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公开(公告)号：US4387076A
公开(公告)日：1983-06-07
申请号：US311221
申请日：1981-10-14
CPC分类号： G01N35/1079 , G01N35/02
摘要： A sample feeding arrangement which receives sealed sample tubes, moves them one at at time to a seal piercing and sample aspiration station, and then discharges the used tubes. This sample feeding arrangement is mounted inside a sample analyzer of the type which previously had operated semiautomatically. Receipt of a sample tube at the infeed station of this feeding arrangement initiates the repositioning of the tube to an aspiration station, which thereat enables all other handling steps of the tube, sample aspiration, and the full system cycle of the analyzer.
摘要翻译： 一个样品进料装置，接收密封的样品管，将它们一次移动到密封穿刺和样品抽吸站，然后排出用过的管。 该样品进料装置安装在以前半自动操作的样品分析仪内部。 在该进料装置的进料站处接收样品管开始将管重新定位到抽吸站，这样可以实现管的所有其他处理步骤，样品抽吸和分析仪的完整系统循环。
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公开(公告)号：US4653719A
公开(公告)日：1987-03-31
申请号：US747426
申请日：1985-06-21
申请人： Pedro P. Cabrera , Glenn D. Talbot
发明人： Pedro P. Cabrera , Glenn D. Talbot
CPC分类号： F16K11/027 , A61M39/28
摘要： A molded flexible fluid conduit and a make/before break pinch valve including a slidably movable pressure member spring biased normally against said conduit in closed condition of the valve, said conduit including a pair of elongate longitudinal unitary purchase formations capable of cooperating with slots carried by the valve whereby the conduit forcibly is pulled or stretched in diametrically opposed directions upon actuation of the valve subsequent to periods of closure so as to force the conduit open to permit flow.
摘要翻译： 一种模制的柔性流体导管和制造/之前断开夹紧阀，包括在阀的闭合状态下通常抵靠所述导管偏压的可滑动移动的压力构件弹簧，所述导管包括一对伸长的纵向单一采购结构，能够与由 阀门，其中导管被强制地拉向或拉伸在径向相反的方向上，在阀门在关闭时间之后启动，以便迫使导管打开以允许流动。
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公开(公告)号：US06322752B1
公开(公告)日：2001-11-27
申请号：US09392161
申请日：1999-09-08
IPC分类号： B01L302
CPC分类号： G01N35/1097 , G01N35/10
摘要： A method and apparatus for aspirating and dispensing precise volumes of liquid, e.g. whole blood, comprises an aspiration probe or needle having an internal volume precisely equal to a desired volume to be dispensed, and a computer-controlled shear valve for trapping aspirated liquid inside the probe for subsequent dispensing. A liquid sensor positioned downstream of the shear valve cooperates with a liquid level sensor on the probe tip to assure that the probe lumen is filled with the aspirated liquid.
摘要翻译： 用于吸取和分配精确体积的液体的方法和装置，例如， 全血包括具有精确地等于要分配的期望体积的内部容积的抽吸探针或针，以及计算机控制的剪切阀，用于将吸入的液体捕获在探针内用于随后的分配。 定位在剪切阀下游的液体传感器与探针尖端上的液位传感器配合，以确保探针腔充满抽吸液体。
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公开(公告)号：US5255568A
公开(公告)日：1993-10-26
申请号：US965095
申请日：1992-10-22
CPC分类号： G01N35/1097 , G01N15/10 , Y10T436/2575
摘要： A method for sampling, metering and delivering precise microliter volume aliquots of a liquid blood sample to mixing and testing means of an electronic blood analysis system for analysis using a sampling and metering valve assembly in which is defined plural through fluid flow paths, one of the flow paths including a loop for metering and isolating a sample aliquot therein, the method comprising the steps of defining first and second dedicated passages within the valve assembly displaced one from the other and from the loop containing the isolated aliquot, introducing an inert gas to the loop to force the aliquot therein to said first dedicated passage at the displaced location thereof, placing the first and second dedicated passages in communicating relationship and introducing lyse reagent to the second dedicated passage to force the isolated aliquot from the first dedicated passage with the lyse reagent to a location exterior of the valve assembly without contaminating any flow paths which has been traversed by the liquid sample or a fluid other than the lyse reagent.
