公开(公告)号：US10954482B2

公开(公告)日：2021-03-23

申请号：US16134746

申请日：2018-09-18

Applicant: President and Fellows of Harvard College

Inventor： Donald E. Ingber ,  Anthony Bahinski ,  Robert Cunningham ,  Josue A. Goss ,  Geraldine A. Hamilton ,  Christopher David Hinojosa ,  Daniel Levner ,  Kevin Kit Parker

IPC: A01N1/02 ,  B01L3/00 ,  C12M1/00 ,  C12M3/00 ,  C12M1/34 ,  B01L9/00 ,  C12M1/42 ,  C12M3/06 ,  G01N33/50

Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.

公开(公告)号：US11773359B2

公开(公告)日：2023-10-03

申请号：US17146264

申请日：2021-01-11

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Donald E. Ingber ,  Anthony Bahinski ,  Robert Cunningham ,  Josue A. Goss ,  Geraldine A. Hamilton ,  Christopher David Hinojosa ,  Daniel Levner ,  Kevin Kit Parker

IPC: C12M3/06 ,  C12M1/34 ,  G01N33/50 ,  B01L3/00 ,  B01L9/00 ,  C12M3/00 ,  C12M1/00 ,  C12M1/42 ,  A01N1/02

CPC classification number: C12M23/16 ,  A01N1/02 ,  B01L3/502715 ,  B01L9/52 ,  C12M21/08 ,  C12M23/42 ,  C12M29/10 ,  C12M35/04 ,  C12M35/08 ,  C12M41/00 ,  G01N33/5082 ,  G01N33/5088 ,  A01N1/021 ,  A01N1/0247 ,  A01N1/0273 ,  B01L3/5027 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2300/044 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/0867 ,  B01L2300/0877 ,  B01L2300/123 ,  B01L2300/18 ,  B01L2400/0487 ,  B01L2400/0622 ,  B01L2400/0644 ,  C12M41/12 ,  C12M41/46 ,  G01N33/5005

Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.

公开(公告)号：US20190032021A1

公开(公告)日：2019-01-31

申请号：US16125433

申请日：2018-09-07

Applicant: President and Fellows of Harvard College

Inventor： Donald E. Ingber ,  Kevin Kit Parker ,  Geraldine A. Hamilton ,  Anthony Bahinski

IPC: C12N5/071 ,  C12M1/42 ,  C12M3/06 ,  C12M1/12 ,  C12M1/00

Abstract: Disclosed herein are organ chips that can be individually used or integrated together to form different microphysiological systems, e.g., for use in cell culturing, drug screening, toxicity assays, personalized therapeutic treatment, scaffolding in tissue repair and/or replacement, and/or pharmacokinetic or pharmacodynamics studies.

公开(公告)号：US20190106665A1

公开(公告)日：2019-04-11

申请号：US16134746

申请日：2018-09-18

Applicant: President and Fellows of Harvard College

Inventor： Donald E. Ingber ,  Anthony Bahinski ,  Robert Cunningham ,  Josue A. Goss ,  Geraldine A. Hamilton ,  Christopher David Hinojosa ,  Daniel Levner ,  Kevin Kit Parker

IPC: C12M3/06 ,  G01N33/50 ,  B01L3/00 ,  B01L9/00 ,  C12M1/42 ,  C12M1/00 ,  A01N1/02 ,  C12M1/34 ,  C12M3/00

Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.

公开(公告)号：US20240182868A1

公开(公告)日：2024-06-06

申请号：US18439694

申请日：2024-02-12

Applicant: President and Fellows of Harvard College

Inventor： Donald E. Ingber ,  Kevin Kit Parker ,  Geraldine A. Hamilton ,  Anthony Bahinski

IPC: C12N5/071 ,  C12M1/00 ,  C12M1/12 ,  C12M1/42 ,  C12M3/06

CPC classification number: C12N5/0697 ,  C12M23/16 ,  C12M23/34 ,  C12M25/02 ,  C12M35/04 ,  C12M35/08

Abstract: Disclosed herein are organ chips that can be individually used or integrated together to form different microphysiological systems, e.g., for use in cell culturing, drug screening, toxicity assays, personalized therapeutic treatment, scaffolding in tissue repair and/or replacement, and/or pharmacokinetic or pharmacodynamics studies.

