公开(公告)号：US07714276B2

公开(公告)日：2010-05-11

申请号：US11541380

申请日：2006-09-29

申请人： Paul Pevsner ,  Frederick Naftolin ,  Douglas C. Miller ,  Dean Hillman ,  Brian K. Stall ,  Steven M. Wishnie

发明人： Paul Pevsner ,  Frederick Naftolin ,  Douglas C. Miller ,  Dean Hillman ,  Brian K. Stall ,  Steven M. Wishnie

IPC分类号： B01D59/44

CPC分类号： G01N33/6851 ,  G01N2800/52 ,  H01J49/164

摘要： The present invention relates to the use of post source decay (PSD) or collision induced dissociation (CID) direct tissue (DT) MALDI-TOF or DT-MALDI-TOF-TOF mass spectrographic identification of biological molecules in a tissue or cellular sample without the need for further protein extraction. This method provides for studying cells or tissues by direct tissue MALDI (DT-MALDI), thereby substituting in situ protein release for further protein extraction. Mass/intensity data was processed with Mascot© software interrogation of the NCBI database. These results are proof of principle that DT-MALDI, combined with bioinformatics, can directly identify proteins in cells and tissues from their mass spectra.

摘要翻译： 本发明涉及在源于组织或细胞样品中的后源衰变（PSD）或碰撞诱导解离（CID）直接组织（DT）MALDI-TOF或DT-MALDI-TOF-TOF质谱图鉴定生物分子的用途，而没有 需要进一步的蛋白质提取。 该方法提供通过直接组织MALDI（DT-MALDI）研究细胞或组织，从而取代原位蛋白质释放进一步的蛋白质提取。 使用NCBI数据库的Mascot©软件询问处理质量/强度数据。 这些结果证明了DT-MALDI与生物信息学结合可以从其质谱中直接鉴定细胞和组织中的蛋白质的原理。

公开(公告)号：US20110062320A1

公开(公告)日：2011-03-17

申请号：US12799576

申请日：2010-04-27

申请人： Paul Pevsner ,  Frederick Naftolin ,  Douglas C. Miller ,  Dean Hillman ,  Brian K. Stall ,  Steven M. Wishnies

发明人： Paul Pevsner ,  Frederick Naftolin ,  Douglas C. Miller ,  Dean Hillman ,  Brian K. Stall ,  Steven M. Wishnies

IPC分类号： H01J49/00

CPC分类号： G01N33/6851 ,  G01N2800/52 ,  H01J49/164

摘要： The present invention relates to the use of post source decay (PSD) or collision induced dissociation (CID) direct tissue (DT) MALDI-TOF or DT-MALDI-TOF-TOF mass spectrographic identification of biological molecules in a tissue or cellular sample without the need for further protein extraction. This method provides for studying cells or tissues by direct tissue MALDI (DT-MALDI), thereby substituting in situ protein release for further protein extraction. Mass/intensity data was processed with Mascot© software interrogation of the NCBI database. These results are proof of principle that DT-MALDI, combined with bioinformatics, can directly identify proteins in cells and tissues from their mass spectra.

摘要翻译： 本发明涉及在源于组织或细胞样品中的后源衰变（PSD）或碰撞诱导解离（CID）直接组织（DT）MALDI-TOF或DT-MALDI-TOF-TOF质谱图鉴定生物分子的用途，而没有 需要进一步的蛋白质提取。 该方法提供通过直接组织MALDI（DT-MALDI）研究细胞或组织，从而取代原位蛋白质释放进一步的蛋白质提取。 使用NCBI数据库的Mascot©软件询问处理质量/强度数据。 这些结果证明了DT-MALDI与生物信息学结合可以从其质谱中直接鉴定细胞和组织中的蛋白质的原理。

公开(公告)号：US08525104B2

公开(公告)日：2013-09-03

申请号：US12799576

申请日：2010-04-27

申请人： Paul Pevsner ,  Frederick Naftolin ,  Douglas C. Miller ,  Dean Hillman ,  Brian K. Stall ,  Steven M. Wishnies

