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公开(公告)号：US07786287B2
公开(公告)日：2010-08-31
申请号：US10510912
申请日：2003-04-11
申请人： Osvaldo A. Flores , Jay Grobler , Edward M. Murray , Paul D. Zuck
发明人： Osvaldo A. Flores , Jay Grobler , Edward M. Murray , Paul D. Zuck
CPC分类号： G01N33/502 , C07K14/005 , C12N15/86 , C12N2730/10122 , C12N2840/203 , C12Q1/34 , C12Q1/6897 , C12Q1/707 , G01N33/5008 , G01N33/5067 , G01N33/5767 , G01N2333/18
摘要： The present invention features assays employing a beta-lactamase reporter system, an HCV replicon enhanced cell, and/or a chimeric HCV replicon containing a 3′ UTR based on the HCV-1a 3′ UTR. These features can be employed alone or together, and are preferably combined together to measure HCV replicon activity and the affect of compounds on such activity.
摘要翻译： 本发明的特征在于使用β-内酰胺酶报道系统，HCV复制子增强细胞和/或含有基于HCV-1a 3'UTR的3'UTR的嵌合HCV复制子。 这些特征可以单独或一起使用，并且优选组合在一起以测量HCV复制子活性和化合物对这种活性的影响。
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公开(公告)号：US08556013B2
公开(公告)日：2013-10-15
申请号：US12427400
申请日：2009-04-21
IPC分类号： B60K11/04
CPC分类号： F01P11/10 , B60K11/08 , B60Y2200/14 , B60Y2200/142 , F01P1/06 , F01P2001/005
摘要： A system for removing heat from the engine compartment (9) of a heavy duty truck. A first ventilating system removes heat from the radiator. It is isolated from a second ventilating system that removes heat from the engine compartment. The first system takes heat from the radiator through a plenum by centrifugal squirrel cage blowers, and is directs it out to ambient by ductwork. The second system draws ambient air generally from back to front of the engine compartment, preferably by cowl induction, without the use of ram air from the vicinity of the radiator. The exits of the two systems are into a slip stream of the heavy duty truck, and the exit of the second ventilating system is into a slip stream of the first, to scavenge air out of the engine compartment.
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3.发明申请公开(公告)号：US20120318593A1
公开(公告)日：2012-12-20
申请号：US13590616
申请日：2012-08-21
CPC分类号： F01P11/10 , B60K11/08 , B60Y2200/14 , B60Y2200/142 , F01P1/06 , F01P2001/005
摘要： A system for removing heat from the engine compartment (9) of a heavy duty truck. A first ventilating system removes heat from the radiator. It is isolated from a second ventilating system that removes heat from the engine compartment. The first system takes heat from the radiator through a plenum by centrifugal squirrel cage blowers, and is directs it out to ambient by ductwork. The second system draws ambient air generally from back to front of the engine compartment, preferably by cowl induction, without the use of ram air from the vicinity of the radiator. The exits of the two systems are into a slip stream of the heavy duty truck, and the exit of the second ventilating system is into a slip stream of the first, to scavenge air out of the engine compartment.
摘要翻译： 用于从重型卡车的发动机舱（9）移除热量的系统。 第一个通风系统从散热器中除去热量。 它与从发动机舱排除热量的第二个通风系统隔离。 第一个系统通过离心式鼠笼式鼓风机从散热器吸收热量，并通过管道系统将其引导到环境中。 第二系统通常从发动机舱的后部至前部抽取环境空气，优选地通过整流罩感应，而不用从散热器附近使用冲压空气。 两个系统的出口进入重型卡车的滑流，第二通风系统的出口进入第一个的滑动流，以将空气从发动机室中排出。
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公开(公告)号：US20090277706A1
公开(公告)日：2009-11-12
申请号：US12427400
申请日：2009-04-21
CPC分类号： F01P11/10 , B60K11/08 , B60Y2200/14 , B60Y2200/142 , F01P1/06 , F01P2001/005
摘要： A system for removing heat from the engine compartment (9) of a heavy duty truck. A first ventilating system removes heat from the radiator. It is isolated from a second ventilating system that removes heat from the engine compartment. The first system takes heat from the radiator through a plenum by centrifugal squirrel cage blowers, and is directs it out to ambient by ductwork. The second system draws ambient air generally from back to front of the engine compartment, preferably by cowl induction, without the use of ram air from the vicinity of the radiator. The exits of the two systems are into a slip stream of the heavy duty truck, and the exit of the second ventilating system is into a slip stream of the first, to scavenge air out of the engine compartment.
