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公开(公告)号：US20090110659A1
公开(公告)日：2009-04-30
申请号：US12221458
申请日：2008-08-01
IPC分类号： A61K38/19 , C07H21/04 , C12N15/64 , C12N1/21 , C12N1/15 , A61P35/00 , C07K14/00 , C12P21/00 , G01N33/53
CPC分类号： C07K16/24 , A61K38/00 , A61K47/642 , C07K14/523 , C07K14/7158 , C07K2317/76 , C07K2319/00
摘要： The invention relates to isolated and/or recombinant nucleic acids which encode a human chemotactic cytokine designated human eotaxin, and to isolated and/or recombinant human eotaxin proteins or polypeptides, including synthetic polypeptides. The invention further relates to recombinant nucleic acid constructs, comprising a nucleic acid which encodes a human eotaxin, a portion thereof, or a variant; to host cells comprising such constructs, useful for the production of recombinant human eotaxin; and to antibodies reactive with human eotaxin, useful in in vitro methods, diagnosis and/or therapy. Also provided are methods of use of the eotaxin proteins, e.g., in the recruitment of eosinophils to a particular site or in the treatment of allergic conditions. Human eotaxins can be used to identify inhibitors (e.g., antagonists) or promoters (agonists) of human eotaxin, which can be used to selectively modulate leukocyte function, in inflammatory and autoimmune diseases, or in infections.
摘要翻译： 本发明涉及编码人类趋化性细胞因子（命名为人类嗜酸细胞活化趋化因子）的分离和/或重组核酸，以及包含合成多肽的分离和/或重组人类嗜酸细胞活化趋化因子蛋白或多肽。 本发明还涉及重组核酸构建体，其包含编码人类嗜酸细胞活化趋化因子，其部分或变体的核酸; 包含可用于生产重组人类嗜酸性粒细胞趋化因子的这种构建体的宿主细胞; 以及可用于体外方法，诊断和/或治疗的与人嗜酸细胞活化趋化因子反应的抗体。 还提供了使用嗜酸细胞活化趋化因子蛋白质的方法，例如将嗜酸性粒细胞募集到特定部位或用于治疗过敏性病症。 人类嗜酸性粒细胞趋化因子可用于鉴定可用于选择性调节白细胞功能，炎性和自身免疫疾病或感染的人类嗜酸细胞活化趋化因子的抑制剂（例如拮抗剂）或启动子（激动剂）。
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公开(公告)号：US07265201B1
公开(公告)日：2007-09-04
申请号：US08494093
申请日：1995-06-23
CPC分类号： C07K16/24 , A61K38/00 , A61K47/642 , C07K14/523 , C07K14/7158 , C07K2317/76 , C07K2319/00
摘要： The present invention relates to isolated and/or recombinant nucleic acids which encode a human chemotactic cytokine designated human eotaxin, and to proteins or polypeptides referred to herein as isolated and/or recombinant human eotaxin, including synthetic polypeptides. The invention further relates to recombinant nucleic acid constructs, comprising a nucleic acid which encodes a human eotaxin of the present invention, a portion thereof, or a variant; to host cells comprising such constructs, useful for the production of recombinant human eotaxin; and to antibodies reactive with human eotaxin, which are useful in in vitro methods, diagnostic and/or therapeutic applications.Also provided are methods of use of the proteins of the present invention, for example in the recruitment of eosinophils to a particular site or in the treatment of allergic conditions. Human eotaxins can be used in assays to identify inhibitors (e.g., antagonists) or promoters (agonists) of human eotaxin function. Agents which inhibit or promote eotaxin function can be administered to an individual, providing a new approach to selective modulation of leukocyte function, which is useful in a variety of inflammatory and autoimmune diseases, or in the treatment of infections.
