公开(公告)号：US10543267B2

公开(公告)日：2020-01-28

申请号：US16196150

申请日：2018-11-20

Applicant: PFIZER INC.

Inventor： Kathrin Ute Jansen ,  Annaliesa Sybil Anderson ,  Judith Absalon ,  Jose Miguel Aste-Amezaga ,  Johannes Frederik Beeslaar ,  David Cooper ,  John Erwin Farley ,  Leah Diane Fletcher ,  Shannon Lea Harris ,  Thomas Richard Jones ,  Isis Kanevsky ,  Lakshmi Khandke ,  Paul Liberator ,  John Lance Perez ,  Lynn Marie Phelan ,  Gary Warren Zlotnick

IPC: A61K39/095 ,  A61K31/7028 ,  A61K47/10 ,  A61K47/18 ,  C07K14/22 ,  C07K16/12 ,  A61K47/26 ,  A61K47/64 ,  A61P31/00

Abstract: In one aspect, the invention relates to a composition including a factor H binding protein (fHBP) and a Neisseria meningitidis non-serogroup B capsular polysaccharide. The invention further relates to uses of a composition that includes fHBP, such as, for example, uses to elicit an immune response against N. meningitidis serogroup B strains and non-serogroup B strains. The compositions and methods described herein are directed to administration in humans, including adults, adolescents, toddlers, and infants.

公开(公告)号：US20240325515A1

公开(公告)日：2024-10-03

申请号：US18621962

申请日：2024-03-29

Applicant: Pfizer Inc.

Inventor： Kaushik Dutta ,  Caitlyn Gallagher ,  Isis Kanevsky ,  Jin-hwan Kim ,  Justin Keith Moran ,  Suddham Singh ,  Abhishek Ravindra Vartak

IPC: A61K39/09 ,  A61K39/00 ,  A61K47/42 ,  A61P31/04

CPC classification number: A61K39/092 ,  A61K47/42 ,  A61P31/04 ,  A61K2039/55505

Abstract: The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates), kits comprising said immunogenic compositions and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in PREVNAR®, SYNFLORIX® and/or PREVNAR 13®. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumococcal infections using said novel immunogenic compositions.

公开(公告)号：US20240189410A1

公开(公告)日：2024-06-13

申请号：US18535116

申请日：2023-12-11

Applicant: Pfizer Inc.

Inventor： Annaliesa Sybil Anderson ,  Marina A. Gonzalez-Garis ,  Lei Hu ,  Isis Kanevsky ,  Paul Arthur Liberator ,  Justin Keith Moran ,  Lynn Marie Phelan ,  Michael William Pride ,  Shuai Shi ,  Naveen Surendran

IPC: A61K39/08 ,  A61K39/39 ,  A61P31/04

CPC classification number: A61K39/08 ,  A61K39/39 ,  A61P31/04 ,  A61K2039/55561

Abstract: The present invention relates to immunogenic compositions that comprise a Clostridioides difficile toxoid A and/or a C. difficile toxoid B, and an adjuvant, and methods of use thereof. The present invention further relate to a methods for eliciting an enhanced immune response in a human against a C. difficile infection. The methods include administering to the human an effective dose of an immunogenic composition, which includes a C. difficile toxoid and an adjuvant, wherein the composition is administered two times.

公开(公告)号：US20230414737A1

公开(公告)日：2023-12-28

申请号：US18343968

申请日：2023-06-29

Applicant: PFIZER INC.