摘要翻译： 用于从重型卡车的发动机舱（9）移除热量的系统。 第一个通风系统从散热器中除去热量。 它与从发动机舱排除热量的第二个通风系统隔离。 第一个系统通过离心式鼠笼式鼓风机从散热器吸收热量，并通过管道系统将其引导到环境。 第二系统通常从发动机舱的后部至前部抽取环境空气，优选地通过整流罩感应，而不用从散热器附近使用冲压空气。 两个系统的出口进入重型卡车的滑流，第二通风系统的出口进入第一个的滑动流，以将空气从发动机室中排出。
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公开(公告)号：US06239270B1
公开(公告)日：2001-05-29
申请号：US08476515
申请日：1995-06-07
申请人： Göran Akerström , Claes Juhlin , Lars Rask , Göran Hjälm , Clarence C. Morse , Edward M. Murray , Gregg R. Crumley
发明人： Göran Akerström , Claes Juhlin , Lars Rask , Göran Hjälm , Clarence C. Morse , Edward M. Murray , Gregg R. Crumley
IPC分类号： A61K317105
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention relates to the isolation of a cDNA clone encoding the calcium sensor in human placenta and subsequent Northern blots confirming the mRNA expression also in human parathyroid and kidney tubule cells. Close sequence similarity is demonstrated with the rat Heymann nephritis antigen, a glycoprotein of the kidney tubule brush border with calcium binding ability. Immunohistochemistry substantiates a tissue distribution of the calcium sensor protein similar to that previously described for the Heymann antigen. It is proposed that the identified calcium sensor protein constitutes a universal sensor for recognition of variation in extracellular calcium, and that it plays a key role for calcium regulation via different organ systems. The calcium sensor protein belongs to the LDL-superfamily of glycoproteins, claimed to function primarily as protein receptors, but with functionally important calcium binding capacity.
摘要翻译： 本发明涉及在人胎盘中分离编码钙传感器的cDNA克隆和随后的Northern印迹，其也证实人甲状旁腺和肾小管细胞中的mRNA表达。 使用大鼠Heymann肾炎抗原（肾小管刷糖蛋白与钙结合能力的糖蛋白）证实了序列相似性。 免疫组织化学证实了钙传感蛋白的组织分布，类似于以前描述的Heymann抗原。 提出鉴定的钙传感器蛋白构成了用于识别细胞外钙的变化的通用传感器，并且其通过不同器官系统对钙调节起关键作用。 钙传感器蛋白属于糖蛋白的LDL超家族，主要作为蛋白质受体起主要作用，但具有功能上重要的钙结合能力。
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公开(公告)号：US07537072B2
公开(公告)日：2009-05-26
申请号：US11932393
申请日：2007-10-31
IPC分类号： B60K11/00
CPC分类号： F01P11/10 , B60K11/08 , B60Y2200/14 , B60Y2200/142 , F01P1/06 , F01P2001/005
摘要： A system for removing heat from the engine compartment (9) of a heavy duty truck. A first ventilating system removes heat from the radiator. It is isolated from a second ventilating system that removes heat from the engine compartment. The first system takes heat from the radiator through a plenum by centrifugal squirrel cage blowers, and is directs it out to ambient by ductwork. The second system draws ambient air generally from back to front of the engine compartment, preferably by cowl induction, without the use of ram air from the vicinity of the radiator. The exits of the two systems are into a slip stream of the heavy duty truck, and the exit of the second ventilating system is into a slip stream of the first, to scavenge air out of the engine compartment.
