公开(公告)号：US20070196377A1

公开(公告)日：2007-08-23

申请号：US10594707

申请日：2005-03-29

申请人： Osamu Ohara ,  Takahiro Nagase ,  Michi Oishi ,  Hiroshi Yokota ,  Osamu Kamida

发明人： Osamu Ohara ,  Takahiro Nagase ,  Michi Oishi ,  Hiroshi Yokota ,  Osamu Kamida

IPC分类号： A61K48/00 ,  C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C07K16/40 ,  A61K39/395 ,  C12P21/06 ,  C12N9/10

CPC分类号： A61K31/7088 ,  C07K14/4702 ,  C07K14/82 ,  G01N33/57446 ,  G01N33/57484 ,  G01N2333/4703 ,  Y10S435/81 ,  Y10S435/975

摘要： A gene encoding a novel protein that works as a guanine nucleotide exchange factor (GEF) for a Rho family protein being one group of small GTP-binding proteins, namely, a polynucleotide shown by the nucleotide sequence set forth in SEQ ID NO: 1, SEQ ID NO: 3, or SEQ ID NO: 5, or the complementary strand, the equivalents of the polynucleotide, a protein encoded by the polynucleotide, a vector containing the polynucleotide, a transformant containing the vector, an antibody against the protein encoded by the polynucleotide, a method of identifying a compound that inhibits the function of the protein encoded by the polynucleotide and/or the expression of the polynucleotide, a method of determining a disease, a pharmaceutical composition, and a reagent kit are provided.

摘要翻译： 编码作为Rho家族蛋白质的鸟嘌呤核苷酸交换因子（GEF）的新型蛋白质的基因是一组小的GTP结合蛋白，即由SEQ ID NO：1所示的核苷酸序列显示的多核苷酸， SEQ ID NO：3或SEQ ID NO：5，或互补链，多核苷酸的等同物，由多核苷酸编码的蛋白质，含有多核苷酸的载体，含有该载体的转化体， 提供多核苷酸，鉴定抑制多核苷酸编码的蛋白质的功能的化合物的方法和/或多核苷酸的表达，确定疾病的方法，药物组合物和试剂盒的方法。

公开(公告)号：US08173778B2

公开(公告)日：2012-05-08

申请号：US12651145

申请日：2009-12-31

申请人： Osamu Ohara ,  Takahiro Nagase ,  Michio Oishi ,  Hiroshi Yokota ,  Osamu Kamida

发明人： Osamu Ohara ,  Takahiro Nagase ,  Michio Oishi ,  Hiroshi Yokota ,  Osamu Kamida

IPC分类号： C07K16/00

CPC分类号： A61K31/7088 ,  C07K14/4702 ,  C07K14/82 ,  G01N33/57446 ,  G01N33/57484 ,  G01N2333/4703 ,  Y10S435/81 ,  Y10S435/975

摘要： A gene encoding a novel protein that works as a guanine nucleotide exchange factor (GEF) for a Rho family protein being one group of small GTP-binding proteins, namely, a polynucleotide shown by the nucleotide sequence set forth in SEQ ID NO: 1, SEQ ID NO: 3, or SEQ ID NO: 5, or the complementary strand, the equivalents of the polynucleotide, a protein encoded by the polynucleotide, a vector containing the polynucleotide, a transformant containing the vector, an antibody against the protein encoded by the polynucleotide, a method of identifying a compound that inhibits the function of the protein encoded by the polynucleotide and/or the expression of the polynucleotide, a method of determining a disease, a pharmaceutical composition, and a reagent kit are provided.

