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    Methods for asymmetrical irradiation of a body cavity
    1.
    发明授权
    Methods for asymmetrical irradiation of a body cavity 有权
    体腔不对称照射方法

    公开(公告)号：US08636637B2

    公开(公告)日：2014-01-28

    申请号：US13571495

    申请日：2012-08-10

    申请人： Paul Lubock ,  Michael L. Jones ,  Frank R. Louw

    发明人： Paul Lubock ,  Michael L. Jones ,  Frank R. Louw

    IPC分类号： A61N5/00

    CPC分类号： A61N5/1014 ,  A61N5/1002 ,  A61N5/1015 ,  A61N2005/1003 ,  A61N2005/1004 ,  A61N2005/1005 ,  A61N2005/1018 ,  A61N2005/1024

    摘要： The disclosure describes devices and methods for asymmetrical irradiation at a body cavity or site, such as after removal of tissue, e.g. biopsy or cancer. One device includes a lumen which is off-set or off-settable from a longitudinal axis to increase the intensity of radiation received from a radiation source by a first tissue portion surrounding the body cavity and to reduce or minimize radiation received by a second tissue portion (e.g. healthy tissue) surrounding the body cavity.

    摘要翻译： 本公开描述了用于在体腔或部位不对称照射的装置和方法，例如在去除组织之后，例如， 活检或癌症。 一个装置包括从纵向轴线偏移或不可固定的内腔，以增加围绕体腔的第一组织部分从辐射源接收的辐射的强度，并且减少或最小化由第二组织部分接收的辐射 （例如健康组织）。

    Cavity-filling biopsy site markers
    2.
    发明授权
    Cavity-filling biopsy site markers 有权
    腔填充活检部位标记

    公开(公告)号：US08626270B2

    公开(公告)日：2014-01-07

    申请号：US13495408

    申请日：2012-06-13

    申请人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones

    发明人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones

    IPC分类号： A61B8/00 ,  A61B8/14 ,  A61B8/08 ,  A61B8/12

    CPC分类号： A61B8/481 ,  A61B6/12 ,  A61B8/0833 ,  A61B10/02 ,  A61B90/39 ,  A61B2017/00004 ,  A61B2090/3908 ,  A61B2090/392 ,  A61B2090/3925 ,  A61B2090/395 ,  A61B2090/3954 ,  A61B2090/3966 ,  A61B2090/3987 ,  A61B2090/3995 ,  A61K49/006 ,  A61K49/222 ,  A61M37/0069

    摘要： The invention provides materials, devices and methods for marking biopsy sites for a limited time. The biopsy-marking materials are ultrasound-detectable bio-resorbable powders, with powder particles typically between about 20 microns and about 800 microns in maximum dimension, more preferably between about 300 microns and about 500 microns. The powders may be formed of polymeric materials containing cavities sized between about 10 microns and about 500 microns, and may also contain binding agents, anesthetic agents, hemostatic agents, and radiopaque markers. Devices for delivering the powders include tubes configured to contain the powders and to fit within a biopsy cannula, the powders being ejected by action of a syringe. Systems may include a tube containing powder, and a syringe containing sterile saline. The tube may be configured to fit within a biopsy cannula such as a Mammotome® or SenoCor 360™ cannula.

    摘要翻译： 本发明提供用于在有限时间内标记活检部位的材料，装置和方法。 活检标记材料是可超声检测的生物可再吸收粉末，粉末颗粒通常在最大尺寸为约20微米至约800微米之间，更优选为约300微米至约500微米。 粉末可以由含有大约10微米至约500微米的空腔的聚合材料形成，并且还可以含有粘合剂，麻醉剂，止血剂和不透射线的标记物。 用于递送粉末的装置包括被配置为容纳粉末并且装配在活检插管内的管，粉末通过注射器的作用喷射。 系统可以包括含有粉末的管和含有无菌盐水的注射器。 管可以被配置成装配在活检插管内，例如Mammotome或SenoCor 360 TM插管。

    Marker or filler forming fluid
    3.
    发明授权
    Marker or filler forming fluid 有权
    标记或填料成型液

