公开(公告)号：US5130231A

公开(公告)日：1992-07-14

申请号：US364893

申请日：1989-06-12

申请人： Paul R. Kennedy ,  Ernest C. Adams ,  William E. Woenke

发明人： Paul R. Kennedy ,  Ernest C. Adams ,  William E. Woenke

IPC分类号： G01N31/22 ,  B01D37/00 ,  B01D61/14 ,  B01D71/00 ,  B01D71/76 ,  C12Q1/00 ,  C12Q1/20 ,  C12Q1/26 ,  C12Q1/28 ,  C12Q1/44 ,  C12Q1/54 ,  C12Q1/58 ,  C12Q1/60 ,  C12Q1/62 ,  G01N33/00 ,  G01N33/48 ,  G01N33/49 ,  G01N33/50 ,  G01N33/52

CPC分类号： C12Q1/26 ,  C12Q1/28 ,  C12Q1/58 ,  G01N33/5002 ,  G01N33/52 ,  C12Q2326/12 ,  Y10S435/805 ,  Y10T436/255

摘要： Single or multiple blood plasma component concentrations are measured by a disposable stick having one or more blood plasma component reactive areas covered by a semipermeable membrane which is permeable by blood plasma or serum components and impermeable by blood cellular and particulate matter. A second overlay may be superposed with the semipermeable membrane over the reactive areas to receive a blood sample and meter and distribute that sample uniformly to the semipermeable membrane which in turn passes the plasma components uniformly to the reactive areas. The overlays are subsequently separable from the reactive area to remove the cellular components and particulate matter and expose the reactive areas for inspection by, for example, color comparison to standardized charts.

摘要翻译： 通过一次性棒测量单次或多次血浆成分浓度，其具有由半透膜覆盖的一个或多个血浆组分反应性区域，所述半透膜可由血浆或血清成分渗透并且可通过血细胞和颗粒物质渗透。 第二覆盖层可以与反应性区域上的半透膜叠加以接收血液样品并测量并将该样品均匀分布到半透膜，该半透膜又使等离子体组分均匀地传递到反应性区域。 覆盖层随后可与反应区域分离，以去除细胞成分和颗粒物质，并通过例如与标准化图表的颜色比较来暴露反应区域进行检查。

公开(公告)号：US4839296A

公开(公告)日：1989-06-13

申请号：US788793

申请日：1985-10-18

申请人： Paul R. Kennedy ,  Ernest C. Adams ,  William E. Woenker

发明人： Paul R. Kennedy ,  Ernest C. Adams ,  William E. Woenker

IPC分类号： G01N31/22 ,  B01D37/00 ,  B01D61/14 ,  B01D71/00 ,  B01D71/76 ,  C12Q1/00 ,  C12Q1/20 ,  C12Q1/26 ,  C12Q1/28 ,  C12Q1/44 ,  C12Q1/54 ,  C12Q1/58 ,  C12Q1/60 ,  C12Q1/62 ,  G01N33/00 ,  G01N33/48 ,  G01N33/49 ,  G01N33/50 ,  G01N33/52

CPC分类号： C12Q1/26 ,  C12Q1/28 ,  C12Q1/58 ,  G01N33/5002 ,  G01N33/52 ,  C12Q2326/12 ,  Y10S435/805 ,  Y10T436/255

摘要： Single or multiple blood plasma component concentrations are measured by a disposable stick having one or more blood plasma component reactive areas covered by a semipermeable membrane which is permeable by blood plasma or serum components and inpermeable by blood cellular and particulate matter. A second overlap may be superposed with the semipermeable membrane over the reactive areas to receive a blood sample and meter and distribute that sample uniformly to the semipermeable membrane which in turn passes the plasma components uniformly to the reactive areas. The overlays are subsequently separable from the reactive area to remove the cellular components and particulate matter and expose the reactive areas for inspection by, for example, color comparison to standardized charts.

