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1.发明申请Novel synergistic combination of gemcitabine with P276-00 or P1446A in treatment of cancer 审中-公开吉西他滨与P276-00或P1446A的新型协同组合治疗癌症公开(公告)号：US20100152129A1
公开(公告)日：2010-06-17
申请号：US12653012
申请日：2009-12-07
申请人： Periyasamy Giridharan , Debarshi Chakrabarti , Amit Khanna , Urvi Ved , Asha Almeida , Somesh Sharma , Muralidhara Padigaru , Arun Balakrishnan
发明人： Periyasamy Giridharan , Debarshi Chakrabarti , Amit Khanna , Urvi Ved , Asha Almeida , Somesh Sharma , Muralidhara Padigaru , Arun Balakrishnan
IPC分类号： A61K31/7068 , C12Q1/68 , A61P35/00
CPC分类号： A61K31/7068 , A61K45/06 , A61K2300/00
摘要： Synergistic combinations of gemcitabine with P276-00 or P1446A and their use in the treatment of cancer are disclosed. The invention further describes novel and unique gene signatures comprising gene markers used to monitor the drug response in a subject treated with the said combinations.
摘要翻译： 公开了吉西他滨与P276-00或P1446A的协同组合及其在治疗癌症中的用途。 本发明还描述了包含用于监测用所述组合治疗的受试者中的药物反应的基因标记的新颖且唯一的基因特征。
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2.发明申请Novel synergistic combination of gemcitabine with P276-00 or P1446A in treatment of cancer 审中-公开吉西他滨与P276-00或P1446A的新型协同组合治疗癌症公开(公告)号：US20110312528A1
公开(公告)日：2011-12-22
申请号：US13157075
申请日：2011-06-09
申请人： Periyasamy Giridharan , Debarshi Chakrabarti , Amit Khanna , Urvi Ved , Asha Almeida , Somesh Sharma , Muralidhara Padigaru , Arun Balakrishnan
发明人： Periyasamy Giridharan , Debarshi Chakrabarti , Amit Khanna , Urvi Ved , Asha Almeida , Somesh Sharma , Muralidhara Padigaru , Arun Balakrishnan
CPC分类号： A61K31/7068 , A61K45/06 , A61K2300/00
摘要： Synergistic combinations of gemcitabine with P276-00 or P1446A and their use in the treatment of cancer are disclosed. The invention further describes novel and unique gene signatures comprising gene markers used to monitor the drug response in a subject treated with the said combinations.
摘要翻译： 公开了吉西他滨与P276-00或P1446A的协同组合及其在治疗癌症中的用途。 本发明还描述了包含用于监测用所述组合治疗的受试者中的药物反应的基因标记的新颖且唯一的基因特征。
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3.发明申请METHOD OF USE OF EPIREGULIN PROTEIN AND NUCLEIC ACID ENCODING THE SAME IN INFLAMMATORY CONDITIONS 审中-公开使用EPIREGULIN蛋白质和将其编码在炎症条件下的核酸的方法公开(公告)号：US20100168008A1
公开(公告)日：2010-07-01
申请号：US12515492
申请日：2007-11-19
申请人： Muralidhara Padigaru , Somesh Sharma , Arvind Thakkar , Anandharajan Rathina Sabapathy , Sapna Hasit Parikh , Usha Ghosh
发明人： Muralidhara Padigaru , Somesh Sharma , Arvind Thakkar , Anandharajan Rathina Sabapathy , Sapna Hasit Parikh , Usha Ghosh
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： The present invention relates to nucleotide and protein sequences of epiregulin and epiregulin like proteins and nucleotides and methods employing them as a drug response marker in inflammatory conditions. The invention also provides epiregulin protein for treatment of inflammatory conditions like psoriasis and rheumatoid arthritis alone or in combination with one or more anti-inflammatory compounds.