摘要翻译： 本发明涉及编码人类趋化性细胞因子（命名为人类嗜酸细胞活化趋化因子）的分离和/或重组核酸，以及本文称为分离和/或重组人类嗜酸细胞活化趋化因子（包括合成多肽）的蛋白质或多肽。 本发明还涉及重组核酸构建体，其包含编码本发明的人类嗜酸细胞活化趋化因子的核酸，其一部分或变体; 包含可用于生产重组人类嗜酸性粒细胞趋化因子的这种构建体的宿主细胞; 以及可用于体外方法，诊断和/或治疗应用的与人类嗜酸细胞活化趋化因子反应的抗体。 还提供了使用本发明的蛋白质的方法，例如将嗜酸性粒细胞募集到特定部位或用于治疗过敏性病症。 人类嗜酸性粒细胞趋化因子可用于测定人类嗜酸细胞活化趋化因子功能的抑制剂（例如拮抗剂）或启动子（激动剂）。 抑制或促进嗜酸细胞活化趋化因子功能的药物可以给予个体，提供了选择性调节白细胞功能的新方法，其可用于各种炎性和自身免疫性疾病，或用于治疗感染。
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公开(公告)号：US07285620B2
公开(公告)日：2007-10-23
申请号：US11133140
申请日：2005-05-19
CPC分类号： C07K16/24 , A61K38/00 , A61K47/642 , C07K14/523 , C07K14/7158 , C07K2317/76 , C07K2319/00
摘要： The invention relates to isolated and/or recombinant nucleic acids which encode a human chemotactic cytokine designated human eotaxin, and to isolated and/or recombinant human eotaxin proteins or polypeptides, including synthetic polypeptides. The invention further relates to recombinant nucleic acid constructs, comprising a nucleic acid which encodes a human eotaxin, a portion thereof, or a variant; to host cells comprising such constructs, useful for the production of recombinant human eotaxin; and to antibodies reactive with human eotaxin, useful in in vitro methods, diagnosis and/or therapy. Also provided are methods of use of the eotaxin proteins, e.g., in the recruitment of eosinophils to a particular site or in the treatment of allergic conditions. Human eotaxins can be used to identify inhibitors (e.g., antagonists) or promoters (agonists) of human eotaxin, which can be used to selectively modulate leukocyte function, in inflammatory and autoimmune diseases, or in infections.
摘要翻译： 本发明涉及编码人类趋化性细胞因子（命名为人类嗜酸细胞活化趋化因子）的分离和/或重组核酸，以及包含合成多肽的分离和/或重组人类嗜酸细胞活化趋化因子蛋白或多肽。 本发明还涉及重组核酸构建体，其包含编码人类嗜酸细胞活化趋化因子，其部分或变体的核酸; 包含可用于生产重组人类嗜酸性粒细胞趋化因子的这种构建体的宿主细胞; 以及可用于体外方法，诊断和/或治疗的与人嗜酸细胞活化趋化因子反应的抗体。 还提供了使用嗜酸细胞活化趋化因子蛋白质的方法，例如将嗜酸性粒细胞募集到特定部位或用于治疗过敏性病症。 人类嗜酸性粒细胞趋化因子可用于鉴定可用于选择性调节白细胞功能，炎性和自身免疫疾病或感染的人类嗜酸细胞活化趋化因子的抑制剂（例如拮抗剂）或启动子（激动剂）。
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4.发明授权公开(公告)号：US07858326B2
公开(公告)日：2010-12-28
申请号：US12221458
申请日：2008-08-01
IPC分类号： G01N33/53 , G01N33/567
CPC分类号： C07K16/24 , A61K38/00 , A61K47/642 , C07K14/523 , C07K14/7158 , C07K2317/76 , C07K2319/00
摘要： The invention relates to isolated and/or recombinant nucleic acids which encode a human chemotactic cytokine designated human eotaxin, and to isolated and/or recombinant human eotaxin proteins or polypeptides, including synthetic polypeptides. The invention further relates to recombinant nucleic acid constructs, comprising a nucleic acid which encodes a human eotaxin, a portion thereof, or a variant; to host cells comprising such constructs, useful for the production of recombinant human eotaxin; and to antibodies reactive with human eotaxin, useful in in vitro methods, diagnosis and/or therapy. Also provided are methods of use of the eotaxin proteins, e.g., in the recruitment of eosinophils to a particular site or in the treatment of allergic conditions. Human eotaxins can be used to identify inhibitors (e.g., antagonists) or promoters (agonists) of human eotaxin, which can be used to selectively modulate leukocyte function, in inflammatory and autoimmune diseases, or in infections.
