公开(公告)号：US20060253705A1

公开(公告)日：2006-11-09

申请号：US11123778

申请日：2005-05-06

申请人： Paul Roberts ,  Laura Benofsky ,  William Holt ,  Leslie Johnson ,  Bryan Willman ,  Madeline Bryant

发明人： Paul Roberts ,  Laura Benofsky ,  William Holt ,  Leslie Johnson ,  Bryan Willman ,  Madeline Bryant

IPC分类号： H04L9/00

CPC分类号： G06F21/52 ,  G06F21/445 ,  G06F21/6209

摘要： Access to an authentication image may be protected so that only authenticated processes have access to the image. The image can be displayed to authenticate a User Interface (UI) to a computer user. The image indicates the UI can be trusted. If the image is not displayed, it may be that an application UI is “spoofed” to trick a user into providing sensitive information. Additionally, a large variety of different images can be used as authentication images, so spoofing one image be recognized by most users. A set of original images may be provided, along with image modification processes which can generate a large number of variations. Techniques for authenticating UIs in a virtual machine context are provided. A secure attention sequence is also provided, which allows users to test whether processes running on a computer are authenticated.

摘要翻译： 可以保护对认证图像的访问，使得只有经过身份验证的进程才能访问图像。 可以显示图像以向用户验证用户界面（UI）。 图像表示UI可以被信任。 如果图像不显示，那么应用程序UI可能会“欺骗”欺骗用户提供敏感信息。 另外，可以使用大量不同的图像作为认证图像，因此欺骗一个图像被大多数用户识别。 可以提供一组原始图像以及可以产生大量变化的图像修改处理。 提供了用于在虚拟机上下文中验证UI的技术。 还提供了一个安全的关注序列，允许用户测试在计算机上运行的进程是否进行身份验证。

公开(公告)号：US20060253706A1

公开(公告)日：2006-11-09

申请号：US11123779

申请日：2005-05-06

申请人： Paul Roberts ,  Laura Benofsky ,  William Holt ,  Leslie Johnson ,  Madeline Bryant ,  Nicholas Nussbaum

发明人： Paul Roberts ,  Laura Benofsky ,  William Holt ,  Leslie Johnson ,  Madeline Bryant ,  Nicholas Nussbaum

IPC分类号： H04L9/00

CPC分类号： G06F21/42 ,  G06F21/52 ,  G06F21/6209

摘要： Access to an authentication image may be protected so that only authenticated processes have access to the image. The image can be displayed to authenticate a User Interface (UI) to a computer user. The image indicates the UI can be trusted. If the image is not displayed, it may be that an application UI is “spoofed” to trick a user into providing sensitive information. Additionally, a large variety of different images can be used as authentication images, so spoofing one image be recognized by most users. A set of original images may be provided, along with image modification processes which can generate a large number of variations. Techniques for authenticating UI's in a virtual machine context are provided. A secure attention sequence is also provided, which allows users to test whether processes running on a computer are authenticated.

摘要翻译： 可以保护对认证图像的访问，使得只有经过身份验证的进程才能访问图像。 可以显示图像以向用户验证用户界面（UI）。 图像表示UI可以被信任。 如果图像不显示，那么应用程序UI可能会“欺骗”欺骗用户提供敏感信息。 另外，可以使用大量不同的图像作为认证图像，因此欺骗一个图像被大多数用户识别。 可以提供一组原始图像以及可以产生大量变化的图像修改处理。 提供了在虚拟机环境中验证UI的技术。 还提供了一个安全的关注序列，允许用户测试在计算机上运行的进程是否进行身份验证。

公开(公告)号：US20060225127A1

公开(公告)日：2006-10-05

申请号：US11097712

申请日：2005-04-01

申请人： Paul Roberts ,  Laura Benofsky ,  William Holt ,  Leslie Johnson ,  Madeline Bryant ,  Nicholas Nussbaum

发明人： Paul Roberts ,  Laura Benofsky ,  William Holt ,  Leslie Johnson ,  Madeline Bryant ,  Nicholas Nussbaum

IPC分类号： H04L9/32

CPC分类号： G06F21/57 ,  G06F21/82 ,  G06F2221/031

摘要： Access to an authentication image may be protected so that only authenticated processes have access to the image. The image can be displayed to authenticate a User Interface (UI) to a computer user. The image indicates the UI can be trusted. If the image is not displayed, it may be that an application UI is “spoofed” to trick a user into providing sensitive information. Additionally, a large variety of different images can be used as authentication images, so spoofing one image be recognized by most users. A set of original images may be provided, along with image modification processes which can generate a large number of variations. Techniques for authenticating UIs in a virtual machine context are provided. A secure attention sequence is also provided, which allows users to test whether processes running on a computer are authenticated.

