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公开(公告)号：US08318109B2
公开(公告)日：2012-11-27
申请号：US12685582
申请日：2010-01-11
申请人： Patrick Saltsman , Mingchao Shen , Jeffrey M. Houkal , Christy A. Lancaster , C. Frederick Battrell , Bernhard H. Weigl
发明人： Patrick Saltsman , Mingchao Shen , Jeffrey M. Houkal , Christy A. Lancaster , C. Frederick Battrell , Bernhard H. Weigl
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01F5/0473 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01L3/5027 , B01L3/502715 , B01L3/502723 , B01L3/502738 , B01L3/502753 , B01L2200/0621 , B01L2200/10 , B01L2300/0636 , B01L2300/0681 , B01L2300/0861 , B01L2300/0867 , B01L2300/1805 , B01L2400/0406 , B01L2400/0481 , B01L2400/0487 , B01L2400/049 , B01L2400/0605 , B01L2400/0633 , F04B43/043 , G01N33/5304 , G01N33/80
摘要： The present invention relates to microfluidic devices and methods for manipulating and analyzing fluid samples. The disclosed microfluidic devices utilize a plurality of microfluidic channels, inlets, valves, filter, pumps, liquid barriers and other elements arranged in various configurations to manipulate the flow of a fluid sample in order to prepare such sample for analysis.
摘要翻译： 本发明涉及用于操纵和分析流体样品的微流体装置和方法。 所公开的微流体装置利用多个微流体通道，入口，阀，过滤器，泵，液体屏障和以各种配置布置的其它元件来操纵流体样品的流动，以制备用于分析的样品。
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公开(公告)号：US20120064612A1
公开(公告)日：2012-03-15
申请号：US13225280
申请日：2011-09-02
申请人： Patrick Saltsman , Mingchao Shen , Jeffrey M. Houkal , Christy A. Lancaster , C. Frederick Battrell , Bernhard H. Weigl
发明人： Patrick Saltsman , Mingchao Shen , Jeffrey M. Houkal , Christy A. Lancaster , C. Frederick Battrell , Bernhard H. Weigl
IPC分类号： C12M1/34
CPC分类号： B01L3/50273 , B01F5/0473 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01L3/5027 , B01L3/502715 , B01L3/502723 , B01L3/502738 , B01L3/502753 , B01L2200/0621 , B01L2200/10 , B01L2300/0636 , B01L2300/0681 , B01L2300/0861 , B01L2300/0867 , B01L2300/1805 , B01L2400/0406 , B01L2400/0481 , B01L2400/0487 , B01L2400/049 , B01L2400/0605 , B01L2400/0633 , F04B43/043 , G01N33/5304 , G01N33/80
摘要： The present invention relates to microfluidic devices and methods for manipulating and analyzing fluid samples. The disclosed microfluidic devices utilize a plurality of microfluidic channels, inlets, valves, filter, pumps, liquid barriers and other elements arranged in various configurations to manipulate the flow of a fluid sample in order to prepare such sample for analysis.
摘要翻译： 本发明涉及用于操纵和分析流体样品的微流体装置和方法。 所公开的微流体装置利用多个微流体通道，入口，阀，过滤器，泵，液体屏障和以各种配置布置的其它元件来操纵流体样品的流动，以制备用于分析的样品。
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公开(公告)号：US07419638B2
公开(公告)日：2008-09-02
申请号：US10870717
申请日：2004-06-17
申请人： Patrick Saltsman , Mingchao Shen , Jeffrey M Houkal , Christy A Lancaster , C. Frederick Battrell , Bernhard H Weigl
发明人： Patrick Saltsman , Mingchao Shen , Jeffrey M Houkal , Christy A Lancaster , C. Frederick Battrell , Bernhard H Weigl
CPC分类号： B01L3/50273 , B01F5/0473 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01L3/5027 , B01L3/502715 , B01L3/502723 , B01L3/502738 , B01L3/502753 , B01L2200/0621 , B01L2200/10 , B01L2300/0636 , B01L2300/0681 , B01L2300/0861 , B01L2300/0867 , B01L2300/1805 , B01L2400/0406 , B01L2400/0481 , B01L2400/0487 , B01L2400/049 , B01L2400/0605 , B01L2400/0633 , F04B43/043 , G01N33/5304 , G01N33/80
摘要： The present invention relates to microfluidic devices and methods for manipulating and analyzing fluid samples. The disclosed microfluidic devices utilize a plurality of microfluidic channels, inlets, valves, filter, pumps, liquid barriers and other elements arranged in various configurations to manipulate the flow of a fluid sample in order to prepare such sample for analysis.