Inventor： Kathrin Ute Jansen ,  Annaliesa Sybil Anderson ,  Judith Absalon ,  Jose Miguel Aste-Amezaga ,  Johannes Frederik Beeslaar ,  David Cooper ,  John Erwin Farley ,  Leah Diane Fletcher ,  Shannon Lea Harris ,  Thomas Richard Jones ,  Isis Kanevsky ,  Lakshmi Khandke ,  Paul Liberator ,  John Lance Perez ,  Lynn Marie Phelan ,  Gary Warren Zlotnick

IPC: A61K39/095 ,  C07K14/22 ,  C07K16/12 ,  A61K47/18 ,  A61K47/10 ,  A61K47/26 ,  A61K31/7028 ,  A61K47/64 ,  A61P31/00 ,  A61K39/12

CPC classification number: A61K39/095 ,  C07K14/22 ,  C07K16/1217 ,  A61K47/183 ,  A61K47/10 ,  A61K47/26 ,  A61K31/7028 ,  A61K47/6415 ,  A61K47/646 ,  A61P31/00 ,  A61K39/12 ,  A61K2039/545

Abstract: In one aspect, the invention relates to a composition including a factor H binding protein (fHBP) and a Neisseria meningitidis non-serogroup B capsular polysaccharide. The invention further relates to uses of a composition that includes fHBP, such as, for example, uses to elicit an immune response against N. meningitidis serogroup B strains and non-serogroup B strains. The compositions and methods described herein are directed to administration in humans, including adults, adolescents, toddlers, and infants.

公开(公告)号：US20220387613A1

公开(公告)日：2022-12-08

申请号：US17824293

申请日：2022-05-25

Applicant: Pfizer Inc.

Inventor： Annaliesa Sybil Anderson ,  Caitlyn Gallagher ,  Jianxin Gu ,  Isis Kanevsky ,  Jin-Hwan Kim ,  Justin Keith Moran ,  Suddham Singh ,  Naveen Surendran

IPC: A61K47/64 ,  A61K39/09 ,  A61P31/04

Abstract: The present invention relates to new conjugated capsular saccharide antigens (glycoconjugates), immunogenic compositions comprising said glycoconjugates and uses thereof.

公开(公告)号：US11730800B2

公开(公告)日：2023-08-22

申请号：US17024618

申请日：2020-09-17

Applicant: PFIZER INC.

Inventor： Kathrin Ute Jansen ,  Annaliesa Sybil Anderson ,  Judith Absalon ,  Jose Miguel Aste-Amezaga ,  Johannes Frederik Beeslaar ,  David Cooper ,  John Erwin Farley ,  Leah Diane Fletcher ,  Shannon Lea Harris ,  Thomas Richard Jones ,  Isis Kanevsky ,  Lakshmi Khandke ,  Paul Liberator ,  John Lance Perez ,  Lynn Marie Phelan ,  Gary Warren Zlotnick

IPC: A61K39/095 ,  A61K47/64 ,  C07K14/22 ,  C07K16/12 ,  A61K39/00 ,  A61K47/18 ,  A61K47/10 ,  A61K47/26 ,  A61K31/7028 ,  A61P31/00 ,  A61K39/12

CPC classification number: A61K39/095 ,  A61K31/7028 ,  A61K39/12 ,  A61K47/10 ,  A61K47/183 ,  A61K47/26 ,  A61K47/646 ,  A61K47/6415 ,  A61P31/00 ,  C07K14/22 ,  C07K16/1217 ,  A61K2039/545 ,  A61K2039/55 ,  A61K2039/55505 ,  A61K2039/6037 ,  A61K2039/70 ,  C12N2770/32434

Abstract: In one aspect, the invention relates to a composition including a factor H binding protein (fHBP) and a Neisseria meningitidis non-serogroup B capsular polysaccharide. The invention further relates to uses of a composition that includes fHBP, such as, for example, uses to elicit an immune response against N. meningitidis serogroup B strains and non-serogroup B strains. The compositions and methods described herein are directed to administration in humans, including adults, adolescents, toddlers, and infants.

公开(公告)号：US10813989B2

公开(公告)日：2020-10-27

申请号：US16704701

申请日：2019-12-05

Applicant: PFIZER INC.

