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    Method of encapsulating cells in a tubular extrudate
    2.
    发明授权
    Method of encapsulating cells in a tubular extrudate 失效
    将细胞包封在管状挤出物中的方法

    公开(公告)号：US5284761A

    公开(公告)日：1994-02-08

    申请号：US827728

    申请日：1992-02-26

    Applicant: Patrick Aebischer ,  Lars Wahlberg

    Inventor： Patrick Aebischer ,  Lars Wahlberg

    IPC: A61F2/02 ,  A61K9/00 ,  A61K9/48 ,  A61K35/12 ,  A61M31/00 ,  B01J13/02 ,  B01J13/04 ,  C12N5/00 ,  C12N5/071 ,  C12N5/0793 ,  C12N11/04 ,  C12N11/08

    CPC classification number: A61K9/0092 ,  A61F2/022 ,  A61K35/12 ,  A61K9/0024 ,  A61K9/0085 ,  A61K9/4816 ,  A61K9/4833 ,  A61M31/002 ,  B01J13/02 ,  B01J13/04 ,  C12N11/04 ,  C12N11/08 ,  C12N5/0012 ,  C12N5/0614 ,  C12N5/0619 ,  A61K2035/126 ,  A61K2035/128 ,  A61M2210/0687 ,  A61M2210/0693 ,  C12N2533/30

    Abstract: Methods and systems are disclosed for encapsulating viable cells which produce biologically-active factors. The cells are encapsulated within a semipermeable, polymeric membrane by co-extruding an aqueous cell suspension and a polymeric solution through a common port to form a tubular extrudate having a polymeric outer coating which encapsulates the cell suspension. For example, the cell suspension and the polymeric solution can be extruded through a common extrusion port having at least two concentric bores, such that the cell suspension is extruded through the inner bore and the polymeric solution is extruded through the outer bore. The polymeric solution coagulates to form an outer coating. As the outer coating is formed, the ends of the tubular extrudate can be sealed to form a cell capsule. In one embodiment, the tubular extrudate is sealed at intervals to define separate cell compartments connected by polymeric links.

    Abstract translation: 公开了用于包封产生生物活性因子的活细胞的方法和系统。 通过将水性细胞悬浮液和聚合物溶液共挤出通过共同的口以形成具有封装细胞悬浮液的聚合物外涂层的管状挤出物，将细胞包封在半透膜聚合物膜内。 例如，细胞悬浮液和聚合物溶液可以通过具有至少两个同心孔的共同挤出口挤出，使得细胞悬浮液通过内孔挤出并且聚合物溶液通过外孔挤出。 聚合物溶液凝结形成外涂层。 当形成外涂层时，管状挤出物的端部可被密封以形成电池盒。 在一个实施方案中，管状挤出物间隔密封以限定通过聚合物连接物连接的分离的细胞室。

    Cell culture-containing tubular capsule produced by co-extrusion
    3.
    发明授权
    Cell culture-containing tubular capsule produced by co-extrusion 失效
    通过共挤出生产含细胞培养的管状胶囊

    公开(公告)号：US5283187A

    公开(公告)日：1994-02-01

    申请号：US638759

    申请日：1991-01-08

    Applicant: Patrick Aebischer ,  Lars Wahlberg

    Inventor： Patrick Aebischer ,  Lars Wahlberg

    IPC: A61F2/02 ,  A61K9/00 ,  A61K9/48 ,  A61K35/12 ,  A61M31/00 ,  B01J13/02 ,  B01J13/04 ,  C12N5/00 ,  C12N5/071 ,  C12N5/0793 ,  C12N11/04 ,  C12N11/08 ,  C12N11/12

    CPC classification number: A61K9/0092 ,  A61F2/022 ,  A61K35/12 ,  A61K9/0024 ,  A61K9/0085 ,  A61K9/4816 ,  A61K9/4833 ,  A61M31/002 ,  B01J13/02 ,  B01J13/04 ,  C12N11/04 ,  C12N11/08 ,  C12N5/0012 ,  C12N5/0614 ,  C12N5/0619 ,  A61K2035/126 ,  A61K2035/128 ,  A61M2210/0687 ,  A61M2210/0693 ,  C12N2533/30

    Abstract: Living cells such as animal cells which produce biologically active factors are encapsulated within a semipermeable, polymeric membrane such as polyacrylate by co-extruding an aqueous cell suspension and a polymeric solution through a common port having at least one concentric bores to form a tubular extrudate having a polymeric membrane which encapsulates the cell suspension. The cell suspension is extruded through an inner bore and the polymeric solution is extruded through an outer bore while a pressure differential is maintained between the cell suspension and the polymeric solution to impede solvent diffusion from the polymeric solution into the cell suspension. The polymeric solution coagulates to form an outer coating or membrane as the polymeric solution and the cell suspension are extruded through the extrusion port. As the outer membrane is formed, the ends of the tubular extrudate are sealed to form a cell capsule. In one embodiment, the tubular extrudate is sealed at intervals to define separate cell compartments connected by polymeric links. In another embodiment, a cell capsule connected to a tethering filament is formed. The polymeric membrane may contain additives such as a surfactant, an anti-inflammatory agent or an anti-oxidant and can be coated with a protective barrier. The cell suspension may contain nutrients and an anchorage substrate.