摘要翻译： 本发明涉及用于操纵和分析流体样品的微流体装置和方法。 所公开的微流体装置利用多个微流体通道，入口，阀，过滤器，泵，液体屏障和以各种配置布置的其它元件来操纵流体样品的流动，以制备用于分析的样品。
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公开(公告)号：US08557198B2
公开(公告)日：2013-10-15
申请号：US13225280
申请日：2011-09-02
申请人： Patrick Saltsman , Mingchao Shen , Jeffrey M. Houkal , Christy A. Lancaster , C. Frederick Battrell , Bernhard H. Weigl
发明人： Patrick Saltsman , Mingchao Shen , Jeffrey M. Houkal , Christy A. Lancaster , C. Frederick Battrell , Bernhard H. Weigl
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01F5/0473 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01L3/5027 , B01L3/502715 , B01L3/502723 , B01L3/502738 , B01L3/502753 , B01L2200/0621 , B01L2200/10 , B01L2300/0636 , B01L2300/0681 , B01L2300/0861 , B01L2300/0867 , B01L2300/1805 , B01L2400/0406 , B01L2400/0481 , B01L2400/0487 , B01L2400/049 , B01L2400/0605 , B01L2400/0633 , F04B43/043 , G01N33/5304 , G01N33/80
摘要： The present invention relates to microfluidic devices and methods for manipulating and analyzing fluid samples. The disclosed microfluidic devices utilize a plurality of microfluidic channels, inlets, valves, filter, pumps, liquid barriers and other elements arranged in various configurations to manipulate the flow of a fluid sample in order to prepare such sample for analysis.
摘要翻译： 本发明涉及用于操纵和分析流体样品的微流体装置和方法。 所公开的微流体装置利用多个微流体通道，入口，阀，过滤器，泵，液体屏障和以各种配置布置的其它元件来操纵流体样品的流动，以制备用于分析的样品。
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公开(公告)号：US20100173395A1
公开(公告)日：2010-07-08
申请号：US12685582
申请日：2010-01-11
申请人： Patrick Saltsman , Mingchao Shen , Jeffrey M. Houkal , Christy A. Lancaster , C. Frederick Battrell , Bernhard H. Weigl
发明人： Patrick Saltsman , Mingchao Shen , Jeffrey M. Houkal , Christy A. Lancaster , C. Frederick Battrell , Bernhard H. Weigl
CPC分类号： B01L3/50273 , B01F5/0473 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01L3/5027 , B01L3/502715 , B01L3/502723 , B01L3/502738 , B01L3/502753 , B01L2200/0621 , B01L2200/10 , B01L2300/0636 , B01L2300/0681 , B01L2300/0861 , B01L2300/0867 , B01L2300/1805 , B01L2400/0406 , B01L2400/0481 , B01L2400/0487 , B01L2400/049 , B01L2400/0605 , B01L2400/0633 , F04B43/043 , G01N33/5304 , G01N33/80
摘要： The present invention relates to microfluidic devices and methods for manipulating and analyzing fluid samples. The disclosed microfluidic devices utilize a plurality of microfluidic channels, inlets, valves, filter, pumps, liquid barriers and other elements arranged in various configurations to manipulate the flow of a fluid sample in order to prepare such sample for analysis.