摘要翻译： 可以保护对认证图像的访问，使得只有经过身份验证的进程才能访问图像。 可以显示图像以向用户验证用户界面（UI）。 图像表示UI可以被信任。 如果图像不显示，那么应用程序UI可能会“欺骗”欺骗用户提供敏感信息。 另外，可以使用大量不同的图像作为认证图像，因此欺骗一个图像被大多数用户识别。 可以提供一组原始图像以及可以产生大量变化的图像修改处理。 提供了用于在虚拟机上下文中验证UI的技术。 还提供了一个安全的关注序列，允许用户测试在计算机上运行的进程是否进行身份验证。

公开(公告)号：US20240351413A1

公开(公告)日：2024-10-24

申请号：US18138540

申请日：2023-04-24

申请人： Leslie Johnson

发明人： Leslie Johnson

IPC分类号： B60J11/08

CPC分类号： B60J11/08

摘要： A windshield protective device for protecting a windshield of a towed vehicle includes a panel, which has a size and a shape that are complementary to a windshield of a vehicle. The panel is resiliently flexible so that the panel is bendable to conform to contours of the windshield. A plurality of webbing straps is attached to a front face of the panel, with each webbing strap extending between and past opposed sides of the panel. The webbing straps thus are extendable around the windshield and into a passenger area of the vehicle. Fasteners are attached to each opposed end of each webbing strap. The fasteners are mutually couplable to secure the panel in a covering position upon the windshield, wherein the panel protects the windshield from damage and soiling.

公开(公告)号：US08669349B2

公开(公告)日：2014-03-11

申请号：US12933882

申请日：2009-03-25

申请人： Leslie Johnson ,  Ling Huang

发明人： Leslie Johnson ,  Ling Huang

IPC分类号： C07K16/46 ,  A61K39/395 ,  C07H21/04

CPC分类号： C07K16/28 ,  C07K16/2803 ,  C07K2317/24 ,  C07K2317/56

摘要： This invention relates to chimeric and humanized antibodies that specifically bind the BCR complex, and particularly chimeric and humanized antibodies to the BCR complex. The invention also relates to methods of using the antibodies and compositions comprising them in the diagnosis, prognosis and therapy of diseases such as cancer, autoimmune diseases, inflammatory disorders, and infectious disease.

摘要翻译： 本发明涉及特异性结合BCR复合物的嵌合和人源化抗体，特别是涉及BCR复合物的嵌合和人源化抗体。 本发明还涉及将抗体及其组合物用于诊断，预后和治疗诸如癌症，自身免疫性疾病，炎症性疾病和感染性疾病的疾病的方法。

公开(公告)号：US20080044417A1

公开(公告)日：2008-02-21

申请号：US11754015

申请日：2007-05-25

申请人： Leslie Johnson ,  Ling Huang

发明人： Leslie Johnson ,  Ling Huang

IPC分类号： A61K39/395 ,  A61P43/00 ,  C07H21/04 ,  C07K16/18 ,  C12N15/00 ,  C12N5/06 ,  C12P21/04 ,  G01N33/564

CPC分类号： A61K39/39 ,  A61K2039/505 ,  A61K2039/55516 ,  C07K16/283 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/52 ,  G01N33/564 ,  G01N33/6893 ,  G01N2800/24

摘要： The present invention relates to humanized FcγRIIB antibodies, fragments, and variants thereof that bind human FcγRIIB with a greater affinity than said antibody binds FcγRIIA. The invention encompasses the use of the humanized antibodies of the invention for the treatment of any disease related to loss of balance of Fc receptor mediated signaling, such as cancer, autoimmune and inflammatory disease. The invention provides methods of enhancing the therapeutic effect of therapeutic antibodies by administering the humanized antibodies of the invention to enhance the effector function of the therapeutic antibodies. The invention also provides methods of enhancing the efficacy of a vaccine composition by administering the humanized antibodies of the invention. The invention encompasses methods for treating an autoimmune disease and methods for elimination of cancer cells that express FcγRIIB.

