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    LATEX-TREATED FILLER SLURRIES FOR USE IN PAPERMAKING
    3.
    发明申请
    LATEX-TREATED FILLER SLURRIES FOR USE IN PAPERMAKING 有权
    用于造纸的LATEX-TREATED FILLER流浆

    公开(公告)号：US20110308753A1

    公开(公告)日：2011-12-22

    申请号：US13221103

    申请日：2011-08-30

    申请人： Makhlouf Laleg ,  Roderick Collins ,  Danielle Gagne ,  Steven Middleton

    发明人： Makhlouf Laleg ,  Roderick Collins ,  Danielle Gagne ,  Steven Middleton

    IPC分类号： D21H17/37 ,  C08K3/30 ,  C08K3/26 ,  C08L33/06 ,  C08K3/34

    CPC分类号： D21H17/67 ,  C01P2004/03 ,  C01P2004/61 ,  C01P2004/62 ,  C09C1/021 ,  C09C1/025 ,  C09C1/42 ,  D21H17/35 ,  D21H17/37 ,  D21H17/675 ,  D21H17/68 ,  D21H17/69 ,  D21H23/04 ,  Y10T428/2998

    摘要： A continuous filler treatment process has been developed to enhance the fixation of anionic latex on filler in a short time. In this process anionic polymer dispersions (latex) are added to common papermaking filler slurries at ambient temperature and then mixed with water of temperature higher than the glass transition temperature (Tg) of the latex used. To efficiently fix the latex the temperature of the filler/latex mixture must be 30-60° C. higher than the Tg of the latex used. The chemical composition of the resin and the type of surfactant used during the emulsion polymerisation process of the polymer latex dispersions are important factors for efficiently fixing the latex onto the filler by adding hot water and improving the properties of paper made with the treated filler. The enhanced fixation of anionic latex onto filler using hot water is done in mixing vessels that can control shear and mixing time. The anionic latexes applied by this process are totally and irreversibly fixed or bound onto the filler particles and the aggregated filler slurry is stable over time. The latex-treated filler slurry can be added to papermaking furnishes at any point prior to the headbox of the paper machine or stored for later use. It can be added to wood-free or wood-containing furnishes commonly used for making fine papers, mechanical pulp papers, and multi-ply paperboards. The latex-treated filler slurry improves filler retention, only slightly reduces sheet strength and improves sizing performance. Furthermore, latex-treated calcium carbonate filler, such as precipitated calcium carbonate (PCC), is more acid-resistant and, when used in manufacturing mechanical pulp paper under neutral conditions, less acid is needed to control the pH.

    摘要翻译： 已经开发了连续的填料处理方法，以在短时间内增强阴离子胶乳在填料上的固定。 在这个过程中，将阴离子聚合物分散体（胶乳）在环境温度下加入普通的造纸填料浆料中，然后与高于所用胶乳的玻璃化转变温度（Tg）的温度的水混合。 为了有效地固定胶乳，填料/胶乳混合物的温度必须比使用的胶乳的Tg高30-60℃。 树脂的化学成分和在聚合物胶乳分散体的乳液聚合过程中使用的表面活性剂的类型是通过加入热水和改进用经处理的填料制备的纸的性能来有效地将胶乳固定到填料上的重要因素。 使用热水将阴离子胶乳固定在填料上进行，可以控制剪切和混合时间的混合容器。 通过该方法施加的阴离子胶乳完全和不可逆地固定或结合到填料颗粒上，并且聚集的填料浆料随时间稳定。 胶乳处理的填料浆料可以在造纸机的流浆箱之前的任何点添加到造纸装置中，或者存储以备后用。 它可以添加到通常用于制造高级纸张，机械纸浆纸和多层纸板的无木材或含木材的配料中。 胶乳处理的填料浆料改善了填料保留性，仅稍微降低了片材强度并提高了施胶性能。 此外，胶乳处理的碳酸钙填料，例如沉淀碳酸钙（PCC），更耐酸，并且当在中性条件下用于制造机械纸浆时，需要较少的酸来控制pH。

    Substituted [4-(4-phenyl-piperazin-1-yl)-cyclohexyl]-urea compounds
    4.
    发明申请
    Substituted [4-(4-phenyl-piperazin-1-yl)-cyclohexyl]-urea compounds 有权
    取代的[4-（4-苯基 - 哌嗪-1-基） - 环己基] - 脲化合物

    公开(公告)号：US20070123542A1

    公开(公告)日：2007-05-31

    申请号：US11453128

    申请日：2006-06-14

    申请人： George Chiu ,  Peter Connolly ,  Jessica Liu ,  Steven Middleton ,  Virginia Pulito ,  Shengjian Li

    发明人： George Chiu ,  Peter Connolly ,  Jessica Liu ,  Steven Middleton ,  Virginia Pulito ,  Shengjian Li

    IPC分类号： A61K31/495 ,  C07D241/04

    CPC分类号： C07D295/155 ,  C07D295/135

    摘要： The present invention relates to substituted [4-(4-phenyl-piperazin-1-yl)-cyclohexyl]-urea compounds of Formula (I) and pharmaceutically acceptable forms thereof, as α1a/α1d adrenoreceptor modulators for the treatment of benign prostatic hypertrophy and lower urinary tract symptoms. The present invention also relates to pharmaceutical compositions comprising said new compounds, new processes to prepare these new compounds and new uses as a medicine as well as methods of treatment.

