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1.发明授权Adamantyl-pyrazole carboxamides as inhibitors of 11β-hdroxysteroid dehydrogenase 有权金刚烷基 - 吡唑甲酰胺作为11＆amp; - 类固醇脱氢酶的抑制剂公开(公告)号：US07728029B2
公开(公告)日：2010-06-01
申请号：US11717996
申请日：2007-03-14
申请人： Kevin William Anderson , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow, Jr. , Kevin Richard Guertin , Nancy-Ellen Haynes , Michael Paul Myers , Sherrie Lynn Pietranico-Cole , Lida Qi , Pamela Loreen Rossman , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Qiang Zhang
发明人： Kevin William Anderson , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow, Jr. , Kevin Richard Guertin , Nancy-Ellen Haynes , Michael Paul Myers , Sherrie Lynn Pietranico-Cole , Lida Qi , Pamela Loreen Rossman , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Qiang Zhang
IPC分类号： A61K31/4155 , A61K31/415 , A61K31/454 , A61K31/5377 , C07D231/14 , C07D401/04 , C07D413/04 , C07D403/04
CPC分类号： C07D403/04 , C07D231/12 , C07D231/16 , C07D231/38 , C07D401/04 , C07D403/02 , C07D407/14 , C07D413/04 , C07D417/04
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如II型糖尿病和代谢综合征。
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公开(公告)号：US07645773B2
公开(公告)日：2010-01-12
申请号：US11650645
申请日：2007-01-08
IPC分类号： A61K31/4709 , A61K31/427 , C07D403/02 , C07D215/00 , C07D277/20
CPC分类号： C07D277/56 , C07D417/06 , C07D417/14
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如II型糖尿病和代谢综合征。
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公开(公告)号：US07345058B2
公开(公告)日：2008-03-18
申请号：US11395763
申请日：2006-03-31
IPC分类号： A61K31/4709 , A61K31/4155 , A61K31/415 , C07D215/08 , C07D231/12
CPC分类号： C07D401/06 , C07D231/14 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/14 , C07D409/14
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如II型糖尿病和代谢综合征。
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公开(公告)号：US07622492B2
公开(公告)日：2009-11-24
申请号：US11507080
申请日：2006-08-18
申请人： Bruce Lester Banner , Joseph Anthony Bilotta , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow, Jr. , Matthew Michael Hamilton , Nancy-Ellen Haynes , Agnieszka Kowalczyk , Alexander Mayweg , Michael Paul Myers , Sherrie Lynn Pietranico-Cole , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Kevin Richard Guertin
发明人： Bruce Lester Banner , Joseph Anthony Bilotta , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow, Jr. , Matthew Michael Hamilton , Nancy-Ellen Haynes , Agnieszka Kowalczyk , Alexander Mayweg , Michael Paul Myers , Sherrie Lynn Pietranico-Cole , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Kevin Richard Guertin
IPC分类号： A61K31/416 , C07D231/54
CPC分类号： C07D231/54
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如II型糖尿病和代谢综合征。
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公开(公告)号：US07652013B2
公开(公告)日：2010-01-26
申请号：US12328874
申请日：2008-12-05
IPC分类号： C07D239/47 , A61K31/513
CPC分类号： C07D239/47
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗诸如肥胖的疾病。
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6.发明申请BIARYLOXYMETHYLARENECARBOXYLIC ACIDS AS GLYCOGEN SYNTHASE ACTIVATORS 审中-公开作为GLYCOGEN SYNTHASE激活剂的双缩醛甲基胆碱公开(公告)号：US20090156635A1
公开(公告)日：2009-06-18
申请号：US12371681
申请日：2009-02-16
IPC分类号： A61K31/4709 , C07D401/10 , A61P3/10
CPC分类号： C07C65/24 , C07C51/09 , C07D213/30 , C07D213/61 , C07D213/64 , C07D213/79 , C07D215/06 , C07D215/14 , C07D231/12 , C07D261/08 , C07D277/56 , C07D307/42 , C07D317/54 , C07D319/08 , C07D333/16 , C07D401/12 , C07D409/12 , C07D417/12 , C07C59/66
摘要： The present invention relates to compounds of formula (I) wherein Ar, Ar2, R2, R3, R4, m, p and s are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases that are associated with the activation of the glycogen synthase enzyme, such as diabetes.