摘要翻译： 本发明涉及上皮蛋白和外调蛋白样蛋白和核苷酸的核苷酸和蛋白质序列以及在炎症状态下使用它们作为药物反应标记的方法。 本发明还提供了用于治疗单独的银屑病和类风湿性关节炎或与一种或多种抗炎化合物组合的炎性病症的外用蛋白。
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公开(公告)号：US07109000B2
公开(公告)日：2006-09-19
申请号：US10087684
申请日：2002-03-01
申请人： Shlomit R. Edinger , John R. MacDougall , Isabelle Millet , Karen Ellerman , David J. Stone , Valerie Gerlach , William M. Grosse , John P. Alsobrook, II , Denise M. Lepley , Daniel K. Rieger , Catherine E. Burgess , Stacie J. Casman , Kimberly A. Spytek , Ferenc L. Boldog , Li Li , Muralidhara Padigaru , Vishnu Mishra , Meera Patturajan , Suresh G. Shenoy , Luca Rastelli , Velizar T. Tchernev , Corine A. M. Vernet , Bryan D. Zerhusen , Uriel M. Malyankar , Xiaojia Guo , Charles E. Miller , Esha A. Gangolli
发明人： Shlomit R. Edinger , John R. MacDougall , Isabelle Millet , Karen Ellerman , David J. Stone , Valerie Gerlach , William M. Grosse , John P. Alsobrook, II , Denise M. Lepley , Daniel K. Rieger , Catherine E. Burgess , Stacie J. Casman , Kimberly A. Spytek , Ferenc L. Boldog , Li Li , Muralidhara Padigaru , Vishnu Mishra , Meera Patturajan , Suresh G. Shenoy , Luca Rastelli , Velizar T. Tchernev , Corine A. M. Vernet , Bryan D. Zerhusen , Uriel M. Malyankar , Xiaojia Guo , Charles E. Miller , Esha A. Gangolli
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K2039/505 , C07K14/705
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：US20060063200A1
公开(公告)日：2006-03-23
申请号：US11051724
申请日：2005-02-02
申请人： David Anderson , Jason Baumgartner , Ferenc Boldog , Stacie Casman , Shlomit Edinger , Esha Gangolli , Valerie Gerlach , Linda Gorman , Xiaojia Guo , Tord Hjalt , Ramesh Kekuda , Li Li , John MacDougall , Uriel Malyankar , Isabelle Millet , Muralidhara Padigaru , Meera Patturajan , Carol Pena , Luca Rastelli , Richard Shimkets , David Stone , Kimberly Spytek , Corine Vernet , Edward Voss , Bryan Zerhusen
发明人： David Anderson , Jason Baumgartner , Ferenc Boldog , Stacie Casman , Shlomit Edinger , Esha Gangolli , Valerie Gerlach , Linda Gorman , Xiaojia Guo , Tord Hjalt , Ramesh Kekuda , Li Li , John MacDougall , Uriel Malyankar , Isabelle Millet , Muralidhara Padigaru , Meera Patturajan , Carol Pena , Luca Rastelli , Richard Shimkets , David Stone , Kimberly Spytek , Corine Vernet , Edward Voss , Bryan Zerhusen
IPC分类号： G01N33/53 , C07H21/04 , C12P21/06 , C07K14/705 , C07K16/18
摘要： Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：US20060009634A1
公开(公告)日：2006-01-12
申请号：US11019711
申请日：2004-12-21
申请人： Ramesh Kekuda , John Alsobrook , Velizar Tchernev , Xiaohong Liu , Kimberly Spytek , Meera Patturajan , William Grosse , Denise Lepley , Catherine Burgess , Corine Vernet , Li Li , Linda Gorman , Shlomit Edinger , Paul Sciore , Karen Ellerman , Uriel Malyankar , Mark Rothenberg , David Stone , Ferenc Boldog , Xiaojia Guo , Suresh Shenoy , David Anderson , Muralidhara Padigaru , Raymond Taupier , Charles Miller , Andrew Eisen
发明人： Ramesh Kekuda , John Alsobrook , Velizar Tchernev , Xiaohong Liu , Kimberly Spytek , Meera Patturajan , William Grosse , Denise Lepley , Catherine Burgess , Corine Vernet , Li Li , Linda Gorman , Shlomit Edinger , Paul Sciore , Karen Ellerman , Uriel Malyankar , Mark Rothenberg , David Stone , Ferenc Boldog , Xiaojia Guo , Suresh Shenoy , David Anderson , Muralidhara Padigaru , Raymond Taupier , Charles Miller , Andrew Eisen