    Abstract translation: 活性细胞如产生生物活性因子的动物细胞被包封在半透性聚合物膜（例如聚丙烯酸酯）内，通过共混挤出水性细胞悬浮液和聚合物溶液通过具有至少一个同心孔的共同孔口形成管状挤出物， 封装细胞悬浮液的聚合物膜。 细胞悬浮液通过内孔挤出，并且聚合物溶液通过外孔挤出，同时在细胞悬浮液和聚合物溶液之间保持压力差以阻止溶剂从聚合物溶液扩散进入细胞悬液。 聚合物溶液凝聚形成外涂层或膜作为聚合物溶液，并且细胞悬浮液通过挤出端口挤出。 当外膜形成时，管状挤出物的端部被密封以形成细胞囊。 在一个实施方案中，管状挤出物间隔密封以限定通过聚合物连接物连接的分离的细胞室。 在另一个实施例中，形成连接到系链细丝的细胞囊。 聚合物膜可以含有添加剂如表面活性剂，抗炎剂或抗氧化剂，并且可以用保护屏障涂覆。 细胞悬浮液可以含有营养物和锚定基质。

    CULTURES OF GFAP+ NESTIN+ CELLS THAT DIFFERENTIATE TO NEURONS
    7.
    发明申请
    CULTURES OF GFAP+ NESTIN+ CELLS THAT DIFFERENTIATE TO NEURONS 有权
    GFAP + NESTIN +细胞与神经元差异的文化

    公开(公告)号：US20080138895A1

    公开(公告)日：2008-06-12

    申请号：US11932349

    申请日：2007-10-31

    Applicant: Lars Wahlberg ,  Kenneth Campbell ,  Charlotta Skogh ,  Cecilia Eriksson ,  Klas Wictorin

    Inventor： Lars Wahlberg ,  Kenneth Campbell ,  Charlotta Skogh ,  Cecilia Eriksson ,  Klas Wictorin

    IPC: C12N5/02 ,  C12N5/06 ,  C12N5/08

    CPC classification number: C12N5/0622 ,  A61K35/12 ,  C12N5/0619 ,  C12N5/0623 ,  C12N2500/90 ,  C12N2501/11

    Abstract: Cultures of cells immunoreactive for glial fibrillary acidic protein (GFAP), as well as for the intermediate filament marker nestin were grown in a medium including epidermal growth factor (EGF) and serum. The cultured cells had the morphology of astroglial cells. The cells can be proliferated in adherent or suspension cultures. Depending on the culture conditions, the cells can be induced to differentiate to neurons or glial cells. The cultures can be expanded over a large number of passages during several months, and survive, express an astroglial phenotype and integrate well after transplantation into both neonatal and adult rat forebrain.

    Abstract translation: 对胶质纤维酸性蛋白（GFAP）以及中间丝标记物巢蛋白免疫反应性细胞的培养物在包括表皮生长因子（EGF）和血清的培养基中生长。 培养的细胞具有星形胶质细胞的形态。 细胞可以在粘附或悬浮培养物中增殖。 根据培养条件，可诱导细胞分化为神经元或神经胶质细胞。 文化可以在几个月内扩大大量的传代，并且生存，表达一种星形胶质细胞表型，并在移植后并入新生大鼠和成年大鼠前脑中。

    Trading System for Handling an Order Matrix
    8.
    发明申请
    Trading System for Handling an Order Matrix 审中-公开
    处理订单矩阵的交易系统

    公开(公告)号：US20090099952A1

    公开(公告)日：2009-04-16

    申请号：US11871231

    申请日：2007-10-12

    Applicant: Lars Wahlberg

    Inventor： Lars Wahlberg

    IPC: G06Q40/00

    CPC classification number: G06Q40/06 ,  G06Q40/00 ,  G06Q40/04

    Abstract: An exchange system and a method for trading orders on an exchange market and a related broker workstation. One or more user defined order matrixes allows a user to design a trading strategy by manually, or by means of algorithms using current and/or historical market data, determine trading parameters such as part order size, price level, time delay between consecutive part orders. An order having a total volume and at least one such order matrix associated therewith is received from a market participant. The order matrix specifies predetermined portions of the order's total volume. A first portion of the order's total volume is determined in accordance with the order matrix and information is sent to display the that portion to the market. A next portion of the order's total volume is generated in accordance with the order matrix and information is then sent to display that portion to the market.