    摘要翻译： 本发明涉及式（I）的取代的[4-（4-苯基 - 哌嗪-1-基） - 环己基] - 脲化合物及其药学上可接受的形式，作为α1a / 用于治疗良性前列腺肥大和下尿路症状的肾上腺素受体调节剂。 本发明还涉及包含所述新化合物的药物组合物，制备这些新化合物的新方法和作为药物的新用途以及治疗方法。

    Latex-treated filler slurries for use in papermaking
    6.
    发明申请
    Latex-treated filler slurries for use in papermaking 有权
    用于造纸的乳胶处理填料浆料

    公开(公告)号：US20080302496A1

    公开(公告)日：2008-12-11

    申请号：US12155496

    申请日：2008-06-05

    申请人： Makhlouf Laleg ,  Roderick Collins ,  Danielle Gagne ,  Steven Middleton

    发明人： Makhlouf Laleg ,  Roderick Collins ,  Danielle Gagne ,  Steven Middleton

    IPC分类号： D21H17/37 ,  C08K3/34 ,  C08K3/26 ,  C08K3/30 ,  C08L33/08

    CPC分类号： D21H17/67 ,  C01P2004/03 ,  C01P2004/61 ,  C01P2004/62 ,  C09C1/021 ,  C09C1/025 ,  C09C1/42 ,  D21H17/35 ,  D21H17/37 ,  D21H17/675 ,  D21H17/68 ,  D21H17/69 ,  D21H23/04 ,  Y10T428/2998

    摘要： A continuous filler treatment process has been developed to enhance the fixation of anionic latex on filler in a short time. In this process anionic polymer dispersions (latex) are added to common papermaking filler slurries at ambient temperature and then mixed with water of temperature higher than the glass transition temperature (Tg) of the latex used. To efficiently fix the latex the temperature of the filler/latex mixture must be 30-60° C. higher than the Tg of the latex used. The chemical composition of the resin and the type of surfactant used during the emulsion polymerisation process of the polymer latex dispersions are important factors for efficiently fixing the latex onto the filler by adding hot water and improving the properties of paper made with the treated filler. The enhanced fixation of anionic latex onto filler using hot water is done in mixing vessels that can control shear and mixing time. The anionic latexes applied by this process are totally and irreversibly fixed or bound onto the filler particles and the aggregated filler slurry is stable over time. The latex-treated filler slurry can be added to papermaking furnishes at any point prior to the headbox of the paper machine or stored for later use. It can be added to wood-free or wood-containing furnishes commonly used for making fine papers, mechanical pulp papers, and multi-ply paperboards. The latex-treated filler slurry improves filler retention, only slightly reduces sheet strength and improves sizing performance. Furthermore, latex-treated calcium carbonate filler, such as precipitated calcium carbonate (PCC), is more acid-resistant and, when used in manufacturing mechanical pulp paper under neutral conditions, less acid is needed to control the pH.

    摘要翻译： 已经开发了连续的填料处理方法，以在短时间内增强阴离子胶乳在填料上的固定。 在这个过程中，将阴离子聚合物分散体（胶乳）在环境温度下加入普通的造纸填料浆料中，然后与高于所用胶乳的玻璃化转变温度（Tg）的温度的水混合。 为了有效地固定胶乳，填料/胶乳混合物的温度必须比使用的胶乳的Tg高30-60℃。 树脂的化学成分和在聚合物胶乳分散体的乳液聚合过程中使用的表面活性剂的类型是通过加入热水和改进用经处理的填料制备的纸的性能来有效地将胶乳固定到填料上的重要因素。 使用热水将阴离子胶乳固定在填料上进行，可以控制剪切和混合时间的混合容器。 通过该方法施加的阴离子胶乳完全和不可逆地固定或结合到填料颗粒上，并且聚集的填料浆料随时间稳定。 胶乳处理的填料浆料可以在造纸机的流浆箱之前的任何点添加到造纸装置中，或者存储以备后用。 它可以添加到通常用于制造高级纸张，机械纸浆纸和多层纸板的无木材或含木材的配料中。 胶乳处理的填料浆料改善了填料保留性，仅稍微降低了片材强度并提高了施胶性能。 此外，胶乳处理的碳酸钙填料，例如沉淀碳酸钙（PCC），更耐酸，并且当在中性条件下用于制造机械纸浆时，需要较少的酸来控制pH。

    System for data analysis
    10.
    发明申请
    System for data analysis 审中-公开
    数据分析系统

    公开(公告)号：US20060015367A1

    公开(公告)日：2006-01-19

    申请号：US11156751

    申请日：2005-06-20

    申请人： Roger Taylor ,  Steven Middleton

    发明人： Roger Taylor ,  Steven Middleton

    IPC分类号： G06Q50/00

    CPC分类号： G06Q50/22 ,  G16H10/60 ,  G16H15/00 ,  G16H40/20 ,  G16H50/70

    摘要： A method and apparatus for analysing data allowing accurate, up to date analysis of the performance of hospitals or hospital trusts as the data is entered into the system. The method and apparatus is optimised for analysing data in such a way as to produce graphical representations allowing easy recognition of groups of patient having or hospitals producing outcomes which have significantly diverged from the desired outcome. The method involves filtering data held within databases to retrieve data belonging to the patient group that is to be analysed. The filtered data is then analysed using statistical calculations and a representation of the analysis is returned to the user for review.

    摘要翻译： 一种用于分析数据的方法和装置，允许在数据输入系统时准确，最新地分析医院或医院信任的表现。 该方法和装置被优化用于分析数据，以便产生图形表示，从而容易地识别具有与预期结果显着不同的结果的患者组或医院。 该方法涉及过滤保存在数据库内的数据以检索属于待分析的患者组的数据。 然后使用统计计算分析经过滤的数据，并将分析的表示返回给用户进行审查。