摘要翻译： 编码作为Rho家族蛋白质的鸟嘌呤核苷酸交换因子（GEF）的新型蛋白质的基因是一组小的GTP结合蛋白，即由SEQ ID NO：1所示的核苷酸序列显示的多核苷酸， SEQ ID NO：3或SEQ ID NO：5，或互补链，多核苷酸的等同物，由多核苷酸编码的蛋白质，含有多核苷酸的载体，含有该载体的转化体， 提供多核苷酸，鉴定抑制多核苷酸编码的蛋白质的功能的化合物的方法和/或多核苷酸的表达，确定疾病的方法，药物组合物和试剂盒的方法。

公开(公告)号：US20100125131A1

公开(公告)日：2010-05-20

申请号：US12651145

申请日：2009-12-31

申请人： Osamu Ohara ,  Takahiro Nagase ,  Michio Oishi ,  Hiroshi Yokota ,  Osamu Kamida

发明人： Osamu Ohara ,  Takahiro Nagase ,  Michio Oishi ,  Hiroshi Yokota ,  Osamu Kamida

IPC分类号： C07K16/00

CPC分类号： A61K31/7088 ,  C07K14/4702 ,  C07K14/82 ,  G01N33/57446 ,  G01N33/57484 ,  G01N2333/4703 ,  Y10S435/81 ,  Y10S435/975

摘要： A gene encoding a novel protein that works as a guanine nucleotide exchange factor (GEF) for a Rho family protein being one group of small GTP-binding proteins, namely, a polynucleotide shown by the nucleotide sequence set forth in SEQ ID NO: 1, SEQ ID NO: 3, or SEQ ID NO: 5, or the complementary strand, the equivalents of the polynucleotide, a protein encoded by the polynucleotide, a vector containing the polynucleotide, a transformant containing the vector, an antibody against the protein encoded by the polynucleotide, a method of identifying a compound that inhibits the function of the protein encoded by the polynucleotide and/or the expression of the polynucleotide, a method of determining a disease, a pharmaceutical composition, and a reagent kit are provided.

摘要翻译： 编码作为Rho家族蛋白质的鸟嘌呤核苷酸交换因子（GEF）的新型蛋白质的基因是一组小的GTP结合蛋白，即由SEQ ID NO：1所示的核苷酸序列显示的多核苷酸， SEQ ID NO：3或SEQ ID NO：5，或互补链，多核苷酸的等同物，由多核苷酸编码的蛋白质，含有多核苷酸的载体，含有该载体的转化体， 提供多核苷酸，鉴定抑制多核苷酸编码的蛋白质的功能的化合物的方法和/或多核苷酸的表达，确定疾病的方法，药物组合物和试剂盒的方法。

公开(公告)号：US07667013B2

公开(公告)日：2010-02-23

申请号：US10594707

申请日：2005-03-29

申请人： Osamu Ohara ,  Takahiro Nagase ,  Michio Oishi ,  Hiroshi Yokota ,  Osamu Kamida

发明人： Osamu Ohara ,  Takahiro Nagase ,  Michio Oishi ,  Hiroshi Yokota ,  Osamu Kamida

IPC分类号： C12N15/11

CPC分类号： A61K31/7088 ,  C07K14/4702 ,  C07K14/82 ,  G01N33/57446 ,  G01N33/57484 ,  G01N2333/4703 ,  Y10S435/81 ,  Y10S435/975

摘要： A gene encoding a novel protein that works as a guanine nucleotide exchange factor (GEF) for a Rho family protein being one group of small GTP-binding proteins, namely, a polynucleotide shown by the nucleotide sequence set forth in SEQ ID NO: 1, SEQ ID NO: 3, or SEQ ID NO: 5, or the complementary strand, the equivalents of the polynucleotide, a protein encoded by the polynucleotide, a vector containing the polynucleotide, a transformant containing the vector, an antibody against the protein encoded by the polynucleotide, a method of identifying a compound that inhibits the function of the protein encoded by the polynucleotide and/or the expression of the polynucleotide, a method of determining a disease, a pharmaceutical composition, and a reagent kit are provided.