摘要翻译： 本发明涉及用于操纵和分析流体样品的微流体装置和方法。 所公开的微流体装置利用多个微流体通道，入口，阀，过滤器，泵，液体屏障和以各种配置布置的其它元件来操纵流体样品的流动，以制备用于分析的样品。
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公开(公告)号：US20090022624A1
公开(公告)日：2009-01-22
申请号：US12182434
申请日：2008-07-30
申请人： Patrick Saltsman , Mingchao Shen , Jeffrey M. Houkal , Christy A. Lancaster , C. Frederick Battrell , Bernhard H. Weigl
发明人： Patrick Saltsman , Mingchao Shen , Jeffrey M. Houkal , Christy A. Lancaster , C. Frederick Battrell , Bernhard H. Weigl
CPC分类号： B01L3/50273 , B01F5/0473 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01L3/5027 , B01L3/502715 , B01L3/502723 , B01L3/502738 , B01L3/502753 , B01L2200/0621 , B01L2200/10 , B01L2300/0636 , B01L2300/0681 , B01L2300/0861 , B01L2300/0867 , B01L2300/1805 , B01L2400/0406 , B01L2400/0481 , B01L2400/0487 , B01L2400/049 , B01L2400/0605 , B01L2400/0633 , F04B43/043 , G01N33/5304 , G01N33/80
摘要： The present invention relates to microfluidic devices and methods for manipulating and analyzing fluid samples. The disclosed microfluidic devices utilize a plurality of microfluidic channels, inlets, valves, filter, pumps, liquid barriers and other elements arranged in various configurations to manipulate the flow of a fluid sample in order to prepare such sample for analysis.
摘要翻译： 本发明涉及用于操纵和分析流体样品的微流体装置和方法。 所公开的微流体装置利用多个微流体通道，入口，阀，过滤器，泵，液体屏障和以各种配置布置的其它元件来操纵流体样品的流动，以制备用于分析的样品。
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7.发明授权Method and system for microfluidic manipulation, amplification and analysis of fluids, for example, bacteria assays and antiglobulin testing 有权用于流体微流控操作，扩增和分析的方法和系统，例如细菌测定和抗球蛋白测试公开(公告)号：US07416892B2
公开(公告)日：2008-08-26
申请号：US10762586
申请日：2004-01-21
申请人： C. Frederick Battrell , Mingchao Shen , Bernhard H. Weigl , Jeffrey M. Houkal , Christy A. Lancaster , Wayne Breidford
发明人： C. Frederick Battrell , Mingchao Shen , Bernhard H. Weigl , Jeffrey M. Houkal , Christy A. Lancaster , Wayne Breidford
CPC分类号： F04B43/043 , B01F5/0473 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/502753 , B01L7/52 , B01L2200/10 , B01L2300/0636 , B01L2300/0681 , B01L2300/0816 , B01L2300/0861 , B01L2300/0867 , B01L2300/1805 , B01L2400/0487 , B01L2400/0633 , C12Q1/686 , Y10T436/107497 , Y10T436/25 , Y10T436/2525 , Y10T436/25375 , C12Q2565/625 , C12Q2565/629
摘要： A microfluidic system for isolation and amplification of DNA or RNA from aqueous solutions and detection of the DNA or RNA on a lateral flow detection strip, including a disposable microfluidic card for use in analysis of bacteria in platelets and an analysis of sexually transmitted diseases (STD) in urine. The card will include an embedded membrane that filters out cells and cellular debris. Any biological debris on the membrane will be lysed and the DNA or RNA amplified via PCR amplification protocol, including appropriate reagents and thermal cycling conditions. The amplified DNA or RNA are transferred to a lateral flow detection strip for a visual diagnostic read out. An alternate embodiment includes a microfluidic card for use in typing antiglobulin assays.
