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公开(公告)号：US08188098B2
公开(公告)日：2012-05-29
申请号：US12433921
申请日：2009-05-01
申请人： Shawn David Erickson , Paul Gillespie , Kevin Richard Guertin , Prabha Saba Karnachi , Kyungjin Kim , Chun Ma , Warren William McComas , Sherrie Lynn Pietranico-Cole , Lida Qi , Jefferson Wright Tilley , Qiang Zhang
发明人： Shawn David Erickson , Paul Gillespie , Kevin Richard Guertin , Prabha Saba Karnachi , Kyungjin Kim , Chun Ma , Warren William McComas , Sherrie Lynn Pietranico-Cole , Lida Qi , Jefferson Wright Tilley , Qiang Zhang
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00
CPC分类号： C07D487/04
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗代谢疾病和病症，例如II型糖尿病。
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2.发明授权Adamantyl-pyrazole carboxamides as inhibitors of 11β-hdroxysteroid dehydrogenase 有权金刚烷基 - 吡唑甲酰胺作为11＆amp; - 类固醇脱氢酶的抑制剂公开(公告)号：US07728029B2
公开(公告)日：2010-06-01
申请号：US11717996
申请日：2007-03-14
申请人： Kevin William Anderson , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow, Jr. , Kevin Richard Guertin , Nancy-Ellen Haynes , Michael Paul Myers , Sherrie Lynn Pietranico-Cole , Lida Qi , Pamela Loreen Rossman , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Qiang Zhang
发明人： Kevin William Anderson , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow, Jr. , Kevin Richard Guertin , Nancy-Ellen Haynes , Michael Paul Myers , Sherrie Lynn Pietranico-Cole , Lida Qi , Pamela Loreen Rossman , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Qiang Zhang
IPC分类号： A61K31/4155 , A61K31/415 , A61K31/454 , A61K31/5377 , C07D231/14 , C07D401/04 , C07D413/04 , C07D403/04
CPC分类号： C07D403/04 , C07D231/12 , C07D231/16 , C07D231/38 , C07D401/04 , C07D403/02 , C07D407/14 , C07D413/04 , C07D417/04
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如II型糖尿病和代谢综合征。
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公开(公告)号：US20090286812A1
公开(公告)日：2009-11-19
申请号：US12433921
申请日：2009-05-01
申请人： Shawn David Erickson , Paul Gillespie , Kevin Richard Guertin , Prabha Saba Karnachi , Kyungjin Kim , Chun Ma , Warren William McComas , Sherrie Lynn Pietranico-Cole , Lida Qi , Jefferson Wright Tilley , Qiang Zhang
发明人： Shawn David Erickson , Paul Gillespie , Kevin Richard Guertin , Prabha Saba Karnachi , Kyungjin Kim , Chun Ma , Warren William McComas , Sherrie Lynn Pietranico-Cole , Lida Qi , Jefferson Wright Tilley , Qiang Zhang
IPC分类号： A61K31/519 , C07D487/04 , A61P3/10
CPC分类号： C07D487/04
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗代谢疾病和病症，例如II型糖尿病。
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公开(公告)号：US07790711B2
公开(公告)日：2010-09-07
申请号：US12172389
申请日：2008-07-14
申请人： Paul Gillespie , Kevin Richard Guertin , Lida Qi , Qiang Zhang
发明人： Paul Gillespie , Kevin Richard Guertin , Lida Qi , Qiang Zhang
IPC分类号： A61K31/55 , A61K31/4439 , A61K31/4155 , A61P3/10 , C07D231/02 , C07D401/06 , C07D413/02 , C07D401/04
CPC分类号： C07D231/38
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如II型糖尿病和代谢综合征。
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公开(公告)号：US20090023709A1
公开(公告)日：2009-01-22
申请号：US12172389
申请日：2008-07-14
申请人： Paul Gillespie , Kevin Richard Guertin , Lida Qi , Qiang Zhang
发明人： Paul Gillespie , Kevin Richard Guertin , Lida Qi , Qiang Zhang
IPC分类号： A61K31/55 , C07D231/02 , C07D401/06 , C07D413/02 , C07D403/02 , C07D401/04 , A61P3/10 , A61K31/4155 , A61K31/4439 , A61K31/454 , A61K31/5377
CPC分类号： C07D231/38
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如II型糖尿病和代谢综合征。
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6.发明申请Adamantyl-pyrazole carboxamides as inhibitors of 11B-hydroxysteroid dehydrogenase 有权金刚烷基 - 吡唑甲酰胺作为11B-羟基类固醇脱氢酶的抑制剂公开(公告)号：US20070225280A1
公开(公告)日：2007-09-27
申请号：US11717996
申请日：2007-03-14
申请人： Kevin William Anderson , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow , Kevin Richard Guertin , Nancy-Ellen Haynes , Michael Paul Myers , Sherrie Lynn Pietranico-Cole , Lida Qi , Pamela Loreen Rossman , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Qiang Zhang
发明人： Kevin William Anderson , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow , Kevin Richard Guertin , Nancy-Ellen Haynes , Michael Paul Myers , Sherrie Lynn Pietranico-Cole , Lida Qi , Pamela Loreen Rossman , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Qiang Zhang
IPC分类号： A61K31/541 , A61K31/496 , A61K31/454 , A61K31/4196 , A61K31/416 , C07D403/02 , C07D417/02
CPC分类号： C07D403/04 , C07D231/12 , C07D231/16 , C07D231/38 , C07D401/04 , C07D403/02 , C07D407/14 , C07D413/04 , C07D417/04
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如II型糖尿病和代谢综合征。
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公开(公告)号：US20070167622A1
公开(公告)日：2007-07-19
申请号：US11650645
申请日：2007-01-08
IPC分类号： C07D417/02
CPC分类号： C07D277/56 , C07D417/06 , C07D417/14
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如II型糖尿病和代谢综合征。
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公开(公告)号：US07645773B2
公开(公告)日：2010-01-12
申请号：US11650645
申请日：2007-01-08
IPC分类号： A61K31/4709 , A61K31/427 , C07D403/02 , C07D215/00 , C07D277/20
CPC分类号： C07D277/56 , C07D417/06 , C07D417/14
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如II型糖尿病和代谢综合征。
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公开(公告)号：US07345058B2
公开(公告)日：2008-03-18
申请号：US11395763
申请日：2006-03-31
IPC分类号： A61K31/4709 , A61K31/4155 , A61K31/415 , C07D215/08 , C07D231/12
CPC分类号： C07D401/06 , C07D231/14 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/14 , C07D409/14
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如II型糖尿病和代谢综合征。
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公开(公告)号：US20060223852A1
公开(公告)日：2006-10-05
申请号：US11395763
申请日：2006-03-31
申请人： Paul Gillespie , Robert Goodnow , Qiang Zhang
发明人： Paul Gillespie , Robert Goodnow , Qiang Zhang
IPC分类号： A61K31/4709 , A61K31/454 , C07D409/14
CPC分类号： C07D401/06 , C07D231/14 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/14 , C07D409/14
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如II型糖尿病和代谢综合征。
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