IPC分类号： C07H21/04
CPC分类号： C07K14/47
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：US20050170380A1
公开(公告)日：2005-08-04
申请号：US10971479
申请日：2004-10-21
申请人： Elma Fernandes , Corine Vernet , Richard Shimkets , David Anderson , Muralidhara Padigaru , Ferenc Boldog , Li Li , Suresh Shenoy , Stacie Casman , Luca Rastelli
发明人： Elma Fernandes , Corine Vernet , Richard Shimkets , David Anderson , Muralidhara Padigaru , Ferenc Boldog , Li Li , Suresh Shenoy , Stacie Casman , Luca Rastelli
CPC分类号： C07K14/47 , A61K38/00 , C07K14/54 , C07K14/705 , C07K14/70571
摘要： The present invention provides novel isolated SECX polynucleotides and the membrane-associated or secreted polypeptides encoded by the SECX polynucleotides. Also provided are the antibodies that immunospecifically bind to a SECX polypeptide or any derivative, variant, mutant or fragment of the SECX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the SECX polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.
摘要翻译： 本发明提供新的分离的SECX多核苷酸和由SECX多核苷酸编码的膜相关或分泌的多肽。 还提供免疫特异性结合SECX多肽或SECX多肽，多核苷酸或抗体的任何衍生物，变体，突变体或片段的抗体。 本发明还提供了其中SECX多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态以及其它用途的方法。
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公开(公告)号：US20050049192A1
公开(公告)日：2005-03-03
申请号：US10635149
申请日：2003-08-06
申请人： Mei Zhong , Weizhen Ji , Xiaojia Guo , Daniel Rieger , Muralidhara Padigaru , Rachel Malcolm , Kimberly Spytek , David Anderson , Linda Gorman , Elina Catterton , John MacDougall , David Stone , Shlomit Edinger
发明人： Mei Zhong , Weizhen Ji , Xiaojia Guo , Daniel Rieger , Muralidhara Padigaru , Rachel Malcolm , Kimberly Spytek , David Anderson , Linda Gorman , Elina Catterton , John MacDougall , David Stone , Shlomit Edinger
CPC分类号： C07H21/04 , A61K38/00 , G01N33/68 , G01N2500/04 , G01N2500/10
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：US07122345B2
公开(公告)日：2006-10-17
申请号：US10042865
申请日：2002-01-09
申请人： Muralidhara Padigaru
发明人： Muralidhara Padigaru
CPC分类号： C07K14/47 , A61K38/00 , G01N33/574 , G01N2333/47
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译： 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。
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公开(公告)号：US20060111561A1
公开(公告)日：2006-05-25
申请号：US11217997
申请日：2005-08-31
申请人： Valerie Gerlach , Elma Fernandes , Richard Shimkets , Meera Patturajan , Vladimir Gusev , Stacie Navara , Velizar Tchernev , David Anderson , Xiaojia Guo , Luca Rastelli , Mei Zhong , Muralidhara Padigaru
发明人： Valerie Gerlach , Elma Fernandes , Richard Shimkets , Meera Patturajan , Vladimir Gusev , Stacie Navara , Velizar Tchernev , David Anderson , Xiaojia Guo , Luca Rastelli , Mei Zhong , Muralidhara Padigaru
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C07K14/475 , C07K16/22
摘要： Disclosed are novel proteins and nucleic acids encoding same. Also disclosed are vectors, host cells, antibodies and recombinant methods for producing the proteins and polynucleotides, as well as methods for using same.
摘要翻译： 公开了编码相同的新蛋白质和核酸。 还公开了用于产生蛋白质和多核苷酸的载体，宿主细胞，抗体和重组方法，以及使用它们的方法。
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