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18 条记录 (耗时 0.04 秒)

    Method for producing secretable glycosyltransferases and other Golgi processing enzymes
    4.
    发明授权
    Method for producing secretable glycosyltransferases and other Golgi processing enzymes 失效
    生产可分泌糖基转移酶和其他高尔基体加工酶的方法

    公开(公告)号：US5032519A

    公开(公告)日：1991-07-16

    申请号：US426577

    申请日：1989-10-24

    申请人： James C. Paulson ,  Eryn Ujita-Lee ,  Karen J. Colley ,  Beverly Adler ,  Jeffrey K. Browne

    发明人： James C. Paulson ,  Eryn Ujita-Lee ,  Karen J. Colley ,  Beverly Adler ,  Jeffrey K. Browne

    IPC分类号： C12N9/10 ,  C12N15/09 ,  C12N15/54 ,  C12N15/55 ,  C12P19/18 ,  C12P19/26 ,  C12R1/91

    CPC分类号： C12N9/1051 ,  C12P19/18 ,  C12P19/26

    摘要： A method for genetically engineering cells to produce soluble and secretable Golgi processing enzymes instead of naturally occurring membrane-bound enzymes. Cells are genetically engineered to express glycosyltransferases which lack both a membrane anchor and a rThis invention was made with government support under Grant Contract Nos. GM-27904 and GM-11557 awarded by the National Institute of Health. The government has certain rights in this invention. The publications and other reference materials referred to herein to describe the background of the invention and to provide additional detail regarding its practice are hereby incorporated by reference. For convenience, the reference materials are numerically referenced and grouped in the appended bibliography.

    摘要翻译： 一种用于遗传工程细胞产生可溶性和可分泌的高尔基体加工酶而不是天然存在的膜结合酶的方法。 细胞被遗传工程化以表达缺少膜锚定和保留信号的糖基转移酶。 所得到的改变的酶变得可溶并且可被细胞分泌而不失去其催化活性。 由细胞分泌可溶性糖基转移酶提供增加的糖基转移酶的产生和简化的恢复。

    COMPOSITIONS AND METHODS FOR INDUCING IMMUNE TOLERANCE
    6.
    发明申请
    COMPOSITIONS AND METHODS FOR INDUCING IMMUNE TOLERANCE 有权
    用于诱导免疫耐受性的组合物和方法

    公开(公告)号：US20130171233A1

    公开(公告)日：2013-07-04

    申请号：US13261580

    申请日：2011-07-29

    申请人： James C. Paulson ,  Matthew MacAuley ,  David Nemazee

    发明人： James C. Paulson ,  Matthew MacAuley ,  David Nemazee

    IPC分类号： A61K39/385 ,  A61K9/127

    CPC分类号： A61K39/0008 ,  A61K9/127 ,  A61K39/001 ,  A61K39/35 ,  A61K39/385 ,  A61K47/6911 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/55555

    摘要： The present invention provides liposomal compositions for inducing immune tolerance. The compounds typically comprise a liposome displaying a specific antigen and also a binding moiety for a sialic acid binding Ig-like lectin (Siglec) expressed on B cells. The invention also provides methods for inducing tolerance to a protein or polypeptide antigen (e.g., a protein antigen) in a subject. The methods involve administering to the subject a pharmaceutical composition that co-presents both the antigen and a glycan ligand for a Siglec expressed on B lymphocytes.

    摘要翻译： 本发明提供用于诱导免疫耐受的脂质体组合物。 化合物通常包含显示特异性抗原的脂质体，以及用于在B细胞上表达的唾液酸结合Ig样凝集素（Siglec）的结合部分。 本发明还提供了诱导受试者中蛋白质或多肽抗原（例如，蛋白质抗原）的耐受性的方法。 所述方法包括对受试者施用共同呈递在B淋巴细胞上表达的Siglec的抗原和聚糖配体的药物组合物。

    Diagnostic evaluation, measurement, and analysis of functional activity in body organs that utilize transmembrane ion polarization and depolarization
    7.
    发明授权
    Diagnostic evaluation, measurement, and analysis of functional activity in body organs that utilize transmembrane ion polarization and depolarization 失效
    使用跨膜离子极化和去极化的身体器官功能活动的诊断评估，测量和分析

    公开(公告)号：US4307726A

    公开(公告)日：1981-12-29

    申请号：US71992

    申请日：1979-09-04

    申请人： James C. Paulson ,  Robert D. Pfeifer

    发明人： James C. Paulson ,  Robert D. Pfeifer

    IPC分类号： A61B5/05

    CPC分类号： A61B5/0507 ,  A61B5/05 ,  A61B5/4519

    摘要： Beams of coherent microwaves or other frequencies of highly directional electromagnetic radiation are passed through the living human body to detect and provide a quantitative analysis of functional activity in the central nervous system and/or in muscle tissue such as that of the heart. Organs to be analyzed are situated in the space of an electrostatic field of oscillating intensity. The directional beam is passed through a body organ situated in this way. The method is of use in detecting degenerative subcortical disease in the brain (e.g., Sulphatide Lipidosis), tissue damage to nerve fibers due to toxic chemicals, and other types of tissue-based functional abnormality. Functional condition of brain and heart generally can be readily analyzed without exposure to ionizing radiation.