摘要翻译： 编码作为Rho家族蛋白质的鸟嘌呤核苷酸交换因子（GEF）的新型蛋白质的基因是一组小的GTP结合蛋白，即由SEQ ID NO：1所示的核苷酸序列显示的多核苷酸， SEQ ID NO：3或SEQ ID NO：5，或互补链，多核苷酸的等同物，由多核苷酸编码的蛋白质，含有多核苷酸的载体，含有该载体的转化体， 提供多核苷酸，鉴定抑制由多核苷酸编码的蛋白质的功能和/或多核苷酸表达的化合物的方法，确定疾病的方法，药物组合物和试剂盒。

公开(公告)号：US20080045608A1

公开(公告)日：2008-02-21

申请号：US11578326

申请日：2005-04-20

申请人： Osamu Ohara ,  Takahiro Nagase ,  Michio Ohishi ,  Hiroshi Yokota ,  Osamu Kamida

发明人： Osamu Ohara ,  Takahiro Nagase ,  Michio Ohishi ,  Hiroshi Yokota ,  Osamu Kamida

IPC分类号： A61K35/00 ,  A61P35/00 ,  C07H21/00 ,  C07K14/00 ,  C07K16/00 ,  C12N1/00 ,  C12N15/63 ,  C12N5/00 ,  C12P21/00 ,  C12Q1/68 ,  G01N33/68

CPC分类号： C07K14/82 ,  A61K38/00 ,  C12Q1/44 ,  G01N2500/00 ,  Y10T436/143333

摘要： A gene encoding a novel protein that binds to a Rho family protein being one group of small GTP binding proteins and is capable of exhibiting a GEF activity, namely, a polynucleotide shown by the nucleotide sequence set forth in SEQ ID NO: 1, or SEQ ID NO: 3, or the complementary strand, the equivalents of the polynucleotide, a protein encoded by the polynucleotide, a vector containing the polynucleotide, a transformant containing the vector, an antibody against the protein encoded by the polynucleotide, a method of identifying a compound that inhibits the function of the protein encoded by the polynucleotide and/or the expression of the polynucleotide, a method of determining a disease, a pharmaceutical composition, and a reagent kit are provided.

摘要翻译： 编码结合Rho家族蛋白的新蛋白质的基因是一组小GTP结合蛋白，并且能够显示GEF活性，即由SEQ ID NO：1所示的核苷酸序列显示的多核苷酸或SEQ ID NO： SEQ ID NO：3或互补链，多核苷酸的等同物，由多核苷酸编码的蛋白质，含有多核苷酸的载体，含有载体的转化体，针对由多核苷酸编码的蛋白质的抗体，鉴定 提供抑制多核苷酸编码的蛋白质的功能和/或多核苷酸的表达的化合物，确定疾病的方法，药物组合物和试剂盒。

公开(公告)号：US20080274954A1

公开(公告)日：2008-11-06

申请号：US11578324

申请日：2005-04-14

申请人： Osamu Ohara ,  Takahiro Nagase ,  Michio Ohishi ,  Hiroshi Yokota ,  Osamu Kamida

发明人： Osamu Ohara ,  Takahiro Nagase ,  Michio Ohishi ,  Hiroshi Yokota ,  Osamu Kamida

IPC分类号： A61K38/00 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  C07K16/18 ,  A61P31/00 ,  C12P21/04 ,  G01N33/00 ,  C12Q1/68

CPC分类号： G01N33/57446 ,  A61K38/00 ,  C07K14/82 ,  C12Q1/44 ,  G01N33/57407 ,  G01N2500/00 ,  Y10T436/143333

摘要： A gene encoding a novel protein having a guanine nucleotide exchange factor (GEF) activity for a Rho family protein being one group of small GTP binding proteins, namely, a polynucleotide shown by the nucleotide sequence set forth in SEQ ID NO: 1, SEQ ID NO: 3, or SEQ ID NO: 5, or the complementary strand, the equivalents of the polynucleotide, a protein encoded by the polynucleotide, a vector containing the polynucleotide, a transformant containing the vector, an antibody against the protein encoded by the polynucleotide, a method of identifying a compound that inhibits the function of the protein encoded by the polynucleotide and/or the expression of the polynucleotide, a method of determining a disease, a pharmaceutical composition, and a reagent kit are provided.