摘要翻译： 一种用于采样，计量和输送液体血液样本的精确微升体积等分试样以混合和测试电子血液分析系统的装置的方法，用于使用采样和计量阀组件进行分析，其中通过流体流动路径限定多个， 流动路径包括用于计量和分离其中的样品等分试样的循环，所述方法包括以下步骤：在所述阀组件内限定第一和第二专用通道，所述第一和第二专用通道从另一个和从包含所分离的等分试样的回路中移出，将惰性气体引入到 将其中的等分试样强制到其位移位置处的所述第一专用通道，将第一和第二专用通道置于连通关系中，并将裂解试剂引入第二专用通道，以迫使来自第一专用通道的分离试样与裂解试剂 到阀组件外部的位置，而不污染任何流动路径 s，其被液体样品或除裂解剂以外的流体所遍历。
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公开(公告)号：US4220621A
公开(公告)日：1980-09-02
申请号：US14306
申请日：1979-02-23
CPC分类号： G01N1/38
摘要： Improvements in a backwash system for diluting apparatus wherein a rinse solution is directed to and through a sample pick-up probe to a receptacle and therefrom to a waste depositary. Either the probe or the receptacle in turn is movable between a first uncoupled condition, along a predetermined or fixed path first to place the receptacle and the delivery end of the sample probe proximate, and second, to establish a fluid tight sealed coupling therebetween. The receptacle includes an entrance recess accommodating an apertured resilient insert which engages the delivery end of the probe to define the sealed coupling. A sensing switch is employed to assure that the rinse solution will not be dispensed as backwash unless the sealed coupling is known to have been established. The sensing switch can be presented in the path of the movable object, the switch being actuated when the movable object has completed its movement to establish the sealed coupling between the receptacle and the delivery end of the sample probe. The switch is scanned to ascertain its state and unless actuated, backwash is prevented.Either both, one or the other of said receptacle and probe are mounted for singular or cooperative combined translatory movement, simultaneously or sequentially.
摘要翻译： 用于稀释装置的反冲洗系统的改进，其中冲洗溶液被引导并通过样品拾取探针到容器，并从其中到达废物保藏库。 探头或插座依次可以在第一非连接状态之间沿着预定或固定的路径移动，以将接收器和样品探针的输送端放置在靠近处，并且在第二非连接状态之间建立流体密封的耦合。 该容器包括容纳有弹性插入件的入口凹槽，其与探针的输送端接合以限定密封的联接件。 使用感测开关来确保冲洗溶液不会作为反冲洗分配，除非已知建立了密封联接。 感测开关可以呈现在可移动物体的路径中，当可移动物体已经完成其运动以建立容器和样品探测器的输送端之间的密封耦合时，开关被致动。 扫描开关以确定其状态，除非启动，否则防止反洗。 所述插座和探针中的一个或另一个安装成用于单一或协作的组合平移运动，同时或顺序地安装。
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公开(公告)号：US5158751A
公开(公告)日：1992-10-27
申请号：US626936
申请日：1990-12-13
CPC分类号： G01N35/1097 , G01N15/10
摘要： A liquid metering and transfer valve assembly having the capability of metering, isolating, transfering and delivering precise microliter volume aliquots of a blood sample, from a source thereof, to mixing and testing chambers of an electronic blood analysis system for analysis, and further, carrying a loop for metering and isolating an additional sample aliquot within the valve assembly in the loop, a first dedicated passageway for introducing a first fluid to the loop to force the additional aliquot from its isolated location to a first dedicated portion of the valve assembly displaced from the loop and a second dedicated portion of the valve assembly to establish a flow path for introducing a lysing reagent to the first dedicated portion to force the additional aliquot from its displaced disposition, as a lyse reagent/aliquot mixture, to a selected additional mixing and testing chamber exterior of the valve assembly without contaminating any interior flow path traversed by a blood sample and associated diluent thereof within the valve assembly.