摘要翻译： 本发明涉及其中Ar，Ar 2，R 2，R 3，R 4，m，p和s如说明书和权利要求书中所定义的式（I）化合物及其药学上可接受的盐。 该化合物可用于治疗和/或预防与糖原合成酶如糖尿病的活化相关的疾病。
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公开(公告)号：US08263656B2
公开(公告)日：2012-09-11
申请号：US12540839
申请日：2009-08-13
申请人： Fariborz Firooznia , Paul Gillespie , Robert Alan Goodnow, Jr. , Tai-An Lin , Achyutharao Sidduri , Sung-Sau So , Jenny Tan
发明人： Fariborz Firooznia , Paul Gillespie , Robert Alan Goodnow, Jr. , Tai-An Lin , Achyutharao Sidduri , Sung-Sau So , Jenny Tan
IPC分类号： A61K31/195 , C07C317/12
CPC分类号： C07C311/29 , C07C311/20 , C07C317/14 , C07C2602/10 , C07D213/34
摘要： The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein R1-R4 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐和酯，其中R 1 -R 4在详细描述和权利要求书中定义。 此外，本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂，可用于治疗与该受体相关的疾病和病症如哮喘。
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公开(公告)号：US20100041760A1
公开(公告)日：2010-02-18
申请号：US12540780
申请日：2009-08-13
申请人： Jean-Baptiste Blanc , Li Chen , Fariborz Firooznia , Paul Gillespie , Robert Alan Goodnow, JR. , Tai-An Lin , Song Pan , Sung-Sau So , HongYing Yun
发明人： Jean-Baptiste Blanc , Li Chen , Fariborz Firooznia , Paul Gillespie , Robert Alan Goodnow, JR. , Tai-An Lin , Song Pan , Sung-Sau So , HongYing Yun
IPC分类号： A61K31/18 , C07C311/00
CPC分类号： C07D295/08 , C07C311/20 , C07C311/29 , C07C311/43 , C07C317/14 , C07C323/66 , C07C323/67 , C07C2601/02 , C07C2601/08 , C07C2602/10
摘要： The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein R1, R2 and R3 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐和酯，其中R 1，R 2和R 3在详细描述和权利要求书中定义。 此外，本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂，可用于治疗与该受体相关的疾病和病症如哮喘。
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公开(公告)号：US20100041713A1
公开(公告)日：2010-02-18
申请号：US12540839
申请日：2009-08-13
申请人： Fariborz Firooznia , Paul Gillespie , Robert Alan Goodnow, JR. , Tai-An Lin , Achyutharao Sidduri , Sung-Sau So , Jenny Tan
发明人： Fariborz Firooznia , Paul Gillespie , Robert Alan Goodnow, JR. , Tai-An Lin , Achyutharao Sidduri , Sung-Sau So , Jenny Tan
IPC分类号： A61K31/18 , C07C311/20 , C07D213/71 , A61K31/4418
CPC分类号： C07C311/29 , C07C311/20 , C07C317/14 , C07C2602/10 , C07D213/34
摘要： The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein R1-R4 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐和酯，其中R 1 -R 4在详细描述和权利要求书中定义。 此外，本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂，可用于治疗与该受体相关的疾病和病症如哮喘。
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公开(公告)号：US20090149466A1
公开(公告)日：2009-06-11
申请号：US12328874
申请日：2008-12-05
IPC分类号： A61K31/513 , C07D403/04
CPC分类号： C07D239/47
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗诸如肥胖的疾病。
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