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1.发明申请Nucleic acid encoding a cobalamin-dependent methionine synthase polypeptide 审中-公开编码钴胺素依赖性甲硫氨酸合成酶多肽的核酸公开(公告)号：US20120295315A1
公开(公告)日：2012-11-22
申请号：US13524184
申请日：2012-06-15
申请人： Oskar Zelder , Wolfgang Grabarse , Corinna Klopprogge , Hartwig Schröder , Stefan Haefner , Anja Knietsch , Andrea Herold
发明人： Oskar Zelder , Wolfgang Grabarse , Corinna Klopprogge , Hartwig Schröder , Stefan Haefner , Anja Knietsch , Andrea Herold
CPC分类号： C12N9/0091 , C12P13/12
摘要： The present invention relates to nulceotide sequences encoding enzymatically active cobalamin-methionine synthase and functional fragments thereof being modified in comparison to the respective wild-type enzyme such that said enzymes show reduced product inhibition by methionine. The present invention also relates to polypeptides being encoded by such nucleotide sequences and host cells comprising such nucleotide sequences. Furthermore, the present invention relates to methods for producing methionine in host organisms by making use of such nucleotide sequences.
摘要翻译： 本发明涉及编码酶促活性钴胺素 - 甲硫氨酸合成酶的核糖核酸序列及其功能片段，其与相应的野生型酶相比被修饰，使得所述酶显示产品抑制蛋氨酸的产物减少。 本发明还涉及由该核苷酸序列编码的多肽和包含该核苷酸序列的宿主细胞。 此外，本发明涉及通过利用这种核苷酸序列在宿主生物体中产生甲硫氨酸的方法。
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2.发明授权公开(公告)号：US08252555B2
公开(公告)日：2012-08-28
申请号：US12521141
申请日：2007-12-21
申请人： Oskar Zelder , Wolfgang Grabarse , Corinna Klopprogge , Hartwig Schröder , Stefan Haefner , Anja Knietsch , Andrea Herold
发明人： Oskar Zelder , Wolfgang Grabarse , Corinna Klopprogge , Hartwig Schröder , Stefan Haefner , Anja Knietsch , Andrea Herold
IPC分类号： C12P21/06
CPC分类号： C12N9/0091 , C12P13/12
摘要： The present invention relates to nucleotide sequences encoding enzymatically active cobalamin-methionine synthase and functional fragments thereof that are modified in comparison to the respective wild-type enzyme such that said enzymes show reduced product inhibition by methionine. The present invention also relates to polypeptides being encoded by such nucleotide sequences and host cells comprising such nucleotide sequences. Furthermore, the present invention relates to methods for producing methionine in host organisms by making use of such nucleotide sequences.
摘要翻译： 本发明涉及编码酶促活性钴胺素 - 甲硫氨酸合成酶的核苷酸序列及其功能片段，其与相应的野生型酶相比被修饰，使得所述酶显示产品对甲硫氨酸的抑制作用降低。 本发明还涉及由该核苷酸序列编码的多肽和包含该核苷酸序列的宿主细胞。 此外，本发明涉及通过利用这种核苷酸序列在宿主生物体中产生甲硫氨酸的方法。
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公开(公告)号：US20100035307A1
公开(公告)日：2010-02-11
申请号：US12521141
申请日：2007-12-21
申请人： Oskar Zelder , Wolfgang Grabarse , Corinna Klopprogge , Hartwig Schröder , Stefan Haefner , Anja Knietsch , Andrea Herold
发明人： Oskar Zelder , Wolfgang Grabarse , Corinna Klopprogge , Hartwig Schröder , Stefan Haefner , Anja Knietsch , Andrea Herold
CPC分类号： C12N9/0091 , C12P13/12
摘要： The present invention relates to nulceotide sequences encoding enzymatically active cobalamin-methionine synthase and functional fragments thereof being modified in comparison to the respective wild-type enzyme such that said enzymes show reduced product inhibition by methionine. The present invention also relates to polypeptides being encoded by such nucleotide sequences and host cells comprising such nucleotide sequences. Furthermore, the present invention relates to methods for producing methionine in host organisms by making use of such nucleotide sequences.
