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    Preparation and use of magnesium amides
    4.
    发明授权
    Preparation and use of magnesium amides 有权
    制备和使用镁酰胺

    公开(公告)号：US08134005B2

    公开(公告)日：2012-03-13

    申请号：US12087351

    申请日：2007-01-18

    申请人： Paul Knochel ,  Arkady Krasovskiy ,  Valeria Krasovskaya ,  Christoph Josef Rohbogner ,  Giuliano Cesar Clososki

    发明人： Paul Knochel ,  Arkady Krasovskiy ,  Valeria Krasovskaya ,  Christoph Josef Rohbogner ,  Giuliano Cesar Clososki

    IPC分类号： C07D295/027 ,  C07D207/00 ,  C07F7/02 ,  C07C211/01

    CPC分类号： C07B49/00 ,  C07F3/003 ,  C07F3/02

    摘要： The present application relates to mixed Mg/Li amides of the general formula R1R2N—Mg(NR3R4)mX,.m zLiY (II) wherein R1, R2, R3, and R4 are, independently, selected from H, substituted or unsubstituted aryl or heteroaryl containing one or more heteroatoms, linear, branched or cyclic, substituted or unsubstituted alkyl, alkenyl, alkynyl, or silyl derivatives thereof; and R1 and R2 together, or R3 and R4 together can be part of a cyclic or polymeric structure; and wherein at least one of R1 and R2 and at least one of R3 and R is other than H; X and Y are, independently, selected from the group consisting of F; Cl; Br; I; CN; SCN; NCO; HaIOn, wherein n=3 or 4 and Hal is selected from Cl, Br and I; NO3; BF4; PF6; H; a carboxylate of the general formula RXCO2; an alcoholate of the general formula ORX; a thiolate of the general formula SRX; RXP(O)O2; or SCORX; or SCSRX; OnSRx, wherein n=2 or 3; or NOn, wherein n=2 or 3; and a derivative thereof; wherein Rx is a substituted or unsubstituted aryl or heteroaryl containing one or more heteroatoms, linear, branched or cyclic, substituted or unsubstituted alkyl, alkenyl, alkynyl, or derivatives thereof, or H; m is O or 1; and z>O; as well as a process for the preparation of the mixed Mg/Li amides and the use of these amides, e.g. as bases.

    摘要翻译： 本申请涉及通式为R 1 R 2 N-Mg（NR 3 R 4）m X，m z L i Y（II）的混合Mg / Li酰胺，其中R 1，R 2，R 3和R 4独立地选自H，取代或未取代的芳基或 含有一个或多个杂原子的杂芳基，其直链，支链或环状的取代或未取代的烷基，烯基，炔基或甲硅烷基衍生物; R 1和R 2一起，或者R 3和R 4一起可以是环状或聚合物结构的一部分; 并且其中R 1和R 2以及R 3和R R中的至少一个不是H; X和Y独立地选自F; Cl; Br; 一世; CN; SCN; NCO; 其中n = 3或4，Hal选自Cl，Br和I; NO3; BF4; PF6; H; 通式为RXCO2的羧酸酯; 通式ORX的醇化物; 通式SRX的硫醇盐; RXP（O）O2; 或SCORX; 或SCSRX; OnSRx，其中n = 2或3; 或NO n，其中n = 2或3; 及其衍生物; 其中Rx是取代或未取代的芳基或含有一个或多个杂原子的直链，支链或环状取代或未取代的烷基，烯基，炔基或衍生物，或H; m为O或1; 和z> O; 以及制备混合的Mg / Li酰胺的方法和这些酰胺的使用，例如。 作为基础。

    Preparation and Use of Magnesium Amides
    6.
    发明申请
    Preparation and Use of Magnesium Amides 有权
    制备和使用镁酰胺

    公开(公告)号：US20090176988A1

    公开(公告)日：2009-07-09

    申请号：US12087351

    申请日：2007-01-18

    申请人： Paul Knochel ,  Arkady Krasovskiy ,  Valeria Krasovskaya ,  Christoph Josef Rohbogner ,  Giuliano Cesar Clososki

    发明人： Paul Knochel ,  Arkady Krasovskiy ,  Valeria Krasovskaya ,  Christoph Josef Rohbogner ,  Giuliano Cesar Clososki

    IPC分类号： C07D211/06 ,  C07D403/02 ,  C07F7/02

    CPC分类号： C07B49/00 ,  C07F3/003 ,  C07F3/02

    摘要： The present application relates to mixed Mg/Li amides of the general formula R1R2N—Mg(NR3R4)mX,m zLiY (II) wherein R1, R2, R3, and R4 are, independently, selected from H, substituted or unsubstituted aryl or heteroaryl containing one or more heteroatoms, linear, branched or cyclic, substituted or unsubstituted alkyl, alkenyl, alkynyl, or silyl derivatives thereof; and R1 and R2 together, or R3 and R4 together can be part of a cyclic or polymeric structure; and wherein at least one of R1 and R2 and at least one of R3 and R is other than H; X and Y are, independently, selected from the group consisting of F; Cl; Br; I; CN; SCN; NCO; HalOn, wherein n=3 or 4 and Hal is selected from Cl, Br and I; NO3; BF4; PF6; H; a carboxylate of the general formula RXCO2; an alcoholate of the general formula ORX; a thiolate of the general formula SRX; RXP(O)O2; or SCORX; or SCSRX; OnSRx, wherein n=2 or 3; or NOn, wherein n=2 or 3; and a derivative thereof; wherein Rx is a substituted or unsubstituted aryl or heteroaryl containing one or more heteroatoms, linear, branched or cyclic, substituted or unsubstituted alkyl, alkenyl, alkynyl, or derivatives thereof, or H; m is O or 1; and z>O; as well as a process for the preparation of the mixed Mg/Li amides and the use of these amides, e.g. as bases.