发明人： Paul Pevsner ,  Frederick Naftolin ,  Douglas C. Miller ,  Dean Hillman ,  Brian K. Stall ,  Steven M. Wishnies

IPC分类号： B01D59/44 ,  H01J49/00 ,  H01J49/40

CPC分类号： G01N33/6851 ,  G01N2800/52 ,  H01J49/164

摘要： The present invention relates to the use of post source decay (PSD) or collision induced dissociation (CID) direct tissue (DT) MALDI-TOF or DT-MALDI-TOF-TOF mass spectrographic identification of biological molecules in a tissue or cellular sample without the need for further protein extraction. This method provides for studying cells or tissues by direct tissue MALDI (DT-MALDI), thereby substituting in situ protein release for further protein extraction. Mass/intensity data was processed with Mascot© software interrogation of the NCBI database. These results are proof of principle that DT-MALDI, combined with bioinformatics, can directly identify proteins in cells and tissues from their mass spectra.

摘要翻译： 本发明涉及在源于组织或细胞样品中的后源衰变（PSD）或碰撞诱导解离（CID）直接组织（DT）MALDI-TOF或DT-MALDI-TOF-TOF质谱图鉴定生物分子的用途，而没有 需要进一步的蛋白质提取。 该方法提供通过直接组织MALDI（DT-MALDI）研究细胞或组织，从而取代原位蛋白质释放进一步的蛋白质提取。 使用NCBI数据库的Mascot©软件询问处理质量/强度数据。 这些结果证明了DT-MALDI与生物信息学结合可以从其质谱中直接鉴定细胞和组织中的蛋白质的原理。

公开(公告)号：US6120086A

公开(公告)日：2000-09-19

申请号：US300192

申请日：1999-04-27

申请人： Douglas C. Miller

发明人： Douglas C. Miller

IPC分类号： B60J3/02 ,  B60J3/00

CPC分类号： B60J3/0278

摘要： A sun visor assembly includes first and second core halves foldable along a common edge to form an outboard cavity. One of the first and second core halves includes a retaining assembly. A cover material is configured for covering the first and second core halves, and includes at least one slit formed therethrough. A support pin assembly includes at least one snap foot insertable through the slit for engagement with the retaining assembly to secure the support pin assembly within the outboard cavity and to secure the cover material to the first and second core halves. A method for forming a sun visor assembly is also provided.

摘要翻译： 遮阳板组件包括沿公共边缘可折叠以形成外侧空腔的第一和第二半部半部。 第一和第二核心半部之一包括保持组件。 覆盖材料构造成用于覆盖第一和第二半部，并且包括形成在其中的至少一个狭缝。 支撑销组件包括至少一个可插入通过狭缝的卡扣脚，用于与保持组件接合以将支撑销组件固定在外侧空腔内并且将盖材料固定到第一和第二半部。 还提供了一种用于形成遮阳板组件的方法。

公开(公告)号：US6076947A

公开(公告)日：2000-06-20

申请号：US141060

申请日：1998-08-27

申请人： Douglas C. Miller

发明人： Douglas C. Miller

IPC分类号： B60J3/02 ,  B60Q3/02 ,  H01C10/44 ,  F21V23/04

CPC分类号： B60Q3/0226 ,  B60J3/0282 ,  H01C10/44

摘要： A visor with an illuminated vanity assembly comprising a base with a closable cover. A dimmer switch is provided on the base for controlling the light output of the illuminated vanity assembly. The dimmer switch comprises a slidable switch electrically coupling a light source contact and a resistor whereby the sliding of the switch relative to the resistor changes the resistance in the circuit to control the light output from the light source.