    公开(公告)号：US08447386B2

    公开(公告)日：2013-05-21

    申请号：US12967639

    申请日：2010-12-14

    申请人： Fred H. Burbank ,  Michael L. Jones ,  Frank Louw ,  Paul Lubock

    发明人： Fred H. Burbank ,  Michael L. Jones ,  Frank Louw ,  Paul Lubock

    IPC分类号： A61B6/00 ,  A61B10/00

    CPC分类号： A61B90/39 ,  A61B2090/3908 ,  A61B2090/3925 ,  A61B2090/3933 ,  A61B2090/3987 ,  A61K49/226

    摘要： A system for at least partially filling and marking a cavity at a site within a patient's body includes a marker delivery device having a chamber configured to contain a marking substance and having a mechanism configured to expel the marking substance. A quantity of the marking substance is contained within the chamber of the marker delivery device. The marking substance is configured to at least partially fill the cavity and form therein a porous bioabsorbable body. A delivery tube is coupled in fluid communication with the chamber of the marker delivery device. The delivery tube has a distal end with a discharge port through which the marking substance is expelled. A releasable remotely detectable distal tip is coupled to the distal end of the delivery tube and is configured to be released to remain within the porous bioabsorbable body within the cavity upon the formation thereof.

    摘要翻译： 一种用于至少部分地填充和标记患者体内的部位的空腔的系统包括标记物输送装置，其具有被配置为容纳标记物质并具有被构造成排出标记物质的机构的室。 标记物质的量被容纳在标记物输送装置的室内。 标记物质构造成至少部分地填充空腔并在其中形成多孔生物可吸收体。 输送管与标记物递送装置的腔室流体连通地联接。 输送管具有远端，其具有排出口，排出标记物质。 可释放的可远程检测的远侧末端联接到输送管的远端，并且构造成在其形成时被释放以保持在腔内的多孔生物可吸收体内。

    Method for maintaining access to a biopsy site
    4.
    发明授权
    Method for maintaining access to a biopsy site 有权
    维持进入活检部位的方法

    公开(公告)号：US08292794B2

    公开(公告)日：2012-10-23

    申请号：US13095304

    申请日：2011-04-27

    申请人： Paul Lubock ,  Michael L. Jones

    发明人： Paul Lubock ,  Michael L. Jones

    IPC分类号： A61N5/00

    CPC分类号： A61M29/02 ,  A61B10/0041 ,  A61B17/0218 ,  A61B90/02 ,  A61B2017/00557 ,  A61B2017/00796 ,  A61B2090/3908 ,  A61M25/10 ,  A61M29/00 ,  A61M2025/1095 ,  A61N5/1015

    摘要： A method for maintaining access to a biopsy site within a patient, includes forming a passageway from an opening in an exterior site on the patient to a desired location for a biopsy specimen within the patient; removing a tissue specimen from the desired location thereby leaving a biopsy cavity; providing a temporary catheter having an elongate shaft, a flexible proximal shaft section, and a distal shaft section having a cavity filling member thereon; inserting the cavity filling member on the distal shaft section into the biopsy cavity; inflating the cavity filling member after inserting the cavity filling member within the biopsy cavity, but before closing the opening, using the flexible proximal shaft section; placing the flexible proximal shaft section at an intracorporeal location; and closing the opening so as to seal the passageway.

    摘要翻译： 一种用于维持进入患者体内的活检部位的方法，包括从病人的外部位置的开口形成通道，以在患者体内用于活检标本的期望位置; 从所需位置移除组织标本，从而留下活检腔; 提供具有细长轴，柔性近轴部分和在其上具有空腔填充构件的远端轴部分的临时导管; 将所述空腔填充构件插入所述远端轴部分到所述活检腔中; 将空腔填充构件插入到活检腔内，但是在使用柔性近端轴段关闭开口之前使空腔填充构件膨胀; 将柔性近轴部分放置在体内位置; 并关闭开口以密封通道。