摘要翻译： 本发明涉及编码酶促活性钴胺素 - 甲硫氨酸合成酶的核苷酸序列及其功能片段，其与相应的野生型酶相比被修饰，使得所述酶显示产品抑制蛋氨酸的产物减少。 本发明还涉及由该核苷酸序列编码的多肽和包含该核苷酸序列的宿主细胞。 此外，本发明涉及通过利用这种核苷酸序列在宿主生物体中产生甲硫氨酸的方法。
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4.发明申请Coryneform Bacteria with Formate-THF-Synthetase and/or Glycine Cleavage Activity 审中-公开具有甲酸-THF合成酶和/或甘氨酸裂解活性的棒状杆菌细菌公开(公告)号：US20100003727A1
公开(公告)日：2010-01-07
申请号：US12519909
申请日：2008-02-14
申请人： Oskar Zelder , Hartwig Schröder , Corinna Klopprogge , Andrea Herold , Stefan Haefner , Thomas A. Patterson , R. Rogers Yocum , Janice G. Pero
发明人： Oskar Zelder , Hartwig Schröder , Corinna Klopprogge , Andrea Herold , Stefan Haefner , Thomas A. Patterson , R. Rogers Yocum , Janice G. Pero
摘要： The present invention relates to microorganisms, in particular C. glutamicum in which the formation of N5,N10-methylene-THF is increased.The present invention also relates to the use of such microorganisms for producing methionine.
摘要翻译： 本发明涉及增加N5，N10-亚甲基-THF的形成的微生物，特别是谷氨酸棒杆菌。 本发明还涉及这种微生物用于产生甲硫氨酸的用途。
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5.发明授权Microorganisms with a reactivation system for cob(I)alamin-dependent methionine synthase 失效具有cob（I）氨基酸依赖性甲硫氨酸合酶活化系统的微生物公开(公告)号：US08163532B2
公开(公告)日：2012-04-24
申请号：US12472432
申请日：2009-05-27
申请人： Oskar Zelder , Hartwig Schröder , Corinna Klopprogge , Andrea Herold , Stefan Haefner , R. Rogers Yocum , Thomas A. Patterson , Mark Williams
发明人： Oskar Zelder , Hartwig Schröder , Corinna Klopprogge , Andrea Herold , Stefan Haefner , R. Rogers Yocum , Thomas A. Patterson , Mark Williams
CPC分类号： C12P13/12 , C12N9/1007
摘要： The present invention relates to microorganisms and methods for producing methionine by reactivation of the MetH enzyme.
摘要翻译： 本发明涉及通过MetH酶的再活化来生产甲硫氨酸的微生物和方法。
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6.发明申请Production Process for Fine Chemicals Using Microorganisms with Reduced Isocitrate Dehydrogenase Activity 审中-公开使用具有降低的异柠檬酸脱氢酶活性的微生物的精细化学品的生产方法公开(公告)号：US20110207183A1
公开(公告)日：2011-08-25
申请号：US12990240
申请日：2009-04-28
申请人： Andrea Herold , Hartwig Schröder , Weol Kyu Jeong , Corinna Klopprogge , Oskar Zelder , Stefan Haefner , Ulrike Richter , Judith Becker , Christoph Wittmann
发明人： Andrea Herold , Hartwig Schröder , Weol Kyu Jeong , Corinna Klopprogge , Oskar Zelder , Stefan Haefner , Ulrike Richter , Judith Becker , Christoph Wittmann
IPC分类号： C12P13/20 , C12P1/00 , C12P1/04 , C12P13/04 , C12P13/00 , C12P13/08 , C12N1/00 , C12N1/21 , C12P13/02 , C12P17/12 , C12P17/10 , C12P13/12 , C12P7/40
CPC分类号： C12P13/001 , C12N9/0006 , C12P13/04 , C12P13/08 , C12P17/12 , C12Y101/01041
摘要： The present invention is directed to a method utilizing a microorganism with reduced isocitrate dehydrogenase activity for the production of fine chemicals. Said fine chemicals may be amino acids, monomers for polymer synthesis, sugars, lipids, oils, fatty acids or vitamins and are preferably amino acids of the aspartate family, especially methionine or lysine, or derivatives of said amino acids, especially cadaverine. Furthermore, the present invention relates to a recombinant microorganism having a reduced isocitrate dehydrogenase activity in comparison to the initial microorganism and the use of such microorganisms in producing fine chemicals such as aspartate family amino acids and their derivatives.