摘要翻译： 一种液体计量和转移阀组件，其具有计量，分离，转移和输送血液样品的精确微升体积等分试样从其来源到用于分析的电子血液分析系统的混合和测试室的能力，并且进一步携带 用于计量和隔离环路内的阀组件内的附加样品等分试样的回路，第一专用通道，用于将第一流体引入回路，以将附加的等分试样从其隔离位置推到阀组件的第一专用部分 循环和阀组件的第二专用部分，以建立用于将裂解试剂引入第一专用部分的流动路径，以将附加的等分试样从其置换的处置作为裂解试剂/等分试样混合物加到选定的附加混合物中， 阀组件的测试室外部，而不会污染由血液穿过的任何内部流动路径 其充分且相关的稀释剂在阀组件内。
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公开(公告)号：US4702889A
公开(公告)日：1987-10-27
申请号：US819381
申请日：1986-01-16
IPC分类号： G01N1/00 , B01L3/02 , B01L99/00 , F16K11/074 , G01N1/38 , G01N35/10 , G01N1/20 , F16K21/02 , F16K23/00
CPC分类号： G01N35/1097 , G01N1/38 , Y10T137/4259
摘要： A liquid diluting and transfer valve has disc like valve elements provided with faces frictionally engaged. The valve further includes passageways for passing both sample liquid and rinse liquid and a continuous groove formed in one of the respective faces. This continuous groove effectively isolates the passageway openings to the faces and is capable of blocking passage of leakage material along the face to the periphery of the engaged face.
摘要翻译： 液体稀释和转移阀具有带有摩擦接合的表面的盘状阀元件。 阀还包括用于通过样品液体和冲洗液体的通道和形成在各个面之一中的连续槽。 这种连续的沟槽有效地将通道开口隔离到面上，并且能够阻止泄漏材料沿面的通过到接合面的周边。
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公开(公告)号：US4152391A
公开(公告)日：1979-05-01
申请号：US861356
申请日：1977-12-16
申请人： Pedro P. Cabrera
发明人： Pedro P. Cabrera
IPC分类号： F16K11/074 , G01N1/00 , G01N1/14
CPC分类号： G01N35/1097
摘要： A liquid transfer valve assembly capable of measuring and transferring plural different volumes from a sample source to defined flow paths under the influence of pressurized fluid. The preferred valve assembly includes a pair of stationary outer disc members and a movable inner disc member sandwiched therebetween, their facing surfaces sealingly frictionally engaged. Each of the discs has a central axial passage arranged for mounting on a spindle, with the sandwiched disc having a radial pin entering its axial passage for cooperation with a slotted spindle, the rotation of the spindle rotating only said sandwiched disc relative between a pair of positions. The center disc carries at least a segmenting bore pair, at least one of the bores being a measuring passage and having a precise volume. A matching port pair is provided in each of the outer discs defining flow paths through the valve arranged selectively to be intercepted by said measuring bore of the segmenting bore pair. The center disc also carries at least one exterior sample loop sealingly fixedly secured thereto and communicating to passageways formed in the disc. A flow path also is defined in said center disc to communicate to the face of said disc opposite to the face from which the exterior sample loop extends, said flow path may take the form of an internal passageway formed interior of the center disc and opening to said opposite face, or, may take the form of a groove. Plural sets of ports are formed in one of the outer discs to establish flow paths communicating to the hollow loop member in one position of the valve and to the flow path in the other condition of the valve. The other outer disc includes a generally arcuate slot for accommodating the sample loop therethrough in assembled condition of the valve, the slot being generally arcuate but including a flat wall portion to accommodate the hollow loop during the movement thereof with movement of the center disc. The center disc is provided with a circumferential notch cooperating with a mounting post to limit the extent of movement of said disc between positions. Proper establishment of the respective flow paths in the two operating positions of the valve is assured. A second external hollow loop is described and is associated with a further flow path in the center disc. Likewise, associated port sets are formed in said other outer disc to establish communication to said second sample loop in one condition of the valve. Each of the loops are of precise internal volume; each serving to measure and to transfer its liquid segment of precise volume to a selected destination. The said further flow path is established as a gallery in the form of an arcuate groove.