Inventor： Kathrin Ute Jansen ,  Annaliesa Sybil Anderson ,  Judith Absalon ,  Jose Miguel Aste-Amezaga ,  Johannes Frederik Beeslaar ,  David Cooper ,  John Erwin Farley ,  Leah Diane Fletcher ,  Shannon Lea Harris ,  Thomas Richard Jones ,  Isis Kanevsky ,  Lakshmi Khandke ,  Paul Liberator ,  John Lance Perez ,  Lynn Marie Phelan ,  Gary Warren Zlotnick

IPC: A61K39/095 ,  A61K31/7028 ,  A61K47/10 ,  A61K47/18 ,  C07K14/22 ,  C07K16/12 ,  A61K47/26 ,  A61K47/64 ,  A61P31/00 ,  A61K39/12 ,  A61K39/00

Abstract: In one aspect, the invention relates to a composition including a factor H binding protein (fHBP) and a Neisseria meningitidis non-serogroup B capsular polysaccharide. The invention further relates to uses of a composition that includes fHBP, such as, for example, uses to elicit an immune response against N. meningitidis serogroup B strains and non-serogroup B strains. The compositions and methods described herein are directed to administration in humans, including adults, adolescents, toddlers, and infants.

公开(公告)号：US10183070B2

公开(公告)日：2019-01-22

申请号：US15883334

申请日：2018-01-30

Applicant: PFIZER INC.

Inventor： Kathrin Ute Jansen ,  Annaliesa Sybil Anderson ,  Judith Absalon ,  Jose Miguel Aste-Amezaga ,  Johannes Frederik Beeslaar ,  David Cooper ,  John Erwin Farley ,  Leah Diane Fletcher ,  Shannon Lea Harris ,  Thomas Richard Jones ,  Isis Kanevsky ,  Lakshmi Khandke ,  Paul Liberator ,  John Lance Perez ,  Lynn Marie Phelan ,  Gary Warren Zlotnick

IPC: A61K39/095 ,  A61K31/7028 ,  A61K47/10 ,  A61K47/18 ,  C07K14/22 ,  C07K16/12 ,  A61K47/26 ,  A61K47/64 ,  A61P31/00

Abstract: In one aspect, the invention relates to a composition including a factor H binding protein (fHBP) and a Neisseria meningitidis non-serogroup B capsular polysaccharide. The invention further relates to uses of a composition that includes fHBP, such as, for example, uses to elicit an immune response against N. meningitidis serogroup B strains and non-serogroup B strains. The compositions and methods described herein are directed to administration in humans, including adults, adolescents, toddlers, and infants.

公开(公告)号：US20240181028A1

公开(公告)日：2024-06-06

申请号：US18513738

申请日：2023-11-20

Applicant: Pfizer Inc.

Inventor： Catherine Alex ,  Annaliesa Sybil Anderson ,  Bishwa Raj Bhetuwal ,  Zecheng Chen ,  Kaushik Dutta ,  Caitlyn Gallagher ,  Jianxin Gu ,  Isis Kanevsky ,  Jin-Hwan Kim ,  Justin Keith Moran ,  Suddham Singh ,  Naveen Surendran ,  Abhishek Ravindra Vartak ,  YuYing Yang

IPC: A61K39/09 ,  A61K47/64

CPC classification number: A61K39/092 ,  A61K47/646

Abstract: The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in Prevnar, Synflorix and/or Prevnar 13. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumoccocal infections using said novel immunogenic compositions.

公开(公告)号：US20220387576A1

公开(公告)日：2022-12-08

申请号：US17824295

申请日：2022-05-25

Applicant: Pfizer Inc.

Inventor： Annaliesa Sybil Anderson ,  Caitlyn Gallagher ,  Jianxin Gu ,  Isis Kanevsky ,  Jin-Hwan Kim ,  Justin Keith Moran ,  Suddham Singh ,  Naveen Surendran

IPC: A61K39/09 ,  A61P31/04

Abstract: The present invention relates to new conjugated capsular saccharide antigens (glycoconjugates), immunogenic compositions comprising said glycoconjugates and uses thereof.