摘要翻译： 编码具有Rho家族蛋白质的鸟嘌呤核苷酸交换因子（GEF）活性的新蛋白质的基因是一组小GTP结合蛋白，即由SEQ ID NO：1，SEQ ID NO：1所示的核苷酸序列所示的多核苷酸 SEQ ID NO：3或SEQ ID NO：5，或互补链，多核苷酸的等同物，由多核苷酸编码的蛋白质，含有多核苷酸的载体，含有该载体的转化体，由该多核苷酸编码的蛋白质的抗体 提供了鉴定抑制多核苷酸编码的蛋白质的功能和/或多核苷酸表达的化合物的方法，确定疾病的方法，药物组合物和试剂盒的方法。

公开(公告)号：US20110223175A1

公开(公告)日：2011-09-15

申请号：US13113157

申请日：2011-05-23

申请人： Osamu Ohara ,  Takahiro Nagase ,  Michio Ohishi ,  Daisuke Okajima ,  Hiroshi Yokota

发明人： Osamu Ohara ,  Takahiro Nagase ,  Michio Ohishi ,  Daisuke Okajima ,  Hiroshi Yokota

IPC分类号： A61K39/395 ,  C07K16/00 ,  A61P25/28 ,  A61P25/24

CPC分类号： G01N33/74 ,  G01N2333/726

摘要： The present invention, the objects of which are to find out a gene encoding a protein having functions equivalent to those of G-protein-coupled receptor (GPCR) and the protein, and to provide a method for identifying a compound that regulates functions and/or expression of the protein, and to provide a useful mean for preventing and/or treating diseases related to the gene and the protein, provides a DNA comprising base sequence described in SEQ ID NO: 1 or complementary strand thereof, complementary strand of the DNA, a protein encoded by the DNA, a vector containing the DNA, a transformant containing the vector, an antibody against the protein, a method for identifying a compound that regulates functions and/or expression of the protein using aforementioned members, an agent for improving and a method for improving depression state, a pharmaceutical composition, and a reagent kit.

摘要翻译： 本发明的目的是找出编码具有与G蛋白偶联受体（GPCR）和蛋白质相同功能的蛋白质的基因，并提供一种鉴定调节功能的化合物和/ 或蛋白质的表达，并且为预防和/或治疗与该基因和蛋白质相关的疾病提供有用的平均值，提供包含SEQ ID NO：1或其互补链中所述的碱基序列的DNA，DNA的互补链 ，由DNA编码的蛋白质，含有该载体的载体，含有该载体的转化子，针对该蛋白质的抗体，使用上述成员鉴定调节蛋白质的功能和/或表达的化合物的方法，改善剂 以及改善抑郁状态的方法，药物组合物和试剂盒。

公开(公告)号：US20060234305A1

公开(公告)日：2006-10-19

申请号：US11436904

申请日：2006-05-18

申请人： Osamu Ohara ,  Takahiro Nagase ,  Michio Ohishi ,  Daisuke Okajima ,  Hiroshi Yokota

发明人： Osamu Ohara ,  Takahiro Nagase ,  Michio Ohishi ,  Daisuke Okajima ,  Hiroshi Yokota

IPC分类号： G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705

CPC分类号： G01N33/74 ,  G01N2333/726

摘要： The present invention, the objects of which are to find out a gene encoding a protein having functions equivalent to those of G-protein-coupled receptor (GPCR) and the protein, and to provide a method for identifying a compound that regulates functions and/or expression of the protein, and to provide a useful mean for preventing and/or treating diseases related to the gene and the protein, provides a DNA comprising base sequence described in SEQ ID NO: 1 or complementary strand thereof, complementary strand of the DNA, a protein encoded by the DNA, a vector containing the DNA, a transformant containing the vector, an antibody against the protein, a method for identifying a compound that regulates functions and/or expression of the protein using aforementioned members, an agent for improving and a method for improving depression state, a pharmaceutical composition, and a reagent kit.