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公开(公告)号：US4148859A
公开(公告)日：1979-04-10
申请号：US906235
申请日：1978-05-15
CPC分类号： G01N1/38
摘要： Improvements in a backwash system for diluting apparatus wherein a rinse solution is directed to the fluid transfer valve thereof and thence back to and through the sample pick-up probe to a receptacle and then to a waste depositary. The receptacle is mounted on a carrier, in turn mounted for movement in a track from a recessed condition, along a path directed first outward and then upward to engage the delivery end of the sample probe in a fluid tight sealed coupling. A plunger of an air cylinder effects the movement of the receptacle in the track. A vacuum operated switch is employed to assure that the rinse solution will not be dispensed as backwash unless the sealed coupling is made. Alternatively, a microswitch can be substituted for the vacuum operated switch and presented in the path of the carrier to be actuated when the carrier has moved sufficiently to establish the sealed coupling between the receptacle and the delivery end of the sample probe. In either instance, the switch is scanned to ascertain its state and unless actuated, backwash is prevented.
摘要翻译： 用于稀释装置的反冲洗系统的改进，其中冲洗溶液被引导到其流体转移阀，然后返回并通过样品拾取器探针到容器，然后返回到废物储存器。 容器安装在载体上，然后安装成沿着凹槽状态的轨道移动，沿着首先向外指向的路径，然后以流体密封的联接器接合样品探针的输送端。 气缸的柱塞影响容器在轨道中的运动。 使用真空操作开关来确保冲洗溶液不会作为反冲洗分配，除非制成密封连接。 或者，当载体已经充分移动以建立插座和样品探针的输送端之间的密封耦合时，微动开关可以代替真空操作的开关并呈现在待致动载体的路径中。 在任一情况下，扫描开关以确定其状态，除非被启动，否则防止回洗。
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公开(公告)号：US4896546A
公开(公告)日：1990-01-30
申请号：US296905
申请日：1989-01-11
CPC分类号： G01N1/38 , G01N35/1097 , G01N15/10
摘要： A rotary liquid metering and transfer valve assembly for a diluting system which includes a pair of stationary valve disc elements sandwiching a central, rotatable valve disc element, said disc elements being coaxially aligned and mounted on a spindle. One of the outer stationary elements has a first external loop secured thereto, said loop having a precise interior volume. An aspirator probe is secured to the other of said stationary elements. The central element has formed therein an axial segmenting passageway having a precise interior volume. A second external loop is secured to the center element. The second loop extends outwardly, preferably radially, of said element and has a precise interior volume. Appropriate interior passageways are provided in the outer elements for directing a liquid sample in a continuous path through the valve assembly, the path including the one segmenting passageway and the first and the second external loops. Additional interior passageways also are provided for coupling the valve assembly to sources of diluent and to exterior destinations. The central element is rotated to isolate the contents of the segmenting passageway and of the first and the second external loops and diluent is fed thereto to drive the isolated contents to said destinations. Only a single loading step is required to obtain three precise volumes of liquid sample. The valve assembly can be rinsed and continuous internals channels are provided for preventing any liquid from reaching the circumferential surface of the valve assembly.
摘要翻译： 一种用于稀释系统的旋转液体计量和转移阀组件，其包括夹持中心可旋转阀盘元件的一对固定阀盘元件，所述盘元件同轴对准并安装在主轴上。 外部固定元件中的一个具有固定到其上的第一外部环，所述环具有精确的内部容积。 抽吸器探针固定到另一个所述固定元件。 中心元件在其中形成有具有精确内部体积的轴向分段通道。 第二个外部环路固定到中心元件。 第二环向外延伸，优选径向延伸，并且具有精确的内部容积。 在外部元件中提供合适的内部通道，用于将液体样品引导通过阀组件的连续路径，路径包括一个分段通道以及第一和第二外部环路。 还提供了另外的内部通道，用于将阀组件连接到稀释剂源和外部目的地。 旋转中心元件以隔离分段通道和第一和第二外部回路的内容物，并且将稀释剂送入其中以将隔离的内容物驱动到所述目的地。 只需要一个单独的装载步骤来获得三个精确体积的液体样品。 可以冲洗阀组件，并且提供连续的内部通道用于防止任何液体到达阀组件的圆周表面。
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