    摘要翻译： 本申请涉及通式为R 1 R 2 N-Mg（NR 3 R 4）m X，m z L i Y（II）的混合Mg / Li酰胺，其中R 1，R 2，R 3和R 4独立地选自H，取代或未取代的芳基或杂芳基 含有一个或多个直链，支链或环状的取代或未取代的烷基，烯基，炔基或甲硅烷基衍生物的杂原子; R 1和R 2一起，或者R 3和R 4一起可以是环状或聚合物结构的一部分; 并且其中R 1和R 2以及R 3和R R中的至少一个不是H; X和Y独立地选自F; Cl; Br; 一世; CN; SCN; NCO; HalOn，其中n = 3或4，Hal选自Cl，Br和I; NO3; BF4; PF6; H; 通式为RXCO2的羧酸酯; 通式ORX的醇化物; 通式SRX的硫醇盐; RXP（O）O2; 或SCORX; 或SCSRX; OnSRx，其中n = 2或3; 或NO n，其中n = 2或3; 及其衍生物; 其中Rx是取代或未取代的芳基或含有一个或多个杂原子的直链，支链或环状取代或未取代的烷基，烯基，炔基或衍生物，或H; m为O或1; 和z> O; 以及制备混合的Mg / Li酰胺的方法和这些酰胺的使用，例如。 作为基础。

    Method of preparing organomagnesium compounds
    7.
    发明授权
    Method of preparing organomagnesium compounds 有权

    公开(公告)号：US07387751B2

    公开(公告)日：2008-06-17

    申请号：US11787974

    申请日：2007-04-18

    申请人： Paul Knochel ,  Arkady Krasovskiy

    发明人： Paul Knochel ,  Arkady Krasovskiy

    IPC分类号： C07F3/04

    CPC分类号： C07B49/00 ,  C07F3/02

    摘要： The present invention is directed to a reagent for use in the preparation of organomagnesium compounds as well as to a method of preparing such organomagnesium compounds. The present invention furthermore provides a method of preparing functionalized or unfunctionalized organic compounds as well as the use of the reagents of the present invention in the preparation of organometallic compounds and their reaction with electrophiles. Finally, the present invention is directed to the use of lithium salts—LiY in the preparation of organometallic compounds and their reactions with electrophiles and to an organometallic compound which is obtainable by the disclosed method.

    Method of preparing organomagnesium compounds
    8.
    发明授权
    Method of preparing organomagnesium compounds 有权
    制备有机镁化合物的方法

    公开(公告)号：US07384580B2

    公开(公告)日：2008-06-10

    申请号：US11097707

    申请日：2005-04-01

    申请人： Paul Knochel ,  Arkady Krasovskiy

    发明人： Paul Knochel ,  Arkady Krasovskiy

    IPC分类号： C07F3/04

    CPC分类号： C07B49/00 ,  C07F3/02

    摘要： The present invention is directed to a reagent for use in the preparation of organomagnesium compounds as well as to a method of preparing such organomagnesium compounds. The present invention furthermore provides a method of preparing functionalized or unfunctionalized organic compounds as well as the use of the reagents of the present invention in the preparation of organometallic compounds and their reaction with electrophiles. Finally, the present invention is directed to the use of lithium salts—LiY in the preparation of organometallic compounds and their reactions with electrophiles and to an organometallic compound which is obtainable by the disclosed method.

    摘要翻译： 本发明涉及用于制备有机镁化合物的试剂以及制备这种有机镁化合物的方法。 本发明还提供了制备官能化或未官能化的有机化合物的方法以及本发明的试剂在制备有机金属化合物中的用途及其与亲电体的反应。 最后，本发明涉及锂盐-LYY在制备有机金属化合物中的用途及其与亲电体的反应以及通过所公开的方法可获得的有机金属化合物。

    Method of preparing organomagnesium compounds
    9.
    发明申请
    Method of preparing organomagnesium compounds 有权
    制备有机镁化合物的方法

    公开(公告)号：US20070194468A1

    公开(公告)日：2007-08-23

    申请号：US11787974

    申请日：2007-04-18

    申请人： Paul Knochel ,  Arkady Krasovskiy

    发明人： Paul Knochel ,  Arkady Krasovskiy

    IPC分类号： C07F3/02

    CPC分类号： C07B49/00 ,  C07F3/02

    摘要： The present invention is directed to a reagent for use in the preparation of organomagnesium compounds as well as to a method of preparing such organomagnesium compounds. The present invention furthermore provides a method of preparing functionalized or unfunctionalized organic compounds as well as the use of the reagents of the present invention in the preparation of organometallic compounds and their reaction with electrophiles. Finally, the present invention is directed to the use of lithium salts—LiY in the preparation of organometallic compounds and their reactions with electrophiles and to an organometallic compound which is obtainable by the disclosed method.

    摘要翻译： 本发明涉及用于制备有机镁化合物的试剂以及制备这种有机镁化合物的方法。 本发明还提供了制备官能化或未官能化的有机化合物的方法以及本发明的试剂在制备有机金属化合物中的用途及其与亲电体的反应。 最后，本发明涉及锂盐-LYY在制备有机金属化合物中的用途及其与亲电体的反应以及通过所公开的方法可获得的有机金属化合物。