公开(公告)号：US20210197196A1

公开(公告)日：2021-07-01

申请号：US16756896

申请日：2018-10-19

Applicant: President and Fellows of Harvard College

Inventor： Aaron L. Glieberman ,  John P. Ferrier ,  John F. Zimmerman ,  Kevin Kit Parker

IPC: B01L3/00 ,  G01N33/50 ,  C12M3/06

Abstract: Some embodiments provide a microfluidic cartridge for automatically hydrodynamically loading objects (e.g., cell clusters) into traps in parallel trapping channels with one object per trap, methods of making such cartridges and methods of use of C such cartridges.

公开(公告)号：US10997871B2

公开(公告)日：2021-05-04

申请号：US15514011

申请日：2015-09-24

Applicant: President and Fellows of Harvard College

Inventor： Kevin Kit Parker ,  Sung-Jin Park ,  Patrick Healy Campbell ,  Johan Ulrik Lind

IPC: G09B23/28 ,  C12M3/00 ,  C12M1/34 ,  C12M1/00 ,  G01N3/32 ,  C12N5/077 ,  C12M1/12 ,  G01N33/50

Abstract: Exemplary embodiments provide systems, devices and methods for simultaneously measuring mechanical and electrophysiological tissue responses (e.g., contractile function, or the like).

公开(公告)号：US20200376170A1

公开(公告)日：2020-12-03

申请号：US16762384

申请日：2018-11-08

Applicant: President and Fellows of Harvard College

Inventor： Seungkuk Ahn ,  Christophe Chantre ,  Grant Michael Gonzalez ,  Kevin Kit Parker

IPC: A61L27/60 ,  A61L27/36 ,  A61L27/24 ,  A61L27/22 ,  A61L27/26

Abstract: The present invention provides polymeric fiber scaffolds, methods and devices suitable for fabricating such polymeric fiber scaffolds, and uses thereof for wound healing.

公开(公告)号：US20200318258A1

公开(公告)日：2020-10-08

申请号：US16679578

申请日：2019-11-11

Applicant: President and Fellows of Harvard College

Inventor： Kevin Kit Parker ,  Grant Michael Gonzalez ,  Holly M. Golecki ,  Kwanwoo Shin ,  Josue A. Goss

IPC: D01D5/18 ,  C08J5/18 ,  D01D5/06 ,  D01F6/60 ,  D01F9/00

Abstract: Exemplary embodiments provide systems, devices and methods for the fabrication of three-dimensional polymeric fibers having micron, submicron and nanometer dimensions, as well as methods of use of the polymeric fibers.

公开(公告)号：US20190106665A1

公开(公告)日：2019-04-11

申请号：US16134746

申请日：2018-09-18

Applicant: President and Fellows of Harvard College

Inventor： Donald E. Ingber ,  Anthony Bahinski ,  Robert Cunningham ,  Josue A. Goss ,  Geraldine A. Hamilton ,  Christopher David Hinojosa ,  Daniel Levner ,  Kevin Kit Parker

IPC: C12M3/06 ,  G01N33/50 ,  B01L3/00 ,  B01L9/00 ,  C12M1/42 ,  C12M1/00 ,  A01N1/02 ,  C12M1/34 ,  C12M3/00

Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.

公开(公告)号：US20180327702A1

公开(公告)日：2018-11-15

申请号：US15777242

申请日：2016-11-18

Applicant: President and Fellows of Harvard College

Inventor： Alanna R. Gannon ,  Aaron L. Glieberman ,  Kevin Kit Parker ,  Benjamin D. Pope ,  Kevin L. Shores ,  Nina R. Sinatra

IPC: C12M3/00 ,  G01N33/50

CPC classification number: C12M23/42 ,  C12M21/08 ,  C12Q1/00 ,  C40B40/10 ,  G01N33/5023 ,  G01N33/507 ,  G01N33/5082

Abstract: Microfluidic systems including a housing configured to receive a cartridge, the cartridge including a plurality of wells for receiving one or more biological cells are described herein. The microfluidic systems include a structure with channels for introducing a medium into the housing and through channels the cartridge. Microfluidic systems including a housing configured to receive a cartridge, the housing including channels for loading one or more biological cells within wells of the cartridge are described herein. Three-dimensional scaffolds, devices, and systems comprising such scaffolds that mimic the in vivo structure, physical properties, and protein composition of extracellular matrix surrounding pancreatic islet cells and adipocytes, and the use of such compositions, devices and systems for, e.g., in vitro drug screening and/or toxicity assays, disease modeling, and therapeutic applications are also described herein.

