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1.发明申请TRICYCLIC COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. 审中-公开三氯化合物，其制备方法和含有它们的药物组合物。公开(公告)号：US20110112104A1
公开(公告)日：2011-05-12
申请号：US12737436
申请日：2009-07-10
IPC分类号： A61K31/4985 , C07D471/14 , C07D241/36 , A61K31/498 , A61P35/00
CPC分类号： C07D471/04 , C07D487/04
摘要： Compounds of formula (I): wherein: A represents a 5, 6 or 7-membered (hetero)aromatic or non-aromatic ring, Z1, Z2 and Z3 each independently of the others represents a CH group or a nitrogen atom, it being understood that at least one of these three groups is a nitrogen atom, X represents an alkylene chain as defined in the description, R2 represents an aryl or heteroaryl group, the group R1 represents a group of formula (II) as defined in the description Medicinal products containing the same which are useful in treating conditions involving a defect in apoptosis.
摘要翻译： 式（I）化合物：其中：A表示5,6或7-元（杂）芳族或非芳族环，Z 1，Z 2和Z 3各自独立地表示CH基团或氮原子， 理解为这三个基团中的至少一个是氮原子，X表示如说明书中所定义的亚烷基链，R 2表示芳基或杂芳基，基团R 1表示如描述中所定义的式（II）基团 含有该物质的产品可用于治疗涉及凋亡缺陷的病症。
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2.发明申请Tricyclic compounds, a process for their preparation and pharmaceutical compositions containing them 审中-公开三环化合物，其制备方法和含有它们的药物组合物公开(公告)号：US20080188460A1
公开(公告)日：2008-08-07
申请号：US12011225
申请日：2008-01-24
IPC分类号： A61K31/55 , C07D241/36 , A61K31/4985 , C07D285/20 , A61K31/5377 , A61P35/00 , A61K31/541 , C07D295/00 , A61K31/5415 , C07D223/02
CPC分类号： C07D471/04 , C07D487/04
摘要： Compounds of formula (I): wherein A represents a 5, 6 or 7-membered (hetero)aromatic or non-aromatic ring, n and n′ represent 0, 1 or 2 X represents an alkylene chain as defined in the description, R3 represents an aryl or heteroaryl group, one of the groups R1 and R2 represents a hydrogen atom and the other represents a group of formula (II) as defined in the description. Medicinal products containing the same which are useful in treating conditions involving a defect in apoptosis.
摘要翻译： 式（I）化合物：其中A表示5,6或7-元（杂）芳族或非芳族环，n和n'表示0,1或2 X表示如说明书中所定义的亚烷基链，R 3 表示芳基或杂芳基，基团R 1和R 2中的一个表示氢原子，另一个表示式 （II）。 含有该药物的药物可用于治疗涉及凋亡缺陷的病症。
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3.发明申请Peptides Which Interact with Anti-Apoptotic Members of the BCL-2 Protein Family, and Uses 失效与BCL-2蛋白家族的抗凋亡成员相互作用的肽及其用途公开(公告)号：US20090325883A1
公开(公告)日：2009-12-31
申请号：US11883400
申请日：2006-01-31
IPC分类号： A61K38/16 , C07K14/00 , C07H21/00 , C07H21/04 , C12N15/63 , C12N1/21 , C12N5/10 , G01N33/566
CPC分类号： C07K14/4747
摘要： The invention lies within the field of seeking out and identifying new peptides which interact with anti-apoptotic members of the Bcl-2 protein family, by means of the two-hybrid system.The invention relates to a method of screening and identifying modulators of the protein interaction between those new peptides and anti-apoptotic members of the Bcl-2 protein family. The modulators identified on the basis of this method are administered to patients with cancer in order to bring about apoptotic-type and/or autophagic-type programmed cell death in those patients.
摘要翻译： 本发明在寻求和鉴定与Bcl-2蛋白家族的抗凋亡成员相互作用的新型肽的领域中，借助于双杂交系统。 本发明涉及筛选和鉴定这些新肽和Bcl-2蛋白家族的抗凋亡成员之间的蛋白质相互作用的调节剂的方法。 基于该方法鉴定的调节剂被施用于患有癌症的患者，以便在那些患者中引起凋亡型和/或自噬型程序性细胞死亡。
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公开(公告)号：US20060183688A1
公开(公告)日：2006-08-17
申请号：US10566668
申请日：2004-08-04
CPC分类号： C07K14/4747 , C07K14/4702
摘要： The invention relates to the identification of a new peptide interacting with the anti-apoptotic proteins Bcl-2, Bcl-W and/or Bcl-XL, and also to screening methods allowing identification of modifiers of those interactions.
摘要翻译： 本发明涉及鉴定与抗凋亡蛋白Bcl-2，Bcl-W和/或Bcl-XL相互作用的新肽，以及鉴定这些相互作用的改性剂的筛选方法。
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5.发明申请UBIQUITIN SPECIFIC PROTEASES RESPONSIBLE FOR MCL-1 STABILITY AND USES THEREOF 审中-公开UBIQUITIN对MCL-1稳定性及其用途负有责任的特定保护公开(公告)号：US20110237644A1
公开(公告)日：2011-09-29
申请号：US12998525
申请日：2009-10-29
CPC分类号： G01N33/5011 , A61K38/00 , C12Q1/37
摘要： Use of a polypeptide selected from the group consisting of USP13, USP26, USP38, USP42 or USP46 as a screening tool for an agent for treating cancer.
