公开(公告)号：US20070049602A1

公开(公告)日：2007-03-01

申请号：US11420425

申请日：2006-05-25

申请人： Paul Hergenrother ,  Karson Putt ,  Grace Chen ,  Jennifer Pearson

发明人： Paul Hergenrother ,  Karson Putt ,  Grace Chen ,  Jennifer Pearson

IPC分类号： A61K31/495 ,  C07D241/04

CPC分类号： A61K31/495 ,  A61P35/00 ,  C07D295/15 ,  C12Q1/37 ,  G01N33/502 ,  G01N33/574 ,  G01N2333/96466 ,  G01N2510/00 ,  G01N2800/52

摘要： Compounds and related methods for synthesis, and the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed in connection with modification of procaspases such as procaspase-3, and particular embodiments are capable of direct activation of procaspase-3 and procaspase-7 to the effector forms of caspase-3 and caspase-7. Procaspase-3 levels can vary among cancer cell types; several types have relatively high levels and can have increased susceptibility to chemotherapy by compounds and methods herein. Therapeutic applications are relevant for a variety of cancer conditions and cell types, e.g. breast, lung, brain, colon, renal, adrenal, melanoma, and others.

摘要翻译： 公开了合成的化合物和相关方法，以及化合物在治疗中用于治疗癌症和选择性诱导细胞凋亡的用途。 公开了与胱天蛋白酶（procaspase）如procaspase-3的修饰有关的化合物，特定实施方案能够将胱天蛋白酶-3和胱天蛋白酶-7的效应物形式直接活化于胱天蛋白酶-3和胱天蛋白酶-7。 Procaspase-3水平可能因癌细胞类型而异; 几种类型具有相对较高的水平，并且可以通过本文的化合物和方法增加对化学疗法的易感性。 治疗应用与各种癌症状况和细胞类型有关，例如， 乳腺，肺，脑，结肠，肾，肾上腺，黑素瘤等。

公开(公告)号：USD875137S1

公开(公告)日：2020-02-11

申请号：US29666823

申请日：2018-10-16

申请人： Jennifer F. Bickerstaff ,  Shawna Marie Kirby ,  Kylie Tuosto ,  John Davidge ,  Danilo Bangit ,  Rajeev Goonewardene ,  Scott Hang Ng ,  Clayton Yan ,  Jasmine Woo ,  Hetal A. Soni ,  Grace Chen

设计人： Jennifer F. Bickerstaff ,  Shawna Marie Kirby ,  Kylie Tuosto ,  John Davidge ,  Danilo Bangit ,  Rajeev Goonewardene ,  Scott Hang Ng ,  Clayton Yan ,  Jasmine Woo ,  Hetal A. Soni ,  Grace Chen

公开(公告)号：US08744971B2

公开(公告)日：2014-06-03

申请号：US13220312

申请日：2011-08-29

申请人： Grace Chen ,  Jennifer Woldman

发明人： Grace Chen ,  Jennifer Woldman

IPC分类号： G06F21/00 ,  G06Q20/00

CPC分类号： G06Q30/0225 ,  G06Q30/0207

摘要： Information regarding a redemption code may include at least one parameter associated with certain redeemable content. Requests may be received from a user. The request may concern access to redeemable content associated with a redemption code. The applicability of parameters is determined as is the redeemable content associated with the identified parameter. The user may then be granted access to the identified redeemable content. The determination of applicable parameters may include identifying an associated modification and applying the modification to the redemption code in order to identify the redeemable content.

摘要翻译： 关于兑换代码的信息可以包括与某些可兑换内容相关联的至少一个参数。 可以从用户接收请求。 该请求可能涉及访问与兑换代码相关联的可兑换内容。 确定参数的适用性以及与所识别的参数相关联的可兑换内容。 然后可以向用户授予对所识别的可兑换内容的访问权限。 确定适用的参数可以包括识别相关联的修改并将修改应用于兑换代码，以便识别可兑换内容。

公开(公告)号：US08370494B1

公开(公告)日：2013-02-05

申请号：US12558697

申请日：2009-09-14

申请人： Grace Chen ,  Bob Schatz ,  Shardul Divatia

发明人： Grace Chen ,  Bob Schatz ,  Shardul Divatia

IPC分类号： G06F15/177 ,  G06F15/16 ,  G06F13/28 ,  G06F11/00

CPC分类号： G06F11/004 ,  G06F11/2023

摘要： Systems, methods, apparatus and software can implement a flexible I/O fence mechanism framework allowing clustered computer systems to conveniently use one or more I/O fencing techniques. Various different fencing techniques can be used, and fencing mechanism can be customized.

