸编码的蛋白质的功能和/或多核苷酸表达的化合物的方法，确定疾病的方法，药物组合物和试剂盒。