摘要翻译： 本发明涉及以与抗体结合FcγRIIA更大的亲和力结合人FcγRIIB的人源化FcγRIIB抗体，其片段和变体。 本发明包括本发明的人源化抗体用于治疗与Fc受体介导的信号传导的平衡丧失有关的任何疾病（例如癌症，自身免疫性和炎症性疾病）的用途。 本发明提供了通过施用本发明的人源化抗体来增强治疗性抗体的治疗效果以增强治疗性抗体的效应子功能的方法。 本发明还提供了通过施用本发明的人源化抗体来增强疫苗组合物的功效的方法。 本发明包括治疗自身免疫疾病的方法和用于消除表达FcγRIIB的癌细胞的方法。

公开(公告)号：US20070037216A1

公开(公告)日：2007-02-15

申请号：US11503399

申请日：2006-08-10

申请人： Leslie Johnson ,  Ling Huang

发明人： Leslie Johnson ,  Ling Huang

IPC分类号： C40B30/06 ,  C40B50/06 ,  C12P21/06 ,  C07H21/04 ,  C12N1/21 ,  C12N5/08 ,  C12N5/06 ,  C12N15/74 ,  C07K16/18

CPC分类号： C07K16/00 ,  A01K2267/01 ,  C07K16/283 ,  C07K2317/10 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2319/30 ,  C12N7/00 ,  C12N15/8509 ,  C12N2795/14043

摘要： The present invention provides a dual expression vector, and methods for its use, for the expression and secretion of a full-length polypeptide of interest in eukaryotic cells, and a soluble domain or fragment of the polypeptide in bacteria. When expressed in bacteria, transcription from a bacterial promoter within a first intron and termination at the stop codon in a second intron results in expression of a fragment of the polypeptide, e.g., a Fab fragment, whereas in mammalian cells, splicing removes the bacterial regulatory sequences located in the two introns and generates the mammalian signal sequence, allowing expression of the full-length polypeptide, e.g., IgG heavy or light chain polypeptide. The dual expression vector system of the invention can be used to select and screen for new monoclonal antibodies, as well as to optimize monoclonal antibodies for binding to antigenic molecules of interest.

摘要翻译： 本发明提供双重表达载体及其用于在真核细胞中表达和分泌全长多肽的方法，以及细菌中多肽的可溶性结构域或片段。 当在细菌中表达时，来自第一内含子内的细菌启动子的转录和终止密码子在第二内含子中终止导致多肽片段的表达，例如Fab片段，而在哺乳动物细胞中，剪接除去细菌调节 位于两个内含子中的序列并产生哺乳动物信号序列，允许表达全长多肽，例如IgG重链或轻链多肽。 本发明的双表达载体系统可用于选择和筛选新的单克隆抗体，以及优化用于结合感兴趣的抗原分子的单克隆抗体。

公开(公告)号：US20060198840A1

公开(公告)日：2006-09-07

申请号：US11397328

申请日：2006-04-03

申请人： William Dall'Acqua ,  Leslie Johnson ,  Elizabeth Ward

发明人： William Dall'Acqua ,  Leslie Johnson ,  Elizabeth Ward

IPC分类号： A61K39/395 ,  C07K16/44

CPC分类号： C07K16/283 ,  A61K38/00 ,  A61K39/00 ,  A61K47/48507 ,  A61K47/6835 ,  A61K49/0002 ,  A61K49/0004 ,  A61K2039/505 ,  C07K2/00 ,  C07K14/70503 ,  C07K16/00 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/53 ,  C07K2317/94 ,  C07K2319/00 ,  C07K2319/30 ,  Y10S435/81

摘要： The present invention provides molecules, including IgGs, non-IgG immunoglobulins, proteins and non-protein agents, that have increased in vivo half-lives due to the presence of an IgG constant domain, or a portion thereof that binds the FcRn, having one or more amino acid modifications that increase the affinity of the constant domain or fragment for FcRn. Such proteins and molecules with increased half-lives have the advantage that smaller amounts and or less frequent dosing is required in the therapeutic, prophylactic or diagnostic use of such molecules.