公开(公告)号：US20140030788A1

公开(公告)日：2014-01-30

申请号：US13812934

申请日：2011-07-29

申请人： Grace Chen ,  Fabio Fachin ,  Mehmet Toner ,  Brian Wardle

发明人： Grace Chen ,  Fabio Fachin ,  Mehmet Toner ,  Brian Wardle

IPC分类号： C12M1/12

CPC分类号： C12M25/16 ,  B01L3/502707 ,  B01L3/502746 ,  B01L3/502761 ,  B01L2200/0652 ,  B01L2200/0668 ,  B01L2300/0896 ,  B01L2400/086 ,  G01N15/1404 ,  G01N2015/1413

摘要： The devices and systems described herein include one or more fluid paths, e.g., channels, and one or more selectively permeable obstacles arranged in the fluid path(s), each including a plurality of aligned nanostructures, e.g., nanotubes or nanorods, defining an outer surface of the obstacle and an internal network of voids. The obstacle(s) can further include binding moieties applied to the outer surface and/or to the surfaces of the individual nanostructures within the obstacle(s). The devices can be manufactured by forming the dense groupings of nanostructures to extend outwards and upwards from a substrate; forming a fluidic channel, bonding the fluidic channel to the substrate; and optionally applying binding moieties to the obstacles. The devices can be used to manipulate cells within fluid samples.

摘要翻译： 本文描述的装置和系统包括一个或多个流体路径，例如通道和布置在流体路径中的一个或多个选择性渗透的障碍物，每个包括多个对准的纳米结构，例如纳米管或纳米棒，限定外部 障碍物的表面和内部的空隙网络。 障碍物还可包括施加到障碍物内的各个纳米结构的外表面和/或表面的结合部分。 可以通过形成从衬底向外和向上延伸的纳米结构的致密分组来制造器件; 形成流体通道，将流体通道粘合到基底上; 并且任选地将结合部分施加到障碍物上。 这些装置可用于操纵流体样品中的细胞。

公开(公告)号：US20130295588A1

公开(公告)日：2013-11-07

申请号：US13884580

申请日：2011-11-09

申请人： Nicholas Watkins ,  Rashid Bashir ,  William Rodriguez ,  Xuanhong Cheng ,  Mehmet Toner ,  Grace Chen ,  Aaron Oppenheimer

发明人： Nicholas Watkins ,  Rashid Bashir ,  William Rodriguez ,  Xuanhong Cheng ,  Mehmet Toner ,  Grace Chen ,  Aaron Oppenheimer

IPC分类号： G01N27/02

CPC分类号： G01N27/02 ,  B01L2200/0652 ,  B01L2300/0877 ,  C12M41/36 ,  G01N15/12 ,  G01N15/1245 ,  G01N33/56972 ,  G01N2015/1006 ,  G01N2015/1486

摘要： This disclosure relates to methods and devices to count particles of interest, such as cells. The methods include obtaining a fluid sample that may contain particles of interest; counting all types of particles in a portion of the sample using a first electrical differential counter to generate a first total; removing any particles of interest from the portion of the fluid sample; counting any particles remaining in the portion of the fluid sample using a second electrical differential counter after the particles of interest are removed to generate a second total; and calculating a number of particles of interest originally in the fluid sample by subtracting the second total from the first total, wherein the difference is the number of particles of interest in the sample. These methods and related devices can be used, for example, to produce a robust, inexpensive diagnostic kit for CD4+ T cell counting in whole blood samples.

摘要翻译： 本公开涉及计算感兴趣的颗粒例如细胞的方法和装置。 所述方法包括获得可含有感兴趣的颗粒的流体样品; 使用第一电差分计数器对样品的一部分中的所有类型的颗粒计数以产生第一总数; 从流体样品的一部分去除任何感兴趣的颗粒; 在除去感兴趣的颗粒之后，使用第二电差速器计数器在流体样品的部分中剩余的任何颗粒计数以产生第二总数; 以及通过从第一个总计中减去第二个总计来计算最初在流体样品中的感兴趣的颗粒数，其中差值是样品中的感兴趣的颗粒数。 这些方法和相关装置可用于例如在全血样品中产生用于CD4 + T细胞计数的稳健且廉价的诊断试剂盒。