摘要翻译： 本发明涉及利用具有降低的异柠檬酸脱氢酶活性的微生物来生产精细化学品的方法。 所述精细化学品可以是氨基酸，用于聚合物合成的单体，糖，脂质，油，脂肪酸或维生素，并且优选天冬氨酸家族的氨基酸，特别是甲硫氨酸或赖氨酸，或所述氨基酸的衍生物，特别是尸胺。 此外，本发明涉及与初始微生物相比具有降低的异柠檬酸脱氢酶活性的重组微生物，以及这些微生物在生产精细化学品如天冬氨酸家族氨基酸及其衍生物中的用途。
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公开(公告)号：US08148117B2
公开(公告)日：2012-04-03
申请号：US12091948
申请日：2006-10-23
申请人： Oskar Zelder , Andrea Herold , Corinna Klopprogge , Hartwig Schröder , Stefan Haefner , Elmar Heinzle , Christoph Wittmann , Jens Kroemer , Janice G. Pero , R. Rogers Yocum , Thomas A. Patterson , Mark Williams , Theron Herman
发明人： Oskar Zelder , Andrea Herold , Corinna Klopprogge , Hartwig Schröder , Stefan Haefner , Elmar Heinzle , Christoph Wittmann , Jens Kroemer , Janice G. Pero , R. Rogers Yocum , Thomas A. Patterson , Mark Williams , Theron Herman
CPC分类号： C12P13/12 , A23K10/16 , A23K20/142 , A23K40/10 , C12N15/52
摘要： The present invention relates to microorganisms and processes for the efficient preparation of L-amino acids such as L-methionine. In particular, the present invention relates to microorganisms and processes in which the formation and/or accumulation of homolanthionine in the methionine pathway is reduced and/or prevented.
摘要翻译： 本发明涉及用于有效制备L-氨基酸如L-甲硫氨酸的微生物和方法。 特别地，本发明涉及微生物和其中甲硫氨酸途径中高山ion素的形成和/或积累减少和/或预防的方法。
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公开(公告)号：US20100047881A1
公开(公告)日：2010-02-25
申请号：US12518531
申请日：2008-06-09
申请人： Oskar Zelder , Hartwig Schröder , Corinna Klopprogge , Andrea Herold , Stefan Haefner , Thomas A. Patterson
发明人： Oskar Zelder , Hartwig Schröder , Corinna Klopprogge , Andrea Herold , Stefan Haefner , Thomas A. Patterson
摘要： The present invention relates to microorganisms with improved efficiency of vitamin B12 utilization.
摘要翻译： 本发明涉及具有提高维生素B12利用效率的微生物。
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9.发明申请Microorganisms with a Reactivation System for cob(I)Alamin-Dependent Methionine Synthase 失效具有重组酶活性的微生物（I）Alamin依赖性甲硫氨酸合成酶公开(公告)号：US20090311756A1
公开(公告)日：2009-12-17
申请号：US12472432
申请日：2009-05-27
申请人： Oskar Zelder , Hartwig Schröder , Corinna Klopprogge , Andrea Herold , Stefan Haefner , R. Rogers Yocum , Thomas A. Patterson , Mark Williams
发明人： Oskar Zelder , Hartwig Schröder , Corinna Klopprogge , Andrea Herold , Stefan Haefner , R. Rogers Yocum , Thomas A. Patterson , Mark Williams
CPC分类号： C12P13/12 , C12N9/1007
摘要： The present invention relates to microorganisms and methods for producing methionine by reactivation of the MetH enzyme.
摘要翻译： 本发明涉及通过MetH酶的再活化来生产甲硫氨酸的微生物和方法。
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公开(公告)号：US20100009416A1
公开(公告)日：2010-01-14
申请号：US12301279
申请日：2007-05-24
申请人： Oskar Zelder , Andrea Herold , Corinna Klopprogge , Hartwig Schröder , Elmar Heinzle , Christoph Wittmann , Jens Kroemer , Janice Pero , Rogers Yocum , Thomas Patterson , Mark Williams , Theron Hermann
发明人： Oskar Zelder , Andrea Herold , Corinna Klopprogge , Hartwig Schröder , Elmar Heinzle , Christoph Wittmann , Jens Kroemer , Janice Pero , Rogers Yocum , Thomas Patterson , Mark Williams , Theron Hermann
CPC分类号： C12P13/12
摘要： The present invention relates to microorganisms and processes for the efficient preparation of L-methionine. In particular, the present invention relates to processes in which the amount of serine available for the metabolism of the microorganism is increased.
摘要翻译： 本发明涉及用于L-甲硫氨酸有效制备的微生物和方法。 特别地，本发明涉及其中可用于微生物代谢的丝氨酸量增加的方法。
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