公开(公告)号：US20150354094A1

公开(公告)日：2015-12-10

申请号：US14763620

申请日：2014-02-13

Applicant: President and Fellows of Harvard College

Inventor： Kevin Kit Parker ,  Grant Michael Gonzalez ,  Holly M. Golecki ,  Kwanwoo Shin ,  Josue Adrian Goss

IPC: D01D5/18 ,  D01F6/60 ,  C08J5/18 ,  D01D5/06

CPC classification number: D01D5/18 ,  C08J5/18 ,  C08J2377/10 ,  D01D5/06 ,  D01F6/605 ,  D01F9/00 ,  D10B2331/021 ,  Y10T428/249921

Abstract: Exemplary embodiments provide systems, devices and methods for the fabrication of three-dimensional polymeric fibers having micron, submicron and nanometer dimensions, as well as methods of use of the polymeric fibers.

Abstract translation: 示例性实施例提供了用于制造具有微米，亚微米和纳米尺寸的三维聚合物纤维的系统，装置和方法以及聚合物纤维的使用方法。

公开(公告)号：US12139821B2

公开(公告)日：2024-11-12

申请号：US17421047

申请日：2020-01-14

Applicant: President and Fellows of Harvard College

Inventor： Qihan Liu ,  Kevin Kit Parker ,  Huibin Chang

IPC: D01D5/14 ,  D01D5/18

Abstract: Systems and methods for focused direction deposition of a micron or nanometer dimension polymeric fiber and materials of such fibers are described herein. Systems and methods employ one or more gas flows to entrain and deflect fibers produced by a rotary jet spinning system forming a focused fiber stream. Some embodiments enable control of alignment and distribution of the fibers with a relatively high fiber throughput.

公开(公告)号：US20230348831A1

公开(公告)日：2023-11-02

申请号：US18346165

申请日：2023-06-30

Applicant: President and Fellows of Harvard College

Inventor： Donald E. Ingber ,  Anthony M. Bahinski ,  Robert Cunningham ,  Josue A. Goss ,  Geraldine A. Hamilton ,  Christopher David Hinojosa ,  Daniel Levner ,  Kevin Kit Parker

IPC: C12M3/06 ,  A01N1/02 ,  C12M1/34 ,  G01N33/50 ,  B01L3/00 ,  B01L9/00 ,  C12M3/00 ,  C12M1/00 ,  C12M1/42

CPC classification number: C12M23/16 ,  A01N1/02 ,  C12M41/00 ,  G01N33/5082 ,  B01L3/502715 ,  B01L9/52 ,  C12M21/08 ,  C12M23/42 ,  C12M29/10 ,  C12M35/04 ,  C12M35/08 ,  G01N33/5088 ,  A01N1/0247 ,  G01N33/5005 ,  A01N1/0273 ,  A01N1/021 ,  B01L3/5027 ,  C12M41/46 ,  C12M41/12 ,  B01L2300/0877 ,  B01L2300/0867 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2300/044 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/123 ,  B01L2300/18 ,  B01L2400/0487 ,  B01L2400/0622 ,  B01L2400/0644

Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.

公开(公告)号：US20220248903A1

公开(公告)日：2022-08-11

申请号：US17679183

申请日：2022-02-24

Applicant: President and Fellows of Harvard College

Inventor： Kevin Kit Parker ,  Alexander Peyton Nesmith ,  Joseph A. Festa ,  Michel Maalouly ,  Elizabeth Olayinka Ogunbiyi

IPC: A47J37/07

Abstract: Devices, systems, and computer-readable medium are provided for a barbecue smoker device. A barbecue smoker device is provided, that includes a multi-wall container, a food platform, a heat source, an air vent at the top of the barbecue smoker device, an air flow control mechanism at the lower portion of the barbecue smoker device, and a plurality of sensors coupled to the barbecue smoker device. The barbeque smoker device may include a control device for automated control of the air flow control mechanism. A system for remotely controlling a barbecue smoker device is provided, where the system includes a barbecue smoker device including a processor and a display unit, a mobile device in wireless communication with the barbecue smoker device, and the mobile device displaying a graphical user interface that is configured to receive input from a user causing a configuration change in the barbecue smoker device.