摘要翻译： 本发明的目的是找出编码具有与G蛋白偶联受体（GPCR）和蛋白质相同功能的蛋白质的基因，并提供一种鉴定调节功能的化合物和/ 或蛋白质的表达，并且为预防和/或治疗与该基因和蛋白质相关的疾病提供有用的平均值，提供包含SEQ ID NO：1或其互补链中所述的碱基序列的DNA，DNA的互补链 ，由DNA编码的蛋白质，含有该载体的载体，含有该载体的转化子，针对该蛋白质的抗体，使用上述成员鉴定调节蛋白质的功能和/或表达的化合物的方法，改善剂 以及改善抑郁状态的方法，药物组合物和试剂盒。

公开(公告)号：US20060252677A1

公开(公告)日：2006-11-09

申请号：US10496224

申请日：2002-11-20

申请人： Osamu Ohara ,  Takahiro Nagase ,  Michio Ohishi ,  Hiroshi Yokota ,  Yasuko Arai

发明人： Osamu Ohara ,  Takahiro Nagase ,  Michio Ohishi ,  Hiroshi Yokota ,  Yasuko Arai

IPC分类号： A61K38/17 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705

CPC分类号： C07K14/47 ,  A61K38/1709 ,  G01N33/6896

摘要： A protein A that binds to the N-methyl-D-aspartate (NMDA) receptor and a protein B that interacts with protein A are provided. Furthermore, based on the marked promotion of the NMDA receptor mediated signal transduction by these proteins, providing a controlling agent (an inhibiting agent or a promoting agent) and a controlling method for the expression and/or the function of these proteins makes possible the elucidation of diseases caused by an anomaly in the NMDA receptor mediated signal transduction or in memory recall, including such neurodegenerative diseases as Alzheimer's disease, Parkinson's disease and polyglutamine disease, and allows for the prevention, improvement or treatment thereof.

摘要翻译： 提供了与N-甲基-D-天冬氨酸（NMDA）受体结合的蛋白A和与蛋白A相互作用的蛋白B. 此外，基于NMDA受体介导的这些蛋白质的信号转导的显着促进，提供控制剂（抑制剂或促进剂）以及这些蛋白质的表达和/或功能的控制方法使得阐明 由NMDA受体介导的信号转导异常或记忆回忆引起的疾病，包括阿尔茨海默病，帕金森病和聚谷氨酸病等神经变性疾病，并且可以预防，改善或治疗。

公开(公告)号：US07977069B2

公开(公告)日：2011-07-12

申请号：US12409847

申请日：2009-03-24

申请人： Osamu Ohara ,  Takahiro Nagase ,  Michio Ohishi ,  Daisuke Okajima ,  Hiroshi Yokota

发明人： Osamu Ohara ,  Takahiro Nagase ,  Michio Ohishi ,  Daisuke Okajima ,  Hiroshi Yokota

IPC分类号： C12N15/12 ,  C07K14/00

CPC分类号： G01N33/74 ,  G01N2333/726

摘要： DNA encoding a cholecystokinin octapeptide sulfated form (CCK-8S) G-protein coupled receptor, a complementary strand thereof, a vector containing the DNA, a transformant containing the vector, a pharmaceutical composition, and a reagent kit are provided. Such DNA and constructs are useful in identifying a compound that inhibits or promotes a function of the protein and/or expression of a DNA encoding the protein. Such DNA and constructs are also useful for identifying an anti-depressant drug or a compound that has an anti-depressant action.

摘要翻译： 提供编码缩胆囊素八肽硫酸盐形式的DNA（CCK-8S）G蛋白偶联受体，其互补链，含有载体的载体，含有载体的转化体，药物组合物和试剂盒。 这样的DNA和构建体可用于鉴定抑制或促进蛋白质的功能和/或表达编码该蛋白质的DNA的化合物。 这样的DNA和构建体也可用于鉴定抗抑郁药或具有抗抑郁作用的化合物。