摘要翻译： 具有照明梳妆台组件的面罩包括具有可封闭盖的基座。 在基座上设有调光开关，用于控制照明的梳妆台组件的光输出。 调光器开关包括电耦合光源触点和电阻器的滑动开关，由此开关相对于电阻器的滑动改变电路中的电阻以控制来自光源的光输出。

公开(公告)号：US5570780A

公开(公告)日：1996-11-05

申请号：US423215

申请日：1995-04-17

申请人： Douglas C. Miller

发明人： Douglas C. Miller

IPC分类号： A45C13/02 ,  A45C13/36 ,  G06F1/16 ,  B65D85/68 ,  B65D81/05

CPC分类号： A45C13/36 ,  A45C13/021 ,  G06F1/1628

摘要： A carrying case for a portable computer or other instrument requiring protection from injury during transport includes a body defining an interior recess, a lid for closing the recess, a bladder assembly in the recess including cushioning bladders and a cushioning and displacement bladder at the bottom of the recess and a sheath overlying the bladder. Insertion of an instrument into the recess collapses the cushioning and displacement bladder to pressurize all of the bladders in the assembly to engage and protect the computer from injury due to inertial shocks. The lid includes an insertion member which engages the computer when the lid is closed to move the computer to the final inserted position and increase the pressure in the bladder assembly.

摘要翻译： 用于便携式计算机或其他仪器的便携式计算机或其他仪器在运输过程中需要保护不受伤害，包括限定内部凹槽的主体，用于关闭凹槽的盖子，包括缓冲气囊的凹槽中的气囊组件和位于底部的缓冲和移动气囊 凹槽和覆盖膀胱的护套。 将仪器插入凹槽中，使缓冲和移动的气囊压缩，以对组件中的所有气囊进行加压，从而接合和保护计算机免受惯性冲击造成的伤害。 盖子包括插入构件，当盖子关闭时与计算机接合以将计算机移动到最终插入位置并增加气囊组件中的压力。

公开(公告)号：US07980636B2

公开(公告)日：2011-07-19

申请号：US11655736

申请日：2007-01-19

申请人： Douglas C. Miller ,  Joshua D. Miller

发明人： Douglas C. Miller ,  Joshua D. Miller

IPC分类号： B60P1/56

CPC分类号： B60P1/56

摘要： An automated gate control system for a vehicle with a load carrying portion capable of carrying a load of material selectively distributable through a gate comprises a driver-accessible control module and a gate actuating mechanism. The driver-accessible control mechanism is positionable within reach of a driver of the vehicle. The gate actuating mechanism is controllably linked to and responsive to control signals from the driver-accessible control module to open and to close the gate to distribute material through the gate as desired. As a result, the driver need not exit the vehicle to move the gate before, after or during a material distribution operation.

摘要翻译： 一种用于具有载荷部分的车辆的自动门控制系统，其能够承载通过门选择性地分配的材料的载荷，包括驾驶员可接近的控制模块和门致动机构。 驾驶员可接近的控制机构可定位在车辆驾驶员的距离内。 闸门致动机构可控制地链接到并响应于来自驾驶员可访问的控制模块的控制信号，以打开和关闭门以根据需要将材料分配通过门。 结果，驾驶员不必在物料分配操作之前，之后或期间离开车辆移动门。

公开(公告)号：US5031950A

公开(公告)日：1991-07-16

申请号：US570864

申请日：1990-08-22

申请人： Douglas C. Miller

发明人： Douglas C. Miller

IPC分类号： B60J3/02

CPC分类号： B60J3/0278

摘要： A mechanism for attaching an outer fabric covering to a plastic shell is provided wherein inner and outer walls integrally formed on the inner periphery of a lower shell half define a channel and a locking wall integrally formed on the inner periphery of an upper shell half locks the covering in the channel when the shell is closed. The attachment mechanism secures the covering to prevent the covering from working loose during normal operation of the sunvisor. The mechanism further includes a peripheral lip integrally formed with the locking wall. The covering is secured between the peripheral lip and a free end portion of the outer wall. The lip has a curved outer surface for receiving one free edge portion of the covering thereon. The outer wall also has a curved outer surface for receiving another free edge portion of the covering thereon. The curved outer surfaces of the outer wall and the lip at least partially define a curved outer surface of the shell when closed.