公开(公告)号：US20130055409A1

公开(公告)日：2013-02-28

申请号：US13220312

申请日：2011-08-29

申请人： Grace Chen ,  Jennifer Woldman

发明人： Grace Chen ,  Jennifer Woldman

IPC分类号： G06F21/24

CPC分类号： G06Q30/0225 ,  G06Q30/0207

摘要： Information regarding a redemption code may include at least one parameter associated with certain redeemable content. Requests may be received from a user. The request may concern access to redeemable content associated with a redemption code. The applicability of parameters is determined as is the redeemable content associated with the identified parameter. The user may then be granted access to the identified redeemable content. The determination of applicable parameters may include identifying an associated modification and applying the modification to the redemption code in order to identify the redeemable content.

摘要翻译： 关于兑换代码的信息可以包括与某些可兑换内容相关联的至少一个参数。 可以从用户接收请求。 该请求可能涉及访问与兑换代码相关联的可兑换内容。 确定参数的适用性以及与所识别的参数相关联的可兑换内容。 然后可以向用户授予对所识别的可兑换内容的访问权限。 确定适用的参数可以包括识别相关联的修改并将修改应用于兑换代码，以便识别可兑换内容。

公开(公告)号：US20130054689A1

公开(公告)日：2013-02-28

申请号：US13220315

申请日：2011-08-29

申请人： Jennifer Woldman ,  Cindy De Guzman ,  Grace Chen

发明人： Jennifer Woldman ,  Cindy De Guzman ,  Grace Chen

IPC分类号： G06F15/16

CPC分类号： H04N21/25866 ,  H04N21/4781 ,  H04N21/4784 ,  H04N21/6581

摘要： Information regarding a user may be indicative of membership in a group. Such information may be maintained for every user associated with a particular system or title. In instances, redeemable content may be offered exclusively to a group. Requests for such content may therefore be received and evaluated to determine whether the requesting user is a member of the particular group. The determination includes an evaluation of information associated with the requesting user. In some instances, the information associated with the requesting user is a user identifier that is indicative of the group membership, and the user identifier may be included in the request. If the user is indeed determined to be a member of the group, access to the redeemable content is granted. Alternatively, if the user is not determined to be a member of the group, access to the redeemable content is denied.

摘要翻译： 关于用户的信息可以指示组中的成员资格。 可以为与特定系统或标题相关联的每个用户维护这样的信息。 在实例中，可兑换内容可以专门提供给组。 因此，可以接收并评估对这些内容的请求以确定请求用户是否是特定组的成员。 确定包括对与请求用户相关联的信息的评估。 在一些情况下，与请求用户相关联的信息是指示组成员身份的用户标识符，并且用户标识符可以被包括在请求中。 如果确实确定用户是该组的成员，则授予对可兑换内容的访问权限。 或者，如果用户未被确定为该组的成员，则拒绝对可兑换内容的访问。

公开(公告)号：USD834058S1

公开(公告)日：2018-11-20

申请号：US29582706

申请日：2016-10-28

申请人： Xue Ding ,  Hetal A. Soni ,  Scott Hang Ng ,  Shawna Marie Kirby ,  Grace Chen

设计人： Xue Ding ,  Hetal A. Soni ,  Scott Hang Ng ,  Shawna Marie Kirby ,  Grace Chen

公开(公告)号：US09703207B1

公开(公告)日：2017-07-11

申请号：US13544480

申请日：2012-07-09

申请人： Daniel L. Cavan ,  Grace Chen

发明人： Daniel L. Cavan ,  Grace Chen

IPC分类号： G03B27/68 ,  G01N21/95 ,  G03F7/20

CPC分类号： G03F7/70275 ,  G01N21/8806 ,  G01N21/9501 ,  G03F7/70291 ,  G03F7/70516 ,  G03F7/7055

摘要： The present invention includes generating illumination, providing a spatial light modulator (SLM) configured to selectably illuminate one or more portions of a surface of a wafer using the generated illumination, receiving a sets of wafer pattern data indicative of one or more patterns of the wafer, translating the wafer along a direction, selectably controlling a pixel configuration of the SLM to control an illumination pattern on the surface of the wafer, a first pixel configuration illuminating a first set of regions of the wafer at an illumination level, an additional pixel configuration illuminating an additional set of regions at an additional illumination level, wherein a pixel pattern of the SLM based on the received sets of wafer pattern data is configured to move across a surface of the SLM synchronously with the pattern of the translated wafer, and detecting illumination from the surface of the wafer.