    Abstract translation: 交易系统和交易市场交易订单和相关经纪人工作站的方法。 一个或多个用户定义的订单矩阵允许用户通过手动或通过使用当前和/或历史市场数据的算法来设计交易策略，确定交易参数，例如部分订单大小，价格水平，连续订单之间的时间延迟 。 从市场参与者接收具有总体积的顺序和与其相关联的至少一个这样的订单矩阵。 订单矩阵指定订单总体积的预定部分。 根据订单矩阵确定订单总体积的第一部分，并发送信息以将该部分显示在市场上。 根据订单矩阵生成订单总体积的下一部分，然后发送信息以将该部分显示在市场上。

    Cultures of GFAP+ nestin+ cells that differentiate to neurons
    9.
    发明授权
    Cultures of GFAP+ nestin+ cells that differentiate to neurons 有权
    培养分化为神经元的GFAP + nestin +细胞

    公开(公告)号：US07651853B2

    公开(公告)日：2010-01-26

    申请号：US11932349

    申请日：2007-10-31

    Applicant: Lars Wahlberg ,  Kenneth Campbell ,  Charlotta Skogh ,  Cecilia Eriksson ,  Klas Wictorin

    Inventor： Lars Wahlberg ,  Kenneth Campbell ,  Charlotta Skogh ,  Cecilia Eriksson ,  Klas Wictorin

    IPC: C12N5/00 ,  C12N5/02 ,  C12N5/06 ,  C12N5/08

    CPC classification number: C12N5/0622 ,  A61K35/12 ,  C12N5/0619 ,  C12N5/0623 ,  C12N2500/90 ,  C12N2501/11

    Abstract: Cultures of cells immunoreactive for glial fibrillary acidic protein (GFAP), as well as for the intermediate filament marker nestin were grown in a medium including epidermal growth factor (EGF) and serum. The cultured cells had the morphology of astroglial cells. The cells can be proliferated in adherent or suspension cultures. Depending on the culture conditions, the cells can be induced to differentiate to neurons or glial cells. The cultures can be expanded over a large number of passages during several months, and survive, express an astroglial phenotype and integrate well after transplantation into both neonatal and adult rat forebrain.

    Abstract translation: 对胶质纤维酸性蛋白（GFAP）以及中间丝标记物巢蛋白免疫反应性细胞的培养物在包括表皮生长因子（EGF）和血清的培养基中生长。 培养的细胞具有星形胶质细胞的形态。 细胞可以在粘附或悬浮培养物中增殖。 根据培养条件，可诱导细胞分化为神经元或神经胶质细胞。 文化可以在几个月内扩大大量的传代，并且生存，表达一种星形胶质细胞表型，并在移植后并入新生大鼠和成年大鼠前脑中。

    Cultures of GFAP+ nestin+ cells that differentiate to neurons
    10.
    发明授权
    Cultures of GFAP+ nestin+ cells that differentiate to neurons 有权
    培养分化为神经元的GFAP + nestin +细胞

    公开(公告)号：US06878543B1

    公开(公告)日：2005-04-12

    申请号：US09696530

    申请日：2000-10-24

    Applicant: Lars Wahlberg ,  Kenneth Campbell ,  Charlotta Skogh ,  Cecilia Eriksson ,  Klas Wictorin

    Inventor： Lars Wahlberg ,  Kenneth Campbell ,  Charlotta Skogh ,  Cecilia Eriksson ,  Klas Wictorin

    IPC: A61K35/12 ,  C12N5/079 ,  C12N5/0793 ,  C12N5/0797 ,  C12N5/06 ,  C12N5/08

    CPC classification number: C12N5/0622 ,  A61K35/12 ,  C12N5/0619 ,  C12N5/0623 ,  C12N2500/90 ,  C12N2501/11

    Abstract: Cultures of cells immunoreactive for glial fibrillary acidic protein (GFAP), as well as for the intermediate filament marker nestin were grown in a medium including epidermal growth factor (EGF) and serum. The cultured cells had the morphology of astroglial cells. The cells can be proliferated in adherent or suspension cultures. Depending on the culture conditions, the cells can be induced to differentiate to neurons or glial cells. The cultures can be expanded over a large number of passages during several months, and survive, express an astroglial phenotype and integrate well after transplantation into both neonatal and adult rat forebrain.

    Abstract translation: 对胶质纤维酸性蛋白（GFAP）以及中间丝标记物巢蛋白免疫反应性细胞的培养物在包括表皮生长因子（EGF）和血清的培养基中生长。 培养的细胞具有星形胶质细胞的形态。 细胞可以在粘附或悬浮培养物中增殖。 根据培养条件，可诱导细胞分化为神经元或神经胶质细胞。 文化可以在几个月内扩大大量的传代，并且生存，表达一种星形胶质细胞表型，并在移植后并入新生大鼠和成年大鼠前脑中。

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