摘要翻译： 本发明涉及编码人类趋化性细胞因子（命名为人类嗜酸细胞活化趋化因子）的分离和/或重组核酸，以及包含合成多肽的分离和/或重组人类嗜酸细胞活化趋化因子蛋白或多肽。 本发明还涉及重组核酸构建体，其包含编码人类嗜酸细胞活化趋化因子，其部分或变体的核酸; 包含可用于生产重组人类嗜酸性粒细胞趋化因子的这种构建体的宿主细胞; 以及可用于体外方法，诊断和/或治疗的与人嗜酸细胞活化趋化因子反应的抗体。 还提供了使用嗜酸细胞活化趋化因子蛋白质的方法，例如将嗜酸性粒细胞募集到特定部位或用于治疗过敏性病症。 人类嗜酸性粒细胞趋化因子可用于鉴定可用于选择性调节白细胞功能，炎性和自身免疫疾病或感染的人类嗜酸细胞活化趋化因子的抑制剂（例如拮抗剂）或启动子（激动剂）。
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公开(公告)号：US07423129B2
公开(公告)日：2008-09-09
申请号：US11900700
申请日：2007-09-13
CPC分类号： C07K16/24 , A61K38/00 , A61K47/642 , C07K14/523 , C07K14/7158 , C07K2317/76 , C07K2319/00
摘要： The invention relates to isolated and/or recombinant nucleic acids which encode a human chemotactic cytokine designated human eotaxin, and to isolated and/or recombinant human eotaxin proteins or polypeptides, including synthetic polypeptides. The invention further relates to recombinant nucleic acid constructs, comprising a nucleic acid which encodes a human eotaxin, a portion thereof, or a variant; to host cells comprising such constructs, useful for the production of recombinant human eotaxin; and to antibodies reactive with human eotaxin, useful in in vitro methods, diagnosis and/or therapy. Also provided are methods of use of the eotaxin proteins, e.g., in the recruitment of eosinophils to a particular site or in the treatment of allergic conditions. Human eotaxins can be used to identify inhibitors (e.g., antagonists) or promoters (agonists) of human eotaxin, which can be used to selectively modulate leukocyte function, in inflammatory and autoimmune diseases, or in infections.
摘要翻译： 本发明涉及编码人类趋化性细胞因子（命名为人类嗜酸细胞活化趋化因子）的分离和/或重组核酸，以及包含合成多肽的分离和/或重组人类嗜酸细胞活化趋化因子蛋白或多肽。 本发明还涉及重组核酸构建体，其包含编码人类嗜酸细胞活化趋化因子，其部分或变体的核酸; 包含可用于生产重组人类嗜酸性粒细胞趋化因子的这种构建体的宿主细胞; 以及可用于体外方法，诊断和/或治疗的与人嗜酸细胞活化趋化因子反应的抗体。 还提供了使用嗜酸细胞活化趋化因子蛋白质的方法，例如将嗜酸性粒细胞募集到特定部位或用于治疗过敏性病症。 人类嗜酸性粒细胞趋化因子可用于鉴定可用于选择性调节白细胞功能，炎性和自身免疫疾病或感染的人类嗜酸细胞活化趋化因子的抑制剂（例如拮抗剂）或启动子（激动剂）。
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公开(公告)号：US07147851B1
公开(公告)日：2006-12-12
申请号：US08700737
申请日：1996-08-15
申请人： Paul D. Ponath , Douglas J. Ringler , S. Tarran Jones , Walter Newman , José Saldanha , Mary M. Bendig
发明人： Paul D. Ponath , Douglas J. Ringler , S. Tarran Jones , Walter Newman , José Saldanha , Mary M. Bendig
IPC分类号： A61K39/395 , C07K16/28 , C07K16/18
CPC分类号： C07K16/2839 , A61K38/00 , C07K14/70503 , C07K2317/24 , C07K2319/00
摘要： The present invention relates to humanized immunoglobulins having binding specificity for α4β7 integrin, comprising an antigen binding region of nonhuman origin (e.g., rodent) and at least a portion of an immunoglobulin of human origin (e.g., a human framework region, a human constant region). In one embodiment, the humanized immunoglobulin can compete with murine Act-1 for binding to human α4β7 integrin. In a preferred embodiment, the antigen binding region of the humanized immunoglobulin comprises each of the complementarity determining regions of the light and heavy chains of the murine Act-1 antibody.
