公开(公告)号：US20180030515A1

公开(公告)日：2018-02-01

申请号：US15453405

申请日：2017-03-08

Applicant: The Broad Institute Inc. ,  Massachusetts Institute of Technology ,  President and Fellows of Harvard College

Inventor： Aviv Regev ,  Evan Zane MACOSKO ,  Steven Andrew MCCARROLL ,  Alexander K. SHALEK ,  Anindita BASU ,  Christopher B. FORD ,  Hongkun PARK ,  David A. WEITZ

IPC: C12Q1/68 ,  G06K19/06 ,  C12N15/10

CPC classification number: C12Q1/6809 ,  C12N15/1096 ,  C12Q1/6834 ,  C12Q1/6869 ,  G06K19/06 ,  C12Q2521/107 ,  C12Q2525/15 ,  C12Q2525/155 ,  C12Q2525/161 ,  C12Q2525/173 ,  C12Q2563/149 ,  C12Q2563/159 ,  C12Q2565/629 ,  C12Q2563/179

Abstract: The present invention generally relates to a combination of molecular barcoding and emulsion-based microfluidics to isolate, lyse, barcode, and prepare nucleic acids from individual cells in a high-throughput manner.

公开(公告)号：US20180311669A1

公开(公告)日：2018-11-01

申请号：US15772035

申请日：2016-10-28

Applicant: THE BROAD INSTITUTE, INC. ,  MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  DANA-FARBER CANCER INSTITUTE, INC.

Inventor： Anindita BASU ,  Christopher B. FORD ,  Aviv REGEV ,  David A. WEITZ ,  Asaf ROTEM ,  Kevin STRUHL

IPC: B01L3/00 ,  C12M3/06 ,  C12M1/32 ,  G01N33/50

CPC classification number: B01L3/502746 ,  B01L3/0241 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/086 ,  C12M23/16

Abstract: The present invention generally relates to a controlled fluidic device to develop spatially complex environments to enhance the rate of evolution in cell populations. The method further provides an enhanced understanding in the emergence, for example, drug resistance during cancer chemotherapy.

公开(公告)号：US20160168386A1

公开(公告)日：2016-06-16

申请号：US14907197

申请日：2014-07-13

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Joanna AIZENBERG ,  Nicolas VOGEL ,  Ian BURGESS ,  Mathias KOLLE ,  Tanya SHIRMAN ,  Stefanie UTECH ,  Katherine PHILLIPS ,  David A. WEITZ ,  Natalie KOAY

IPC: C09C1/00 ,  A61K8/19 ,  C09D17/00 ,  A61K8/81 ,  A61K8/29 ,  A61Q1/02 ,  C09C3/06 ,  A61K8/25

CPC classification number: C09C1/0081 ,  A61K8/0283 ,  A61K8/19 ,  A61K8/25 ,  A61K8/29 ,  A61K8/8176 ,  A61K2800/412 ,  A61K2800/43 ,  A61K2800/5922 ,  A61Q1/02 ,  A61Q1/06 ,  C01P2004/64 ,  C09C1/62 ,  C09C3/06 ,  C09D17/006

Abstract: A structurally colored pigment is described that contains a plurality of photonic crystal particles dispersed in a medium, where each photonic crystal particles contains a plurality of spectrally selective absorbing components dispersed within the photonic crystal particle. In certain embodiments, each photonic crystal particle has a predetermined minimum number of repeat units of the photonic crystal structure. The structurally colored material provides improved reflectance, long-term stability, and control of the desired optical effects. The fabrication techniques described herein also provide high throughput and high yield allowing use in wide ranging applications from cosmetics, paints, signs, sensors, to packaging material.

Abstract translation: 描述了包含分散在介质中的多个光子晶体颗粒的结构着色的颜料，其中每个光子晶体颗粒包含分散在光子晶体颗粒内的多个光谱选择性吸收组分。 在某些实施方案中，每个光子晶体颗粒具有预定的最小数量的光子晶体结构的重复单元。 结构着色的材料提供改善的反射率，长期稳定性和所需光学效果的控制。 本文描述的制造技术还提供高产量和高产量，允许在从化妆品，油漆，标志，传感器到包装材料的广泛应用中使用。

公开(公告)号：US20220002554A1

公开(公告)日：2022-01-06

申请号：US17476950

申请日：2021-09-16

Applicant: President and Fellows of Harvard College

Inventor： Joanna AIZENBERG ,  Nicolas VOGEL ,  Ian BURGESS ,  Mathias KOLLE ,  Tanya SHIRMAN ,  Stefanie UTECH ,  Katherine Reece PHILLIPS ,  David A. WEITZ ,  Natalie KOAY

IPC: C09C1/00 ,  A61K8/19 ,  C09C1/62 ,  A61K8/02 ,  A61Q1/06 ,  A61K8/25 ,  A61K8/29 ,  A61K8/81 ,  A61Q1/02 ,  C09C3/06 ,  C09D17/00

Abstract: A pigment comprising a plurality of photonic crystal particles dispersed in a medium, each photonic crystal particles containing a plurality of spectrally selective absorbing components dispersed within each photonic crystal particle that selectively absorb electromagnetic radiation without substantially absorbing electromagnetic radiation near a resonant wavelength of each photonic crystal particle, wherein each photonic crystal particle has a predetermined minimum number of repeat units of a photonic crystal structure, wherein the predetermined minimum number of repeat units is related to the resonant wavelength, the full-width at half maximum of the resonant wavelength, and the refractive index contrast in the photonic crystal.

公开(公告)号：US20190127782A1

公开(公告)日：2019-05-02

申请号：US16244058

申请日：2019-01-09

Applicant: The Broad Institute, Inc. ,  Massachusetts Institute of Technology ,  President and Fellows of Harvard College

Inventor： Aviv REGEV ,  Evan Zane MACOSKO ,  Steven Andrew MCCARROLL ,  Alexander K. SHALEK ,  Anindita BASU ,  Christopher B. FORD ,  Hongkun PARK ,  David A. WEITZ

IPC: C12Q1/6809 ,  G06K19/06 ,  C12Q1/6834 ,  C12Q1/6869 ,  C12N15/10

Abstract: The present invention generally relates to a combination of molecular barcoding and emulsion-based microfluidics to isolate, lyse, barcode, and prepare nucleic acids from individual cells in a high-throughput manner.

公开(公告)号：US20180098936A1

公开(公告)日：2018-04-12

申请号：US15560653

申请日：2016-03-23

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Donald E. INGBER ,  David A. WEITZ ,  Jonathan DIDIER ,  Maximilian ZIERINGER

IPC: A61K9/00 ,  A61K9/113 ,  A61K9/50 ,  A61K47/32 ,  A61K47/26 ,  A61K47/44 ,  A61K47/34 ,  A61K47/06

CPC classification number: A61K9/0019 ,  A61K9/113 ,  A61K9/1273 ,  A61K9/5089 ,  A61K47/06 ,  A61K47/26 ,  A61K47/32 ,  A61K47/34 ,  A61K47/44

Abstract: Embodiments of various aspects described herein relate to methods and compositions for injecting and/or delivering high viscosity and/or high concentration active agent solutions. In some embodiments, the methods and compositions described herein can be used for subcutaneous administration.