摘要翻译： 用于从重型卡车的发动机舱（9）移除热量的系统。 第一个通风系统从散热器中除去热量。 它与从发动机舱排除热量的第二个通风系统隔离。 第一个系统通过离心式鼠笼式鼓风机从散热器吸收热量，并通过管道系统将其引导到环境中。 第二系统通常从发动机舱的后部至前部抽取环境空气，优选地通过整流罩感应，而不用从散热器附近使用冲压空气。 两个系统的出口进入重型卡车的滑流，第二通风系统的出口进入第一个的滑动流，以将空气从发动机室中排出。
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公开(公告)号：US20080099261A1
公开(公告)日：2008-05-01
申请号：US11932393
申请日：2007-10-31
IPC分类号： B60K11/00
CPC分类号： F01P11/10 , B60K11/08 , B60Y2200/14 , B60Y2200/142 , F01P1/06 , F01P2001/005
摘要： A system for removing heat from the engine compartment (9) of a heavy duty truck. A first ventilating system removes heat from the radiator. It is isolated from a second ventilating system that removes heat from the engine compartment. The first system takes heat from the radiator through a plenum by centrifugal squirrel cage blowers, and is directs it out to ambient by ductwork. The second system draws ambient air generally from back to front of the engine compartment, preferably by cowl induction, without the use of ram air from the vicinity of the radiator. The exits of the two systems are into a slip stream of the heavy duty truck, and the exit of the second ventilating system is into a slip stream of the first, to scavenge air out of the engine compartment.
摘要翻译： 用于从重型卡车的发动机舱（9）移除热量的系统。 第一个通风系统从散热器中除去热量。 它与从发动机舱排除热量的第二个通风系统隔离。 第一个系统通过离心式鼠笼式鼓风机从散热器吸收热量，并通过管道系统将其引导到环境中。 第二系统通常从发动机舱的后部至前部抽取环境空气，优选地通过整流罩感应，而不用从散热器附近使用冲压空气。 两个系统的出口进入重型卡车的滑流，第二通风系统的出口进入第一个的滑动流，以将空气从发动机室中排出。
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8.发明授权Methods using human calcium sensor protein, fragments thereof and DNA encoding same 失效使用人类钙传感蛋白，其片段和编码相同DNA的方法公开(公告)号：US06187548B1
公开(公告)日：2001-02-13
申请号：US08652877
申请日：1996-05-23
申请人： Göran Akerström , Claes Juhlin , Lars Rask , Göran Hjälm , Clarence C. Morse , Edward M. Murray , Gregg R. Crumley
发明人： Göran Akerström , Claes Juhlin , Lars Rask , Göran Hjälm , Clarence C. Morse , Edward M. Murray , Gregg R. Crumley
IPC分类号： G01N3353
CPC分类号： C07K14/4728 , A61K38/00 , C07K14/705
摘要： The present invention relates to the isolation of a cDNA clone encoding the calcium sensor in human placenta and subsequent Northern blots confirming the mRNA expression also in human parathyroid and kidney tubule cells. Close sequence similarity is demonstrated with the rat Heymann nephritis antigen, a glycoprotein of the kidney tubule brush border with calcium binding ability. Immunohistochemistry substantiates a tissue distribution of the calcium sensor protein similar to that previously described for the Heymann antigen. It is proposed that the identified calcium sensor protein constitutes a universal sensor for recognition of variation in extracellular calcium, and that it plays a key role for calcium regulation via different organ systems. The calcium sensor protein belongs to the LDL-superfamily of glycoproteins, claimed to function primarily as protein receptors, but with functionally important calcium binding capacity.
摘要翻译： 本发明涉及在人胎盘中分离编码钙传感器的cDNA克隆和随后的Northern印迹，其也证实人甲状旁腺和肾小管细胞中的mRNA表达。 使用大鼠Heymann肾炎抗原（肾小管刷糖蛋白与钙结合能力的糖蛋白）证实了序列相似性。 免疫组织化学证实了钙传感蛋白的组织分布，类似于以前描述的Heymann抗原。 提出鉴定的钙传感器蛋白构成了用于识别细胞外钙的变化的通用传感器，并且其通过不同器官系统对钙调节起关键作用。 钙传感器蛋白属于糖蛋白的LDL超家族，主要作为蛋白质受体起主要作用，但具有功能上重要的钙结合能力。
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