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公开(公告)号：US07402410B2
公开(公告)日：2008-07-22
申请号：US11511164
申请日：2006-08-28
申请人： Paul D. Ponath , Douglas J. Ringler , S. Tarran Jones , Walter Newman , José Saldanha , Mary M. Bendig
发明人： Paul D. Ponath , Douglas J. Ringler , S. Tarran Jones , Walter Newman , José Saldanha , Mary M. Bendig
CPC分类号： C07K16/2839 , A61K38/00 , C07K14/70503 , C07K2317/24 , C07K2319/00
摘要： The present invention relates to isolated nucleic acids encoding humanized immunoglobulins having binding specificity for α4β7 integrin, isolated nucleic acids encoding a humanized immunoglobulin heavy chain and isolated nucleic acids encoding a humanized light chain having binding specificity for α4β7 integrin. The invention also relates to expression vectors and host cells comprising a nucleotide sequence which encodes a humanized immunoglobulin or antigen-binding fragment thereof having binding specificity for α4β7. The invention further relates to methods of preparing a humanized immunoglobulin, humanized immunoglobulin heavy chain and humanized immunoglobulin light chain that has binding specificity for α4β7 integrin.
摘要翻译： 本发明涉及编码对α4β7整联蛋白具有结合特异性，编码人源化免疫球蛋白重链的分离的核酸和编码具有α4β7整联蛋白的结合特异性的人源化轻链的分离的核酸的分离的核酸。 本发明还涉及包含编码具有对α4β7具有结合特异性的人源化免疫球蛋白或其抗原结合片段的核苷酸序列的表达载体和宿主细胞。 本发明还涉及制备对α4β7整联蛋白具有结合特异性的人源化免疫球蛋白，人源化免疫球蛋白重链和人源化免疫球蛋白轻链的方法。
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公开(公告)号：US20090011464A1
公开(公告)日：2009-01-08
申请号：US12214304
申请日：2008-06-18
申请人： Paul D. Ponath , Douglas J. Ringler , S. Tarran Jones , Walter Newman , Jose Saldanha , Mary M. Bendig
发明人： Paul D. Ponath , Douglas J. Ringler , S. Tarran Jones , Walter Newman , Jose Saldanha , Mary M. Bendig
摘要： The present invention relates to isolated nucleic acids encoding humanized immunoglobulins having binding specificity for α4β7 integrin, isolated nucleic acids encoding a humanized immunoglobulin heavy chain and isolated nucleic acids encoding a humanized light chain having binding specificity for α4β7 integrin. The invention also relates to expression vectors and host cells comprising a nucleotide sequence which encodes a humanized immunoglobulin or antigen-binding fragment thereof having binding specificity for α4β7. The invention further relates to methods of preparing a humanized immunoglobulin, humanized immunoglobulin heavy chain and humanized immunoglobulin light chain that has binding specificity for α4β7 integrin.