摘要翻译： 提供了一种将外部织物覆盖物附接到塑料外壳的机构，其中一体地形成在下壳体半部的内周上的内壁和外壁限定了通道，并且一体地形成在上壳半部的内周上的锁定壁锁定 当壳体关闭时，在通道中覆盖。 安装机构固定覆盖物，以防止遮阳罩正常工作时遮盖物松动。 该机构还包括与锁定壁一体形成的外围唇缘。 覆盖件固定在周缘和外壁的自由端部分之间。 唇缘具有弯曲的外表面，用于接收其上的覆盖物的一个自由边缘部分。 外壁还具有弯曲的外表面，用于接收其上的覆盖件的另一自由边缘部分。 当封闭时，外壁和唇缘的弯曲外表面至少部分地限定外壳的弯曲外表面。

公开(公告)号：US08703949B2

公开(公告)日：2014-04-22

申请号：US13196921

申请日：2011-08-03

申请人： Subo Liao ,  Peter X. Wang ,  David W. Berberich ,  Douglas C. Miller

发明人： Subo Liao ,  Peter X. Wang ,  David W. Berberich ,  Douglas C. Miller

IPC分类号： C07D489/00 ,  C07D221/22 ,  C07D221/28 ,  A61K31/44 ,  C07D211/00 ,  C07D213/00 ,  C07D215/00 ,  C07D217/00 ,  C07D219/00 ,  C07D221/00 ,  C07D471/00 ,  C07D491/00 ,  C07D498/00 ,  C07D513/00 ,  C07D515/00 ,  C07D489/08

CPC分类号： C07D489/02

摘要： The present invention provides processes for the preparation of N-alkyl morphinans without the isolation of nor-morphinan intermediates. In particular, the invention provides tandem hydrolysis/alkylation reactions for the synthesis of N-alkyl morphinans.

摘要翻译： 本发明提供了在不分离去甲吗喃中间体的情况下制备N-烷基吗啡喃的方法。 特别地，本发明提供了用于合成N-烷基吗啡喃的串联水解/烷基化反应。

公开(公告)号：US20110204203A1

公开(公告)日：2011-08-25

申请号：US12711143

申请日：2010-02-23

申请人： Douglas C. Miller

发明人： Douglas C. Miller

IPC分类号： F16M11/08 ,  F16M13/02

CPC分类号： B60Q1/18 ,  B60Q1/0483 ,  B60Q1/122 ,  B60Q2300/122 ,  Y10T74/1836

摘要： A steerable vehicle lighting system includes a steerable platform assembly and a control assembly. The steerable platform assembly has a body adapted to be mounted to a vehicle, a platform adapted to receive a payload and adapted to rotate with respect to the body, an actuator at least partially placed in the body, and an actuator rod rotatably mated to the actuator and rotatably mated to the platform. A rotation of the actuator rotates the platform. The control assembly includes a first wheel adapted to be placed on a rotating portion of a steering apparatus, a transducer adapted to be mated to a stationary portion of the steering apparatus, a second wheel mated to a rotatable portion of the transducer and adapted to be rotated by the first wheel, and an elastic member that elastically urges the transducer and the second wheel towards the first wheel.

摘要翻译： 可操纵的车辆照明系统包括可操纵的平台组件和控制组件。 可转向平台组件具有适于安装到车辆的主体，适于接收有效载荷并适于相对于主体旋转的平台，至少部分地放置在主体中的致动器以及可旋转地配合到主体的致动器杆 执行器并可旋转地配合到平台。 致动器的旋转使平台旋转。 控制组件包括适于放置在转向装置的旋转部分上的第一轮，适于与转向装置的固定部分配合的换能器，与转换器的可旋转部分配合的第二轮， 由第一轮旋转，弹性部件弹性地将换能器和第二轮朝向第一轮推压。