公开(公告)号：US20050142145A1

公开(公告)日：2005-06-30

申请号：US11062080

申请日：2005-02-18

申请人： Theresa Wizemann ,  Scott Koenig ,  Leslie Johnson

发明人： Theresa Wizemann ,  Scott Koenig ,  Leslie Johnson

IPC分类号： C12N15/09 ,  A61K39/00 ,  A61K39/09 ,  A61K39/395 ,  A61K39/40 ,  A61P31/04 ,  A61P37/04 ,  C07K14/315 ,  C07K16/12 ,  A61K39/02 ,  C07H21/04 ,  C12N9/52

CPC分类号： C07K14/3156 ,  A61K39/00

摘要： The present invention provides bacterial immunogenic agents for administration to humans and non-human animals to stimulate an immune response. It particularly relates to the vaccination of mammalian species with pneumococcal derived polypeptides that include an alpha helix but exclude a choline binding region as a mechanism for stimulating production of antibodies that protect the vaccine recipient against infection by pathogenic bacterial species. In another aspect the invention provides antibodies against such proteins and protein complexes that may be used as diagnositics and/or as protective/treatment agents for pathogenic bacterial species.

摘要翻译： 本发明提供用于给予人和非人动物以刺激免疫应答的细菌免疫原性试剂。 其特别涉及哺乳动物物种与肺炎球菌来源的多肽的免疫接种，包括α螺旋，但不排除胆碱结合区域，作为刺激保护疫苗接受者免受病原菌种感染的抗体产生的机制。 在另一方面，本发明提供抗这种蛋白质和蛋白质复合物的抗体，其可以用作诊断和/或作为病原菌物种的保护/治疗剂。

公开(公告)号：US20080095766A1

公开(公告)日：2008-04-24

申请号：US11763434

申请日：2007-06-14

申请人： Scott Koenig ,  Ronald Wilder ,  Ezio Bonvini ,  Leslie Johnson ,  Stanley Pillemer

发明人： Scott Koenig ,  Ronald Wilder ,  Ezio Bonvini ,  Leslie Johnson ,  Stanley Pillemer

IPC分类号： A61K39/395 ,  A61P1/00 ,  A61P17/06 ,  A61P19/02 ,  A61P25/00 ,  A61P3/10 ,  A61P35/00 ,  A61P37/06

CPC分类号： C07K16/2809 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/545 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/71

摘要： The present invention provides methods of treating, preventing, slowing the progression of, or ameliorating the symptoms of T cell mediated immunological diseases, particularly autoimmune diseases (e.g., autoimmune diabetes (i.e. type 1 diabetes or insulin-dependent diabetes mellitus (IDDM)) and multiple sclerosis) through the use of anti-human CD3 antibodies. The antibodies of the invention of the invention are preferably used in low dose dosing regimens, chronic dosing regimens or regimens that involve redosing after a certain period of time. The methods of the invention provide for administration of antibodies that specifically bind the epsilon subunit within the human CD3 complex. Such antibodies modulate the T cell receptor/alloantigen interaction and, thus, regulate the T cell mediated cytotoxicity associated with autoimmune disorders. Additionally, the methods of the invention provide for use of anti-human CD3 antibodies modified such that they exhibit reduced or eliminated effector function and T cell activation as compared to non-modified anti-human CD3 antibodies.

摘要翻译： 本发明提供治疗，预防，减缓T细胞介导的免疫疾病，特别是自身免疫疾病（例如，自身免疫性糖尿病（即1型糖尿病或胰岛素依赖性糖尿病（IDDM））的症状的进展或改善的方法，以及 多发性硬化）通过使用抗人CD3抗体。 本发明的本发明的抗体优选用于低剂量给药方案，慢性给药方案或方案，其涉及经过一段时间后的再次给药。 本发明的方法提供了特异性结合人CD3复合物内的ε亚基的抗体的施用。 这种抗体调节T细胞受体/同种异体抗原相互作用，因此调节与自身免疫疾病相关的T细胞介导的细胞毒性。 此外，本发明的方法提供使用经修饰的抗人CD3抗体，使得与未修饰的抗人CD3抗体相比，它们表现出降低或消除的效应子功能和T细胞活化。