摘要翻译： 本发明涉及编码对α4β7整联蛋白具有结合特异性，编码人源化免疫球蛋白重链的分离的核酸和编码具有α4β7整联蛋白的结合特异性的人源化轻链的分离的核酸的分离的核酸。 本发明还涉及包含编码具有对α4β7具有结合特异性的人源化免疫球蛋白或其抗原结合片段的核苷酸序列的表达载体和宿主细胞。 本发明还涉及制备对α4β7整联蛋白具有结合特异性的人源化免疫球蛋白，人源化免疫球蛋白重链和人源化免疫球蛋白轻链的方法。
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公开(公告)号：US20080070300A1
公开(公告)日：2008-03-20
申请号：US11900700
申请日：2007-09-13
申请人： Paul Ponath , Shixin Qin , Douglas Ringler , Walter Newman , Charles Mackay
发明人： Paul Ponath , Shixin Qin , Douglas Ringler , Walter Newman , Charles Mackay
CPC分类号： C07K16/24 , A61K38/00 , A61K47/642 , C07K14/523 , C07K14/7158 , C07K2317/76 , C07K2319/00
摘要： The invention relates to isolated and/or recombinant nucleic acids which encode a human chemotactic cytokine designated human eotaxin, and to isolated and/or recombinant human eotaxin proteins or polypeptides, including synthetic polypeptides. The invention further relates to recombinant nucleic acid constructs, comprising a nucleic acid which encodes a human eotaxin, a portion thereof, or a variant; to host cells comprising such constructs, useful for the production of recombinant human eotaxin; and to antibodies reactive with human eotaxin, useful in in vitro methods, diagnosis and/or therapy. Also provided are methods of use of the eotaxin proteins, e.g., in the recruitment of eosinophils to a particular site or in the treatment of allergic conditions. Human eotaxins can be used to identify inhibitors (e.g., antagonists) or promoters (agonists) of human eotaxin, which can be used to selectively modulate leukocyte function, in inflammatory and autoimmune diseases, or in infections.
摘要翻译： 本发明涉及编码人类趋化性细胞因子（命名为人类嗜酸细胞活化趋化因子）的分离和/或重组核酸，以及包含合成多肽的分离和/或重组人类嗜酸细胞活化趋化因子蛋白或多肽。 本发明还涉及重组核酸构建体，其包含编码人类嗜酸细胞活化趋化因子，其部分或变体的核酸; 包含可用于生产重组人类嗜酸性粒细胞趋化因子的这种构建体的宿主细胞; 以及可用于体外方法，诊断和/或治疗的与人嗜酸细胞活化趋化因子反应的抗体。 还提供了使用嗜酸细胞活化趋化因子蛋白质的方法，例如将嗜酸性粒细胞募集到特定部位或用于治疗过敏性病症。 人类嗜酸性粒细胞趋化因子可用于鉴定可用于选择性调节白细胞功能，炎性和自身免疫疾病或感染的人类嗜酸细胞活化趋化因子的抑制剂（例如拮抗剂）或启动子（激动剂）。
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公开(公告)号：US20060141567A1
公开(公告)日：2006-06-29
申请号：US11133140
申请日：2005-05-19
申请人： Paul Ponath , Shixin Qin , Douglas Ringler , Walter Newman , Charles Mackay
发明人： Paul Ponath , Shixin Qin , Douglas Ringler , Walter Newman , Charles Mackay
CPC分类号： C07K16/24 , A61K38/00 , A61K47/642 , C07K14/523 , C07K14/7158 , C07K2317/76 , C07K2319/00
摘要： The invention relates to isolated and/or recombinant nucleic acids which encode a human chemotactic cytokine designated human eotaxin, and to isolated and/or recombinant human eotaxin proteins or polypeptides, including synthetic polypeptides. The invention further relates to recombinant nucleic acid constructs, comprising a nucleic acid which encodes a human eotaxin, a portion thereof, or a variant; to host cells comprising such constructs, useful for the production of recombinant human eotaxin; and to antibodies reactive with human eotaxin, useful in in vitro methods, diagnosis and/or therapy. Also provided are methods of use of the eotaxin proteins, e.g., in the recruitment of eosinophils to a particular site or in the treatment of allergic conditions. Human eotaxins can be used to identify inhibitors (e.g., antagonists) or promoters (agonists) of human eotaxin, which can be used to selectively modulate leukocyte function, in inflammatory and autoimmune diseases, or in infections.
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