摘要翻译： 一种用于从水溶液中分离和扩增DNA或RNA的微流体系统，并检测侧流检测条上的DNA或RNA，包括用于血小板中细菌分析的一次性微流控卡和性传播疾病分析（STD ）在尿液。 该卡将包括一个过滤掉细胞和细胞碎片的嵌入膜。 膜上的任何生物碎片将被裂解，并通过PCR扩增方案扩增DNA或RNA，包括适当的试剂和热循环条件。 将扩增的DNA或RNA转移到侧向流动检测条中以进行视觉诊断读出。 替代实施方案包括用于分选抗球蛋白测定的微流控卡。
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公开(公告)号：US20050106066A1
公开(公告)日：2005-05-19
申请号：US10870717
申请日：2004-06-17
申请人： Patrick Saltsman , Mingchao Shen , Jeffrey Houkal , Christy Lancaster , C. Battrell , Bernhard Weigl
发明人： Patrick Saltsman , Mingchao Shen , Jeffrey Houkal , Christy Lancaster , C. Battrell , Bernhard Weigl
CPC分类号： B01L3/50273 , B01F5/0473 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01L3/5027 , B01L3/502715 , B01L3/502723 , B01L3/502738 , B01L3/502753 , B01L2200/0621 , B01L2200/10 , B01L2300/0636 , B01L2300/0681 , B01L2300/0861 , B01L2300/0867 , B01L2300/1805 , B01L2400/0406 , B01L2400/0481 , B01L2400/0487 , B01L2400/049 , B01L2400/0605 , B01L2400/0633 , F04B43/043 , G01N33/5304 , G01N33/80
摘要： The present invention relates to microfluidic devices and methods for manipulating and analyzing fluid samples. The disclosed microfluidic devices utilize a plurality of microfluidic channels, inlets, valves, filter, pumps, liquid barriers and other elements arranged in various configurations to manipulate the flow of a fluid sample in order to prepare such sample for analysis.
摘要翻译： 本发明涉及用于操纵和分析流体样品的微流体装置和方法。 所公开的微流体装置利用多个微流体通道，入口，阀，过滤器，泵，液体屏障和以各种配置布置的其它元件来操纵流体样品的流动，以制备用于分析的样品。
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9.发明申请Method and system for microfluidic manipulation, amplification and analysis of fluids, for example, bacteria assays and antiglobulin testing 有权用于流体微流控操作，扩增和分析的方法和系统，例如细菌测定和抗球蛋白测试公开(公告)号：US20050013732A1
公开(公告)日：2005-01-20
申请号：US10762586
申请日：2004-01-21
申请人： C. Battrell , Mingchao Shen , Bernhard Weigl , Jeffrey Houkal , Christy Lancaster , Wayne Breidford
发明人： C. Battrell , Mingchao Shen , Bernhard Weigl , Jeffrey Houkal , Christy Lancaster , Wayne Breidford
CPC分类号： F04B43/043 , B01F5/0473 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/502753 , B01L7/52 , B01L2200/10 , B01L2300/0636 , B01L2300/0681 , B01L2300/0816 , B01L2300/0861 , B01L2300/0867 , B01L2300/1805 , B01L2400/0487 , B01L2400/0633 , C12Q1/686 , Y10T436/107497 , Y10T436/25 , Y10T436/2525 , Y10T436/25375 , C12Q2565/625 , C12Q2565/629
摘要： A microfluidic system for isolation and amplification of DNA or RNA from aqueous solutions and detection of the DNA or RNA on a lateral flow detection strip, including a disposable microfluidic card for use in analysis of bacteria in platelets and an analysis of sexually transmitted diseases (STD) in urine. The card will include an embedded membrane that filters out cells and cellular debris. Any biological debris on the membrane will be lysed and the DNA or RNA amplified via PCR amplification protocol, including appropriate reagents and thermal cycling conditions. The amplified DNA or RNA are transferred to a lateral flow detection strip for a visual diagnostic read out. An alternate embodiment includes a microfluidic card for use in typing antiglobulin assays.
摘要翻译： 一种用于从水溶液中分离和扩增DNA或RNA的微流体系统，并检测侧流检测条上的DNA或RNA，包括用于血小板中细菌分析的一次性微流控卡和性传播疾病分析（STD ）在尿液。 该卡将包括一个过滤掉细胞和细胞碎片的嵌入膜。 膜上的任何生物碎片将被裂解，并通过PCR扩增方案扩增DNA或RNA，包括适当的试剂和热循环条件。 将扩增的DNA或RNA转移到侧向流动检测条中以进行视觉诊断读出。 替代实施方案包括用于分选抗球蛋白测定的微流控卡。
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