公开(公告)号：US10087422B2

公开(公告)日：2018-10-02

申请号：US14363105

申请日：2012-12-10

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Donald E. Ingber ,  Kevin Kit Parker ,  Geraldine A. Hamilton ,  Anthony Bahinski

IPC: C12N5/071 ,  C12M1/00 ,  C12M3/06 ,  C12M1/12 ,  C12M1/42

Abstract: Disclosed herein are organ chips that can be individually used or integrated together to form different microphysiological systems, e.g., for use in cell culturing, drug screening, toxicity assays, personalized therapeutic treatment, scaffolding in tissue repair and/or replacement, and/or pharmacokinetic or pharmacodynamics studies.

公开(公告)号：US09725687B2

公开(公告)日：2017-08-08

申请号：US14362841

申请日：2012-12-10

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  VANDERBILT UNIVERSITY

Inventor： John P. Wikswo ,  Philip C. Samson ,  Frank Emmanuel Block, III ,  Ronald S. Reiserer ,  Kevin Kit Parker ,  John A. McLean ,  Lisa Joy McCawley ,  Dmitry Markov ,  Daniel Levner ,  Donald E. Ingber ,  Geraldine A. Hamilton ,  Josue A. Goss ,  Robert Cunningham ,  David E. Cliffel ,  Jennifer Robin McKenzie ,  Anthony Bahinski ,  Christopher David Hinojosa

IPC: A01N1/00 ,  C12M3/06 ,  C12M3/00 ,  A01N1/02 ,  G01N33/50 ,  B01L9/00 ,  C12M1/00 ,  C12M1/42 ,  B01L3/00 ,  C12M1/34

CPC classification number: C12M23/16 ,  A01N1/02 ,  A01N1/021 ,  A01N1/0247 ,  A01N1/0273 ,  B01L3/5027 ,  B01L3/502715 ,  B01L9/52 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2300/044 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/0867 ,  B01L2300/0877 ,  B01L2300/123 ,  B01L2300/18 ,  B01L2400/0487 ,  B01L2400/0622 ,  B01L2400/0644 ,  C12M21/08 ,  C12M23/42 ,  C12M29/10 ,  C12M35/04 ,  C12M35/08 ,  C12M41/00 ,  C12M41/12 ,  C12M41/46 ,  G01N33/5005 ,  G01N33/5082 ,  G01N33/5088

Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.

公开(公告)号：US20150004077A1

公开(公告)日：2015-01-01

申请号：US14362841

申请日：2012-12-10

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  VANDERBILT UNIVERSITY

Inventor： John P. Wikswo ,  Philip C. Samson ,  Frank Emmanuel Block, III ,  Ronald S. Reiserer ,  Kevin Kit Parker ,  John A. McLean ,  Lisa Joy McCawley ,  Dmitry Markov ,  Daniel Levner ,  Donald E. Ingber ,  Geraldine A. Hamilton ,  Josue A. Goss ,  Robert Cunningham ,  David E. Cliffel ,  Jennifer Robin McKenzie ,  Anthony Bahinski ,  Christopher David Hinojosa

IPC: G01N33/50

CPC classification number: C12M23/16 ,  A01N1/02 ,  A01N1/021 ,  A01N1/0247 ,  A01N1/0273 ,  B01L3/5027 ,  B01L3/502715 ,  B01L9/52 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2300/044 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/0867 ,  B01L2300/0877 ,  B01L2300/123 ,  B01L2300/18 ,  B01L2400/0487 ,  B01L2400/0622 ,  B01L2400/0644 ,  C12M21/08 ,  C12M23/42 ,  C12M29/10 ,  C12M35/04 ,  C12M35/08 ,  C12M41/00 ,  C12M41/12 ,  C12M41/46 ,  G01N33/5005 ,  G01N33/5082 ,  G01N33/5088

Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.

Abstract translation: 本发明提供了用于这种微生物系统的活体器官和支持结构的集成的片上微生物系统表示。

公开(公告)号：US20140342445A1

公开(公告)日：2014-11-20

申请号：US14363105

申请日：2012-12-10

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Donald E. Ingber ,  Kevin Kit Parker ,  Geraldine A. Hamilton ,  Anthony Bahinski

IPC: C12N5/071

CPC classification number: C12N5/0697 ,  C12M23/16 ,  C12M23/34 ,  C12M25/02 ,  C12M35/04 ,  C12M35/08

Abstract: Disclosed herein are organ chips that can be individually used or integrated together to form different microphysiological systems, e.g., for use in cell culturing, drug screening, toxicity assays, personalized therapeutic treatment, scaffolding in tissue repair and/or replacement, and/or pharmacokinetic or pharmacodynamics studies.

Abstract translation: 本文公开了可以单独使用或整合在一起以形成不同的微生物系统的器官碎片，例如用于细胞培养，药物筛选，毒性测定，个性化治疗处理，组织修复和/或替代中的支架和/或药代动力学 或药效学研究。