摘要翻译： 单次或多次血浆成分浓度通过一次性棒测量，其具有由半透膜覆盖的一个或多个血浆组分反应性区域，其可由血浆或血清成分渗透并且不能通过血细胞和颗粒物质渗透。 第二重叠可以与反应性区域上的半透膜叠加以接收血液样品并测量并将该样品均匀分布到半透膜，该半透膜又使等离子体组分均匀地传递到反应性区域。 覆盖层随后可与反应区域分离，以去除细胞成分和颗粒物质，并通过例如与标准化图表的颜色比较来暴露反应区域进行检查。

公开(公告)号：US4786596A

公开(公告)日：1988-11-22

申请号：US703335

申请日：1985-02-20

申请人： Ernest C. Adams

发明人： Ernest C. Adams

IPC分类号： C12Q1/26 ,  G01N33/52 ,  G01N33/98 ,  C12Q1/28

CPC分类号： C12Q1/26 ,  G01N33/525 ,  G01N33/98 ,  Y10S435/805 ,  Y10S436/90 ,  Y10S436/904 ,  Y10T436/204165

摘要： Ethyl alcohol test strip fabricating and use techniques for testing an individual's saliva to determine his sobriety are disclosed. The test strips employ an alcohol oxidase, Peroxidase and an hydrogen donor indicator such as Tetraalkylbenzidine in a carrier matrix supported on the strip with the alcohol oxidase functioning as a catalyst to convert any ethanol present along with ambient oxygen to acetaldehyde and hydrogen peroxide. The peroxidase function as catalyst to induce a color change in the hydrogen donor and convert the hydrogen peroxide to water. The method of fabricating the test strip involves multiple steps of reagent application and hot air drying.

摘要翻译： 公开了用于测试个人唾液以确定他的清醒度的乙醇测试条的制造和使用技术。 测试条在负载在条带上的载体基质中使用醇氧化酶，过氧化物酶和氢供体指示剂，例如四烷基联苯胺，醇氧化酶用作催化剂，以将存在的任何乙醇与环境氧转化为乙醛和过氧化氢。 过氧化物酶起催化剂的作用，引起氢供体中的颜色变化并将过氧化氢转化为水。 制造测试条的方法涉及试剂应用和热空气干燥的多个步骤。

公开(公告)号：US5166051A

公开(公告)日：1992-11-24

申请号：US564631

申请日：1990-08-08

申请人： Yvonne M. Killeen ,  Ernest C. Adams ,  Karen R. Mason

发明人： Yvonne M. Killeen ,  Ernest C. Adams ,  Karen R. Mason

IPC分类号： G01N33/52 ,  G01N33/543

CPC分类号： G01N33/521 ,  G01N33/54366 ,  Y10S435/969 ,  Y10S435/97 ,  Y10S435/975 ,  Y10S436/805

摘要： A diagnostic test strip for chemically determining whole blood analytes comprises a support, a porous detection zone membrane affixed to the support, and an overlay membrane affixed to the support and in overlying and continuous contact with the detection zone membrane. The overlay membrane has a crenating agent for the exclusion of whole red blood cells from the pores of the detection zone membrane.

摘要翻译： 用于化学测定全血分析物的诊断测试条包括支持体，固定在支撑体上的多孔检测区膜，以及附着在支撑体上并覆盖并与检测区膜连续接触的覆盖膜。 覆盖膜具有用于从检测区膜的孔排除整个红细胞的渐渗剂。

公开(公告)号：US4542103A

公开(公告)日：1985-09-17

申请号：US552482

申请日：1983-11-16

申请人： Ernest C. Adams

发明人： Ernest C. Adams

IPC分类号： G01N33/543 ,  G01N33/54

CPC分类号： G01N33/54313

摘要： A method for determining the amount of IgG present in a neonatal foal or calf or in the colostrum of a dam or cow. The method involves contacting a body fluid sample with biologically inert latex particles, measuring the amount of agglutination which occurs, and determining the amount of IgG present. The latex particles are diluted to a final concentration of from about 0.25 to 2.0 percent (w/v) at a pH of from about 7.5 to 9.0 with a buffer. The body fluid is diluted to a range of from 0.01:5 parts to 0.01:2160 parts, v/v basis, at a pH of from about 7.5 to 9.0.

摘要翻译： 用于确定存在于新生儿驹或小腿中或存在于大坝或母牛初乳中的IgG的量的方法。 该方法包括使体液样品与生物惰性胶乳颗粒接触，测量发生的凝集的量，并确定存在的IgG的量。 用缓冲液将胶乳颗粒在约7.5至9.0的pH下稀释至约0.25至2.0％（w / v）的终浓度。 将体液以约7.5至9.0的pH稀释至0.01:5份至0.01:2160份，v / v的范围。