    Tissue irradiation
    5.
    发明授权
    Tissue irradiation 有权
    组织照射

    公开(公告)号：US08273006B2

    公开(公告)日：2012-09-25

    申请号：US12386100

    申请日：2009-04-14

    申请人： Paul Lubock ,  Michael L. Jones

    发明人： Paul Lubock ,  Michael L. Jones

    IPC分类号： A61N5/00

    CPC分类号： A61N5/1015 ,  A61B2017/3419 ,  A61N2005/1005

    摘要： Devices and methods are disclosed for treatment to tissue surrounding a body cavity or other intracorporeal site, such as after removal of tissue, e.g. cancer. Such a device includes a treatment location on a distal portion of the device with one or more radiation shielding components that partially encircle a radiation source at the treatment location to control emitted radiation from the radiation source. The device minimizes radiation damage to healthy tissue surrounding the body cavity or other site while irradiating tissue not shielded by the radiation shielding components. A device embodying features of the invention can include a sealing member at a location on a shaft of the device proximal to a treatment location to seal the passageway leading to the body cavity.

    摘要翻译： 公开了用于治疗围绕体腔或其他体内部位的组织的装置和方法，例如在去除组织后，例如， 癌症。 这种装置包括在装置的远端部分上的处理位置，其中一个或多个辐射屏蔽部件在处理位置部分地环绕辐射源以控制来自辐射源的辐射。 该装置最小化对体腔或其他部位周围的健康组织的辐射损伤，同时辐射未被辐射屏蔽部件屏蔽的组织。 体现本发明特征的装置可包括密封构件，该密封构件位于靠近处理位置的装置的轴上的位置处，以密封通向体腔的通道。

    Imageable biopsy site marker
    10.
    发明申请
    Imageable biopsy site marker 审中-公开
    可成像的活检部位标记

    公开(公告)号：US20090131825A1

    公开(公告)日：2009-05-21

    申请号：US12317100

    申请日：2008-12-18

    申请人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones ,  Nancy Forcier

    发明人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones ,  Nancy Forcier

    IPC分类号： A61B17/34

    CPC分类号： A61B90/39 ,  A61B10/02 ,  A61B2017/00004 ,  A61B2090/3788 ,  A61B2090/3908 ,  A61B2090/3925 ,  A61B2090/3929 ,  A61B2090/3933 ,  A61B2090/395 ,  A61B2090/3975 ,  A61B2090/3987 ,  A61B2090/3995 ,  A61K49/006 ,  A61M37/0069

    摘要： A biopsy site marker having at least one small marker body or pellet of bioresorbable material such as gelatin, collagen, polylactic acid, polyglycolic acid which has a radiopaque object, preferably with a non-biological configuration. The at least one bioresorbable body or pellet with a radiopaque object is deposited into the biopsy site, by a delivery device that includes an elongated tubular body with a piston slidable within the tubular body. One end of the tube is placed into the biopsy site. At least one but preferably several marker bodies or pellets are deposited sequentially into the biopsy site through the tube. At least the bioresorbable materials of the detectable markers remain present in sufficient quantity to permit detection and location of the biopsy site at a first time point (e.g., 2 weeks) after introduction but clear from the biopsy site or otherwise do not interfere with imaging of tissues adjacent the biopsy site at a second time point (e.g., 5-7 months) after introduction.

    摘要翻译： 活检部位标记物，其具有至少一个生物可再吸收材料的小标记体或颗粒，例如具有不透射线对象的明胶，胶原，聚乳酸，聚乙醇酸，优选具有非生物构型。 具有不透射线物体的至少一个生物可吸收体或丸粒通过包括细长管状体的递送装置沉积到活检部位中，所述细长管状体具有可在管状体内滑动的活塞。 将管的一端放入活检部位。 至少一个但优选几个标记体或丸粒通过管子依次沉积到活检部位。 至少可检测标记的生物可吸收材料保持足够的量，以允许在引入之后的第一时间点（例如2周）检测和定位活检部位，但是从活组织检查部位清除，否则不干扰成像 导入后的第二时间点（如5-7个月）附近的组织组织。