    摘要翻译： 相干微波或高频定向电磁辐射的其他频率的光束通过活的人体，以检测并提供中枢神经系统和/或肌肉组织（例如心脏）的功能活性的定量分析。 要分析的器官位于振荡强度的静电场的空间中。 定向梁穿过以这种方式设置的身体器官。 该方法可用于检测大脑中的退行性皮质下疾病（例如硫酸亚油脂），由于毒性化学物质引起的对神经纤维的组织损伤以及其它类型的基于组织的功能异常。 脑和心脏的功能状况通常可以容易地分析而不暴露于电离辐射。

    Control of immune responses by modulating activity of glycosyltransferases
    9.
    发明授权
    Control of immune responses by modulating activity of glycosyltransferases 失效
    通过调节糖基转移酶的活性来控制免疫应答

    公开(公告)号：US06376475B1

    公开(公告)日：2002-04-23

    申请号：US09087117

    申请日：1998-05-29

    申请人： Jamey D. Marth ,  James C. Paulson

    发明人： Jamey D. Marth ,  James C. Paulson

    IPC分类号： C12Q148

    CPC分类号： C12N15/1137 ,  A01K67/0271 ,  A01K2217/075 ,  C12N9/1081

    摘要： The invention provides methods for inhibiting immune responses by inhibiting the biosynthesis of the sialyl galactosides that are involved in immune responses. In particular, B lymphocyte-mediated immune responses are mediated by interfering with synthesis of &agr;2,6 sialylgalactosides, while T lymphocyte-mediated immune responses are inhibited by blocking synthesis of &agr;2,3 sialylgalactosides. The inhibition is accomplished by, for example, inhibiting the activity of a glycosyltransferase involved in synthesis of the respective sialyl galactoside.

    摘要翻译： 本发明提供了通过抑制参与免疫应答的唾液酸半乳糖苷的生物合成来抑制免疫应答的方法。 特别地，通过干扰α2,6唾液酸半乳糖苷的合成来介导B淋巴细胞介导的免疫应答，而通过阻断α2,3唾液酸半乳糖苷的合成来抑制T淋巴细胞介导的免疫应答。 通过例如抑制参与合成唾液酸半乳糖苷的糖基转移酶的活性来实现抑制。

    Liposome targeting compounds and related uses
    10.
    发明授权
    Liposome targeting compounds and related uses 有权
    脂质体靶向化合物及相关用途

    公开(公告)号：US09326939B2

    公开(公告)日：2016-05-03

    申请号：US13261581

    申请日：2011-07-29

    申请人： James C. Paulson ,  Weihsu Claire Chen ,  Norihito Kawasaki ,  Corwin Nycholat

    发明人： James C. Paulson ,  Weihsu Claire Chen ,  Norihito Kawasaki ,  Corwin Nycholat

    IPC分类号： A61K9/127 ,  A61K39/00 ,  A61K31/715 ,  A61K49/00

    CPC分类号： A61K9/1271 ,  A61K9/127 ,  A61K31/715 ,  A61K39/00 ,  A61K49/0084

    摘要： The present invention provides liposome targeting compounds for targeting cells expressing sialic acid binding Ig-like lectin (Siglec). The liposome compounds typically comprise a binding moiety that is a glycan ligand of the Siglec on the target cell. The liposome compounds also incorporate or encapsulate a biological agent (e.g., an antigen or a therapeutic agent) that can be delivered to the target cell to modulate or kill the target cell. The invention also provides methods of using the liposome targeting compounds for targeted delivery of antigen and for modulating immune cells or immune responses.

    摘要翻译： 本发明提供用于靶向表达唾液酸结合Ig样凝集素（Siglec）的细胞的脂质体靶向化合物。 脂质体化合物通常包含作为靶细胞上Siglec的聚糖配体的结合部分。 脂质体化合物还掺入或包封可以递送至靶细胞以调节或杀死靶细胞的生物试剂（例如，抗原或治疗剂）。 本发明还提供了使用靶向靶向化合物靶向递送抗原和调节免疫细胞或免疫应答的方法。