摘要翻译： 使用选自USP13，USP26，USP38，USP42或USP46的多肽作为治疗癌症的药物的筛选工具。
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6.发明授权Peptides which interact with anti-apoptotic members of the Bcl-2 protein family, and uses 失效与Bcl-2蛋白家族的抗凋亡成员相互作用的肽和用途公开(公告)号：US07927813B2
公开(公告)日：2011-04-19
申请号：US11883400
申请日：2006-01-31
CPC分类号： C07K14/4747
摘要： The invention relates to a method of screening and identifying modulators of the protein interaction between new peptides and anti-apoptotic members of the Bcl-2 protein family. The modulators identified on the basis of this method are administered to patients with cancer in order to bring about apoptotic-type and/or autophagic-type programmed cell death in those patients.
摘要翻译： 本发明涉及筛选和鉴定Bcl-2蛋白家族的新肽和抗凋亡成员之间的蛋白质相互作用的调节剂的方法。 基于该方法鉴定的调节剂被施用于患有癌症的患者，以便在那些患者中引起凋亡型和/或自噬型程序性细胞死亡。
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7.发明申请Motif of the Beclin Protein Which Interacts with Anti-Apoptotic Members of the Bcl-2 Protein Family, and Uses 失效与Bcl-2蛋白家族的抗凋亡成员相互作用的Beclin蛋白的主题及其用途公开(公告)号：US20090099072A1
公开(公告)日：2009-04-16
申请号：US11883438
申请日：2006-01-31
CPC分类号： G01N33/57496 , C07K14/4747 , G01N33/542 , G01N2510/00
摘要： The invention relates to a method of identifying modulators of programmed cell death, comprising an interaction between a motif of Beclin protein and an anti-apoptotic member of the family of Bcl-2 proteins and the detection of said interaction be means of fluorescence polarisation. The modulators identified on the basis of said method are administered to cancer patients in order to induce apoptotic- and/or autophagic-type programmed cell death. The invention also relates to a motif of the Beclin protein which can interact with an anti-apoptic member of the family of Bcl-2 proteins and to the use thereof in order to induce programmed cell death in a cancer patient.
摘要翻译： 本发明涉及鉴定程序性细胞死亡调节剂的方法，其包括Beclin蛋白的基序与Bcl-2蛋白家族的抗凋亡成员之间的相互作用以及所述相互作用的检测是荧光偏振的手段。 基于所述方法鉴定的调节剂被施用于癌症患者以诱导凋亡和/或自噬型程序性细胞死亡。 本发明还涉及可与Bcl-2蛋白家族的抗宿主成分相互作用的Beclin蛋白的主题及其在癌症患者中诱导程序性细胞死亡的用途。
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公开(公告)号：US07459434B2
公开(公告)日：2008-12-02
申请号：US10566668
申请日：2004-08-04
CPC分类号： C07K14/4747 , C07K14/4702
摘要： The invention relates to the identification of a new peptide interacting with the anti-apoptotic proteins Bcl-2, Bcl-W and/or Bcl-XL, and also to screening methods allowing identification of modifiers of those interactions.
摘要翻译： 本发明涉及鉴定与抗凋亡蛋白Bcl-2，Bcl-W和/或Bcl-XL相互作用的新肽，以及鉴定这些相互作用的改性剂的筛选方法。
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9.发明授权Motif of the beclin protein which interacts with anti-apoptotic members of the Bcl-2 protein family, and uses 失效与Bcl-2蛋白家族的抗凋亡成员相互作用的beclin蛋白的主题和用途公开(公告)号：US07919233B2
公开(公告)日：2011-04-05
申请号：US11883438
申请日：2006-01-31
IPC分类号： G01N33/574 , G01N33/53
CPC分类号： G01N33/57496 , C07K14/4747 , G01N33/542 , G01N2510/00
摘要： The invention relates to a method of identifying modulators of programmed cell death, comprising an interaction between a motif of Beclin protein and an anti-apoptotic member of the family of Bcl-2 proteins and the detection of said interaction be means of fluorescence polarization. The modulators identified on the basis of said method are administered to cancer patients in order to induce apoptotic- and/or autophagic-type programmed cell death. The invention also relates to a motif of the Beclin protein which can interact with an anti-apoptic member of the family of Bcl-2 proteins and to the use thereof in order to induce programmed cell death in a cancer patient.
摘要翻译： 本发明涉及鉴定程序性细胞死亡调节剂的方法，其包括Beclin蛋白的基序与Bcl-2蛋白家族的抗凋亡成员之间的相互作用以及所述相互作用的检测是荧光偏振的手段。 基于所述方法鉴定的调节剂被施用于癌症患者以诱导凋亡和/或自噬型程序性细胞死亡。 本发明还涉及可与Bcl-2蛋白家族的抗宿主成分相互作用的Beclin蛋白的主题及其在癌症患者中诱导程序性细胞死亡的用途。
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